Staphylococcus epidermidis adalah bakteri pemicu peradangan pada jerawat.

Tanaman
yang telah banyak diteliti sebagai antibakteri dan dapat menghambat pertumbuhan
Staphylococcus epidermidis adalah daun binahong (Anredera cordifolia (Ten,) Steenis), oleh
karena itu daun binahong di ekstrak terlebih dahulu lalu di formulasi menjadi sediaan masker
gel peel-off dengan variasi konsentrasi film agent dan gelling agent. Tujuan penelitian ini
untuk memformulasi sediaan masker gel peel-off ekstrak daun binahong dan menguji sifat
fisik, stabilitas, dan aktivitasnya terhadap bakteri Staphylococcus epidermidis.
Ekstraksi daun binahong menggunakan metode maserasi dengan pelarut etanol 96%.
Variasi konsentrasi ekstrak yang digunakan adalah 10%, 15%, 20%, 25%, 30%. Sediaan
masker gel peel-off dari setiap formula di uji organoleptis, homogenitas, pH, viskositas, daya
sebar, dan daya lekat, stabilitasnya dan aktivitasnya terhadap bakteri Staphylococcus
epidermidis. Data yang dianalisa secara statistik dengan uji kolmogorov-smirnov dilanjutkan
dengan ANNOVA.
Hasil penelitian menyatakan bahwa ekstrak daun binahong dapat dibuat menjadi
sediaan masker gel peel-off dan mempunyai aktivitas antibakteri. Perbedaan konsentrasi basis
gelatin dan HPMC berpengaruh terhadap sifat fisik sediaan, stabilitas dan aktivitasnya.
Masker gel peel-off ekstrak daun binahong dengan berbagai konsentrasi basis memiliki
aktivitas antibakteri. Hasil uji statistik terhadap aktivitas antibakteri menyatakan bahwa
kelima formula memiliki aktivitas antibakteri yang berbeda secara signifikan.

Staphylococcus epidermidis is a bacterium that triggers inflammation of acne. Plant that have been
widely studied as antibacterial and can inhibit the growth of Staphylococcus epidermidis is binahong
leaves (Anredera cordifolia (Ten,) Steenis), therefore binahong leaves are extracted first and then
formulated into peel-off gel mask with vary of concentrations of film agents and gelling agent. The
purpose of this study was to formulate the binahong leaves extract peel-off gel mask and test its
physical properties, stability, and activity against the Staphylococcus epidermidis.

Extracti of binahong leaves obtained by maceration method with ethanol 96%. Variations in extract
concentrations used were 10%, 15%, 20%, 25%, 30%. The peel-off gel masks from each formula were
tested for organoleptic, homogenity, pH, viscosity, dispersion and adhesion, their stability and
activity against the Staphylococcus epidermidis. Data were analyzed statistically by the Kolmogorov-
Smirnov test followed by ANNOVA.

The results of the study stated that binahong leaf extract can be made into peel-off gel mask and
have antibacterial activity. The difference in the base concentration of gelatin and HPMC had an
effect on the physical properties of the preparation, stability and activity. The peel-off gel mask of
the binahong leaf extract with various base concentrations has antibacterial activity. The results of
statistical tests on antibacterial activity stated that the five formulas have significantly different
antibacterial activity.