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PERNYATAAN PERSETUJUAN

Skripsi ini telah disetujui untuk dipertahankan

di hadapan tim penguji

Medan, 28 Februari 2020

Dosen Pembimbing

(Rahmi Syaflida, drg.,Sp.BM (K))

NIP. 19840724 200801 2 006

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 DAFTAR ISI

Halaman

HALAMAN JUDUL......................................................................................
HALAMAN PERSETUJUAN ....................................................................... ii
DAFTAR ISI .................................................................................................. iii
DAFTAR TABEL .......................................................................................... vi
DAFTAR GAMBAR ..................................................................................... vii
DAFTAR LAMPIRAN .................................................................................. viii
BAB 1 PENDAHULUAN
1.1 Latar Belakang ............................................................................. 1
1.2 Rumusan Masalah ........................................................................ 7
1.3 Hipotesis ....................................................................................... 7
1.4 Tujuan Penelitian.......................................................................... 7
1.5 Manfaat Penelitian........................................................................ 7
1.5.1 Manfaat Teoritis ................................................................. 7
1.5.2 Manfaat Praktis .................................................................. 8

BAB 2 TINJAUAN PUSTAKA

2.1 Gigi Impaksi ................................................................................. 9
2.1.1 Definisi Gigi Impaksi ........................................................ 9
2.1.2 Klasifikasi Gigi Impaksi .................................................... 9
2.2 Odontektomi ................................................................................. 11
2.2.1 Indikasi dan Kontraindikasi Odontektomi ......................... 11
2.2.2 Prosedur Odontektomi ....................................................... 12
2.2.3 Komplikasi Pasca Odontektomi ........................................ 12
2.3 Penyembuhan Luka ...................................................................... 13
2.3.1 Fisiologi Penyembuhan Luka ............................................. 13
2.3.2 Fase Penyembuhan Luka .................................................... 14
2.3.2.1 Fase Inflamasi ........................................................ 14
2.3.2.2 Fase Proliferasi....................................................... 15
2.3.2.3 Fase Maturasi ......................................................... 16
2.3.3 Klasifikasi Penyembuhan Luka .......................................... 16
2.3.3.1 Penyembuhan Luka Primer.................................... 16
2.3.3.2 Penyembuhan Luka Sekunder ............................... 16
2.3.3.3 Penyembuhan Luka Tersier ................................... 17
2.3.4 Faktor-faktor yang Mempengaruhi Penyembuhan Luka ... 17
2.3.5 Mekanisme Penyembuhan Luka Pasca Odontektomi ........ 18

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 2.4 Aloe vera ...................................................................................... 19
2.4.1 Sejarah Aloe vera ............................................................... 19
2.4.2 Morfologi Aloe vera ........................................................... 20
2.4.3 Kandungan Aloe vera ......................................................... 21
2.4.4 Manfaat Aloe vera .............................................................. 21
2.5 Ekstraksi ....................................................................................... 22
2.6 Bentuk Sediaan ............................................................................. 23
2.7 Aloclair ......................................................................................... 26
2.7.1 Efek Samping Aloclair ....................................................... 27
2.7.2 Efek Overdosis Aloclair ..................................................... 27
2.8 Kerangka Teori ............................................................................. 28
2.9 Kerangka Konsep ......................................................................... 29

BAB 3 METODOLOGI PENELITIAN

3.1 Jenis Penelitian ............................................................................ 30
3.2 Lokasi dan Waktu Penelitian........................................................ 30
3.2.1 Lokasi Penelitian ................................................................ 30
3.2.2 Waktu Penelitian ................................................................ 30
3.3 Populasi dan Sampel .................................................................... 30
3.3.1 Populasi .............................................................................. 30
3.3.2 Sampel ................................................................................ 31
3.3.2.1 Besar Sampel ......................................................... 31
3.3.2.2 Sampling ................................................................ 31
3.4 Kriteria Inklusi dan Ekslusi .......................................................... 32
3.4.1 Kriteria Inklusi ................................................................... 32
3.4.2 Kriteria Ekslusi ................................................................... 32
3.5 Variabel Penelitian ....................................................................... 32
3.5.1 Variabel Bebas ................................................................... 32
3.5.2 Variabel Terikat.................................................................. 32
3.6 Skrining Fitokimia Simplisia Aloe vera ....................................... 32
3.6.1 Pemeriksaan Alkaloid ........................................................ 32
3.6.2 Pemeriksaan Flavonoid ...................................................... 33
3.6.3 Pemeriksaan Glikosida ....................................................... 33
3.6.4 Pemeriksaan Saponin ......................................................... 34
3.6.5 Pemeriksaan Tanin ............................................................. 34
3.6.6 Hasil Skrining Fitokimia .................................................... 34
3.7 Definisi Operasional ..................................................................... 35
3.8 Alat dan Bahan Penelitian ............................................................ 36
3.8.1 Alat Penelitian .................................................................... 36
3.8.2 Bahan Penelitian ................................................................. 36
3.9 Alur Penelitian.............................................................................. 36
3.10 Metode Pengumpulan Data ........................................................ 37
3.11 Analisis Data .............................................................................. 38

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 3.12 Etika Penelitian .......................................................................... 38

BAB 4 HASIL PENELITIAN

4.1 Distribusi Hasil Penelitian ............................................................ 39
4.2 Distribusi Skor Gingival Index Kelompok Penelitian .................. 39
4.3 Rata-Rata Skor Gingival Index Kelompok Penelitian
pada Hari ke-1, Hari ke-3 dan Hari ke-7 ...................................... 40

BAB 5 PEMBAHASAN ................................................................................ 45

BAB 6 KESIMPULAN DAN SARAN ......................................................... 49

6.1 Kesimpulan................................................................................... 49
6.2 Saran ............................................................................................. 49

DAFTAR PUSTAKA .................................................................................... 51

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 DAFTAR TABEL

Tabel Halaman

1. Perbedaan antara sediaan krim dengan gel ....................................... 25

2. Hasil skrining fitokimia ekstrak etanol gel Aloe vera 90% ............. 34
3. Definisi Operasional ........................................................................ 35
4. Distribusi Sampel............................................................................. 39
5. Distribusi skor gingival index tiap kelompok .................................. 39
6. Uji normalitas kelompok perlakuan dan kelompok kontrol ............ 40
7. Rata-rata skor gingival index pada hari ke-1, hari ke-3 dan hari ke-7
pasca odontektomi ........................................................................... 40
8. Kelompok Kontrol ........................................................................... 41
9. Kelompk Perlakuan ......................................................................... 43

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 DAFTAR GAMBAR

Gambar Halaman

1. Klasifikasi gigi impaksi berdasarkan angulasi molar ketiga ........ 10

2. Klasifikasi Pell dan Gregory berdasarkan posisi gigi .................. 10
3. Klasifikasi Pell dan Gregory berdasarkan hubungan oklusal ..... 11
4. Fase penyembuhan luka ............................................................... 14
5. Potongan melintang Aloe vera ..................................................... 20
6. Maserasi ....................................................................................... 23
7. Bentuk sediaan gel ....................................................................... 24
8. Sediaan pabrikan Aloclair ............................................................ 26

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 DAFTAR LAMPIRAN

Lampiran

1. Daftar Riwayat Hidup

2. Lembar Penjelasan Kepada Calon Subjek Penelitian
3. Lembar Persetujuan Setelah Penjelasan (Informed Consent)
4. Rincian Biaya Penelitian
5. Jadwal Kegiatan
6. Surat Ethical Clearance
7. Dokumentasi
8. Output Hasil Penelitian
9. Surat Izin Penelitian

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