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Leukemea QUZ

1-A 55-year-old man goes to a physician complaining of increased fatigue and


exertional dyspnea. He is diagnosed with leukemia. He undergoes genetic
trialling, which reveals a t(9;22) translocation. Which of the following would a
complete blood count most likely show?
A. Increased lymphocyte count
B. Increased neutrophil count
C. Numerous lymphoblasts
D. Numerous myeloblasts
E. Pancytopenia

2-A 31-year-old vegan attends her GP practice complaining of


fatigue. The GP is concerned about her dietary content and
requests blood tests. She complains of no other symptoms and
denies having heavy menses or any bleeds rectally. The GP is
concerned about iron deficiency anaemia. Which of the following
is not a recognised sign of iron deficiency anaemia?
_ a. Koilonychia.
_ b. Angular stomatitis.
_ c. Dysphagia.
_ d. Peripheral neuropathy.
_ e. Tongue atrophy

3-A 10-year-old boy presents to A&E with abdominal pain and


fatigue. The onset of the pain has been acute over the past 6
hours and is generalised. On further questioning he has no previous
abdominal pathology and no clinical findings on examination.
A family history reveals a cousin who suffers from sickle
cell disease. Which of the following clinical features is NOT
consistent with a diagnosis of sickle cell disease?
_ a. Pallor.
_ b. Splenomegaly.
_ c. Bone pain.
_ d. Leg ulcers.
_ e. Gallstones.

4-Which of the following facts about chronic leukaemia is


INCORRECT?
_ a. CLL is a chronic incurable condition.
_ b. Ionising radiation is a known cause of CML.
_ c. CLL cells contain the Philadelphia chromosome.
_ d. Early disease prognosis for CLL is 8–10 years.
_ e. CLL is a malignant disease of B-lymphocytes

5-A 42-year-old man presents to his GP with a 2-month history


of a painless lump in his neck. He has noticed this lump grow
slowly bigger and as he had been feeling tired with sweats at
night he had thought it was lymph node from a ‘head cold’.
Recently he has noticed that he cannot enjoy wine or beer
anymore because they cause him pain. Which of the following
diagnoses is the most likely?
_ a. Hodgkin’s lymphoma.
_ b. Infectious mononucleosis.
_ c. Non-Hodgkin’s lymphoma.
_ d. Polycythaemia rubra vera.
_ e. Myelodysplastic syndrome (MDS).

6-A 25-year-old man presents to his GP complaining of difficulty


sleeping. He complains that he feels very hot at night and finds
that his work is suffering during the day. Otherwise he complains
of no problems, but on questioning he admits to slight
weight loss and examination reveals a unilateral cervical mass.
The mass is in the anterior compartment of the neck; it is not
tethered to the skin and does not move on swallowing or protrusion
of the tongue. What is the most likely diagnosis in
this case?
_ a. Hodgkin’s lymphoma.
_ b. Sarcoidosis.
_ c. Tuberculosis.
_ d. Anxiety.
_ e. Acute lymphocytic leukaemiav

7-A 45-year-old woman presents to accident and emergency with


abdominal pain. She is tested for pregnancy, urinary tract infection
and undergoes abdominal examination. She is found to
have an enlarged spleen with pain localised to the left upper
quadrant. Blood tests reveal a haemoglobin level of 9.8 g/dL
with an mean cell volume (MCV) of 92fL. WBC was 26 _ 109
and platelet count was 135 _ 109. Which of the following chromosomal
translocations is most likely to be found in sufferers of
this condition?
_ a. t(8;14)
_ b. t(9;22)
_ c. t(14;21)
_ d. t(11;22)
_ e. t(4;14)

7-Whichof the following causes of anemia is associated with


microcytosis

a. Folic acid deficiency


b. Therapy with zidovudine (AZT)
c. Hypothyroidism
d. Alcohol
e. Thalassemia

9-Which of the following disorders is associated with


thrombocytosis

a. Disseminated intravascular coagulation


b. A plastic anemia
c. Postsplenectomy
d. Hypersplenism
e. Prosthetic valves

9-Tear drop cells are found at increasing number in all of the following cases,
EXCEPT:
A- Thalassemias.
B- Myelofibrosis.
C- BM tumors.
D- Extramedullary hemopoiesis.
E- None of the above

10-Left shift in a blood film means:


A- Presence of all blood cell types.
B- Presence of immature granulocytes.
C- Presence of NRBCs.
D- Presence of immature platelet forms.
E- None of the above

11-Choose the correct order for the steps of hemostasis.

A) blood coagulation, platelet plug formation, blood vessel spasm

B) platelet plug formation, blood coagulation, blood vessel spasm

C) blood vessel spasm, platelet plug formation, blood coagulation

D) blood vessel spasm, blood coagulation, platelet plug formation

12-Bleeding Disorders

a) Bleeding is likely when the platelet count reaches a level of 140,000

b) Bleeding time is increased in haemophilia

c) Excessive bleeding following multiple transfusions of stored blood is mainly due to a


deficinecy of platelets and factors 5 and 8

d) All coagulation proteins are synthesised by the liver and require vitamin K for their
synthesis

e)The haemostatic effectiveness of platlets decays over 7 days in stored blood


13the bleeding time

a)correlates well with the platelet count


b)correlates well with platlet function
c)can be prolonged in pre-eclampsia
d)is useful in determining the coagulation status of per-eclamptics
d)is approximately 1 minute in a normal individual
14-The bleeding time is increased by:

a) Haemolytic anaemia
b) Thrombocytopenia
c) vitamin C deficiency
d) vitamin K overdose
e) Von willebrands disease

15-11.the bleeding time is prolonged in the following

A..haemophilia
b.idiopathic thrombocytopenic purpura
c.warfarin overdose
d.aspirin therapy
e.vitamin C deficiency
16-Common Hereditary Bleeding Disorder
Von Willebrand’s Disease
Bernard-Soulier syndrome
Hemophilia
disseminated intravascular coagulation
16-20 yr.
pt. presents pre operative

aPTT :78/32
PT: 13/12
BT: 13min
Platelet : 350*100/microL

which one of the foll is true:


1. infusion of factor VIII
2. infusion of cryo ppt. will not be followed by improvement in coagulation
3.epistaxis is uncommon.
4.lack of platelet aggregation in response of ristocetin is a common feature of
this disease
17-The most specific investigation among the following in Disseminated
Intravascular Coagulation is?
A. APTT
B. Bleeding time
C. Fibrinogen assays
D. d-Dimer assays
18-All of the following statements are true regarding the von willebrand's
disease, except?
A. Platelet count is abnormal
B. Platelet count is normal
C. Decreased coagulation with ADP
D. Decreased time on Ristocetin test

Leuk QUZ1

1-All of the followings are myeloproliferative disorder


EXCEPT:
a- Polycythemia verra

b- Myelo fibrosis

c- Essential thromobocythemia

d Chr. Myeloid leukemia

e-acute myeloid leukemia

2-which one of the following is not a feature in haemophilia?

(a) Increased prothrombing time


(b) Decreased prothrombing time
(c) Bleeding in to tissues and joints
(d) Decreased factor VIII levels