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Sampel 200 mg Konsentrasi (ppm)

HCl 0.1N 3
6
4
di timbang serbuk karbamazepin standar dilarutkan 8
10
12
14
Ditimbang serbuk karbamazepin sebanyak 50 mg, kemudian dilarutkan dalam 500 ml HCl 0,1 N dalam labu ukur (100 p
Kemudian diambil diambil 0.15 ml larutan stok kemudian di genapkan dengan HCL 0.1 N hingga 5 ml
larutan induk 100 ppm

100 x V = 3 x 5 ml
v = 0.15 ml

100 x v = 14 x 5 ml
Absorbansi (a.u.)
0.1633
0.2124
0.3271
0.4405
0.5557
0.6654
0.7713
1 N dalam labu ukur (100 ppm)
Kurva Kalibrasi

Konsentrasi (ppm) Absorbansi (a.u.)


3 0.1633
4 0.2124
6 0.3271
0.9
8 0.4405
10 0.5557 0.8
12 0.6654 f(x) = 0.105664285714286 x + 0.02
0.7 R² = 0.993639676407968
14 0.7713
0.6

Absorbansi (a.u.)
0.5

0.4

0.3

0.2

0.1

0
3 4 6 8 10
Konsentrasi (ppm)
Persamaan Kurva Kalibrasi
y = 0.0535x + 0.0117

0.9

0.8
f(x) = 0.105664285714286 x + 0.0253
0.7 R² = 0.993639676407968

0.6

0.5 y= 0.0535x+0.0117
0.4 Absorbansi (a.u.)
Linear (Absorbansi (a.u.))
0.3

0.2

0.1

0
3 4 6 8 10 12 14
Konsentrasi (ppm)
0535x+0.0117
Hasil Uji Disolusi y = 0.0558 x - 0.0068

Tablet 1
Waktu Sampling Absorbansi Konsentrasi Faktor Konsentrasi Faktor Koreksi
(menit) (a.u.) Sampel (ppm) Pengenceran (ppm) Konsentrasi
10 0.2262 4.17562724014 10 41.7562724014 0
15 0.3496 6.38709677419 10 63.8709677419 0.7096774194
30 0.5075 9.21684587814 10 92.1684587814 0.4639585822
45 0.5873 10.646953405 10 106.46953405 1.02409398646
60 0.6202 11.2365591398 10 112.365591398 1.18299482278
Tablet 2
Waktu Sampling Absorbansi Konsentrasi Faktor Konsentrasi Faktor Koreksi
(menit) (a.u.) Sampel (ppm) Pengenceran (ppm) Konsentrasi
10 0.2132 3.94265232975 10 39.4265232975 0
15 0.3152 5.770609319 10 57.70609319 0.43807248108
30 0.481 8.74193548387 10 87.4193548387 0.64117881322
45 0.5617 10.188172043 10 101.88172043 0.97132616487
60 0.609 11.0358422939 10 110.358422939 1.13201911589
Tablet 3
Waktu Sampling Absorbansi Konsentrasi Faktor Konsentrasi Faktor Koreksi
(menit) (a.u.) Sampel (ppm) Pengenceran (ppm) Konsentrasi
10 0.2164 4 10 40 0
15 0.3545 6.47491039427 10 64.7491039427 0.44444444444
30 0.555 10.0681003584 10 100.681003584 0.71943448825
45 0.6438 11.6594982079 10 116.594982079 1.1186778176
60 0.6876 12.4444444444 10 124.444444444 1.29549980088
Tablet 4
Waktu Sampling Absorbansi Konsentrasi Faktor Konsentrasi Faktor Koreksi
(menit) (a.u.) Sampel (ppm) Pengenceran (ppm) Konsentrasi
10 0.2266 4.182795698925 10 41.8279569892 0
15 0.3292 6.021505376344 10 60.2150537634 0.46475507766
30 0.4968 9.025089605735 10 90.2508960573 0.66905615293
45 0.5897 10.68996415771 10 106.899641577 1.00278773397
60 0.6504 11.77777777778 10 117.777777778 1.1877737953
Tablet 5
Waktu Sampling Absorbansi Konsentrasi Faktor Konsentrasi Faktor Koreksi
(menit) (a.u.) Sampel (ppm) Pengenceran (ppm) Konsentrasi
10 0.2316 4.272401433692 10 42.7240143369 0
15 0.3196 5.849462365591 10 58.4946236559 0.47471127041
30 0.4684 8.516129032258 10 85.1612903226 0.64994026284
45 0.5424 9.84229390681 10 98.4229390681 0.94623655914
60 0.6517 11.80107526882 10 118.010752688 1.09358821187
Tablet 6
Waktu Sampling Absorbansi Konsentrasi Faktor Konsentrasi Faktor Koreksi
(menit) (a.u.) Sampel (ppm) Pengenceran (ppm) Konsentrasi
10 0.2378 4.3835125448 10 43.835125448 0
15 0.3447 6.29928315412 10 62.9928315412 0.48705694942
30 0.4939 8.97311827957 10 89.7311827957 0.69992035046
45 0.5806 10.5268817204 10 105.268817204 0.99701314217
60 0.626 11.3405017921 10 113.405017921 1.16965352449
Kekuatan Sediaan (mg) 200
Medium disolusi 900 mL
Waktu
Konsentrasi Jumlah
Q (%) Sampling Tablet 1
Aktual (ppm) Terdisolusi (mg)
41.7562724 37.58064516 18.79% (menit) 10 18.79%
64.3349263241 57.9014336917219 28.95% 15 28.95%
93.1925527678 83.8732974910394 41.94% 30 41.94%
107.493628037 96.7442652329749 48.37% 45 48.37%
113.548586221 102.193727598566 51.10% 60 51.10%

Konsentrasi Jumlah Ta
Aktual (ppm) Terdisolusi (mg) 0.6
39.4265232975 35.4838709677419 17.74%
58.144165671 52.3297491039427 26.16%
88.0605336519 79.2544802867384 39.63% 0.5
102.853046595 92.5677419354839 46.28%
111.490442055 100.341397849462 50.17%

Jumlah terdisolusi (%)


0.4
Konsentrasi Jumlah
Q (%)
Aktual (ppm) Terdisolusi (mg)
40 36 18.00% 0.3
65.1935483871 58.6741935483871 29.34%
101.400438072 91.260394265233 45.63%
0.2
117.713659896 105.94229390681 52.97%
125.739944245 113.165949820789 56.58%
0.1
Konsentrasi Jumlah
Q (%)
Aktual (ppm) Terdisolusi (mg)
41.8279569892 37.6451612903226 18.82%
0
60.6798088411 54.6118279569892 27.31% 10 15
90.9199522103 81.8279569892473 40.91% Wak
107.902429311 97.1121863799283 48.56%
118.965551573 107.068996415771 53.53% 0.6

Konsentrasi Jumlah
Q (%) 0.5
Aktual (ppm) Terdisolusi (mg)
42.7240143369 38.4516129032258 19.23%
58.9693349263 53.0724014336918 26.54%
0.4
85.8112305854 77.2301075268817 38.62%
99.3691756272 89.4322580645161 44.72%
Rataan Q

0.3
119.1043409 107.193906810036 53.60%

Konsentrasi Jumlah
Q (%) 0.2
Aktual (ppm) Terdisolusi (mg)
43.835125448 39.4516129032258 19.73%
63.4798884906 57.1318996415771 28.57% 0.1

0
10 15
Waktu Sam
Rat
0.2

0.1
90.4311031462 81.3879928315412 40.69%
106.265830346 95.639247311828 47.82%
0
114.574671446 103.117204301075 51.56% 10 15
Waktu Sam
Tablet 2 Tablet 3 Tablet 4 Tablet 5 Tablet 6 Rataan Q
17.74% 18.00% 18.82% 19.23% 19.73% 18.72%
26.16% 29.34% 27.31% 26.54% 28.57% 27.81%
39.63% 45.63% 40.91% 38.62% 40.69% 41.24%
46.28% 52.97% 48.56% 44.72% 47.82% 48.12%
50.17% 56.58% 53.53% 53.60% 51.56% 52.76%

Tablet 1
Tablet 2
Tablet 3
Tablet 4
Tablet 5
Tablet 6

15 30 45 60

Waktu Sampling (menit)

Rataan Q

0 15 30 45 60
Waktu Sampling (menit)
Rataan Q

0 15 30 45 60
Waktu Sampling (menit)
Standar Deviasi
0.68%
1.21%
2.22%
2.54%
2.11%

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