Lap PBL Kel 3 Endo Fix
Lap PBL Kel 3 Endo Fix
LAPORAN PBL
MODUL 1“BERAT BADAN MENURUN”
SKENARIO 1
KELOMPOK 2
FAKULTAS KEDOKTERAN
UNIVERSITAS MUSLIM INDONESIA
MAKASSAR
2019
KATA PENGANTAR
Dengan menyebut
nama Allah SWT yang Maha Pengasih lagi Maha Panyayang, kami panjatkan
puja dan puji syukur atas kehadirat-Nya, yang telah melimpahkan rahmat,
hidayah, dan inayah-Nya kepada kami, sehingga kami dapat menyelesaikan
laporan PBL modul 1 dengan judul “Berat Badan Menurun” ini dengan baik.
Adapun laporan PBL modul 1 dengan judul “Berat Badan Menurun” ini telah
kami usahakan semaksimal mungkin dan tentunya dengan bantuan berbagai
pihak, sehingga dapat memperlancar pembuatan laporan ini. Untuk itu kami tidak
lupa menyampaikan banyak terima kasih kepada semua pihak yang telah
membantu kami dalam pembuatan laporan ini. Terutama kepada dr. Sri Wahyuni
Gayatri,M.kes. selaku pembimbing kami yang senantiasa membimbing kami
dalam menyelesaikan laporan ini.
Namun tidak lepas dari semua itu, kami menyadari sepenuhnya bahwa ada
kekurangan baik dari segi penyusun bahasanya maupun segi lainnya. Oleh karena
itu dengan lapang dada dan tangan terbuka kami membuka selebar-lebarnya bagi
pembaca yang ingin memberi saran dan kritik kepada kami sehingga kami dapat
memperbaiki laporan kami.
Makassar, 9 Mei 2019
Tim Penyusun
1st scenario
A 45 years old male. Came to the general practicioner clinic with chif
complaints of decreased weight experienced since the last 2 months.
Accompanied by a feeling of weakness and fatigue even without excessive
physical activity. Patients also complain of often feeling hungry and thirsty
and needle tingling senasation in both legs.
a. Hard word
b. Key word
1. A male, 45 years old
2. Decreased weight since the last 2 months
3. Feeling weakness and fatigue
4. Often feeling hungry and thirsty
5. Needle tingling sensation in both legs
c. Question
1. The organ that involved in regulation og weight loss are according to
scenario!
2. Is there relation between patient’s gender and age and his chif another
complaints?
3. Is there relation between lost weight with his another complaints?
4. Why the patient lose weight while he often feels hungry?
5. What makes patient feels needle tingling sensation in both of his legs?
6. How to diagnose the patient according to the scenario?
7. What is the differential diagnose?
8. What is the first therapy according to the diagnose?
9. What is the Islamic perspective according to the scenario?
d. Answer
1. The organs that are involved in the scenario Multiple endocrine glands:
gland Hypofise
gland Thyreoidea
gland suprarenalis
pancreas
Testicular / ovarian
thymus
A gland "two in one" organ: there are two parts of the gland with each
function
layout:
lobe
1. The anterior lobe (Adenohypophyse) Pars: Pars ant / distal Infundibulum:
Pars Intermedia 2. Posterior lobe (Neurohyphophyse) Eminentia median:
lobe neural stem Infundibulum
2. The anterior lobe> posterior lobe anterior lobe of the structure "celluler"
(glandular)
vascularization
There are two parts: the cortex (outer 9/10) and medulla (inside, 1/10)
Have hilar: located on the anterior facies, skipped vasa lymphe suprarenalis
and vessels.
layout:
vascularization:
VENA:
pancreas
LAY:
Retroperitoneal in cav.abd
Transverse almost horizontal with cauda part rather ride to the splenic
hilum
Posted at post exchanges DDG omentalis
At the level of V.L2 to Th12-L1
Combined KEL. Exocrine and KEL. Endocrine
KEL section. exocrine which has ductus Pancreaticus
Sections:
1. Caput PANCREATIS:
epigastric region
Located in the arch of the letter "C" duodenum (pars sup + desc +
horizontal)
S / d limit incisura PANCREATICA
2. CORPUS PANCREATIS:
epigastric region
Mulaipdincisurapancreatica
Diventral aortic & rensin, in the dorsal gastric
S / d limit lig.lienorenale
3. Cauda PANCREATIS:
The left hypochondrium Regio
In the lig.lienorenale, enter the splenic hilum
Thyreoidea gland:
LAY
o Diventral:
o Covered:
- larynx
- trachea
- Oesphagus
- Carotid Sheath
- N. Recurrens laryngeus
Attached to the larynx -> join the movement up and down the
larynx
vascularization
THYMUS
Located :
TESTIS
Structure
OVARIAN:
HEPATIC
The liver is the largest organ in the abdominal cavity, the liver is the
superior part of the abdominal cavity. Located in the region of the right
hipokondrium, epigastric and can sometimes reach regions hipokondrium
left. In the adult liver weighs about 2% of body weight.
The liver is divided into four lobes, namely lobes dextra, caudate lobe,
the left lobe and Quadratus. Having a thin layer of connective tissue called
Glisson's capsule, and on the outside is covered by the peritoneum. The
area where the exit sign in the blood vessels of the liver known as the
hilum or porta hepatis. Tubes contained in this area such as the portal vein,
hepatic artery propia, and there dextra and the left hepatic duct.
Veins in the liver that carries blood out from the liver to the inferior
vena cava is the vein hepatica. Meanwhile, the blood vessels and arteries
hepatic portal venous flow towards the porta hepatica.
Innervation of the liver is divided into two parts and the surface of the
liver parenchyma. In the parenchyma, managed by N. innervation from the
plexus hepaticus hepaticus. Getting the sympathetic and parasympathetic
innervation of NX while on the surface of innervation of nervi
intercostales get down.
2. Is there relation between patient’s gender and age and his chif another
complaints?
In endocrine and metabolism system, there are two diseases that can cause drastic
weight loss, Such as:
Diabetes Mellitus
Because there is a defect in insulin secretion (insufficient insulin)
as well as a disruption of insulin (insulin resistance) resulting in blood
glucose can not enter into muscle cells and fat tissue. As a result, to obtain
an energy source for survival and carrying out its functions, the muscles
and fat tissue will solve the energy reserves contained within itself through
the process of glycogenolysis and lipolysis. The process of glycogenolysis
and lipolysis that continues in the end will cause muscle mass and fat
tissue decrease and weight loss occurs.
Hyperthyroid
Hyperthyroid (Thyrotoxicosis) is a clinical syndrome that occurs due to
increased levels of thyroid hormone (T3) circulating in the body.
Triyodotironin (T3) will increase oxygen consumption and heat production
through stimulation of Na+, K+ and ATPase in almost all body tissues
(except the brain, spleen and testis) which will ultimately increase the
basal metabolic rate. Thyroid hormones will also stimulate an increase in
protein structure synthesis and ultimately lead to reduced muscle mass.
Referensi :
Uncontrolled blood glucose level leads to increased hepatic glucose output. First,
liver glycogen stores are mobilized then hepatic gluconeogenesis is used to
produce glucose. Insulin deficiency also impairs non hepatic tissue utilization of
glucose. In particular in adipose tissue and skeletal muscle, insulin stimulates
glucose uptake. This is accomplished by insulin mediated movement of glucose
transporters proteins to the plasma membrane of these tissues. Reduced glucose
uptake by peripheral tissues in turn leads to a reduced rate of glucose metabolism.
In addition, the level of hepatic glucokinase is regulated by insulin. Therefore, a
reduced rate of glucose phosphorylation in hepatocytes leads to increased delivery
to the blood. Other enzymes involved in anabolic metabolic metabolism of
glucose are affected by insulin.
The combination of increased hepatic glucose production as decompensation of
lack of insulin in the tissue lead to increase metabolism of lipid and protein to
produce energy causing a reduction in overall body weight. The combination of
increased hepatic glucose and reduced peripheral tissues metabolism leads to
elevated plasma glucose levels. When the capacity of the kidneys to absorb
glucose is surpressed, glucosuria ensues. Glucose is an osmotic diuretic and an
increase in renal loss of glucose is accompanied by loss of water and electrolyte.
The result of the loss of water (and overall volume) leads to the activation of the
thirst mechanism (polydipsia). The negative caloric balance, which results from
the glucosuria and tissue catabolism leads to an increase in appetite and food
intake that is polyphagia.
5. What makes patient feels needle tingling sensation in both of his legs?
In our body, there is the process of glycolysis, i.e break down one molecule of
glucose into two molecules of pyruvic acid. When the body gets enough oxygen
supply, then the process of Glycolysis is passed to the process of oxidative
decarboxylation, kreb cycle, and the electron, and finally transport produce ATP.
ATP is the energy needed by the body to process of contraction and relaxation.
ATP is required during the processing of the sarcoplasmic reticulum in active
transport to remove and insert the Ca ion. another story when the body does not
get oxygen supply. Then the process of Glycolysis is passed to the process of
lactic acid fermentation that produce lactic acid. The lactic acid that builds up in
the body will interfere with the blood flow so it does not start, this is what causes
cramps. In addition, the process of anaerobic process known it only produces two
molecules of ATP alone, so it is not enough to meet the active transport process in
the sarcoplasmic reticulum. It also causes the contraction process of relaxation is
interrupted and eventually the cramps
Ref: Guyton . 1996 . Fisiologi Manusia dan Mekanisme Penyakit . Jakarta : EGC
Anamnesis
Before carrying out further history, the first thing that must be stated is the
patient's identity, namely age, sex, race, marital status, and occupation.
a. Current History
This includes major complaints and follow-up history. The main complaint is a
complaint that makes someone come to a health service to seek help, for example:
fever, shortness of breath, low back pain, etc. This main complaint should be no
Asked whether the patient had had similar illness before, if and when it happened
and how many times and given any medication, old treatment, hospitalization,
This is to find out the patient's social status, which includes education, work,
marriage, habits that are often done (sleep patterns, eating, alcohol or smoking,
drugs, sexual activity, financial resources, and health insurance).
A. Patient Identity:
1. Name: -
2. Age: 45 years.
3. Gender: Male.
7. Other complaints that accompany: fast hungry and thirsty and often feel
tingling in both legs
8. History of habits: -
9. Treatment history: -
Diagnosis
Diabetes is diagnosed by testing the blood for sugar levels. Blood is tested in the
morning after you have fasted overnight. Typically, the body keeps blood sugar
levels beteen 70 and 100 mg/dl, even afer fasting. If a blood sugar level after
Laboratory test are also used routinely to evaluate diabetes, these include:
Lipid Profile
Reference: Siti Setiati dkk. 2014. Buku Ajar Ilmu Penyakit Dalam. Jilid II Edisi
VI. Jakarta: Interna publishing.
2. Epidemiology
The incidence of Type 2 DM in women is higher than that of men. Women are
more at risk of developing diabetes because physically women have a greater
chance of increasing their body mass index. Basic Health Research Results in
2008 showed that the prevalence of DM in Indonesia was up to 57%, in 2012 the
incidence of diabetes mellitus in the world was 371 million, where the proportion
of diabetes mellitus type 2 was 95% of the world population suffering from
diabetes mellitus and only 5 % of these suffer from type 1 diabetes mellitus
3. Pathophysiology
In the pathophysiology of type 2 diabetes there are several conditions that play a
role, namely:
1. Insulin resistance
2. Pancreatic B cell dysfunction
Type 2 diabetes mellitus is not caused by a lack of insulin secretion, but because
insulin target cell cells fail or are unable to respond to insulin normally. This
condition is commonly referred to as "insulin resistance". Insulin resistance occurs
mostly as a result of obesity and lack of physical activity and aging. In patients
with type 2 diabetes mellitus can also occur excessive hepatic glucose production
but no autoimmune destruction of langerhans B cells such as type 2 diabetes
mellitus. Deficiency of insulin function in diabetics type 2 mellitus is only relative
and not absolute.
In the early stages of developing type 2 diabetes mellitus, B cells showed a
disruption in first-phase insulin secretion, meaning that insulin secretion failed to
compensate for insulin resistance. If not handled properly, in the next
development there will be damage to pancreatic B cells. Damage to pancreatic B
cells will occur progressively often will cause insulin deficiency, so that
eventually patients need exogenous insulin. In patients with type 2 diabetes
mellitus, these two factors are generally found, namely insulin resistance and
insulin deficiency.
4. Risk factors
The increase in the number of DM patients, most of whom are type 2 diabetes
mellitus, is related to several factors, namely irreversible risk factors, altered risk
factors and other factors. According to the American Diabetes Association (ADA)
that DM is associated with irreversible risk factors including family history with
DM (first degree relative), age ≥45 years, ethnicity, childbirth history with a
baby's birth weight> 4000 grams or history of having suffered Gestational
diabetes and a history of births with low weight (<2.5 kg). Changable risk factors
include obesity based on BMI ≥25kg / m2 or abdominal circumference ≥80 cm in
women and ≥90 cm in men, lack of physical activity, hypertension, dyslipidemia
and unhealthy diet.
Other factors associated with diabetes risk are those with polycystic
ovarysindrome (PCOS), metabolic syndrome patients who have a disturbed
glucose tolerance (TGT) or impaired fasting blood glucose (GDPT) before, have a
history of cardiovascular diseases such as stroke, CHD, or peripheral arterial
Diseases (PAD ), alcohol consumption, stress factors, smoking habits, gender,
consumption of coffee and caffeine.
a. Obesity (overweight)
There is a significant correlation between obesity and blood glucose levels, in the
degree of obesity with BMI> 23 can cause an increase in blood glucose levels to
200mg%. 1,2
b. Hypertension
The incidence of hypertension is closely related to the improper storage of salt and
water, or the increased pressure from the body on peripheral blood circulation.
c. Family History of Diabetes Mellitus
A person suffering from Diabetes Mellitus is thought to have a diabetes gene. It is
suspected that diabetes talent is a recessive gene. Only people who are
homozygous with these recessive genes suffer from Diabetes Mellitus.
d. Dislipedimia
Is a condition characterized by an increase in blood fat levels (Triglycerides> 250
mg / dl). There is a relationship between increases in insulin plasma and low HDL
(<35 mg / dl) often found in diabetic patients.
e. Age
Based on the research, the most age affected by Diabetes Mellitus is> 45 years. 6.
Childbirth history of recurrent abortion, giving birth to a disabled baby or baby
weight> 4000gram
f. Genetic Factors
Type 2 DM originates from genetic interactions and various mental factors. This
disease has long been thought to be associated with familial aggregation. The risk
of emperis in the case of type 2 diabetes will increase two to six times if the parent
or sibling experiences this disease.
g. Alcohol and cigarettes
Changes in lifestyle are associated with an increased frequency of type 2 DM.
Although most of these increases are associated with increased obesity and a
reduction in physical inactivity, other factors associated with changes from the
traditional westernized environment include changes in consumption. alcohol and
cigarettes, also play a role in increasing type 2 diabetes. Alcohol will interfere
with blood sugar metabolism, especially in DM patients, so it will complicate the
regulation of blood sugar and increase blood pressure. A person will increase
blood pressure when consuming ethyl alcohol more than 60 ml / day which is
equivalent to 100 ml proof whiskey, 240 ml of wine or 720 ml. Risk factors for
non-communicable diseases, including Type 2 diabetes, are divided into two. The
first is risk factors that cannot change, for example age, genetic factors,
unbalanced eating patterns of sex, marital status, education level, occupation,
physical activity, smoking habits, alcohol consumption, Body Mass Index
5. Clinical symptoms
Symptoms of diabetes mellitus can be distinguished into acute and chronic
- Acute symptoms of diabetes mellitus, namely: Polyphagia (lots of food)
polydipsia (lots of drinking), Polyuria (lots of urination / frequent urination at
night), appetite increases your body weight drops rapidly (5-10 kg within 2-4
weeks ), easily tired.
- Chronic symptoms of diabetes mellitus, namely: Tingling, skin feels hot or like
punctured needles, numbness in the skin, cramps, fatigue, easy drowsiness,
blurred vision, easily shaky and easily loose teeth, decreased sexual ability even in
men, impotence can occur , in pregnant women there are often miscarriages or
fetal deaths in the womb or with babies born more than 4kg.
6. Diagnosis
Typical complaints and symptoms plus the results of blood glucose testing when>
200 mg / dl, fasting blood glucose> 126 mg / dl is enough to make a diagnosis of
DM. For the diagnosis of DM and other glucose tolerance disorders blood glucose
was examined 2 hours after glucose load. At least 2 times abnormal blood glucose
level is needed to confirm another day's diagnosis of DM or abnormal Oral
Glucose Tolerance Test (OGTT). Confirmation is not necessary in the typical
circumstances of hyperglycemia with acute metabolic decompensation, such as
ketoacidosis, rapid weight loss.
There is a difference between a DM diagnostic test and a screening check.
Diagnostic tests are performed on those who show symptoms of DM, while
screening aims to identify those who are asymptomatic, but have a risk of DM
(age> 45 years, overweight, hypertension, DM family history, history of recurrent
abortion, giving birth to babies> 4000 gr , HDL cholesterol <= 35 mg / dl, or
triglycerides ≥ 250 mg / dl). Diagnostic tests are performed on those with positive
filter tests.
Screening can be done by checking the current blood glucose level or fasting
blood glucose level, then it can be followed by a standard oral glucose tolerance
test (OGTT)
7. Management
The objectives of DM Management are:
- Short term: loss of complaints and signs of DM, maintaining a sense of comfort
and achieving the target of controlling blood glucose.
- Long term: prevented and hampered progression of microangiopathic
complications, makroangiopathy and neuropathy.
The ultimate goal of management is a decrease in DM morbidity and mortality.
To achieve this goal, it is necessary to control blood glucose, blood pressure, body
weight and lipid profile, through patient management holistically by teaching self-
care and Diet
1. Diet
The principle of regulating food for people with diabetes is almost the same as the
recommended diet for the general public, namely a balanced diet and in
accordance with the calorie and nutritional needs of each individual. In people
with diabetes, it is important to emphasize the importance of regular eating in
terms of meal schedules, type and amount of food, especially in those who use
blood glucose-lowering drugs or insulin. The recommended standard is food with
a balanced composition in terms of carbohydrates 60-70%, fat 20-25% and protein
10-15%. To determine nutritional status, calculated by BMI (Body Mass Index).
The Body Mass Index (BMI) or Body Mass Index (BMI) is a simple tool or way
to monitor the nutritional status of adults, especially those related to underweight
and overweight. To find out the value of this BMI, it can be calculated by the
following formula:
b. Chronic Complications
- Macrovascular complications
Macrovascular complications, which often develop in people with DM are brain
thrombocytes (blood clots in some brain), experiencing coronary heart disease
(CHD), congestive heart failure, and stroke.
- Microvascular complications
Microvascular complications mainly occur in people with type 1 DM such as
nephropathy, diabetic retinopathy (blindness), neuropathy, and amputation
10. Prevention
Prevention of diabetes mellitus is divided into four parts, namely:
- Prevention of Premodial Premodial Prevention is
efforts to provide conditions to the community that allow the disease not to get
support from habits, lifestyle and other risk factors. This precondition must be
created with multimitra. Premodial prevention of DM disease, for example, is to
create preconditions so that people feel that westernized food consumption is a
poor diet, a relaxed lifestyle or lack of activity, and obesity is not good for health.
- Primary prevention
Primary prevention is an effort aimed at people who belong to high risk groups,
namely those who have not suffered from DM, but have the potential to suffer
from DM including:
a. Old age group (> 45 years)
b. Obesity (BB (kg)> 120% BB dream or BMI> 27 (kglm))
c. High blood pressure (> 140i90mmHg)
d. Family history of DM
e. History of pregnancy with BB babies born> 4000 gr.
f. Disiipidemia (HvL <35 mg / dl and or triglycerides> 250 mg / dl).
g. Ever TGT or fasting blood glucose is interrupted (GDPT)
For primary prevention must be subject to factors that influence the emergence of
DM and efforts to eliminate these factors. Therefore it is very important in this
prevention. From an early age, an understanding of the importance of regular
physical activities, patterns and types of healthy foods should be planted to keep
the body from being too fat: and the risk of smoking to health.
- Secondary prevention
Secondary prevention is an effort to prevent or inhibit the emergence of
complications by the act of early detection and treatment since the beginning of
the disease. In the management of DM patients, it must be watched out from the
start and wherever possible the possibility of chronic complications is possible.
The main pillars of DM management include:
a. counseling
b. food planning
c. physical exercise
d. hypoglycemic drug.
- Tertiary Prevention
Tertiary prevention is an effort to prevent further disability and rehabilitate
patients as early as possible, before the disability persists. Holistic and integrated
health services between related disciplines are needed, especially in referral
hospitals, for example experts from other disciplines such as experts in heart
disease, eyesight, medical rehabilitation, nutrition and others.
• Hyperthyroidism
1. Definition
2. Classification
• Toxic Difusa Goiter (Graves ’Disease)
Graves' disease is more common in women than men, symptoms can occur at
various ages, especially at the age of 20-40 years. Hereditary factors can also
affect the occurrence of disorders of the immune system, which is where
antibodies attack cells in the body itself.
• Subacute Thyroiditis
• Postpartum Thyroiditis
Occurs in 5-10% of women in the first 3 - 6 months after giving birth and occurs
for 1-2 months. Generally the gland will return to normal slowly.
3. Etiology
Other causes of hyperthyroidism which are rare in addition to graves' disease are:
4. Pathophysiology
5. Clinical Manifestations
7. Reproductive disorders
6. Diagnostic Check
1. Blood tests that measure HT levels (T3 and T4), TSH, and TRH will ensure the
diagnosis of the condition and localization of the problem at the level of the
central nervous system or thyroid gland.
3. T4 free (thyroxine)
4. T3 free (triiodothyronine)
7. Management
Conservative
Management of Graves' disease
Beta blockers such as propranolol are given along with antithyroid drugs. Because
the clinical manifestations of hyperthyroidism are a result of sympathetic
activation stimulated by thyroid hormones, the clinical manifestations will be
reduced by the administration of beta blockers; Beta blockers reduce tachycardia,
anxiety and excessive sweating. Propranolol also inhibits the change of peripheral
thyroxine to triiodothyronine. Indications:
3) Preparation of thyroidectomy
5) Thyroid crisis
Adinergic ß blockers at the start of therapy are given, while waiting for the patient
to become euthyroid after 6-12 weeks of anti-thyroid administration. Propanolol
doses 40-200 mg in 4 doses at the start of treatment, the patient controls after 4-8
weeks. After euthyroid, monitor every 3-6 months: monitor symptoms and clinical
signs, as well as Lab.FT4 / T4 / T3 and TSHs. After euthyroid is reached, the anti-
thyroid drug is reduced in dosage and maintained the smallest dose which still
gives an euthyroid state for 12-24 months. Then the treatment was stopped, and it
was assessed whether there was a remission. Remission is said if after 1 year the
antithyroid drug is stopped, the patient is still euthyroid, although later it can
remain euthyroid or collapse.
The duration of therapy with antithyroid drugs in Graves' disease is quite variable
and can range from 6 months to 20 years. Remissions that are maintained can be
predicted with the following characteristics:
Surgical
1. Radioactive iodine
2. Thyroidectomy
8. Complications
2. Planning meals
Stranded diets for people with DM are foods with a balanced composition in
terms of carbohydrates, protein and fat. The recommended nutritional
composition is as follows:
Carbohydrate 60 - 70% j
Protein 10 - 15%
Fat 20 - 25%
The number of calories given is adjusted to the nutritional status and activities of
the patient and is intended to achieve and maintain ideal body weight.
3. Physical Exercise
A. Oral hypoglycemic drugs: Currently there are 5 types of OHO available in the
market. OHO is metabolized and secreted in the liver and kidneys. Therefore it is
not recommended to be given to patients with impaired liver and kidney function,
because it can cause deterioration in the function of the two organs and can cause
drug accumulation in the body.
1. Sulfonilurea group
2. Meglitinide group
This class of drugs also stimulates pancreatic insulin secretion, but the working
time is very short, so it is the chosen drug for DM patients with high post prandail
blood glucose levels (2 hours after meals).
The drug group has the main work to suppress liver glucose production and
improve insulin resistance. The drug does not suppress appetite and can even
cause nausea, making it suitable for people who are obese. The feared side effect
of this drug is the occurrence of lactic acidosis, therefore it is not recommended
for patients with DM with a tendency to hypoxiaemia (eg, heart disease and
severe pulmonary perfusion). This medicine can be given before meals, but if
there is nausea it can be given at the same time or after meals.
This drug works as a competitive inhibitor with carbohydrates, thus inhibiting the
absorption of carbohydrate absorption. Suitable given to patients with DM with
appetite that is difficult to control and also useful to suppress post prandial blood
glucose levels. This drug can cause discomfort in the abdomen such as bloating
and flatulence so that the administration should be at mealtime.
5. Thyozolidindiones group
This group of drugs has a major role as an Insulin sensitizer, improving insulin
resistance is peripheral, so it is suitable given to patients with suspected insulin
resistance (fat). When given this drug, strict liver function monitoring (every 3
months) must be carried out because it is hepatotoxic.
1. Type 1 DM
2. DM type with:
a. Keto acidosis
B. TIROTOXYSIS THERAPY
Although the basis of Graves' disease is an autoimmune process, the main goal of
therapy for this disease is to control hyperthyroidism. There are currently 3
therapeutic modalities, namely: Anti-thyroid medication, surgery and
radiotherapy.
2. Operation
a. Beta blockers.
Propranolol 10 - 40 mg / day (tid) functions to control symptoms of
tahicardia, hypertension and atrial fibrillation. Can also be a medicine OAT
helper because it also inhibits the conversion of T4 to T3.
b. Barbiturates
Phenobarbital is used as a sedative (sedataif) and can also accelerate T4
metabolism so that it can reduce levels T4 in the blood.
“Tidaklah anak Adam memenuhi wadah yang lebih buruk dari perut. Cukuplah
bagi anak Adam memakan beberapa suapan untuk menegakkan punggungnya.
Namun jika ia harus (melebihkannya), hendaknya sepertiga perutnya (diisi) untuk
makanan, sepertiga untuk minuman dan sepertiga lagi untuk bernafas”
- Allah berfirman,