Antepartum

Syntocinon® (oxytocin) is indicated for the initiation or improvement of uterine contractions, where this
is desirable and considered suitable, in order to achieve early vaginal delivery for fetal or maternal
reasons. It is indicated for (1) induction of labor in patients with a medical indication for the initiation of
labor, such as Rh problems, maternal diabetes, pre-eclampsia at or near term, when delivery is in the
best interest of mother and fetus or when membranes are prematurely ruptured and delivery is indicated;
(2) stimulation or reinforcement of labor, as in selected cases of uterine inertia; (3) as adjunctive therapy
in the management of incomplete or inevitable abortion. In the first trimester, curettage is generally
considered primary therapy. In the second trimester abortion, oxytocin infusion will often be successful
in emptying the uterus. Other means of therapy, however, may be required in such cases.

Postpartum

Syntocinon® (oxytocin) injection is indicated to produce uterine contractions during the third stage of
labor and to control postpartum bleeding or hemorrhage.

See all Syntocinon indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Syntocinon (Oxytocin)

Oxytocin More Than Mere 'Love Hormone' 

Source: MedicineNet Smoking and Quitting Smoking Specialty [2010.11.16]
Title: Oxytocin More Than Mere 'Love Hormone'
Category: Health News
Created: 11/16/2010 11:00:00 AM
Last Editorial Review: 11/16/2010

more news >>

Published Studies Related to Syntocinon (Oxytocin)

Five Unit Bolus Oxytocin at Cesarean Delivery in Women at Risk of Atony: A Randomized, Double-
Blind, Controlled Trial. [2010.10.01]
Background: IV bolus oxytocin is used routinely during cesarean delivery to prevent postpartum
hemorrhage. Its adverse hemodynamic effects are well known, resulting in a recent change in dose from
10 IU to 5... These results suggest that an oxytocin infusion may be adequate without the need for a
bolus, even in high-risk patients.

Using intraumbilical vein injection of oxytocin in routine practice with active management of the third
stage of labor: a randomized controlled trial. [2010.09]
OBJECTIVE: To estimate the efficacy of the routine use of intraumbilical vein injection of oxytocin
with active management of the third stage of labor in reducing blood loss and length of the third stage...
CONCLUSION: The use of intraumbilical injection of oxytocin with the active management of the third
stage of labor significantly reduced postpartum blood loss and the duration of the third stage.
CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov, www.clinicaltrials.gov, NCT01094028.
LEVEL OF EVIDENCE: I.

Titrated oral misoprostol solution compared with intravenous oxytocin for labor augmentation: a
randomized controlled trial. [2010.09]
OBJECTIVE: To compare titrated oral misoprostol to intravenous oxytocin for labor augmentation
among women at 36 to 42 weeks of gestation with spontaneous onset of active labor... CONCLUSION:
Labor augmentation with titrated oral misoprostol or intravenous oxytocin resulted in similar rates of
vaginal delivery within 12 and 24 hours. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov,
www.clinicaltrials.gov, NCT00695331. LEVEL OF EVIDENCE: I.

A randomized controlled trial comparing vaginal misoprostol versus Foley catheter plus oxytocin for
labor induction. [2010.08]
OBJECTIVE: To compare effectiveness and safety of 25 microg vaginal misoprostol versus Foley
catheter and oxytocin for cervical ripening and labor induction in pregnant women with unripe cervices.
DESIGN: Randomized controlled trial. SETTING: A public maternity in Recife, Brazil. SAMPLE: A
total of 240 pregnant women... CONCLUSIONS: Vaginal misoprostol is more effective than and as safe
as Foley catheter and oxytocin for induction of labor in term and post-term pregnancy.

Carbetocin versus oxytocin for the prevention of postpartum haemorrhage following caesarean section:
the results of a double-blind randomised trial. [2010.07]
OBJECTIVE: To compare the effectiveness of carbetocin and oxytocin when they are administered
after caesarean section for prevention of postpartum haemorrhage (PPH). STUDY DESIGN: Double-
blind randomised single centre study (1:1 ratio). SETTING: Teaching hospital in Bristol, UK with 6000
deliveries per annum. POPULATION: Women at term undergoing elective or emergency caesarean
section under regional anaesthesia, excluding women with placenta praevia, multiple gestation and
placental abruption... CONCLUSIONS: Carbetocin is associated with a reduced use of additional
oxytocics. It is unclear whether this may reduce rates of PPH and blood transfusions.

more studies >>

Clinical Trials Related to Syntocinon (Oxytocin)

The Association Between Fluid Administration, Oxytocin Administration, and Fetal Heart Rate
Changes [Recruiting]
Fetal heart rate patterns are an important parameter in the diagnosis of non-reassuring fetal status.
Combined-spinal epidural analgesia is a method of initiating labor analgesia used by approximately
90% of the parturients at Prentice Women's Hospital. Optimizing the variables which could affect fetal
heart rate patterns at the time of initiation of analgesia, such as fluid administration and oxytocin
management, could help us provide better care for our patients and their fetuses.

Hypotheses: Patients who receive a 1000 mL fluid bolus and lower rates of oxytocin administration will
have fewer non-reassuring FHR changes.

Oxytocin Treatment of Schizophrenia [Recruiting]