LEARNING OBJECTIVES
At the end of the lecture the student should be able to know the
• Disorders of ADH
• Clinical correlate
body
processes
PITUITARY GLAND (HYPOPHYSIS)
• Lies in the sella turcica, a bony cavity at the base of the brain
hormone water
• Synthesized in hypothalamus
• Neurohormones
intact
OXYTOCIN
• Breast-feeding
• Childbirth (parturition)
sensitive to oxytocin
• Positive feedback
• Osmotic pressure
secretion parallels osmotic pressure.
• Volume effects
Baroreceptor mediated.
• Others
1. Antidiuretic actions
• Increases permeability of the collecting ducts to water
• V2 receptors
2. Vasopressor actions
• V1 receptors, non-hormonal
ACTION OF ADH
• Diabetes Insipidus
Secretion (SIADH)
DIABETES INSPIDUS
• TYPES
• Surgery
• Tumor
• Illness
• Head Injury
NEPHROGENIC DIABETES INSIPIDUS
CAUSES OF SIADH
• Pulmonary disease
• Carcinoma (Lung)
• Drugs
• Surgery
• Idiopathic
References
K, Chaudhry M.
3. Causes. By Mayo Clinic staff.
http://www.mayoclinic.com/health/diabetes-
insipidus/DS00799/DSECTION=causes