Abstract
Androgen plays a major role in early stage of prostate cancer. Many studies have
indicated that the length of CAG repeat in exon 1 of the androgen receptor gene is
associated with the risk of prostate cancer in different ethnicities. Different length of
CAG repeats may form different protein structure, and then influence the affinity with
androgen, which in turn to have differential transactivity for the downstream target
genes. In this study, we analyzed the length of CAG repeats in 118 samples, including
57 patients with prostate cancer and 61 controls (benign prostate hyperplasia patients
We extracted patients’ and controls’ DNA from paraffin embedded tissues then
amplified DNA by using Polymerase Chain Reaction (PCR). After verifying the PCR
For statistical analysis, we used Student’s test and odds ratio. In prostate cancer
patients, the length of CAG repeat is 22.4+/-2.84 (mean +/- standard deviation); in
difference identified between these two groups (p=0.29). Men with short CAG
repeats (n < 23) had 1.72-fold increased risk for prostate cancer compared to those
with long CAG repeats (n > or = 23) by odds ratio, but no significance (odds ratio, 1.72;
Abstract
patients always suffered from chemotherapy and surgery. In order to improve their
quality of life, finding out a new approach for medications is truly necessary.
powerful tool, to select specific protein markers which are able to provide useful
information for drug design. In this study, we tried to find out biomarkers of breast
cancer for diagnosis in early stage. Hopefully, based on the new selected markers, the
newly designed drugs will help current medications for breast cancers.
We obtained four sets of breast cancer tissues and normal breast tissues from
expression level on the corresponding spots between cancer and normal groups. We
extracted the proteins by using in-gel digestion and these proteins were identified by
These proteins are associated with energy metabolism, protein folding, cytoskeleton
structure and cell communication. We are going to find out the roles of these
proteins in tumor development and try to identify them as potential biomarkers for