A Pilot Study of a Kampo Formula, EH0202, with Intriguing Results for ... http://www.liebertonline.com/doi/abs/10.1089/107555304323062400?p...

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A Pilot Study of a Kampo Formula, EH0202, with Intriguing Results • Email to a colleague
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Takahisa Ushiroyama, Satoshi Yoshida, Keiichi Tadaki, Atsushi Ikeda, Minoru Ueki. The • Citation Alert
Journal of Alternative and Complementary Medicine. April 2004, 10(2): 397-399. What is RSS?
doi:10.1089/107555304323062400. • Most read articles
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Published in Volume: 10 Issue 2: July 5, 2004 • Most cited articles
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Takahisa Ushiroyama • CiteULike

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Department of Obstetrics and Gynecology, Osaka Medical College, Osaka, Japan • Digg This
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Satoshi Yoshida
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Product Category Management Institute for Consumer Healthcare Yamanouchi • Twitter
Pharmaceutical Co., Ltd., Tokyo, Japan

Keiichi Tadaki • PubMed citation

Medical Information, Marketing Division, Sanwell Co., Ltd., Tokyo, Japan • Related articles in:
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Atsushi Ikeda
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Department of Obstetrics and Gynecology, Osaka Medical College, Osaka, Japan
for
Minoru Ueki Authors:
Department of Obstetrics and Gynecology, Osaka Medical College, Osaka, Japan
Takahisa Ushiroyama
Satoshi Yoshida
Objectives: To investigate the effects of EH0202, a Japanese herbal supplement, on the Keiichi Tadaki
immune and endocrine systems in women with menopausal symptoms. Atsushi Ikeda
Design and subjects: Thirty-two (32) postmenopausal women (53.0 ± 5.1 years old) Minoru Ueki
presenting with menopausal complaints were enrolled in a clinical study. Patients were given Keyword:
an herbal supplement, EH0202 (6 g per day for 6 months) and were assessed for reduction
of their overall symptoms using Greene's Climacteric Scale and Visual Analog Scale. Plasma
interleukin-6 (IL-6), soluble IL-6 receptor, tumor necrosis factor-α, granulocyte macrophage-
colony stimulating factor (GM-CSF), granulocyte-colony stimulating factor, folliclestimulating
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hormone (FSH), and luteinizing hormone concentrations were measured before and 6
months after EH0202 adminstration.

Results: There was a significant decrease in the climacteric scale score (p = 0.0007) and
visual analogue scale (p < 0.0001) after 6 months of EH0202 treatment. There was
significant increase (p = 0.0097) in plasma GM-CSF levels and a significant decrease (p =
0.018) in plasma FSH levels after 6 months of EH0202 administration.

Conclusions: EH0202 (MACH) decreased the plasma FSH level and stimulated
myelopoiesis through the cytokine system, thereby clinically reduced menopausal symptoms
in postmenopausal women. Therefore, in postmenopausal women, this product probably
acts as an immunomodulator and endocine modulator.

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A Pilot Study of a Kampo Formula, EH0202, with Intriguing Results for ... http://www.liebertonline.com/doi/abs/10.1089/107555304323062400?p...

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