DAFTAR ISI

HALAMAN JUDUL........................................................................................ i

HALAMAN PERSETUJUAN ......................................................................... ii

PRAKATA ....................................................................................................... iii

DAFTAR ISI .................................................................................................... v

DAFTAR SINGKATAN ................................................................................ ix

DAFTAR TABEL ............................................................................................ x

DAFTAR LAMPIRAN .................................................................................... xi

INTISARI......................................................................................................... xii

BAB I PENDAHULUAN ........................................................................... 1

1.1. Latar Belakang.......................................................................... 1

1.2. Rumusan Masalah ............................... ..................................... 4

1.3. Tujuan Penelitian ...................................................................... 4

1.3.1. Tujuan Umum.......................................... ..................... 4

1.3.2. Tujuan Khusus.............................................. ................ 4

1.4. Manfaat ..................................................................................... 5

1.4.1. Manfaat Teoritis............................................................ 5

1.4.2. Manfaat Praktis ............................................................. 5

BAB II TINJAUAN PUSTAKA .................................................................. 6

2.1. Sindrom Syok Dengue .............................................................. 6

2.1.1. Definisi ......................................................................... 6

2.1.2. Pengelolaan Syok.......................................................... 8

2.2. Demam Berdarah Dengue ........................................................ 9

2.2.1. Definisi.................... ..................................................... 9

2.2.2. Etiologi ......................................................................... 10

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 2.2.3. Penularan Demam Berdarah Dengue............................ 11

2.2.4. Patofisiologi .................................................................. 11

2.2.5. Manifestasi Klinis ......................................................... 15

2.2.6. Diagnosis ...................................................................... 18

2.2.7. Klasifikasi Derajat Penyakit DBD ................................ 20

2.2.8. Penatalaksanaan ............................................................ 20

2.2.9. Komplikasi.................................................................... 24

2.2.10. Prognosis ...................................................................... 25

2.2.11. Kriteria Memulangkan Pasien................................. ..... 25

2.2.12. Pencegahan ................................................................... 26

2.3. Trombosit ................................................................................. 27

2.3.1. Definisi ......................................................................... 27

2.3.2. Pembentukan trombosit ................................................ 27

2.3.3. Hemostasis Oleh trombosit ........................................... 27

2.3.4. Hitung Trombosit.......................................................... 29

2.3.5. Trombositopenia ........................................................... 31

2.3.6. Hubungan Trombositopenia Dengan Kejadian Syok ... 32

2.4. Hematokrit ................................................................................ 35

2.4.1. Definisi ......................................................................... 35

2.4.2. Faktor yang Mempengaruhi Nilai Hematokrit ............. 35

2.4.3. Metode Pemeriksaan ..................................................... 36

2.4.4. Cara Pemeriksaan ......................................................... 36

2.4.5. Nilai Rujukan hematokrit ............................................. 37

2.5. Hubungan Antara Kadar Hematokrit dengan Derajat

Keparahan Dengue............................ ....................................... 37

2.6. Kerangka Teori ......................................................................... 40

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 2.7. Kerangka Konsep ..................................................................... 41

2.8. Hipotesis ................................................................................... 41

BAB III METODE PENELITIAN ................................................................ 42

3.1 Jenis Penelitian ......................................................................... 42

3.2 Variabel Penelitian ................................................................... 42

3.2.1 Variabel Bebas .............................................................. 42

3.2.2 Variabel Terikat ............................................................ 42

3.3 Definisi Operasional Variabel .................................................. 42

3.3.1. Demam Berdarah Dengue dengan Trombositopenia

Disertai Hemokonsentrasi............................................. 42

3.3.2. Syok .............................................................................. 43

3.4 Populasi dan Sampel................................................................. 44

3.4.1. Populasi ........................................................................ 44

3.4.1.1. Populasi Target ............................................... 44

3.4.1.2. Populasi Terjangkau ....................................... 44

3.4.2. Sampel .......................................................................... 44

3.4.3. Kriteria Inklusi dan Eksklusi ........................................ 45

3.4.4. Besar Sampel ................................................................ 46

3.4.5. Teknik Sampling........................................................... 47

3.5 Instrumen Penelitian ................................................................. 47

3.6 Rancangan Penelitian ............................................................... 47

3.7 Cara penelitian .......................................................................... 48

3.7.1 Perencanaan .................................................................... 48

3.7.2 Pelaksanaan Penelitian .................................................... 48

3.7.2.1. Perizinan ......................................................... 48

3.7.2.2. Pengumpulan Data.......................................... 48

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 3.7.2.3. Analisis Hasil Laboratorium........................... 48

3.7.2.4. Analisis Data .................................................. 48

3.7.2.5. Penulisan Laporan .......................................... 49

3.8 Tempat dan Waktu ................................................................... 49

3.8.1. Tempat Penelitian ......................................................... 49

3.8.2. Waktu Penelitian........................................................... 49

3.9 Teknik Analisis Data ................................................................ 50

BAB IV HASIL PENELITIAN DAN PEMBAHASAN ............................... 51

4.1. Hasil Penelitian ......................................................................... 51

4.2. Pembahasan .............................................................................. 53

BAB V KESIMPULAN DAN SARAN ....................................................... 57

5.1. Kesimpulan ............................................................................... 57

5.2. Saran ......................................................................................... 57

DAFTAR PUSTAKA.............................................. ........................................ 59

LAMPIRAN ..................................................................................................... 62

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