WAKTU PERDARAHAN DAN WAKTU KOAGULASI

Kelompok Waktu Perdarahan Waktu Koagulasi

Kontrol Negatif 157.17 ± 35.02 171.5 ± 22.45
Ekstrak 220.67 ± 26.13 184.17 ± 33.14
Kontrol Positif 260 ± 38.98 212.83 ± 36.85
Sediaan 231.5 ± 42.47 188 ± 24.31

Multiple Comparisons

95% Confidence

Mean Interval

Difference Lower Upper

Dependent Variable (I) Kelompok (J) Kelompok (I-J) Std. Error Sig. Bound Bound

Waktu Tukey Kontrol Ekstrak -63.500* 20.880 .030 -121.94 -5.06

Perdarahan HSD Negatif Kontrol Positif -102.833 *
20.880 .000 -161.28 -44.39

Sediaan -74.333* 20.880 .010 -132.78 -15.89

*
Ekstrak Kontrol Negatif 63.500 20.880 .030 5.06 121.94

Kontrol Positif -39.333 20.880 .266 -97.78 19.11

Sediaan -10.833 20.880 .954 -69.28 47.61

Kontrol Kontrol Negatif 102.833* 20.880 .000 44.39 161.28

Positif Ekstrak 39.333 20.880 .266 -19.11 97.78

Sediaan 28.500 20.880 .535 -29.94 86.94

*
Sediaan Kontrol Negatif 74.333 20.880 .010 15.89 132.78

Ekstrak 10.833 20.880 .954 -47.61 69.28

Kontrol Positif -28.500 20.880 .535 -86.94 29.94

Waktu Koagulasi Tukey Kontrol Ekstrak -12.667 17.204 .881 -60.82 35.49
HSD Negatif Kontrol Positif -41.333 17.204 .109 -89.49 6.82

Sediaan -16.500 17.204 .774 -64.65 31.65

Ekstrak Kontrol Negatif 12.667 17.204 .881 -35.49 60.82

Kontrol Positif -28.667 17.204 .367 -76.82 19.49

Sediaan -3.833 17.204 .996 -51.99 44.32

Kontrol Kontrol Negatif 41.333 17.204 .109 -6.82 89.49

Positif Ekstrak 28.667 17.204 .367 -19.49 76.82

Sediaan 24.833 17.204 .488 -23.32 72.99

Sediaan Kontrol Negatif 16.500 17.204 .774 -31.65 64.65

Ekstrak 3.833 17.204 .996 -44.32 51.99

Kontrol Positif -24.833 17.204 .488 -72.99 23.32

*. The mean difference is significant at the 0.05 level.

 Waktu Perdarahan dan Waktu Koagulasi
300
250

Waktu (detik)
200
150
100
50
0
Kontrol Negatif Ekstrak Kontrol Positif Sediaan
Kelompok

Waktu Perdarahan Linear (Waktu Perdarahan)

Waktu Koagulasi Linear (Waktu Koagulasi)

PARAMETER DARAH

Kelompok WBC HGB RBC PLT

Kontrol Negatif 16.62 ± 4.23 14.20 ± 2.06 8.46 ± 1.23 463 ± 92.51
Ekstrak 19.90 ± 3.05 14.58 ± 0.42 8.62 ± 0.50 410.50 ± 134.23
Kontrol Positif 20.35 ± 6.32 13.75 ± 0.81 8.44 ± 0.42 393.33 ± 108.69
Sediaan 19.87 ± 4.99 14 ± 0.82 8.60 ± 0.68 348.50 ± 104.46

HGB
RBC
PLT WBC
463 8.62 8.6
50014.8 410.5
14.58 393.33 25 19.9 20.35 19.87
8.6
400 348.5 16.62
20
14.2
14.4
8.46
300
8.5 8.44 14 15
200 14 13.75 10
8.4
100 5
13.6
8.3
0 0
Kontrol
Kontrol
13.2 Ekstrak
Ekstrak Kontrol
KontrolPositif
Positif Sediaan
Sediaan Kontrol Ekstrak Kontrol Positif Sediaan
Negatif
Negatif
Kontrol Ekstrak Kontrol Positif Sediaan Negatif
Negatif

SERAPAN PLASMA

Kelompok Absorban 0 Absorban induksi ADP Selisih

Kontrol Negatif 0.187 ± 0.052 0.106 ± 0.038 0.081 ± 0.042
Ekstrak 0.219 ± 0.077 0.089 ± 0.026 0.131 ± 0.074
Kontrol Positif 0.196 ± 0.024 0.135 ± 0.042 0.061 ± 0.131
Sediaan 0.111 ± 0.012 0.093 ± 0.023 0.017 ± 0.005
 Multiple Comparisons
LSD

95% Confidence
Interval

Dependent Mean Std. Lower Upper

Variable (I) Kelompok (J) Kelompok Difference (I-J) Error Sig. Bound Bound

Absorban 0 Kontrol Ekstrak .08543 .04954 .100 -.0179 .1888

Negatif Aspirin .00903 .04954 .857 -.0943 .1124

Nanoemulsi -.02335 .04954 .643 -.1267 .0800

Ekstrak Kontrol Negatif -.08543 .04954 .100 -.1888 .0179

Aspirin -.07640 .04954 .139 -.1797 .0269

Nanoemulsi -.10878* .04954 .040 -.2121 -.0054

Aspirin Kontrol Negatif -.00903 .04954 .857 -.1124 .0943

Ekstrak .07640 .04954 .139 -.0269 .1797

Nanoemulsi -.03238 .04954 .521 -.1357 .0710

Nanoemulsi Kontrol Negatif .02335 .04954 .643 -.0800 .1267

Ekstrak .10878* .04954 .040 .0054 .2121

Aspirin .03238 .04954 .521 -.0710 .1357

Abs Induksi Kontrol Ekstrak .04192* .01887 .038 .0026 .0813
ADP Negatif Aspirin .02928 .01887 .136 -.0101 .0686
*
Nanoemulsi .04640 .01887 .023 .0070 .0858
*
Ekstrak Kontrol Negatif -.04192 .01887 .038 -.0813 -.0026
Aspirin -.01263 .01887 .511 -.0520 .0267
Nanoemulsi .00448 .01887 .815 -.0349 .0438
Aspirin Kontrol Negatif -.02928 .01887 .136 -.0686 .0101
Ekstrak .01263 .01887 .511 -.0267 .0520
Nanoemulsi .01712 .01887 .375 -.0222 .0565
Nanoemulsi Kontrol Negatif -.04640* .01887 .023 -.0858 -.0070
Ekstrak -.00448 .01887 .815 -.0438 .0349
Aspirin -.01712 .01887 .375 -.0565 .0222
Selisih Kontrol Ekstrak .04352 .04510 .346 -.0506 .1376
Absorban Negatif Aspirin -.02025 .04510 .658 -.1143 .0738

Nanoemulsi -.06975 .04510 .138 -.1638 .0243

Ekstrak Kontrol Negatif -.04352 .04510 .346 -.1376 .0506

Aspirin -.06377 .04510 .173 -.1578 .0303

Nanoemulsi -.11327* .04510 .021 -.2073 -.0192

Aspirin Kontrol Negatif .02025 .04510 .658 -.0738 .1143

 Ekstrak .06377 .04510 .173 -.0303 .1578

Nanoemulsi -.04950 .04510 .285 -.1436 .0446

Nanoemulsi Kontrol Negatif .06975 .04510 .138 -.0243 .1638

*
Ekstrak .11327 .04510 .021 .0192 .2073

Aspirin .04950 .04510 .285 -.0446 .1436

*. The mean difference is significant at the 0.05 level.

Serapan Plasma
0.25
0.2
0.15
Nilai

0.1
0.05
0
Kontrol Negatif Ekstrak Kontrol Positif Sediaan
Kelompok

Absorban 0 Linear (Absorban 0)

Absorban induksi ADP Linear (Absorban induksi ADP)
Selisih Linear (Selisih)

UJI MDA

Kelompok MDA Plasma MDA Hati MDA Otak

(nmol/ml) (nmol/gram) (nmol/gram)
Kontrol Negatif 2.255 ± 0.768 3.503 ± 0.030 2.786 ± 0.052
Ekstrak 2.218 ± 0.106 3.883 ± 0.012 2.770 ± 0.103
Kontrol Positif 2.0127 ± 0.143 4.211 ± 0.014 3.032 ± 0.041
Sediaan 1.9359 ± 0.085 4.026 ± 0.013 2.974 ± 0.032

2.26
MDA Plasma (nmol/ml)
2.3 2.22
MDAMDA
OtakHati
(nmol/gram)
(nmol/gram) 2.1 2.01
1.94
Kadar MDA

3.03
kadar MDA

3.1 4.21 2.97 4.03 1.9

3 3.5 3.88
2.9 4
2.79 2.77 1.7
2.8 Kontrol Ekstrak Kontrol Positif Sediaan
2.7 3
Kadar MDA

Negatif
2.6 2
Rata-rata

Kontrol Ekstrak Kontrol Sediaan

Negatif Positif Kelompok
1
0 Kelompok
Kontrol Negatif Ekstrak Kontrol Positif Sediaan
Kelompok