LAMPIRAN STABILITAS

1. Data hasil uji stabilitas dipercepat terhadap kadar zat akitf Asam Laktat dalam
sediaan krim. Uji dilakukan pada suku 40°±2°C dan kelembapan 75% ± 5%.

Kadar Asam Laktat

Waktu
No
(bulan)
Batch 1 Batch 2 Batch

1 0 100,09 100,12 99,92

2 1 99,65 99,72 99,63
3 2 99,14 99,12 99,05
4 3 98,62 98,83 98,81
5 6 98,41 98,21 98,42
BATCH 1
Kadar awal t = 0 bulan = 100,09 %
Kadar awal t = 1 bulan = 99,65 %
Harga kinetika order (k)
(k 1 x t 1)
log S1=log S 0−
2,303
( k 1 x 1)
log 99,85=log 100,0 9−
2,303
k 1=0,004407
Kadar awal t = 2 bulan = 99,14 %
Harga kinetika order (k)
(k 2 x t 2)
log S2=log S 0−
2,303
( k 2 x 2)
log 99 , 14=log 100,0 9−
2,303
k 2=0,00 4769
Kadar awal t = 3 bulan = 98,62 %
Harga kinetika order (k)
(k 3 x t 3 )
log S3=log S 0−
2,303
(k 3 x 3)
log 9 8 , 62=log 100,0 9−
2,303
 k 3=0,00 4933
Kadar awal t = 6 bulan = 98,41 %
Harga kinetika order (k)
( k 6 x t6 )
log S6 =log S 0−
2,303
( k 4 x 6)
log 98 , 41=log 100,0 9−
2,303
k 6=0,00 2822

k 1 +k 2+ k 3 +k 6 0,00 4407+ 0,00 4769+0,00 4933+ 0,00 2822

k rata−rata= = =0,00 4233
4 4

Perhitungan Expired Date:

Jika minimal kadar adalah 90%, maka:

( k rata−rata x t 90 %)
log S6 =log S 0−
2,303
( 0,001901 x t )
log 90=log 100,09−
2,303
t = 25,1098 bulan ≈ 2 tahun

BATCH 2
Kadar awal t = 0 bulan = 100,12 %
Kadar awal t = 1 bulan = 99,72 %
Harga kinetika order (k)
(k 1 x t 1)
log S1=log S 0−
2,303
(k 1 x 1)
log 99 , 72=log 100,12−
2,303
k 1=0,003704
Kadar awal t = 2 bulan = 99,12 %
Harga kinetika order (k)
(k 2 x t 2)
log S2=log S 0−
2,303
 (k 2 x 2)
log 99 , 1 2=log 100,12−
2,303
k 2=0,00 4870
Kadar awal t = 3 bulan = 98,83 %
Harga kinetika order (k)
(k 3 x t 3 )
log S3=log S 0−
2,303
(k 3 x 3)
log 98,83=log 100,12−
2,303
k 3=0,00 4224
Kadar awal t = 6 bulan = 98,21 %
Harga kinetika order (k)
( k 6 x t6 )
log S6 =log S 0−
2,303
(k 4 x 64)
log 98,21=log 100,12−
2,303
k 6=0,00 3161

k 1 +k 2+ k 3 +k 6 0,00 3704+0,00 4870+0,00 4224 +0,0 3161

k rata−rata= = =0,00 3990
4 4

Perhitungan Expired Date:

Jika minimal kadar adalah 90%, maka:

( k rata−rata x t 90 %)
log S6 =log S 0−
2,303
(0,001893 x t )
log 90=log 100,12−
2,303
t = 26,7135 bulan ≈ 2 tahun 2 bulan

BATCH 3
Kadar awal t = 0 bulan = 99,92 %
Kadar awal t = 1 bulan = 99,63 %
Harga kinetika order (k)
(k 1 x t 1)
log S1=log S 0−
2,303
 (k 1 x 1)
log 99,6 3=log 99,92−
2,303
k 1=0,00 4607
Kadar awal t = 2 bulan = 99,05 %
Harga kinetika order (k)
(k 2 x t 2)
log S2=log S 0−
2,303
( k 2 x 2)
log 99,5 0 5=log 99,92−
2,303
k 2=0,00 5223
Kadar awal t = 3 bulan = 98,81 %
Harga kinetika order (k)
(k 3 x t 3 )
log S3=log S 0−
2,303
(k 3 x 3)
log 9 8 , 81=log 99,92−
2,303
k 3=0,04291
Kadar awal t = 6 bulan = 98,42 %
Harga kinetika order (k)
( k 6 x t6 )
log S6 =log S 0−
2,303
(k 4 x 64 )
log 98,4 2=log 99,92−
2,303
k 6=0,00 2805

k 1 +k 2+ k 3 +k 6 0,00 4607+ 0,005223+ 0,00 4291+0,00 2805

k rata−rata= = =0,002077
4 4

Perhitungan Expired Date:

Jika minimal kadar adalah 90%, maka:

( k rata−rata x t 90 %)
log S6 =log S 0−
2,303
(0,002077 x t)
log 90=log 99,92−
2,303
t = 24,7135 bulan ≈ 2 tahun