Healing the Brain Applied

Neurobiology 2008

Dr. Dietrich Klinghardt, M.D., PhD.

February 22-24 2008
Kirkland, WA
 Neurology Illness Statistics
„ WASHINGTON (Reuters) – Journal of Neurology:

„ Multiple sclerosis, Parkinson's disease and other neurological diseases may be far more common than most
people had believed, according to new estimates published on Monday. Nearly one out of 1,000 Americans has
multiple sclerosis or MS and one out of 100 elderly Americans has Parkinson's disease the survey found."Our
estimate of MS prevalence is about 50 percent higher than a comprehensive review from 1982," said Dr. Deborah
Hirtz of the National Institute of Neurological Disorders and Stroke, who led the survey.It is not clear whether the
disease is actually more common or if it is being diagnosed more accurately, she said.

„ The new survey, published in the journal Neurology, also found the rate of Alzheimer’s Disease was up
substantially from past estimates, with 67 out of 1,000 Americans over the age of 65 affected.Nearly 10 out of
1,000 older Americans have Parkinson's disease, and four out of every 100,000 has amyotrophic lateral sclerosis,
also called ALS or Lou Gehrig's disease, the survey found.

„ The survey projects that the number of people with Parkinson's will double from about 4.3 million people now to
9 million people worldwide over the next 25 years.It corroborated other studies on childhood neurological
disorders, finding that nearly six out of every 1,000 children has autism, and two out of every 1,000 children has
cerebral palsy.

„ Hirtz and colleagues reviewed studies from nearly 500 medical papers published between 1990 and 2005 for their
report.They found that 101 out of every 100,000 Americans has a traumatic brain injury each year, 50 percent
fewer than previous estimates.
„ More than 180 out of every 100,000 people suffer a stroke each year, and close to five out of every 100,000 have
a new spinal cord injury each year.

„ Steven Albert of the Department of Behavioral and Community Health Sciences at the University of Pittsburgh
said the impact of Alzheimer's will be substantial as the population ages."Current projections of AD (Alzheimer's
disease) suggest that there will be about 10 million cases in the United States in 2050, of which 6 million are
expected to have moderate or severe dementia," Albert wrote in a commentary in the journal.

„ There is currently no cure and treatments only delay the progression of Alzheimer's slightly. There is also no cure
for MS or for Parkinson's, although drugs can also delay their progression.
 Parkinson’s Abstract
„ Kidd PM. Parkinson's disease as multifactorial oxidative neurodegeneration: implications for integrative
management. Altern Med Rev. 2000 Dec;5(6):502-29.

„ Parkinson's disease (PD) is the most common movement pathology, severely afflicting dopaminergic neurons
within the substantia nigra (SN) along with non-dopaminergic, extra-nigral projection bundles that control circuits
for sensory, associative, premotor, and motor pathways. Clinical, experimental, microanatomic, and biochemical
evidence suggests PD involves multifactorial, oxidative neurodegeneration, and that levodopa therapy adds to the
oxidative burden.

„ The SN is uniquely vulnerable to oxidative damage, having high content of oxidizable dopamine, neuromelanin,
polyunsaturated fatty acids, and iron, and relatively low antioxidant complement with high metabolic rate.
Oxidative phosphorylation abnormalities impair energetics in the SN mitochondria, also intensifying oxygen free
radical generation.

„ These pro-oxidative factors combine within the SN dopaminergic neurons to create extreme vulnerability to
oxidative challenge. Epidemiologic studies and long-term tracking of victims of MPTP (1-methyl-4-phenyl-1,2,3,6,-
tetrahydropyridine) poisoning, suggest oxidative stress compounded by exogenous toxins may trigger the
neurodegenerative progression of PD. Rational, integrative management of PD requires:
„
„ (1) dietary revision, especially to lower calories;
„ (2) rebalancing of essential fatty acid intake away from pro-inflammatory and toward anti-inflammatory
prostaglandins;
„ (3) aggressive repletion of glutathione and other nutrient antioxidants and cofactors;
„ (4) energy nutrients acetyl L-carnitine, coenzyme Q10, NADH, and the membrane phospholipid
phosphatidylserine (PS),
„ (5) chelation as necessary for heavy metals; and
„ (6) liver P450 detoxification support.
 Nutritional Support Protocols

2 North Rd. East Windsor, CT 06088 Phone (800) 847-8302

Fax (860) 627-0661 www.designsforhealth.com
 Brain Injury Recovery Protocol
„ Nutritional Support Protocol
„ Lifestyle Recommendations:
„ 1. Practice good sleep habits and get between 8-9 hours of sleep a night.
„ 2. Engage in 30 minutes of intense aerobic exercise 4-5 times a week.
„ 3. Engage in mental exercise by consistently learning new skills and information.
„ 4. Avoid exposure to chemicals including skincare and hair care products such as Grecian Formula
„ (contains lead), lipstick (contains aluminum), deodorant (aluminum), toxic cleaning products and
„ artist’s paints.
„ 5. Build positive relationships in your life; practice clear communication, cooperation and forgiveness.
„ 6. Listen to a lot of great music.
„ Dietary Recommendations:
„ 1. Choose lean, clean quality protein at each meal (chicken breast, turkey breast, lean beef, fish -
„ especially salmon and tuna, lowfat cottage cheese, lowfat string cheese, eggs and whey protein).
„ 2. Emphasize omega 3 fatty acids (salmon, mackerel, herring, tuna) and omega 9 fats (olive oil,
„ olives, almonds, hazelnuts, avocados, macadamia oil and coconut oil).
„ 3. Consume 10 servings of vegetables/fruits every day. In addition, substitute complex carbohydrates
„ (non-starchy vegetables and whole grains) for refined and simple carbohydrates. Eliminate refined
„ carbohydrates from the diet (this includes bread, cereal or pasta made with white flour, white rice,
„ white potatoes, sugar, corn syrup, honey and candy).
„ 4. Limit or avoid trans fatty acids (hydrogenated vegetable oil, margarine and shortening). Cook with
„ olive oil.
„ 5. Drink at least 64 ounces of filtered, bottled or non-chlorinated water every day. In addition, drink
„ 2-3 cups of green tea daily.
„ 6. Avoid or limit caffeine, alcohol and other potentially neurotoxic compounds like aspartame and MSG.
„ Supplement Recommendations:
„ The following supplements are in addition to Twice Daily Essential Packets to supply your
„ core vitamins, minerals, antioxidants and essential fatty acids.
„ Brain Vitale: 2 with breakfast and lunch, 4 per day
„ Krill Oil: 2 with each meal, 6 per day
„ Three-A-Day Antioxidant: 1 with each meal, 3 per day
„ Pregnenolone: 1 dropper 3 times per day
„ Inflammatone: 2 caps 3 times per day
„ 2 North Rd. East Windsor, CT 06088 Phone (800) 847-8302 Fax (860) 627-0661 www.designsforhealth.com
„ THIS INFORMATION IS PROVIDED FOR THE USE OF PHYSICIANS AND OTHER LICENSED HEALTH CARE PRACTITIONERS ONLY. THIS INFORMATION
„ IS INTENDED FOR PHYSICIANS AND OTHER LICENSED HEALTH CARE PROVIDERS TO USE AS A BASIS FOR DETERMINING WHETHER OR NOT TO
„ RECOMMEND THESE PRODUCTS TO THEIR PATIENTS. THIS MEDICAL AND SCIENTIFIC INFORMATION IS NOT FOR USE BY CONSUMERS. THE
DIETARY
„ SUPPLEMENT PRODUCTS OFFERED BY DESIGNS FOR HEALTH ARE NOT INTENDED FOR USE BY CONSUMERS AS A MEANS TO CURE, TREAT,
PREVENT,
„ DIAGNOSE, OR MITIGATE ANY DISEASE OR OTHER MEDICAL CONDITION. ®
 ADD/ADHD Support Protocol
„ Nutritional Support Protocol
„ Lifestyle Recommendations:
„ 1. Avoid video and computer games, minimize tv viewing.
„ 2. Interactive metronome, biofeedback and neurofeedback, brain gym exercises
„ 3. Physical exercise involving coordination.
„ Dietary Recommendations:
„ 1. Avoid candy and desserts. Xylitol is an excellent sweetener and helps to prevent cavities and ear
„ infections.
„ 2. Avoid NutraSweet and other artificial sweeteners
„ 3. Avoid white flour and all refined carbohydrates including cereals and pasta especially those that are
„ made with yeast such as bread, bagels and English muffins. Replace these with brown rice, sweet
„ or white potato and oatmeal.
„ 4. Increase consumption of omega 3's (salmon, mackerel, herring, tuna, or flax oil).
„ 5. Eat protein at every meal including eggs, fish, chicken and lean meat.
„ 6. Avoid hydrogenated vegetable oils.
„ 7. Healthy snacks would be vegetables, nuts, olives, avocado, celery with almond butter, PaleoBars,
„ and Brain Power Sours.
„ 8. Eat 5-9 servings of fresh fruits and vegetables daily OR add one heaping tablespoon of PaleoGreens
„ to your favorite drink.
„ 9. Replace sugar with the polyol sugar xylitol.
„ 10. Carry PaleoMeal Packets and/or PaleoBars with you throughout the day to prevent missing meals or
„ snacks.
„ Supplement Recommendations:
„ The following supplements are in addition to Twice Daily Essential Packets to
„ supply your core vitamins, minerals, antioxidants and essential fatty acids.
„ Krill Oil: 1 with breakfast and 1 with dinner, 2 per day
„ Neurolink: 2 per meal
„ Carnitine Synergy: 2 - 6 per day
„ Phosphatidyl Serine: 2 - 4 caps or 1/4 to 1/2 tsp. per day
„ Note: These are adult doses. For children, divide by weight difference. For example, assuming 120 lb
„ adult, a 40 lb child would get 1/3 the dosage.
„ THIS INFORMATION IS PROVIDED FOR THE USE OF PHYSICIANS AND OTHER LICENSED HEALTH CARE PRACTITIONERS ONLY. THIS INFORMATION
„ IS INTENDED FOR PHYSICIANS AND OTHER LICENSED HEALTH CARE PROVIDERS TO USE AS A BASIS FOR DETERMINING WHETHER OR NOT TO
„ RECOMMEND THESE PRODUCTS TO THEIR PATIENTS. THIS MEDICAL AND SCIENTIFIC INFORMATION IS NOT FOR USE BY CONSUMERS. THE
DIETARY
„ SUPPLEMENT PRODUCTS OFFERED BY DESIGNS FOR HEALTH ARE NOT INTENDED FOR USE BY CONSUMERS AS A MEANS TO CURE, TREAT,
PREVENT,
„ DIAGNOSE, OR MITIGATE ANY DISEASE OR OTHER MEDICAL CONDITION. ®
 Alzheimer’s Protocol
„ Nutritional Support Protocol
„ Lifestyle Recommendations:
„ 1. Avoid alcohol and any over the counter medications unless prescribed by your doctor.
„ 2. Exercise daily such as brisk walking to increase circulation.
„ 3. Avoid exposure to chemicals including skincare and hair care products such as Grecian Formula
„ (contains lead), lipstick (contains aluminum), deodorant (aluminum), cleaning products and
„ artists paints.
„ 4. Do mental exercises such as brain gym or crossword puzzles.
„ Dietary Recommendations:
„ 1. Avoid or limit caffeine, alcohol and other potentially neurotoxic compounds like aspartame and MSG.
„ 2. Avoid pesticides, herbicides and chemicals by eating organic fruits and vegetables.
„ 3. Stabilize blood sugar by eating protein at every meal, 3 times per day. Hypoglycemia, lack of
„ glucose, can damage brain cells.
„ 4. Drink purified water, at least 8 glasses per day.
„ 5. Eat 5-9 servings of fresh fruits and vegetables daily OR add one heaping tablespoon of PaleoGreens
„ to your favorite drink.
„ 6. Replace sugar with the polyol sugar xylitol.
„ 7. Carry PaleoMeal Packets and/or PaleoBars with you throughout the day to prevent missing meals or
„ snacks.
„ Supplement Recommendations:
„ The following supplements are in addition to Twice Daily Essential Packets to
„ supply your core vitamins, minerals, antioxidants and essential fatty acids.
„ Brain Vitale: 1/2 tspn powder (in water or juice) with breakfast and
„ lunch, 1 tspn per day OR 2 caps with breakfast and lunch,
„ 4 caps per day
„ Glutathione Power: 1/2 tspn (in water or juice) with breakfast
„ Lipoic Supreme: 1 capsule with breakfast, 300 mg per day
„ Krill Oil: 2 softgels per day with breakfast, 2 per day
„ *Q-Avail 100mg or
„ CoQ10 Synergy Powder: 1-2 softgels per day, or up to 1 tsp powder per day
„ 2 North Rd. East Windsor, CT 06088 Phone (800) 847-8302 Fax (860) 627-0661 www.designsforhealth.com
„ THIS INFORMATION IS PROVIDED FOR THE USE OF PHYSICIANS AND OTHER LICENSED HEALTH CARE PRACTITIONERS ONLY. THIS INFORMATION
„ IS INTENDED FOR PHYSICIANS AND OTHER LICENSED HEALTH CARE PROVIDERS TO USE AS A BASIS FOR DETERMINING WHETHER OR NOT TO
„ RECOMMEND THESE PRODUCTS TO THEIR PATIENTS. THIS MEDICAL AND SCIENTIFIC INFORMATION IS NOT FOR USE BY CONSUMERS. THE
DIETARY
„ SUPPLEMENT PRODUCTS OFFERED BY DESIGNS FOR HEALTH ARE NOT INTENDED FOR USE BY CONSUMERS AS A MEANS TO CURE, TREAT,
PREVENT,
„ DIAGNOSE, OR MITIGATE ANY DISEASE OR OTHER MEDICAL CONDITION. ®
 Anxiety Protocol
„ Nutritional Support Protocol
„ Lifestyle Recommendations:
„ 1. Control stress and avoid extra obligations.
„ 2. Avoid smoking and alcohol consumption.
„ 3. Get regular exercise such as yoga, tai chi, walking.
„ 4. Avoid consumption of known or suspected food allergies.
„ 5. Check adrenal function and address sleep quality and quantity.
„ Dietary Recommendations:
„ 1. Avoid all sugars including fruit and fruit juices.
„ 2. Avoid white flour and all refined carbohydrates including cereals and pasta especially those that are
„ made with yeast such as bread, bagels and English muffins.
„ 3. Get a balance of omega 3's (salmon, mackerel, herring, tuna) and omega 9 fats (olive oil, olives,
„ almonds, hazelnuts, avocados).
„ 4. Stabilize blood sugar by eating protein at every meal including fish, chicken and lean meat.
„ 5. Avoid hydrogenated vegetable oils and fried foods.
„ 6. Cook with olive oil.
„ 7. Snack on vegetables and small amounts of nuts, olives or avocado.
„ 8. Excellent snacks are almonds, celery with almond butter, PaleoBars and Brain Power Sours.
„ 9. Do not skip meals.
„ 10. Eat 5-9 servings of fresh fruits and vegetables daily OR add one heaping tablespoon of PaleoGreens
„ to your favorite drink.
„ 11. Replace sugar with the polyol sugar xylitol.
„ 12. Carry PaleoMeal Packets and/or PaleoBars with you throughout the day to prevent missing meals or
„ snacks.
„ Supplement Recommendations:
„ The following supplements are in addition to Twice Daily Essential Packets to
„ supply your core vitamins, minerals, antioxidants and essential fatty acids.
„ StressArrest Capsules: 1-4 per day
„ Inositol: 1-2 teaspoons at bedtime
„ Taurine Powder/Capsules: 2 grams (powder) or 1 capsule twice per day
„ 2 North Rd. East Windsor, CT 06088 Phone (800) 847-8302 Fax (860) 627-0661 www.designsforhealth.com
„ THIS INFORMATION IS PROVIDED FOR THE USE OF PHYSICIANS AND OTHER LICENSED HEALTH CARE PRACTITIONERS ONLY. THIS INFORMATION
„ IS INTENDED FOR PHYSICIANS AND OTHER LICENSED HEALTH CARE PROVIDERS TO USE AS A BASIS FOR DETERMINING WHETHER OR NOT TO
„ RECOMMEND THESE PRODUCTS TO THEIR PATIENTS. THIS MEDICAL AND SCIENTIFIC INFORMATION IS NOT FOR USE BY CONSUMERS. THE
DIETARY
„ SUPPLEMENT PRODUCTS OFFERED BY DESIGNS FOR HEALTH ARE NOT INTENDED FOR USE BY CONSUMERS AS A MEANS TO CURE, TREAT,
PREVENT,
„ DIAGNOSE, OR MITIGATE ANY DISEASE OR OTHER MEDICAL CONDITION. ®
 Depression Protocol
„ Nutritional Support Protocol
„ Lifestyle Recommendations:
„ 1. Take long vacations and get adequate sleep.
„ 2. Avoid extra stress and obligations.
„ 3. Rule out heavy metal toxicity, overgrowth of candida albicans, and hormone imbalance.
„ 4. Rule out hypothyroidism, hypoglycemia, and weak adrenal function.
„ 5. Avoid smoking and alcohol consumption.
„ 6. Engage in regular aerobic exercise such as walking, yoga, or tai chi.
„ Dietary Recommendations:
„ 1. Whey Protein or other Quality Protein is essential at every meal to stabilize blood sugar levels.
„ 2. Avoid sugar and sweetened products.
„ 3. Wheat and Dairy avoidance may prove extremely helpful for stabilizing moods.
„ 4. Avoid sugar and concentrate on fish and foods high in omega 3 fatty acids such as salmon,
„ mackerel, and tuna.
„ 5. Avoid allergic foods.
„ 6. Eat 5-9 servings of fresh fruits and vegetables daily OR add one heaping tablespoon of PaleoGreens
„ to your favorite drink.
„ 7. Replace sugar with the polyol sugar xylitol.
„ 8. Carry PaleoMeal Packets and/or PaleoBars with you throughout the day to prevent missing meals or
„ snacks.
„ Supplement Recommendations:
„ The following supplements are in addition to Twice Daily Essential Packets to
„ supply your core vitamins, minerals, antioxidants and essential fatty acids.
„ Phosphatidyl Serine: 100-1,000 mg
„ L-Carnitine: 500-2,000 mg
„ Folic Acid/B12: 1 mg of each
„ Omega 3s/Krill: 2,000 mg, 2-4 daily
„ 5-HTP: 50-300 mg
„ Inositol: 1-2 grams
„ 2 North Rd. East Windsor, CT 06088 Phone (800) 847-8302 Fax (860) 627-0661 www.designsforhealth.com
„ THIS INFORMATION IS PROVIDED FOR THE USE OF PHYSICIANS AND OTHER LICENSED HEALTH CARE PRACTITIONERS ONLY. THIS INFORMATION
„ IS INTENDED FOR PHYSICIANS AND OTHER LICENSED HEALTH CARE PROVIDERS TO USE AS A BASIS FOR DETERMINING WHETHER OR NOT TO
„ RECOMMEND THESE PRODUCTS TO THEIR PATIENTS. THIS MEDICAL AND SCIENTIFIC INFORMATION IS NOT FOR USE BY CONSUMERS. THE
DIETARY
„ SUPPLEMENT PRODUCTS OFFERED BY DESIGNS FOR HEALTH ARE NOT INTENDED FOR USE BY CONSUMERS AS A MEANS TO CURE, TREAT,
PREVENT,
„ DIAGNOSE, OR MITIGATE ANY DISEASE OR OTHER MEDICAL CONDITION. ®
 Epilepsy Protocol
„ Nutritional Support Protocol
„ Lifestyle Recommendations:
„ 1. Avoid steroids such as dehydroepiandrosterone.
„ 2. Check for hormonal imbalances, low progesterone can be trigger for seizures.
„ 3. Practice good sleep habits and get between 8-9 hours of sleep a night.
„ 4. Engage in 30 minutes of intense aerobic exercise 4-5 times a week.
„ 5. Engage in mental exercise by consistently learning new skills and information.
„ 4. Try therapeutic body-based methods such as: chiropractic and message which are examples of
„ this type of therapy.
„ Dietary Recommendations:
„ 1. Consider a ketogenic diet; it has been shown to be successful in children with chronic seizures.
„ 2. Emphasize omega 3 fatty acids (salmon, mackerel, herring, tuna) and omega 9 fats (olive oil,
„ olives, almonds, hazelnuts, avocados, macadamia oil and coconut oil).
„ 3. Choose lean, clean quality protein at each meal (chicken breast, turkey breast, lean beef, fish -
„ especially salmon and tuna, lowfat cottage cheese, lowfat string cheese, eggs and whey protein).
„ 3. Limit or avoid trans fatty acids (hydrogenated vegetable oil, margarine and shortening). Cook with
„ olive oil.
„ 4. Drink at least 64 ounces of filtered, bottled or non-chlorinated water every day. In addition, drink
„ 2-3 cups of green tea daily.
„ 5. Avoid or limit caffeine, alcohol and other potentially neurotoxic compounds like aspartame and MSG.
„ Supplement Recommendations:
„ The following supplements are in addition to Twice Daily Essential Packets to
„ supply your core vitamins, minerals, antioxidants and essential fatty acids.
„ Water Ease: 1 capsule with breakfast & 1 packet with lunch
„ Krill Oil: 1 softgel per day
„ CarniClear (L-Carnitine): 1 tsp. before breakfast daily
„ 2 North Rd. East Windsor, CT 06088 Phone (800) 847-8302 Fax (860) 627-0661
www.designsforhealth.com
„ THIS INFORMATION IS PROVIDED FOR THE USE OF PHYSICIANS AND OTHER LICENSED HEALTH CARE PRACTITIONERS ONLY. THIS
INFORMATION
„ IS INTENDED FOR PHYSICIANS AND OTHER LICENSED HEALTH CARE PROVIDERS TO USE AS A BASIS FOR DETERMINING WHETHER
OR NOT TO
„ RECOMMEND THESE PRODUCTS TO THEIR PATIENTS. THIS MEDICAL AND SCIENTIFIC INFORMATION IS NOT FOR USE BY
CONSUMERS. THE DIETARY
„ SUPPLEMENT PRODUCTS OFFERED BY DESIGNS FOR HEALTH ARE NOT INTENDED FOR USE BY CONSUMERS AS A MEANS TO CURE,
TREAT, PREVENT,
„ DIAGNOSE, OR MITIGATE ANY DISEASE OR OTHER MEDICAL CONDITION. ®
 Herpes Protocol
„ Nutritional Support Protocol
„ Lifestyle Recommendations:
„ 1. Avoid stress and extra obligations.
„ 2. Get regular exercise such as walking, yoga, tai chi.
„ 3. Avoid corticosteroids and NSAIDS (if possible).
„ 4. Always balance arginine supplementation with the amino acid lysine.
„ Dietary Recommendations:
„ 1. Avoid wheat flour and dairy products.
„ 2. Avoid sugar and hydrogenated oils.
„ 3. Avoid alcohol consumption and caffeine.
„ 4. Avoid refined and processed foods.
„ 5. Avoid omega 6 oils such as safflower, sunflower, corn and soybean oil.
„ 6. Nuts contain arginine which depletes the anti-viral nutrient lysine. Frequent consumption of nuts
„ can cause a viral outbreak.
„ 7. Eat omega 3 anti-inflammatory foods such as salmon, mackerel and tuna.
„ 8. Consume green drinks (PaleoGreens) or fresh vegetable juices.
„ 9. Helpful teas: chamomile, green tea, echinacea or slippery elm.
„ Supplement Recommendations:
„ The following supplements are in addition to Twice Daily Essential Packets to
„ supply your core vitamins, minerals, antioxidants and essential fatty acids.
„ Allicidin: 1 capsule with each meal, 3 per day
„ Immunitone Plus: 2 capsules with breakfast and lunch, 4 per day
„ Lysine: 2 capsules with breakfast and lunch, 4 per day
„ Olive Leaf Extract: 1 capsule with breakfast and lunch, 2 per day
„ Stellar C: 1 capsule with breakfast and lunch, 2 per day
„ 2 North Rd. East Windsor, CT 06088 Phone (800) 847-8302 Fax (860) 627-0661
www.designsforhealth.com
„ THIS INFORMATION IS PROVIDED FOR THE USE OF PHYSICIANS AND OTHER LICENSED HEALTH CARE PRACTITIONERS ONLY. THIS
INFORMATION
„ IS INTENDED FOR PHYSICIANS AND OTHER LICENSED HEALTH CARE PROVIDERS TO USE AS A BASIS FOR DETERMINING WHETHER
OR NOT TO
„ RECOMMEND THESE PRODUCTS TO THEIR PATIENTS. THIS MEDICAL AND SCIENTIFIC INFORMATION IS NOT FOR USE BY
CONSUMERS. THE DIETARY
„ SUPPLEMENT PRODUCTS OFFERED BY DESIGNS FOR HEALTH ARE NOT INTENDED FOR USE BY CONSUMERS AS A MEANS TO CURE,
TREAT, PREVENT,
„ DIAGNOSE, OR MITIGATE ANY DISEASE OR OTHER MEDICAL CONDITION. ®
 Insomnia Protocol
„ INSOMNIA
„ Nutritional Support Protocol
„ Lifestyle Recommendations:
„ 1. Engage in regular aerobic exercise such as walking, swimming, yoga, or tai chi.
„ 2. Avoid extra stress and obligations.
„ 3. Rule out hormone imbalance/deficiencies.
„ 4. Rule out hypothyroidism, hypoglycemia, and weak adrenal function.
„ 5. Avoid smoking and alcohol consumption.
„ 6. Avoid caffeine containing products, stimulant-containing herbs, and hypoglycemic conditions
„ 7. Exercise late in the day.
„ 8. Check prescription drugs for side effects. Many contain caffeine.
„ Dietary Recommendations:
„ 1. Eat turkey or drink warm milk before bed as they contain tryptophan. Calcium and magnesium at
„ bedtime have a relaxing effect on the body and can aid sleep.
„ 2. Whey Protein or other quality protein is essential at every meal to stabilize blood sugar levels.
„ 3. Avoid sugar and sweetened products.
„ 4. Avoid allergic foods.
„ Supplement Recommendations:
„ The following supplements are in addition to Twice Daily Essential Packets to
„ supply your core vitamins, minerals, antioxidants and essential fatty acids.
„ Inositol: ¼ to 1 tsp. or more before bed
„ StressArrest: 1 or more capsules before bed
„ 5-HTP: 1 or more capsules before bed
„ If needed:
„ Melatonin: 1 tablet before bed
„ 2 North Rd. East Windsor, CT 06088 Phone (800) 847-8302 Fax (860) 627-0661
www.designsforhealth.com
„ THIS INFORMATION IS PROVIDED FOR THE USE OF PHYSICIANS AND OTHER LICENSED HEALTH CARE PRACTITIONERS ONLY. THIS
INFORMATION
„ IS INTENDED FOR PHYSICIANS AND OTHER LICENSED HEALTH CARE PROVIDERS TO USE AS A BASIS FOR DETERMINING WHETHER
OR NOT TO
„ RECOMMEND THESE PRODUCTS TO THEIR PATIENTS. THIS MEDICAL AND SCIENTIFIC INFORMATION IS NOT FOR USE BY
CONSUMERS. THE DIETARY
„ SUPPLEMENT PRODUCTS OFFERED BY DESIGNS FOR HEALTH ARE NOT INTENDED FOR USE BY CONSUMERS AS A MEANS TO CURE,
TREAT, PREVENT,
„ DIAGNOSE, OR MITIGATE ANY DISEASE OR OTHER MEDICAL CONDITION. ®
 Migraine Protocol
„ Nutritional Support Protocol
„ Lifestyle Recommendations:
„ 1. Control stress and avoid extra obligations.
„ 2. Avoid smoking and alcohol consumption.
„ 3. Avoid use of toxic cleaning chemicals and recreational drugs.
„ Dietary Recommendations:
„ 1. Avoid Tyramine containing foods such as aged cheeses; brewers yeast and yeast containing
„ foods such as bread and soups; pickled, aged, smoked and fermented meats including
„ frankfurters, pepperoni, salami, bacon, bologna, and ham; chocolate, citrus fruits, red wine,
„ and beer.
„ 2. Avoiding Tannin containing foods may be helpful such as black teas, many herb teas, apple
„ juice, dates, kiwi, peaches, berries, coffee, carob, alfalfa, walnuts and pecans.
„ 3. Dairy products often aggravate sinus congestion which can contribute to migraines.
„ 4. Avoid known food allergens.
„ 5. Eat a diet high in omega 3 fats including fish such as salmon, mackerel and tuna.
„ Supplement Recommendations:
„ The following supplements are in addition to Twice Daily Essential Packets to
„ supply your core vitamins, minerals, antioxidants and essential fatty acids.
„ Feverfew Synergy: 2 with breakfast and 2 with lunch, 4 per day
„ B-Supreme: 1 with breakfast and 1 with lunch, 2 per day
„ Amino-D-Tox: 2 capsules with breakfast, lunch and dinner, 6 per day
„ Probiotic Synergy: 1/2 teaspoon with breakfast and lunch or 2 capsules daily
„ *In cases of premenstrual migraines, check hormone levels. Progesterone levels may need to be
„ increased by direct supplementation or indirectly by giving Pregnenolone and/or DHEA.
„ 2 North Rd. East Windsor, CT 06088 Phone (800) 847-8302 Fax (860) 627-0661
www.designsforhealth.com
„ THIS INFORMATION IS PROVIDED FOR THE USE OF PHYSICIANS AND OTHER LICENSED HEALTH CARE PRACTITIONERS ONLY. THIS
INFORMATION
„ IS INTENDED FOR PHYSICIANS AND OTHER LICENSED HEALTH CARE PROVIDERS TO USE AS A BASIS FOR DETERMINING WHETHER
OR NOT TO
„ RECOMMEND THESE PRODUCTS TO THEIR PATIENTS. THIS MEDICAL AND SCIENTIFIC INFORMATION IS NOT FOR USE BY
CONSUMERS. THE DIETARY
„ SUPPLEMENT PRODUCTS OFFERED BY DESIGNS FOR HEALTH ARE NOT INTENDED FOR USE BY CONSUMERS AS A MEANS TO CURE,
TREAT, PREVENT,
„ DIAGNOSE, OR MITIGATE ANY DISEASE OR OTHER MEDICAL CONDITION. ®
 Multiple Sclerosis (MS) Protocol
„ Nutritional Support Protocol
„ Supplement Recommendations:
„ The following supplements are in addition to Twice Daily Essential Packets to
„ supply your core vitamins, minerals, antioxidants and essential fatty acids.
„ Ultra B12- Folate: 2-4 capsules
„ Krill Oil: 2-4 softgels
„ Brain Vitale: ½ teaspoon
„ N-Acetyl Cysteine: 1 capsule per day
„ Ultimate Antiox-LS: 3 per day
„ The goal is to remove all foods that may be triggering the body to attack its own
„ tissues. Researchers believe that one of the possible causes of autoimmune ailments,
„ such as MS, is certain foods that are new to humanity (grain products, dairy products,
„ lentils and beans, and yeasted foods) which have only appeared in the past 40,000
„ years. Meats, nuts, vegetables and fruits have been eaten for over 2 million years.
„ Therefore, returning to a diet that is made of meat, nuts, and produce may remove
„ one of the main offending causes behind autoimmune problems. It can take 3-6
„ months to assess whether this dietary elimination of mimetic proteins in allergenic
„ foods is effective. Check for candida albicans infection. Mercury is also considered to
„ be possible contributing cause of MS.
„ Diet: Dairy, grain, yeast and legume free, high in EFAs
„ 2 North Rd. East Windsor, CT 06088 Phone (800) 847-8302 Fax (860) 627-0661
www.designsforhealth.com
„ THIS INFORMATION IS PROVIDED FOR THE USE OF PHYSICIANS AND OTHER LICENSED HEALTH CARE PRACTITIONERS ONLY. THIS
INFORMATION
„ IS INTENDED FOR PHYSICIANS AND OTHER LICENSED HEALTH CARE PROVIDERS TO USE AS A BASIS FOR DETERMINING WHETHER
OR NOT TO
„ RECOMMEND THESE PRODUCTS TO THEIR PATIENTS. THIS MEDICAL AND SCIENTIFIC INFORMATION IS NOT FOR USE BY
CONSUMERS. THE DIETARY
„ SUPPLEMENT PRODUCTS OFFERED BY DESIGNS FOR HEALTH ARE NOT INTENDED FOR USE BY CONSUMERS AS A MEANS TO CURE,
TREAT, PREVENT,
„ DIAGNOSE, OR MITIGATE ANY DISEASE OR OTHER MEDICAL CONDITION. ®
 MS and Fatigue
„ Therapy Found To Relieve Fatigue Of Multiple Sclerosis Patients

„ Science Daily — COLUMBUS, Ohio - For the first time, researchers here have found an effective therapy that can alleviate
the fatigue often accompanying multiple sclerosis. Many therapies have been developed to treat symptoms of multiple
sclerosis, but few have helped, to any degree, the excessive, debilitating fatigue that accompanies other disease symptoms
in some patients. Their study appears today in the Journal of Neurology, Neurosurgery and Psychiatry.

„ Dr. Kottil W. Rammohan, neurologist at The Ohio State University Medical Center, and his colleagues wondered whether the
drug modafinil might be effective in relieving this fatigue. Modafinil is used currently in the treatment of narcolepsy, a
disease in which patients experience uncontrolled daytime sleepiness.
„ "We were very pleased to find that a medication that was effective against narcolepsy was able to treat the fatigue
associated with multiple sclerosis." Two doses of modafinil (200 and 400 mg) were compared against a placebo in 72
patients with multiple sclerosis ranging in age from 18 to 65. It was observed that the 200 mg dose of the drug
administered once daily showed highly significant improvement in patients. Three separate instruments of rating fatigue
were used, and all three showed concordant response to this drug. No previous drug has been able to show this degree of
improvement in treating multiple sclerosis-related fatigue in any previous clinical trial.

„ Fatigue is one of the most common and disabling symptoms of multiple sclerosis. It affects 75 to 90 percent of patients with
the disease. As many as 46 to 66 percent of multiple sclerosis patients experience fatigue on a daily basis.
„ Rammohan said that more studies are needed to better understand the dosage and length of therapy necessary for
patients, but he hopes more neurologists will start using modafinil for the treatment of severe fatigue that often
accompanies multiple sclerosis.

„ Also participating in this study were researchers at Kaiser Permanente in San Diego. Multiple sclerosis is an unpredictable,
progressive disease in which scattered patches of nerve fibers in the brain and spinal cord lose "myelin," their protective
covering. Resultant loss of neurological function can manifest with a multitude of symptoms.

„ In addition to fatigue, patients experience a combination of a number of symptoms that include visual loss, loss of motor
function, sensory impairment, imbalance, bowel and bladder dysfunction, and sometimes problems related to cognition,
memory and personality. Multiple sclerosis is a common disorder and affects about 350,000 people in the United States,
mostly women.

„ Note: This story has been adapted from a news release issued by Ohio State University
 MS & Hyperbaric Oxygen Treatment
„ K. Paul Stoller, MD
Assitant Clinical Professor Pediatrics, UNM School of Medicine
President, International Hyperbaric Medical Association
MS is a demyelinating disease of the central nervous system (CNS). It is characterized by exacerbations, remissions, and stability The
long awaited drug that was to give hope to thousands of sufferers of Multiple Sclerosis (MS) was voluntarily pulled from the market the
last weekend in February due to the death of one patient and the CNS injury of another. Biogen and Elan shares fell 40% and 60%
respectively, but belying this tragedy is the fact that two decades ago another drug showing tremendous promise for treating MS - one
with virtually no serious side effects, but it never had a chance to come to the fore because market driven forces didn’t want it to be
recognized.
B.H. Fischer, a tenured professor at New York University became the principal investigator of a study funded by the Multiple Sclerosis
(MS) Society, which receives substantial financial support from the pharmaceutical industry. The MS Society in the USA had a very
difficult time accepting the results of the work Dr. Fischer had completed and made their objections known. The study required multiple
revisions to tone down the results so they would be bland and noncontroversal enough for New England Journal of Medicine editors to
print, on January 27th 1983 the results of Fischer’s study were published: “Hyperbaric-oxygen treatment of Multiple Sclerosis: A
randomized placebo-controlled, double blind study.”
What Fischer found was that there were significant improvement in objective measurements and treatment effect persisted at 1-year
follow-up (Fischer BH, et al NEJM 1983; 308:181-186). Despite the positive results, and the treatment languished for lack of financial
support and sponsorship. Fischer himself faired less well and was expunged from the NYU faculty and his chamber chopped up and sent
to the city dump. Two years later, M.P. Barnes published another double-blind, placebo controlled study showing statistically significant
improvement in bladder and bowel control (Barnes MP, Bates D, Cartlidge NEF, et al. Hyperbaric oxygen and multiple sclerosis: Short-
term results of a placebo-controlled, double-blind trial. Lancet 1985;i:297-300). Associated Press sent out an article saying the study
showed hyperbaric oxygen ineffective and that the Barnes study contradicted
the Fischer study.
In 1987, a follow-up study was published in the Journal of Neurology, Neurosurgery, and Psychiatry, which not only confirmed the
results of the Fischer study, but revealed significant preservation of cerebellar function (coordination) with hyperbaric oxygen (Barnes,
MP et al: Hyperbaric oxygen therapy in the treatment of multiple sclerosis. J Neurol Neurosurg Psychiatry 50(11):1402-6, 1987). But
now no one was even listening.

In the United Kingdom, the Fischer article had prompted an eight year longitudinal study of hyperbaric oxygen and MS that showed a
significant difference in the relapse rates of patients being treated with oxygen under pressure and those that were not so treated. A
Trust was created which went onto open over 60 hyperbaric charity clinics, and today using oxygen under pressure has become the
mainstay of MS therapy in the UK with well over 1.5 million treatments completed to date. Hyperbaric oxygen stabilizes the network of
capillaries in the brain called the Blood-Brain-Barrier which is exactly the same mechanism behind the effectiveness of the drug Tysabri –
neither treatment is a cure for the disease, but both alter the natural history of the disease in a favorable fashion. One had a
pharmaceutical company behind it and one didn’t because oxygen is not patentable – end of story?
 MS & NAD
„ Can A Vitamin Alleviate Chronic, Progressive Multiple Sclerosis?

„ Science Daily — Researchers have found a possible way to protect people with multiple sclerosis (MS) from severe long-term disability: increase
nervous-system levels of a vital compound, called nicotinamide adenine dinucleotide (NAD), by giving its chemical precursor -- nicotinamide, a form of
vitamin B3.

„ Current therapies for MS mainly address the relapsing-remitting phase of the disease, but some of these have severe side effects, and most patients
eventually enter a chronic progressive phase for which there is no good treatment. Using a mouse model of MS, researchers in the Neurobiology
Program at Children's Hospital Boston found strong evidence that nicotinamide may protect against nerve damage in the chronic progressive phase,
when the most serious disabilities occur. Their findings appear in a cover article in the September 20 Journal of Neuroscience.

„ MS is a neurologic disorder in which nerve fibers, or axons, are damaged through inflammation, loss of their insulating myelin coating, and
degeneration. This damage disrupts nerves' ability to conduct electrical impulses to and from the brain, causing such symptoms as fatigue, difficulty
walking, pain, spasticity, and emotional and cognitive changes. Current treatments mainly protect against inflammation and myelin loss, but do not
completely prevent long-term axon damage. A team led by Shinjiro Kaneko, MD, a research fellow at Children's, and senior investigator Zhigang He,
PhD, also from Children's, worked with mice that had an MS-like disease called experimental autoimmune encephalitis (EAE). Through careful
experiments, they showed that nicotinamide protected the animals' axons from degeneration -- not only preventing axon inflammation and myelin loss,
but also protecting axons that had already lost their myelin from further degradation.

„ Intriguingly, mice with EAE who received daily nicotinamide injections under their skin had a delayed onset of neurologic disability, and the severity of
their deficits was reduced for at least eight weeks after treatment. The greater the dose of nicotinamide, the greater the protective effect. [See
accompanying figure.]On a scale of 1 to 5 (1 indicating mild weakness only in the tail, 4 indicating paralysis involving all four limbs, and 5, death from
the disease), mice receiving the highest doses of nicotinamide had neurologic scores between 1 and 2, while control mice had scores between 3 and 4.
All differences between treated groups and controls were statistically significant.

„ Mice with the greatest neurologic deficits had the lowest levels of NAD in their spinal cord, and those with the mildest deficits had the highest NAD
levels. Mice that had higher levels of an enzyme that converts nicotinamide to NAD (known as Wlds mice) responded best to treatment.Moreover,
nicotinamide significantly reduced neurologic deficits even when treatment was delayed until 10 days after the induction of EAE, raising hope that it will
also be effective in the later stages of MS. "The earlier therapy was started, the better the effect, but we hope nicotinamide can help patients who are
already in the chronic stage," says Kaneko.In other experiments, the researchers demonstrated that nicotinamide works by increasing levels of NAD in
the spinal cord and that NAD levels decrease when axons degenerate. Finally, they showed that giving NAD directly also prevented axon degeneration.

„ NAD is used extensively by cells to produce energy through the breakdown of carbohydrates. Its chemical precursor, nicotinamide, has several
characteristics that make it a promising therapeutic agent: it readily crosses the blood-brain barrier, is inexpensive and available in any drugstore, and
its close relative, vitamin B3, is already used clinically to treat pellagra (vitamin B3 deficiency), high cholesterol, and other disorders. Although
nicotinamide is thought to have few side effects, the doses used in mice would translate to much higher human doses than are normally used clinically,
so would need to be tested for safety.

„ "We hope that our work will initiate a clinical trial, and that nicotinamide could be used in real patients," Kaneko says. "In the early phase of MS, anti-
inflammatory drugs may work, but long-term you need to protect against axonal damage."The research was funded by the National Multiple Sclerosis
Society and the National Institute of Neurological Disorders and Stroke.
„ Note: This story has been adapted from a news release issued by Children's Hospital Boston.
 MS & Soy
„ Natural, Soy-based Substance Might Help Fight Multiple Sclerosis, Neuroscientists Find

„ Science Daily — A natural substance made from soy appears to have amazing restorative powers when given to animals with a multiple
sclerosis (MS)-like disease.

„ Using an animal model of MS, neurologists at Jefferson Medical College found that giving doses of a substance called Bowmann-Birk
Inhibitor Concentrate (BBIC) dramatically improved the animals' ability to move and walk. The scientists, led by A. M. Rostami, M.D.,
Ph.D., professor and chair of the Department of Neurology at Jefferson Medical College of Thomas Jefferson University and the Jefferson
Hospital for Neuroscience in Philadelphia, say the treatment's effects may be useful in conjunction with more mainstream therapies such
as beta-interferon in helping patients with MS. They report their findings December 12, 2006 in the journal Multiple Sclerosis.
„ MS, one of the most common neurological diseases affecting young adults, is thought to be an autoimmune disease (in which the body
attacks its own tissue) affecting the central nervous system (CNS). In MS, the myelin coating of nerve fibers becomes inflamed and
scarred. As a result, "messages" cannot be sent through the nervous system.

„ Dr. Rostami, who is also director of the Neuroimmunology Laboratory in the Department of Neurology at Jefferson Medical College, and
his group used an animal model of experimental autoimmune encephalomyelitis (EAE), which mimics MS, to investigate BBIC's potential
immune system-suppressing properties. BBIC inhibits proteases, enzymes that play important roles in the inflammation and
demyelination processes that are at the heart of MS. It has been used for other conditions, notably precancerous conditions in the
mouth. He and his co-workers compared two groups of animals with EAE. One group received BBIC, while the other received only an
inert substance. "Animals that received BBIC were able to walk while those that didn't get the drug were not," he says. He notes that the
animals aren't cured but can walk with some limp or weakness. "The results are promising because this is a safe, natural compound
from soybean and is given orally."

„ Further analysis revealed that the central nervous systems of animals that received BBIC showed "significantly less inflammation and
demyelination" than those that didn't receive the therapy. "It's the first time that BBIC has been used in an EAE model and has shown
significant disease suppression, and we hope it can eventually be used in humans," says Dr. Rostami. His group's next step is to design
clinical trials in humans. The scientists are not sure how BBIC works in multiple sclerosis, but they theorize that it suppresses the
immune response to some extent, in addition to inhibiting proteases. Dr. Rostami sees BBIC as being used as a single therapy or in
conjunction with other drugs in treating MS. He notes that because current therapies for MS involve injecting drugs such as interferon
and copaxane, one goal is to develop an oral agent. BBIC could be given by pill daily.

„ Over 400,000 Americans acknowledge having MS, though nearly one million Americans may be living with the disease. Symptoms can
include fatigue, loss of coordination, muscle weakness, numbness, inability to walk or use hands and arms, pain, vision problems, slurred
speech and bladder/bowel dysfunction.

„ Note: This story has been adapted from a news release issued by Thomas Jefferson University.
 MS Tips
„ Hypericum gespritzt 2 ml plus Aloe D 2 (Frima Schumacher
Deutschland)gespritzt 2 ml, je nach Stresssituation bzw. auch als
Kur zwei Mal die Woche, in Italien hat meine beste Freundin ein
Alternativkurzentrum, die beste Erfahrungen damit haben - ich aber
auch.

„ Weiters sehr gut ist Inositol mit Cholin gemischt eins zu eins (ab
besten gewonnen von der Brennessel), wobei zusätzlich Vitamin B
zu nehmen ist. Natürlich kann man einwenden, da nehm ich gleich
Lecithin, aber oft, wie ich auch bei mir bemerkt habe, ist das Pulver
Inositol mit Cholin gemischt ein Teelöffel über den Tag gemischt mit
einen halben Liter Wasser weitaus besser und man fühlt sich
wirklich viel stärker.
 MS Workbook Reference
„ The MS Workbook
„ By authors: Kurt Johnson, Dawn Ehde, George Kraft, Robert Fraser
„ Your Essential Guide to Living Well with MS
You can live a fuller and more rewarding life with multiple sclerosis. In this book you'll find clear,
practical tips for taking care of your health, your livelihood, and your relationships-step-by-step
advice for creating real change in your life.
Recommended by leaders in the nation's top MS organizations, this book offers you more than
just strategies for dealing with physical challenges. The authors, a team of experienced doctors
and psychologists, offer tips to help you manage the emotional aspects of MS, too. Put these
clear and straightforward techniques to use in your life today for greater physical comfort and
mobility, financial security, and a more positive state of mind.
Learn how to:
- Manage your physical and mental health care
- Negotiate accommodation and comfort issues in the workplace
- Stay on top of financial matters, including health insurance
- Foster a strong sense of spirituality and community
- Enjoy more intimate relationships and a better sex life
- Utilize government and private resources and other sources of support
 Bartonella & Vitamin D
„ JAMA. 1998 Feb 18;279(7):532-4. Related Articles, Links
Hypercalcemia due to endogenous overproduction of active vitamin D in identical twins with cat-scratch disease.
Bosch X. Internal Medicine Unit, Hospital Casa Maternitat, Corporacio Sanitaria Clinic, Barcelona, Spain.
„
CONTEXT: The extrarenal synthesis of active vitamin D sterols has a central causative role in the hypercalcemia
associated with various granulomatous diseases.
„
OBJECTIVE: To study the calcium metabolism in patients with cat- scratch disease who have hypercalcemia.
„ DESIGN: Case report. SETTING: University hospital in Barcelona, Spain.
„
PATIENTS: Two identical twins who developed asymptomatic hypercalcemia during the acute phase of cat-scratch
disease.
„
MAIN OUTCOME MEASURES: Serial measures of calcium homeostasis and metabolism over a 2-month period.
„
RESULTS: On admission and 6 and 7 days later, both patients were found to have increased levels of serum and
urinary calcium, serum phosphate, and serum 1,25-dihydroxyvitamin D [1,25(OH)2D], whereas they had normal
values of serum 25-hydroxyvitamin D and urinary
cyclic adenosine monophosphate and decreased serum concentrations of intact parathyroid hormone. Sixteen and
20 days after admission, these abnormalities had resolved without treatment. A direct correlation was observed
between the serum 1,25(OH)2D levels and both the serum and 24-hour urinary calcium concentrations. Also, the
concentrations of calcium and
„ 1,25(OH)2D paralleled the clinical activity of the infectious disease over the period these
parameters were measured.
„
CONCLUSIONS: Our cases provide evidence that cat-scratch disease can produce hypercalcemia through the
unregulated production of the metabolite 1,25(OH)2D. Cat-scratch disease should be added to the list of
granuloma-forming diseases that are responsible for 1,25(OH)2D-mediated hypercalcemia.
 Bartonella & Teeth
„ Researchers conclude Napoleon's troops felled by lice
By Thomas H. Maugh II
„
Los Angeles Times: Louse-borne diseases such as typhus and trench fever devastated Napoleon's army during his
ill-fated invasion of Russia in 1812, killing nearly one-third of his army, according to a study by French
researchers.
Napoleon invaded Russia with half a million men that summer, but escaped with only a few thousand. Twenty-
five thousand French soldiers escaped to Vilnius, Lithuania during the retreat, but only 3,000 survived to continue
the retreat. The rest were buried in mass graves.
„
Historians have long stressed the role of disease in the deaths, but now Dr. Didier Raoult and his colleagues at
the Universite de la Mediterranee in Marseille, France, have provided the first firm evidence confirming this
supposition. The team worked with remains found during construction at a former Soviet Army barracks in the
northern suburbs of Vilnius.
„
Napoleon's soldiers were known to be plagued with body lice, Raoult said.
The team found body segments of five lice among clothing remnants from the soldiers. Three of the five lice
contained DNA from "Bartonella quintana," which causes the disease known as trench fever, they reported this
week in the online version of the Journal of Infectious Diseases.
„
They also studied dental pulp from the unerupted teeth of 35 soldiers. Teeth from seven of the soldiers carried
DNA from "B. quintana" and those from three others contained DNA from "Rickettsia prowazakii," which causes
epidemic typhus.
When the DNA of such a deadly agent is present in teeth, the team wrote, "It is very likely that the organism was
the cause of death."
 Babesia
„ PIROPLASMOSIS (Babesiosis)
„
Piroplasms are not bacteria, they are protozoans. Therefore, they will not be eradicated by any of the currently
used Lyme treatment regimens. Therein lies the significance of co-infections — if a Lyme patient has been
extensively treated yet is still ill, suspect a co-infection.

„ Babesia infection is becoming more commonly recognized, especially in patients who already have Lyme Disease.
It has been published that as many as 66% of Lyme patients show evidence of co-infection with Babesia. It has
also been reported that Babesial infections can range in severity from mild, subclinical infection, to fulminant,
potentially life-threatening illness. The more severe presentations are more likely to be seen in
immunocompromised and elderly patients. Milder infections are often missed because the symptoms are
incorrectly ascribed to Lyme. Babesial infections, even mild ones, may recrudesce and cause severe illness. This
phenomenon has been reported to occur at any time, even up to several years after the initial infection.
Furthermore, asymptomatic carriers pose risks: to the blood supply as this infection has been reported to be
passed on by blood transfusion, and to the unborn child from an infected mother as it can be transmitted in
utero. Some quotes from the literature: Krause, PJ. Spielman, A, Telford, SR et.al. Persistent parasitemia after
acute Babesiosis N Engl J Med 1998. 339:160

„ “The clinical spectrum of human Babesiosis ranges from an apparently silent infection to a fulminant malaria-like
disease.” “When left untreated, silent Babesial infection may persist for months to years." “Silent infections, which
occur in about a third of infected people, may recrudesce." “Babesial infection may recrudesce after many months
of asymptomatic parasitemia.” “Although parasites were initially detected microscopically in the blood of two of
the untreated subjects, and all of the treated subjects, none could be found a week after the onset of illness.”
“Persistent symptoms of Babesiosis accompanied persistent blood-borne Babesial DNA.” “The persistence of
seroreactivity increasingly correlated with the persistence of Babesial DNA.” “In those with only subtle symptoms,
Babesiosis often remains undiagnosed.”

„ “Furthermore, physicians tend not to recognize Babesial infection in those who are co-infected with the agent of
Lyme Disease, because Babesial symptoms tend to be ascribed to Lyme Disease.”
“Physicians caring for patients with moderate to severe Lyme disease should consider obtaining diagnostic tests
for Babesiosis and possibly other tick-borne pathogens... especially in patients experiencing "atypical Lyme
disease” or patients in whom the response to antibiotic treatment is delayed or absent.”
„
Krause, PJ, Telford, SR, Spielman, A, et.al. Concurrent Lyme disease and Babesiosis. JAMA 1996. 275 (21):1657
 Brain and Herpes
„ Herpes Virus May Play Role In Central Nervous System Diseases

„ ScienceDaily (Dec. 25, 2007) — Scientists have discovered evidence suggesting a herpesvirus may be responsible
for some cases of meningitis and encephalitis.
„ Human herpesvirus 6 (HHV-6) is one of the most prevalent in humans. There are two variants of HHV-6, HHV-6A
and HHV-6B which is attributed to a common childhood disease characterized by a high fever and rash. Studies
indicate that by age 3 the majority of children have been infected by HHV-6, after which the virus persists in the
salivary glands into adulthood. The virus may remain dormant or reactivate in immunocompetent or
immunocompromised individuals.
„ Over a span of four years, researchers from the New York State Department of Public Health, Albany and SUNY,
Albany collected specimens from patients hospitalized with symptoms of encephalitis and meningitis, and tested
them for the presence of HHV-6. The majority of the specimens were taken from cerebrospinal fluid and some of
the symptoms exhibited by the patients include fever, altered mental status, and abnormal CSF profile, as well as
seizures in those ages 3 and under.
„ Adapted from materials provided by American Society for Microbiology.
„ Need to cite this story in your essay, paper, or report? Use one of the following formats:
„ American Society for Microbiology (2007, December 25). Herpes Virus May Play Role In Central Nervous System
Diseases. ScienceDaily. Retrieved December 26, 2007, from http://www.sciencedaily.com-
/releases/2007/12/071221094901.htm

„ Human Herpes Virus 6B Is Associated With Mesial Temporal Lobe Epilepsy

„ ScienceDaily (May 30, 2007) — There is strong evidence that one particular type of epilepsy is associated with a
viral infection, according to new research. The international group of researchers, led by Steve Jacobson from
National Institute of Neurological Disorders and Stroke, USA, found DNA from the virus, Human Herpes Virus 6B
(HHV-6B) in specific regions of the brains in 11 of 16 patients with mesial temporal lobe epilepsy (MTLE) referred
for investigation compared with zero of seven (0%) patients without MTLE.
„ Citation: Fotheringham J, Donati D, Akhyani N, Fogdell-Hahn A, Vortmeyer A, et al. (2007) Association of human
herpesvirus- 6B with mesial temporal lobe epilepsy. PLoS Med 4(5):
e180.(http://medicine.plosjournals.org/perlserv/"request=get-document&doi=10.1371/journal.pmed.0040180)
„ Adapted from materials provided by Public Library of Science.
 Lyme and Mycoplasma
„ What If It's Not Lyme Disease? - Groundbreaking Research May Provide Answers To Why Many Chronic
Sufferers Don't Respond To Treatment
„ Main Category: University of New Haven
Article Date: 13 Jun 2007 - 1:00 PDT
It is common knowledge that Lyme disease can be difficult to diagnose and treat, but, according to Eva Sapi, Ph.D.,
assistant professor of cellular and molecular biology at the University of New Haven-and unbeknownst to the public and
even many physicians-the deer ticks so notorious for carrying Lyme disease may often carry other crippling bacteria.
Sapi, an assistant professor of biology and environmental science at the University of New Haven, and several graduate
students recently presented research demonstrating that over 84 percent of the ticks they tested were infected by
Mycoplasma pathogens, bacteria which can wreak havoc reminiscent of the Borrelia bacterium responsible for Lyme disease.
"Doctors are starting to realize that some of the patients who exhibit symptoms of Lyme disease but don't respond to
treatment may be infected with a Mycoplasma pathogen," Sapi says. "We now have evidence of the presence of human
pathogenic Mycoplasma species in deer ticks."
Sapi presented the research, "Recent Discoveries of Novel Pathogens in Ixodes Ticks in Southern Connecticut," during the
national Lyme disease conference at UNH in May, and will submit it for publishing later this month. She notes that other
studies have shown that some patients not responding to treatment for Lyme disease have responded to treatment for
Mycoplasma. Determined to find the "missing link," Sapi and her cohorts tested 150 deer ticks for Mycoplasm bacteria, with
over 84 percent of the ticks exhibiting infection with a single Mycoplasma pathogen. Co-infection rates were also very
significant, at 27 percent, and three percent of the ticks were infected with all three Mycoplasma pathogens.
"More comprehensive studies on the transmission of Mycoplasma from ticks to humans need to be carried out to prove
whether they are, in fact, transmitted from the ticks to humans," Says Sapi. "But, in the meantime, more doctors should
consider testing suspected Lyme disease patients who are not responding well to treatment for Mycoplasma."
A leader in experiential learning, the University of New Haven provides its students with a unique combination of solid liberal
arts and real-world, hands-on professional training. A private University founded in 1920, UNH has a full-time undergraduate
enrollment of more than 2,400 students-with 70 percent residing on its 80-acre main campus-and a graduate school
enrollment that exceeds 1,700. The University offers more than 80 undergraduate degrees and more than 25 graduate
degrees through its four colleges, in fields such as sports management, nutrition and dietetics, forensic science, music and
sound recording, engineering, computer science, fire science and criminal justice. University of New Haven students study
abroad through a variety of distinctive programs.
 Brain and Mercury
„ Studies Link Other Ills to Mercury, Too
„ By MARIAN BURROS Published: January 23, 2008
„ In the past few years, several studies have concluded that elevated mercury levels may be associated not only with neurological
problems but with cardiovascular disease among adults as well.One of the studies, reported by Dr. Eliseo Guallar, an associate professor
of epidemiology at the Johns Hopkins School of Public Health, in 2002 in The New England Journal of Medicine, looked at men in
European countries and Israel. The mercury levels among men who had had a heart attack were 15 percent higher than those who had
not.
„ In 2006, a National Academy of Sciences’ Institute of Medicine report titled “Seafood Choices: Balancing Benefits and Risks”
acknowledged some of these findings, saying that “increased methylmercury exposure might be a risk factor for adult cardiovascular
toxicity.” The report added, “For child neurodevelopment and adult cardiovascular health, emerging evidence suggests that the health
benefits of seafood consumption are greater among individuals whose body burden of methylmercury is lower.”
„ Other studies have concluded that the benefits of consuming fish, because it contains omega-3 fatty acids that may help prevent heart
disease, may outweigh the risks of mercury contamination. Dr. Dariush Mozaffarian, a cardiologist and assistant professor of medicine
and epidemiology at Harvard Medical School, said that “the evidence is inconsistent that high mercury level has any effect” on the risk of
cardiovascular death among adults. More research had to be done, Dr. Mozaffarian said.But some researchers who have examined the
links between mercury and cardiovascular disease agree with Dr. Ellen Silbergeld, professor of environmental health sciences and
epidemiology at Johns Hopkins School of Public Health, who said “the existing evidence is strong and striking,” even though more
studies were needed
„ “It is very unwise to wait until we have complete scientific truth,” said Dr. Philippe Grandjean, adjunct professor of environmental health
at the Harvard School of Public Health and chairman of the department of environmental medicine at the University of Southern
Denmark. “The prudent judgment is to protect human health.” There is also recent epidemiological evidence on the relationship between
mercury and neurological problems. One study, published in Environmental Health in 2003, linked low-level methylmercury exposure
with impaired dexterity and concentration. The greater the mercury level, the greater the effect, the researchers found. The study also
suggested that adults exposed to methylmercury might be at risk for vision loss and numbness of fingers and toes as well as blood
pressure and fertility problems.
„ Increasing numbers of physicians are reporting on signs of mercury poisoning among patients who eat large quantities of fish.Dr. Jane
Hightower, a clinician and diagnostician in San Francisco, evaluated more than 100 patients who had vague, unexplained symptoms. Of
them, 89 percent had mercury in their blood that exceeded the level considered acceptable by the Environmental Protection Agency.
The symptoms included memory lapses, hair loss, fatigue, sleeplessness, tremors, headaches, muscle and joint pain, trouble thinking,
gastrointestinal disturbances and an inability to do complex tasks.Dr. Hightower tracked 67 of the patients, directing them to stop eating
all fish. After 41 weeks, all but two had blood mercury levels lower than the level considered acceptable. Her clinical observations,
published in 2003 in Environmental Health Perspectives, indicate that such neurological problems in otherwise healthy adults recede
when blood mercury levels go down.
„ No one is recommending that people stop eating fish, unless their blood mercury levels are dangerously high. In fact, health
professionals and researchers encourage eating seafood selectively, choosing species, like salmon and sardines, that have high omega-3
fatty acids and low levels of mercury. Fish in the diet “is not an all-or-nothing story,” Dr. Silbergeld said. “The trick is to figure out which
ones to eat.”
 Brain and Folate
„ Key vitamin deficiency linked to tripled risk of dementia study:
„ Tue Feb 5, 9:25 AM ET

„ PARIS (AFP) - Lack of folate, also called vitamin B-9, may triple the risk of developing dementia in old age,
according to a study published Tuesday. Researchers in South Korea measured naturally occurring folate levels in
518 elderly persons, none of whom showed any signs of dementia, and then tracked their development over 2.4
years.

„ At the end of the period, 45 of the patients had developed dementia, including 34 diagnosed with Alzheimer's
disease, said the study, published by the British Medical Association's Journal of Neurology, Neurosurgery and
Psychiatry.When the researchers, led by Jin-Sang Yoon of Chonnam National University in Kwangju, South Korea,
remeasured folate levels, they uncovered a strong link with the dementia.Even after other factors were taken into
account -- including age, disability, alcohol consumption, weight change -- "the onset of dementia was
significantly associated with an exaggerated decline in folate," the researchers concluded.

„ Folate and folic acid, another form of the compound, are essential for the creation of new cells in the body.The
compound occurs naturally in leafy vegetables such as spinach, turnip greens, lettuces, dried beans and peas and
in certain fruits.An study published last year in The Lancet showed an improvement in short-term memory,
mental agility and verbal fluency among persons over 50 who took a daily dose of 800 micrograms (mcg) of folic
acid. The US recommended daily dose is 400 mcg.

„ Taking folic acid before conception and throughout the first trimester helps a mother ensure that her child will not
develop certain brain and spinal cord defects, including spina bifida, according to previous research
 Brain – Magnetic Fields
„ Transcranial Magnetic Stimulation Reduces Auditory Hallucinations in Schizophrenia
„ NEW YORK (Reuters Health) medscape- Apr 20 - Slow repetitive transcranial magnetic stimulation appears to be
an effective treatment for resistant auditory hallucinations in schizophrenic patients, according to results of a
meta-analysis published in the March issue of the Journal of Clinical Psychiatry.

„ "Slow repetitive transcranial magnetic stimulation (rTMS), at a frequency of 1 Hz, has been proposed as a
treatment for auditory hallucinations," Dr. Andre Aleman, of the University of Groningen, the Netherlands, and
colleagues write. "Several studies have now been reported regarding the efficacy of TMS treatment, but results
were inconsistent.“

„ They therefore applied meta-analytic techniques integrate data from 10 trials of rTMS that were sham-controlled
and met inclusion criteria. All of the studies targeted the left temporoparietal cortex using 1 Hz rTMS. A total of
212 subjects were included in the studies.

„ A significant mean weighted effect size was observed for rTMS versus sham across the 10 studies (d = 0.76, p =
0.0001). Significant heterogeneity was observed among individual effect sizes. When only the nine studies that
used continuous stimulation were included, the mean effect size increased to 0.88 (p < 0.0001), and
heterogeneity disappeared.

„ The team found no significant effect of rTMS on a composite index of general psychotic symptoms.
„ On a clinical level, the investigators note, rTMS may be a promising method for reducing the frequency and
intensity of auditory hallucinations in treatment-resistant schizophrenic patients.

„ "On a more fundamental note, the evidence of reduction of hallucinations after magnetic stimulation over the left
temporoparietal cortex may yield clues to the pathophysiology of auditory hallucinations," Dr. Aleman's team
points out. "That is, the finding that reducing cortical excitability in speech perception areas may interfere with
hallucinations suggests aberrant activation of language perception areas as a cause of auditory hallucinations.
Options for Elimination
of Neurotoxins
 Injections for Detox
„ DMPS: 3 mg/kg once per month i.m or slow i.v.
„ IV Vitamin C: 37-50 grams in 500 ml distilled water with 10 ml Ca gluconate
„ Glutathione: 1200 mg 1-3x weekly, IV push
„ Alpha-lipoic acid: 600 mg in normal saline (250 cc) over 1 hr
„ Phospholipids (Lipostabil – German product): 2 ampoules diluted with client’s blood (50:50) given
slow IV over 3 minutes
„ Calcium EDTA: 4-10 ml slow IV push once weekly
„ Zinc DTPA (not available in the US)
„ Desferal: 500 mg in 4 divided doses over 4 days, 500 mg/week or up to 1x monthly (Kruck
protocol for Alzheimer’s disease)
„ DMPS and glutathione: very effective in neural therapy and ganglion blocks (9 part procaine, 1
part glutathione or DMPS)
 Oral Detox Agents
„ Chlorella: 4-16 grams/day
„ Cilantro: 10-15 drops in hot water at night, or topical as segmental therapy treatment
„ “Matrix Metals” 2-8 sprays twice daily
„ NDF and NDF Plus (nanonized cilantro and chlorella): 1-10 drops twice daily
„ Malic acid (aluminum)
„ Intestinal binding: beta sitosterol, charcoal, chlorella, apple pectin
„ DMSA: 10 mg/kg/day in divided doses q3-4 h (3 days on, 11 days off)
„ D-Penicillamine (Russell Jaffe protocol)
„ D-Alpha Lipoic: 100 mg q 3-4 hours (600 mg/day)- helps glutathione bound toxins to make it through the cell wall
„ Organic freeze dried garlic (energetically enhanced from BioPure) : 2-3 caps after each meal 3-4 times/day
„ Phospholipid Exchange (from BioPure: energized phospholipids, alpha-Lipoic acid, magnesium and Na-EDTA)-
enhances acetylcholine in the brain
„ cold processed whey (branched chain amino acids)
„ Forceful electrolyte supplementation (Matrix Electrolyte from BioPure is the most balanced and best tolerated
formula for metal detox)
„ Forceful trace mineral supplementation, including copper (only Albion chelated minerals are absorbed in sufficient
quantity, from Design for Health)
„ Carnosine: 1000 mg 3x daily (prevents collagen breakdown)
„ Branched chain amino acids: valine, leucine and iso-leucine (high in all whey products)
„ Correct neurotransmitter imbalances (use Braverman test from “The Edge Effect”)
„ Dopamine is most depleted when chronic infections are present. Use Mucuna powder as precursor
 Adjunctive Modalities
„ Sauna
„ Electro-mobilization (Toxaway foot bath, KMT 24, KMT 300)
„ Mercury vapor lamp
„ Photo-mobilization (IR- light shield, Photon Wave, Dinshah color therapy, Mandel color puncture,
BioPure eye glasses)
„ Colon hydrotherapy
„ Lymphatic drainage (KMT or Vodder technique)
„ Foot pads (Segiun, Kinotakara)
„ Applied Psychoneurobiology / MFT
„ Alpha tocopherol: 1200-2400 IU/day during acute reverse toxicity
„ Methylcobalamin: IV with procaine (McGuff: (800) 854-7220)
„ Selenium: locks Hg into inert complex, which can be removed via sauna tx
„ Hyaluronic acid: enhances IV therapy
Blood Brain Barrier Visual

Diagram of a cerebral capillary enclosed in astrocyte end-feet. Characteristics of the blood-brain barrier are
indicated: (1) tight junctions that seal the pathway between the capillary (endothelial) cells; (2) the lipid
nature of the cell membranes of the capillary wall which makes it a barrier towater-soluble molecules; (3),
(4), and (5) represent some of the carriers and ion channels; (6) the 'enzymatic barrier'that removes
molecules from the blood; (7) the efflux pumps which extrude fat-soluble molecules that have crossed into
the cells
 Blood Brain Barrier History
„ The blood-brain barrier (BBB) is a membranic structure that acts primarily to protect the brain from chemicals
in the blood, while still allowing essential metabolic function. It is composed of endothelial cells, which are packed
very tightly in brain capillaries. This higher density restricts passage of substances from the bloodstream much
more than endothelial cells in capillaries elsewhere in the body. Astrocyte cell projections called astrocytic feet
(also known as "glial limitans") surround the endothelial cells of the BBB, providing biochemical support to those
cells. The BBB is distinct from the similar blood-cerebrospinal fluid barrier, a function of the choroidal cells of the
choroid plexus.

„ The existence of such a barrier was first noticed in experiments by Paul Ehrlich in the late-19th century. Ehrlich
was a bacteriologist who was studying staining, used for many studies to make fine structures visible. When
injected, some of these dyes (notably the aniline dyes that were then popular) would stain all of the organs of an
animal except the brain. At the time, Ehrlich attributed this to the brain simply not picking up as much of the dye.

„ However, in a later experiment in 1913, Edwin Goldmann (one of Ehrlich's students) injected the dye into the
spinal fluid of the brain directly. He found that in this case the brain would become dyed, but the rest of the body
would not. This clearly demonstrated the existence of some sort of barrier between the two. At the time, it was
thought that the blood vessels themselves were responsible for the barrier, as no obvious membrane could be
found. The concept of the blood-brain barrier (then termed hematoencephalic barrier) was proposed by Lina
Stern in 1921.[1] It was not until the introduction of the scanning electron microscope to the medical research
fields in the 1960s that the actual membrane could be demonstrated.

„ It was once believed that astrocytes rather than epithelial cells were the basis of the blood-brain barrier because
of the densely packed astrocyte processes that surround the epithelial cells of the BBB.
 Blood Brain Barrier Physiology
„ In the rest of the body outside the brain, the walls of the capillaries (the smallest of the blood vessels) are made
up of endothelial cells which are fenestrated, meaning they have small gaps called fenestrations. Soluble
chemicals can pass through these gaps, from blood to tissues or from tissues into blood. However in the brain
endothelial cells are packed together more tightly with what are called tight junctions. This makes the blood-brain
barrier block the movement of all molecules except those that cross cell membranes by means of lipid solubility
(such as oxygen, carbon dioxide, ethanol, and steroid hormones) and those that are allowed in by specific
transport systems (such as sugars and some amino acids). Substances with a molecular weight higher than 500
daltons (500 u) generally cannot cross the blood-brain barrier, while smaller molecules often can. In addition, the
endothelial cells metabolize certain molecules to prevent their entry into the central nervous system. For
example, L-DOPA, the precursor to dopamine, can cross the BBB, whereas dopamine itself cannot. (As a result, L-
DOPA is administered for dopamine deficiences (e.g., Parkinson's disease) rather than dopamine).

„ In addition to tight junctions acting to prevent transport in between endothelial cells, there are two mechanisms
to prevent passive diffusion through the cell membranes. Glial cells surrounding capillaries in the brain pose a
secondary hindrance to hydrophilic molecules, and the low concentration of interstitial proteins in the brain
prevent access by hydrophilic molecules.[2]

„ The blood-brain barrier protects the brain from the many chemicals flowing within the blood. However, many
bodily functions are controlled by hormones in the blood, and while the secretion of many hormones is controlled
by the brain, these hormones generally do not penetrate the brain from the blood. This would prevent the brain
from directly monitoring hormone levels. In order to control the rate of hormone secretion effectively, there exist
specialised sites where neurons can "sample" the composition of the circulating blood. At these sites, the blood-
brain barrier is 'leaky'; these sites include three important 'circumventricular organs', the subfornical organ, the
area postrema and the organum vasculosum of the lamina terminalis (OVLT).

„ The blood-brain barrier acts very effectively to protect the brain from many common infections. Thus, infections
of the brain are very rare. However, since antibodies are too large to cross the blood-brain barrier, infections of
the brain which do occur are often very serious and difficult to treat.
 Blood Brain Barrier Papers
„ New Method For Crossing Blood-Brain Barrier Patented
„ ScienceDaily (May 26, 2007) — The blood-brain barrier is a group of cells that line the brain’s blood vessels, protecting vital brain
structures from foreign substances. The barrier has posed enormous difficulties for researchers who want to deliver therapeutic drugs to
the brain to treat tumors, infections and degenerative brain diseases such as Alzheimer’s and Parkinson’s. Researchers are hopeful that
this will some day be helpful to patients, according to Daniel Alkon, M.D., scientific director of BRNI.
„ “This may lead to a powerful new tool that clinicians can use to treat brain diseases,”
„ U.S. patent number 7,220,833, “Artificial Low-Density Lipoprotein Carriers for Transport of Substances Across the Blood-Brain Barrier,”
was issued to BRNI for this development May 22.
„ Adapted from materials provided by West Virginia University.
„ Transport System Smuggles Medicines Into Brain
„ ScienceDaily (Feb. 16, 2005) — Dutch researcher Corine Visser investigated a new way of transporting medicines into the brain. Her
approach made use of an iron transport system located on the blood-brain barrier. The smaller the medicine, the more easily it
penetrates the brain. A special barrier between the blood and the brain, the so-called blood-brain barrier (BBB), protects the brain from
toxic substances. It only lets through important nutrients for the brain such as iron, glucose and oxygen. Visser allowed larger
molecules, such as medicines, to pass through the blood-brain barrier by attaching these to the iron-containing
„ The research was funded by the Netherlands Organisation for Scientific Research.
„ Adapted from materials provided by Netherlands Organization For Scientific Research.
„ Blood-brain Barrier: A Misunderstood Key To Finding Life-saving Cures To Brain Disease
„ ScienceDaily (Dec. 18, 2007) — An international team of scientists that includes a Saint Louis University researcher suggest several
strategies to propel research for treatments of brain diseases that include multiple sclerosis, Alzheimer's disease, obesity and stroke in
the January issue of the Lancet Neurology.
„ The blood-brain barrier is a gate-keeping system of cells that protects the brain from toxins and lets in nutrients. Because it passes no
judgment on which foreign substances are there to treat diseases and which are penetrating the brain to do harm, it locks all of them
out. That makes getting drugs into the brain where they can do their work in treating brain diseases difficult.
„ Sometimes the blood-brain barrier lets in things that it shouldn't and doesn't let out things that it should. Learning more about the
secrets of the blood-brain barrier system is critical in understanding Alzheimer's disease, for instance, because the BBB makes it difficult
to target medication where it's needed in the brain and won't allow toxic amyloid beta proteins, believed to cause Alzheimer's, to drain
out of the brain.
„ (BBB), is available in an early online edition on Dec. 17.
„ University Of Maryland Researchers Discover "Key" To Blood-Brain Barrier
„ ScienceDaily (Jan. 4, 2000) — Findings Could Lead to New Treatments for Brain Disorders
„ Researchers at the University of Maryland School of Medicine in Baltimore have identified a receptor in the human brain that regulates
the interface between the bloodstream and the brain, which is known as the blood-brain barrier. This breakthrough could lead to a
better understanding of this nearly impenetrable barrier and to treatment of diseases that affect the brain, such as Multiple Sclerosis,
brain tumors, meningitis, Alzheimer's disease, and HIV infection. The findings are published in the January issue of the Journal of
Neurochemistry.
„ Adapted from materials provided by University Of Maryland Medical Center.
„ University Of Maryland Medical Center (2000, January 4). University Of Maryland Researchers Discover "Key" To Blood-Brain Barrier.
ScienceDaily. Retrieved December 18, 2007, from http://www.sciencedaily.com- /releases/2000/01/000104065455.htm