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Julia V.

Vaglenova
US citizen
766 Parkview Rd. home: 567-525-4257
Findlay, 45840, OH cell 334-524-1632
jvc5ce4a@westpost.net
Qualification Summary
Neurobiologist, neurophysiologist, and neuropharmacologist with 20+ years experi
ence in development of behavioral and pharmacological experimental models for in
vestigation of biomarkers, new pharmacological drugs, noxas, and teratogens on C
NS.
Strong experience and interests in:
* Neurobiology and Neuropsychopharmacology of learning and memory, anxiety and o
ther behavioral paradigms: The relationship between in vivo and in vitro drug ef
fects on CNS.
* Identification and assessment of biochemical and molecular targets in
neurotransmitter systems responsible for cognitive enhancement or decline.
* Teratogenic effects of ethanol, nicotine, caffeine and other stimulants, GHB,
and gamma - ray irradiation on learning and memory.
* Neurobiology of postnatal development and adolescence period. Identification a
nd assessment of biochemical and molecular targets in neurotransmitter systems a
nd growth factors involved in neuro damage effects after pharmacological manipul
ations with psychotropic drugs.
* Pharmacology of cognitive enhancers and other drugs and substances that might
promote recovery of cognitive functions following brain damage.
* Biochemistry and molecular biology of extrahepatic ethanol metabolism.
*Teaching experience in Introduction of Cell and Molecular Biology, Experimental
Neuropsychopharmacology, General Biology, Neurobiology, Physiology, and Patholo
gy of CNS, Pharmacology of CNS.
Strong communication and collaboration skills
Design, implement and manage multidisciplinary research projects. Train and supe
rvise
technicians, undergraduate and graduate students. Collaborate with medical resea
rchers, chemists, biologists and electrophysiologists from academia, industry an
d government agencies to produce more than 20 peer-reviewed publications, numero
us conference presentations, and successful competitive grant proposals. Fluent
in English, Spanish, Russian, and Bulgarian.
Education:
Ph.D., Biology and Pharmacology, Bulgarian Academy of Sciences, Sofia, Bulgaria
1992
M.S. Biology, State University, Sofia, Bulgaria.
B.S. Biology, State University, Sofia, Bulgaria,
B.S in Medical Technology, Bulgarian Medical Academy, Sofia, Bulgaria, with spec
ialization in clinical biochemistry, microbiology, pathophysiology , pathology a
nd clinical laboratory.
.
Research and Professional Experience:
University of Findlay, OH, 2008-09.
Assistant Professor, adjunct faculty, School of Science and Collage of Pharmacy
Teaching Introduction of Cell and Molecular Biology
Auburn University, AL, Department of Pharmacal Sciences, School of Pharmacy, (20
00-2007)
Assistant Research Professor, Co-PI of the project: "Assessment of developmental
teratogenicy of nicotine: Pharmacological intervention by nootropic drugs" with
the financial support of $796,000.
Teaching and advising graduate and undergraduate students in the field of neurob
iology and pharmacology of learning and memory, anxiety, and other behavioral pa
radigms, pre- and/or post-natal and adolescent development, toxicity and teratog
enicyty of different noxas.
Research Fellow II. Detection of long-term effects of fetal alcohol and nicotine
exposure, as well as the detrimental effects of their combined use in specific
dose-dependent experimental models. Investigation of nicotine neurotransmission
effects on schizophrenia and other mental diseases. Create a behavioral laborato
ry, using locomotor activity, novelty seeking behavior, anxiety state, learning
and memory methods, and other functional paradigms. Develop in vivo models for p
harmacotherapy of long-term effects following fetal alcohol or nicotine exposure
.
Autonomous University of Barcelona, Spain, Department of Biochemistry and Molecu
lar Biology, 1996-2000.
Visiting Professor 1999-2000.
Postdoctoral Fellow (1996-1999). Detection of Alcohol dehydrogenaze mRNA in huma
n and rat brain tissue, gastrointestinal tract and blood vessels. Development Di
oxigenin immunohistochemical and in situ hybridization techniques for detection
of gene expression of ADH.
Bulgarian Academy of Sciences, Sofia, Bulgaria, Department of Experimental Psych
opharmacology, Institute of Human and Animal Physiology 1986-2003.
Assistant Professor 1992-2003 Advising and teaching graduate students in the fie
ld of Experimental Neuropsychopharmacology and Anatomy and Pathophysiology of CN
S
Graduate student 1986-1992. Research was focused on the relationships between CN
S functions and overt behavior, with emphasis on the use of pharmacological mani
pulations that reveal mechanism of actions of different psychotropic drugs. Of p
articular interest were mechanisms implicated in cognition and CNS damage follow
ing prenatal exposure to different pharmacological and toxic substances, especia
lly ethanol. Pioneer designed study for treatment options for amelioration of Fe
tal Alcohol Spectrum Disorders.
Military Hospital, Sofia, Bulgaria
Medical Technologist. Blood and histological sampling, blood biochemistry invest
igation, basic microbiology and cell culture techniques.
THECHNICAL SKILLS
* Behavior Pharmacology (locomotor activity, Active and Passive avoidance test,
Plus maze anxiety test, analgesia, novelty seeking behavioral test, seizure acti
vity test, pharmacological stereotypy test and any pharmacological behavioral te
sts for investigation of pathophysiological changes in small lab animals.
* Surgery of small lab animals.
* Fine surgery skills for separation of the brain structures (hippocampus, stria
tum, meanings, cerebellum, pond),
* Pharmacological dosing and IP, SC, PO administration.
* Statistical data analysis relevant to behavioral sciences
* Blood sampling of lab animals (rabbits, cats, dogs, rats, mice)
* Skills of a phlebotomist
* Basic microbiology skills
* Basic histology skills as sliding, staining, and so on
* Protein Biochemistry (Electrophoresis and protein activity)
* Spectroscopy (UV-VIS, IR, Fluorescence)
* Molecular Biology (cloning, PCR, DNA sequencing, Cell culture, protein and gen
e expression)
Honors, Awards, and Recognitions:
1986-1992 Doctoral Research Fellowship, Department of Experimental Neuropsychoph
armacology, Bulgarian Academy of Sciences, Sofia, Bulgaria.
1996: Postdoctoral Award, European Community Program "Tempus.
1997: Postdoctoral Award, Catalan Government, Catalonia, Spain
1999: Visiting Professor, Autonomous University of Barcelona, Barcelona, Spain.
Included in Manchester WHO's WHO 2005/2006 "Honors Edition" of the most accompl
ished women in US.
Research grants and contracts:
National Fund of Scientific Investigation, Sofia, Bulgaria (1994-1997, 5000.00$,
PI). Behavior changes and pharmacological interventions after gamma irradiati
on in utero.
Philip Morris External Research Program, "Assessment of the developmental terato
genicity of nicotine: Pharmacological intervention by nootropic drugs." 06/01/03
-05/31/06, 795, 000.00$, Co-PI).
Professional Societies: National Society for Neuroscience

List of Publications:
Vaglenova J., Parameshwaran K., Suppiramaniam V, Breese CR, Pandiella N, Birru
S. (2008): Long-lasting teratogenic effects of nicotine on cognition: gender spe
cificity and role of AMPA receptor function. Neurobiology of Learning and Memory
. 90: 527-36
Vaglenova J, Pandiella N, Wijayawardhane NK, Vaithianathan T, Birru S, Breese CR
, Suppiramaniam VD, Clark R (2008): Aniracetam reversed learning and memory defi
cits following prenatal ethanol exposure by modulating functions of synaptic AMP
A receptors. Neuropsychopharmacology, 33(5):1071-83.
Wijayawardhane N, Shonesy BS, Vaithianathan T, Pandiella N, Vaglenova V, Breese
CR, Dityatev A, Suppiramaniam (2008): Ameliorating effects of preadolescent an
iracetam treatment on prenatal ethanol-induced impairment in AMPA receptor activ
ity. Neurobiology of Dis: 29(1):81-91
Wijayawardhane N, Shonesy BS, Vaglenova V, Vaithianathan V, Carpenter M, Bree
se CR, Dityatev A, Suppiramaniam (2007): Postnatal aniracetam treatment improve
s prenatal ethanol induced attenuation of AMPA receptor-mediated synaptic transm
ission. Neurobiology of Dis 26: 696-706
Vaglenova J, Sanjay B and Breese CR: The effects of nicotine on learning and mem
ory of adolescent rats during chronic exposure and withdrawn. (Submitted)
Vaglenova J, Sanjay B, Noemi M. Pandiella and Breese CR (2004): An assessment of
the long-term developmental and behavioral teratogenicity of prenatal nicotine
exposure Behavior Brain Res 150, 159-170.
Vaglenova J, Martinez C, Porte S, Duester G, Farres J, and Pares X (2003): Expre
ssion, Localization and Potential Physiological Significance of Alcohol dehydro
genase in the rat gastrointestinal tract. Eur. J. Biochemistry, 270 (12); 2652-6
2.
Narayanan U, Birru S, Vaglenova J, Breese CR (2002): Nicotinic receptor expressi
on following nicotine exposure via maternal milk. Neuroreport May 24; 13(7):961-
3
Martinez SE, Vaglenova J, Sabria J, Martinez C, Farres J, and Pares X (2001): Di
stribution of Alcohol dehydrogenase mRNA in the rat Central Nervous System. Cons
equences for Brain Ethanol and Retinoid Metabolism. Eur J Biochem 268 (19):5045-
56.
Vaglenova and Petkov (2001): Can nootropic drugs be effective against the impact
of ethanol teratogenicity on cognitive performance. European Neuropsychopharmac
ology. 11, 33 40.
Vaglenova J and Petkov (1998): Fetal Alcohol Effects in rats exposed pre and po
stnatally to a low dose of ethanol. Alcohol Clinic Exp Res 223:697 703.
Allali-Hassani A., S.E. Martinez, J.M. Peralba, J. Vaglenova, F. Vidal, C.Richar
t, J. Farres, and X. Pares (1997): Alcohol dehydrogenase of human and rat blood
vessels. Role in ethanol metabolism, FEBS Lett 405, 26-30.
Petkov V.V., D. Stoyanovsky, V.D. Petkov, U. Vuglenova (1992): Lipid Peroxidatio
n (LPO) in brain structures of rat with model of Fetal Alcohol Syndrome (FAS), B
ul Exp Biol Med (Moscow), 2, 500-502.
Hadjiivanova, Chr., V. D. Petkov, L. Alova, V. V. Petkov, J. Vaglenova (1991). E
ffects of Chronic Maternal Ethanol Consumption on Offspring Brain Muscarinic and
Beta-adrenoreceptors. Acta Physiol. Pharmacol. Bulg. 17, 1, 44-51.
Petkov, V. D., E. Konstantinova, V. V. Petkov, J. Vaglenova (1991). Learning and
Memory in Rats Exposed Pre-and Postnatally to Alcohol. An Attempt at Pharmacolo
gical Control, Meth Find Exp Clin Pharmacology, 13, 1, 43-50.
Lolova, I., V. Lolov, V. V. Petkov, J. Vaglenova (1989). Changes in the Synapse
s of the Rat Hippocampus Following Pre- and Postnatal Alcohol Exposure, Anat. An
z. 169, 285-294.
CHAPTERS and ABSTRACTS in the BOOKS:
X. Pares, S Martinez, A. Allali-Hassani, E. Borras, J. Farres, S. Matrtras, A.
Rosell, and J. Vaglenova (2001): Distribution of alcohol dehydrogenase in human
organs. Chapter: Alcohol metabolism, alcohol sensivity, and alcoholism. In: Alc
ohol in health and disease (Agarwal D.P. and Seitz H.K., eds). Marcel Dekker, In
c, New York, USA
E. Martinez, S. Porte, J. Vaglenova, X. Pares, J. Farres: " Histological localiz
ation of alcohol dehydrogenase: methods, approaches and applications" In: Compre
hensive Handbook of Alcohol Related Pathology vol 3, pp-1473-86 (Eds: V.R. Preed
y and R.R. Watson)., Academic Press (Elsevier Science), UK, 2004
Wijayawardhane NK*; J.Vaglenova, Vaithianathan T, Sims SM, Pandiella NM; Breese
CR, Suppiramaniam VD. Prenatal alcohol exposure and glutamatergic synaptic dysf
unction. Washington, DC, USA, 35th anual Neuroscience Meeting, 2005, November 12
-16; Press Book Part II; 200-201.
Parameshwaran K, Vaithianathan T, Kanju PM, Pandiella NM, Vaglenova J, Bree
se CR, Suppiramaniam V. Memory deficit related to prenatal nicotine exposure:
Role of hippocampal synaptic glutamatergic (AMPA) neurotransmitting. Washington,
DC, USA, 35th Annual Neuroscience Meeting, 2005, November 12-16. Press Book Pa
rt II; 324-325.
Wijayawardhane NK*; Vaithianathan, Pandiella NM, Colbert K, Huggins KW, Breese
CR, J.Vaglenova, Suppiramaniam VD. Postnatal aniracetam treatment ameliorates l
earning and memory deficits in rat offspring exposed to prenatal ethanol. Atlant
a, GA, USA, 36th annual Neuroscience Meeting, 2006, October 13-18. Press Book Pa
rt II; 110-111.
J.Vaglenova, Breese CR, Paramechwaran. Prenatal nicotine exposure causes long-la
sting teratogenic effects on cognition. Atlanta, GA, USA, 36th annual Neuroscien
ce Meeting, 2006, October 13-18. Press Book Part II; 267- 208.
International presentations: in
A Vaglenov, B Shinn, R Dudley, J Crea, J Vaglenova, S Lalchev, V Petkova, K Done
va, A Simonian. Genotoxic exposure assessment in tannery workers with evaluation
of antimutagenic properties of centrum(R). 10th International Conference on Env
ironmental Mutagens (ICEM), Firenze, Italy, 20-25 August, 2009. Poster
J.Vaglenova, Breese CR, Paramechwaran. Prenatal nicotine exposure causes long-la
sting teratogenic effects on cognition. Atlanta, GA, USA, 36th annual Neuroscien
ce Meeting, 2006.POSTER
Wijayawardhane NK*; Vaithianathan, Pandiella NM, Colbert K, Huggins KW, Breese
CR, J.Vaglenova, Suppiramaniam VD. Postnatal aniracetam treatment ameliorates l
earning and memory deficits in rat offspring exposed to prenatal ethanol. Atlant
a, GA, USA, 36th annual Neuroscience Meeting, 2006. ORAL
N.M.Pandiella, K.Wijayawardhane, S.Birru; E.M.-Josephson*; C.R.-Breese;
J.Vaglenova. Effective intervention of the cognitive deficits caused by prenatal
nicotine exposure with aniracetam. Washington, DC, USA, 35th Annual Neuroscienc
e Meeting, 2005, November 12-16, POSTER
J.Vaglenova*. Aniracetam, a potential therapeutic agent in reversing learning an
d memory deficits caused by prenatal ethanol exposure. Washington, DC, USA, 35th
Annual Neuroscience Meeting, 2005, November 12-16, POSTER
N.K.Wijayawardhane*; J.Vaglenova; T.Vaithianathan; C.M.sims; N.M.Pandiella;
C.R.Breese; V.D.Suppiramaniam. Prenatal alcohol exposure and glutamatergic synap
tic dysfunction. Washington, DC, USA, 35th Annual Neuroscience Meeting, 2005, No
vember 12-16, POSTER
K.Parameshwaran, T.Vaithianathan, P.M.Kanju, N.M.Pandiella, J.Vaglenova, C.R.Bre
ese, V.Suppiramaniam. Memory deficit related to prenatal nicotine exposure: Role
of hippocampal synaptic glutamatergic (AMPA) neurotransmitting. Washington, DC,
USA, 35th Annual Neuroscience Meeting, 2005, November 12-16.
KAN Wijayawardhane, NMPandiella, T Vaithianathan, CR Breese, J Vaglenova, V.Supp
iramaniam. Synaptic Glutamate (AMPA) dysfunction in prenatal alcohol exposure. A
nnual Metting of the Southeastern Pharmacology Society(SEPS) and Southeastern So
ciety of Toxicology (SESOT), 19-21 October 2005, Vanderbilt University, Nashvill
e, Tennessee, USA, ORAL
*Vaglenova J, Sanjay B and Breese CR: "Comparative evaluation of development and
behavioural teratogenic effects of two doses of nicotine". San Diego, CA, USA,
Neuroscience Meeting, 2004, October 23-27, POSTER
J. Vaglenova, S. Birru, and C.R. Breese: "Comparison of the Behavioral teratogen
icity of prenatal alcohol and nicotine exposure". 2004 RSA Meeting, Vancouver, C
anada, June
26-30, POSTER
Oelfke, E., Vaglenova, J., Birru, S., Pandiella, N., Breese, C.R. Developmental
effects of prenatal alcohol and nicotine exposure. Pharmacy Student Research For
um, Eastern States, Morgantown, WV, October, 2004.
Birru, S., Knapp, D.J., Vaglenova, J., Overstreet, D., Breese, G.R., Breese, C.R
. Alterations in neuronal nicotinic receptors in neonatally 6-hydroxydopamine le
sioned rats. Southeastern Pharmacology Symposium, Mercer University, Atlanta, GA
, October, 2003.
Gustman, T., Mayo, T., Birru, S., Vaglenova, J., Breese, C.R. Tolerance and nico
tinic receptor regulation following re-exposure to nicotine. Pharmacy Student Re
search Forum, Morgantown, WV, 2002.
Mayo, T., Gustman, T., Hubbard, J.E., Birru, S., Vaglenova, J., Breese, C.R. NMD
A receptor blockade by dizocilpine (MK-801) inhibits nicotine-induced upregulati
on of the high affinity neuronal nicotinic receptors: theoretical implications f
or schizophrenia. Pharmacy Student Research Forum, Morgantown, WV, 2002. 13
S.E. Martinez, J. Vaglenova, J. Farres, X. Pares. "Ethanol and retinoid metaboli
sm in the gastrointestinal tract". 8th Congress of the European Society for Biom
edical Research on Alcoholism. Paris, France, September, 15-18, 2001, ORAL
S.E. Martinez, J. Vaglenova, J. Sabria, J. Farres, X. Pares: "Distribution of a
lcohol dehydrogenase in Brain". 8th Congress of the European Society for Biomedi
cal Research on Alcoholism. Paris, France, 2001 September, 15-18, ORAL
J. Vaglenova, S.E. Martinez, J. Farres, X. Pares:"Distribution of alcohol dehydr
ogenase in rat brain and digestive tract tissues. 10th International Meeting of
Enzymology and Molecular Biology of Carbonyl Metabolism. Taos, New Mexico, USA,
July 1-5, 2000, ORAL
Talukdar, S., Sanjay, B., Narayanan, U., Sanga, M., Vaglenova, J., Breese, C.R.
Effect of fetal alcohol and nicotine exposure on nicotinic receptor expression.
Southeastern Pharmacology Symposium, Jackson, MS, August 10-12, 2000.
SE Martinez, J. Vaglenova, B. Crosas, J. Farres, X. Pares: "Localization of clas
s I and class IV alcohol dehydrogenase in brain tissues". 7 th Congress of the
European Society for Biomedical Research on Alcoholism, Barcelona, Spain, 1999,
POSTER
J. Vaglenova, S.E. Martinez, A. Allali-Hassani, J. M. Peralba, B. Crosas, M.C. M
artinez, J. Farres, X. Pares:"Region-specific distribution of alcohol dehydrogen
ase in gastrointestinal and vascular tissues". The ninth Congress of the Intern
ational Society for Biomedical Research on Alcoholism. Copenhagen, Denmark. 1998
Publication: Alcoholism, Clin. Exp. Res. 22 (1998) 174A, POSTER
Allali-Hassani, A., Crosas, B., Martinez, S.E., Peralba, J.M., Vaglenova, J., Fa
rres, J., Pares, X; "Human and rat class IV alcohol dehydrogenase: Exchange at r
esidue 294 accounts for major differences in kinetic properties": Eighth Congres
s European Society for Biomedical Research on Alcoholism (ESBRA), Stockholm, Swe
den, 28 June-1 July 1997, ORAL
Allali-Hassani, A., Crosas, B., Martinez, S.E., Peralba, J.M., Vaglenova, J., Fa
rres, J., Pares, X; "Human and rat class IV alcohol dehydrogenase: Exchange at r
esidue 294 accounts for major differences in kinetic properties": Eighth Congres
s European Society for Biomedical Research on Alcoholism (ESBRA), Stockholm, Swe
den, 28 June-1 July 1997, ORAL
Pares X., Allali-Hassani A., Martinez S.E., Peralba J.M., Vaglenova J., Crosas
B., Farres J:"Gastrointestinal and vascular alcohol metabolism". 6th Congress of
the European Society for Biomedical Research on Alcoholism. Barcelona, Spain, 2
8 June-1 July 1996, POSTER

Theaching:
Biol 152 at the University of Findlay 2008-09
Developmental Biology, Toxicology and Behavioral Teratology, elective course for
undergraduate students in the School of Pharmacy, Auburn University, AL, USA, s
pring 2006.
Drugs of abuse pharmacology and pathophysiology for graduate students at Auburn
University, AL, USA, spring 2006.
General Biology for undergraduate students in the Faculty of Biology, State Univ
ersity, Sofia, Bulgaria, 1992-1994. This course included Introduction to Biology
, Concepts in Biology I and II, General Genetics, Cell Biology, Molecular Biolog
y
Experimental Neuropharmacology and Pathohysiology for garduate students in the D
epartment of Experimental Psychopharmacology, Institute of Human and Animal Phys
iology, Bulgarian Academy of Sciences, Sofia, Bulgaria, 1992-1996.

Professional Duties and Comitties:


Wijayawardhane Nayanakanthi (advisor, Ph. D. student, 2007-05-15, Dissertation)
Therapeutic effects of aniracetam on cognitive deficits induced by ethanol terat
ogenicity: A novel treatment approach through synaptic AMPA receptor modulation.
Department of Pharmacal Science, Harrison School of Pharmacy, Auburn University
, Auburn, Al
Sanjay Birru (co- advisor, Ph. D student), Effect of reduced NMDA receptor funct
ion on expression and function of neuronal nicotinic receptors: theoretical impl
ications for schizophrenia. graduated, Fall 2004
Kodeeswaran Parameshwaran (co-advisor), Spring 2008, Department of Pharmacal Sci
ence, Harrison School of Pharmacy, Auburn University, Auburn, Al
Manuscript ad hoc reviewer for Brain Research and Behavioral Brain Research.
Manuscript ad hoc reviewer for Life Sciences
Manuscript ad hoc reviewer for Behavioral Pharmacology