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PAPER NAME : MINOR 10

1) Which of the following is also considered as local hormones:

A) Histamine

B) 5 hydroxy tryptamine

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C) kinins

D) All of above

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Correct Answer is D

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EXP : Autocoids are formed in various tissues and are considered to act as local hormones. They have a

local regulatory functions to be performed in the body. The autocoids are histamine, 5-HT, Kinins,

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Prostaglandins (PG)

2) Which of the following action of histamine would NOT be inhibited by mepyramine of

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diphenhydramine:

A) Contraction of smooth muscles of Bronchi

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B) Contraction of smooth muscles of intestine

C) Gastric acid secretion

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D) All would be inhibited

Correct Answer is C
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EXP : Histamine acts on H1 and H2 receptors. Contraction of bronchi and intestinal smooth muscles
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are mediated by H1 receptors while gastric acid secretion, cardiac accelerator effects are mediated by

h2 receptors. Mepyramine and diphenhydramine are inhibitors of H1 receptors while Ranitidine and
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cimetidine blocks actions of H2 receptors.

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3) Which of the following is 5-HT antagonist:

A) Buspirone

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B) Dexfenfluramine

C) Ondansetron

D) Sumatriptan

Correct Answer is C

EXP : Except ondansetron all are 5-HT agonists. Ondansetron is 5-HT3 antagonist and approved for

m
the use in prevention of nausea vomiting associated with cancer chemotherapy. Buspirone-5-HT1a

agonist-anxiolytic; Dexfenfluramine-5-HT agonist-Anorexient (antiobesity agent); Sumatriptan- 5HT1d

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agonist-acute migraine and cluster headache

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4) Selective Serotonin Reuptake inhibitor (SSRI) is

A) Fluoxetine

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B) Ondansetron

C) Chlorpromazine m
D) Ketanserin

Correct Answer is A
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EXP : In addition to fluoxetine other is paroxetine is another SSRI and used as antidepressants. Others
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are 5 HT-antogonist.

5) The following autocoid has important role in termination of pregnancy (i.e. in abortion) and

induction of labour:
.b

A) Histamine
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B) 5HT

C) Prostaglandin
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D) Kinin
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Correct Answer is C

6) Which of the following may be used as antiulcer:

A) Histamine
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B) Prostaglandin

C) Kinin

D) All may be used

Correct Answer is B

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7) Dinoprostone is:

A) A synthetic histamine analogue

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B) A synthetic Prostaglandin analogue

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C) A synthetic 5HT analogue

D) None of the above

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Correct Answer is B

EXP : Dinoprostone is a synthetic PGE-2 analogue and used to cause abortion.

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8) The following form of iron is absorbed from Gastrointestinal tract:

A) Ferrous
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B) Ferric

C) Ionic form does not affect absorption because it is actively transported

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D) Both are absorbed

Correct Answer is A
.b

EXP : For absorption ferric ion must be converted to ferrous form to become absorbable.
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9) A person is on tetracycline therapy. Following is likely to happen:

A) Iron absorption would impaired

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B) Iron absorption would enhanced

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C) No effect would be there

D) Iron would remain in ferrous form in GIT

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Correct Answer is A

EXP : Tetracycline forms an insoluble iron chelate, resulting in impaired uptake of both substances.

10) Iron is stored intracellularly as

A) Ferritin

B) Transferrin

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C) In both of the form

D) None of the above

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Correct Answer is A

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EXP : Iron is stored as ferritin. Transferrin carries iron in plasma.

11) Vitamin B12 is important in

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A) Blood coagulation

B) Folate synthesis m
C) Blood hemorrhage

D) All
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Correct Answer is B
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EXP : Vitamin B12 is important in biochemical rection of conversion of methyl tetrahydrofolate to

tetrahydrofolate.

12) Latanoprost, travaprost and unoprostone are used in glaucoma; they act via
.b

A) PGF2 receptor
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B) PGE2 receptor

C) PGD2 receptor
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D) PGI2 receptor
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Correct Answer is A

13) Heparin acts as anticoagulant by blocking

A) Stuart Prower factor

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B) Proconvertin

C) Hageman factor

D) Christmas factor

Correct Answer is A

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14) Hemophilia Cis caused by defect in factor no

A) VIII

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B) IX

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C) XI

D) XIII

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Correct Answer is C

15) Therapeutic Drug Monitoring is not needed when: m

A) the drug in question has a narrow therapeutic range

B) the pharmacological effects can be clinically quantified

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C) the therapeutic effect can not be readily assessed by the clinical observation

D) large individual variability in steady state plasma concentration exits at any given dose
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Correct Answer is B

16) Which of the following drug do not need Therapeutic Drug Monitoring in geriatrics
.b

A) Phenytoin
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B) Digoxin

C) Gentamicin
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D) Amoxycillin
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Correct Answer is D

EXP : Amoxicillin is antibiotic do not need TDM while digoxin is narrow therapeutic index drug. In

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older age the liver and kidney functioning is weakened hence the drugs having impact on liver

(Phenytoin) and kidney (Gentamicin-renal toxicity is adverse effect)

17) Therapeutic index is :

A) LD 50/ED50

B) ED 50/LD 50

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C) LD 50/IC 50

D) None of the above

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Correct Answer is A

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18) Which of the following induce microsomal enzymes:

A) Rifampicin

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B) Ethanol

C) Carbamazepine m
D) All of above

Correct Answer is D
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19) Grey baby syndrome is caused by:
ph

A) Aspirin

B) Chloremphenicol

C) Amoxicillin
.b

D) Piroxicam
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Correct Answer is B

20) Which of the following is not the extracting media in systemic injection test for plastics, IP 2007-
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A) PEG 400
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B) PEG 4000

C) Arachis Oil

D) Ethanol 5% v/v
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Correct Answer is B

21) Eye irritation test for packages intended for ophthalmic preparation is performed on which of the

following animal in accordance to IP 2007:

A) Guinea Pig

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B) Rat

C) Dog

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D) None of the above

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Correct Answer is D

EXP : Eye irritation test is performed on rabbit s eye according to IP 2007

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22) Due to which of the following substances the amber colored glass is capable of protecting light and

UV radiations: m
A) Copper Oxide

B) Zinc Oxide
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C) Iron Oxide

D) Boron Oxide
ph

Correct Answer is C

23) In accordance to IP 2007, which of the following test is applicable for type IV glass:
.b

A) Hydrolytic Resistance test

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B) Powdered Glass test

C) Water Attack test

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D) None of the above

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Correct Answer is D

EXP : In IP 2007 only three types of glasses are described type I,II and III. In USP there are 4 types and

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type 4 is NP grade and powdered glass test is used for it

24) Which of the following test is official for Rubber closures for parenteral use in IP

A) Fragmentation test

B) Heavy metal test

C) Self Sealability test

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D) All of above

Correct Answer is D

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25) In fragmentation test (IP 2007) for butyl rubber, the number of particles (0.5 micron) is limited up

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to

A) 10

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B) 15

C) 20 m
D) 5

Correct Answer is C
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EXP : Butyl rubbers are having less elasticity and more brittleness than other rubbers hence the limit is
ph

kept 15 while for other rubbers the linit prescribed is 10 (IP 2007)

26) In accordance with IP 2007, which one of the following animal is used for subcutaneous injection

method in testing of plastic containers for parenteral use:

.b

A) Rabbit
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B) Guinea pig

C) Mice
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D) anyone of the above may be used if it is healthy and free from disease
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Correct Answer is A

27) Find the drug belonging to Aryl acetic acid analogues

A) Indomethacin
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B) Tolmetin sodium

C) Zomepirac

D) Sulindac

Correct Answer is D

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EXP : All the drugs bear an aryl acetic acid ring butIndomethacin, Tolmetin sodium, Zomepirac bear a

heteroatom in the aryl ring attached to the acetic acid moiety while sulindac does not.

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28) Name the starting material used for the synthesis of Naproxen

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A) 2-Methoxy Naphthalene

B) 4-Naphthol

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C) 4-Methoxy Naphthalene

D) 2-Naphthol m
Correct Answer is A

29) Which of the following antianginal drug directly relaxes smooth muscles of coronary vessels
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A) Propranolol

B) Dilitiazem
ph

C) Aspirin

D) Amyl Nitrite
.b

Correct Answer is D
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30) In the synthesis of Ibuprofen Isobutyl benzene is converted into 4-Isobutyl acetophenonein the

presence of acetyl chloride and AlCl3 .Identify the reaction type

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A) Willlgerodts reaction
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B) Friedal Crafts reaction

C) Acetylation

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D) Wolf-Kishner reaction

Correct Answer is B

31) Action of sodium metal on Methylacetylsalicylate yields

A) 4-hydroxycoumarin

B) Methyl salicylate

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C) Menadione

D) Aspirin

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Correct Answer is A

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32) In Amino alkyl ether ---- nitrogen gives maximum antihistaminic activity

A) Primary

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B) Secondary

C) Tertiary m
D) Aromatic

Correct Answer is C
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33) In Pheniramine maleate introduction of Chloro group in benzene ring will
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A) Increae Potency

B) Decrease Potency

C) Not change Potency

.b

D) Change its activity

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Correct Answer is A

34) Identify the H2 receptor antagonist which possess Furan ring

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A) Famotidine
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B) Ranitidine

C) Omeperazole

D) Cimetidine
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Correct Answer is A

35) Find the First starting material for the synthesis of Promethazine

A) Phenothiazine

B) Diphenylamine

m
C) Methylamine

D) Benzyl amine

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Correct Answer is B

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36) Name the 4-hydroxycoumarin derivative which is used as anticoagulant drug

A) Heparine

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B) Warfarin

C) Menadione m
D) Aspirin

Correct Answer is B
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37) In the NSAIDS which functional group is responsible for gastric irritation?

A) Ester
ph

B) Phenolic

C) Carboxylic acid
.b

D) Aldehyde
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Correct Answer is B

38) Name the ethylene diamine antihistaminic drug in which one of the aromatic rings is substituted by
w

pyrimidine ring
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A) Tripelennamine

B) Pyrilamine

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C) Methapyrilene

D) Thonzylamine

Correct Answer is D

39) Autocoidal used in treatment of Alopecia....

A) Doxaprost

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B) Viproprost

C) Butaprost

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D) All of these

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Correct Answer is B

40) Select the flavoprotiens

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A) L Amino acid oxidase

B) Xanthine oxidase m
C) Both

D) None of these
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Correct Answer is C
ph

41) In biological oxidation "Dehydrogenases" utilizes following coenzyme

A) Nicoitinamide & Riboflavin:As H carrier

B) Riboflavin:As Oxygen carrier

.b

C) Nicoitinamide & Riboflavin:As Oxygen carrier

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D) Nicoitinamide:As H carrier

Correct Answer is A
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42) Select the right statement

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A) Shelf life of a drug relates time to day 90% of original concentration

B) Stability of a drug relates half life

C) Both a & b
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D) Shelf life of a drug relates half life of the drug

Correct Answer is C

43) Select the wrong match for flavonoids

A) Vitamin K

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B) Plant sec metabolite

C) Ketone containing compounds

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D) All of these

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Correct Answer is A

44) Select the flavonoidal glycoside

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A) Quercetin

B) Citrus bioflavonoids m
C) Rutin

D) All of these
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Correct Answer is D

45) Citrus contains flavanoidal glycoside hesperdin. The aglycon part & its chemical nature is
ph

A) hespertin:Flavonone

B) hespertin:Flavonol
.b

C) Rutin:Flavonone
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D) Quercetin:Flavanol

Correct Answer is A
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46) Chemically Leucoanthocyanidin are

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A) Flavan-3,4-diol

B) Flavan-1,4-diol

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C) Flavan-4-ol

D) Flavan-3-ol

Correct Answer is A

47) The term "Functional foods" means

A) Food claimed to have a health-promoting or disease-preventing property

m
B) Food with basic function of supplying nutrients

C) Medicines

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D) Any processed food

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Correct Answer is A

48) "Dietary Supplement Health and Education Act" was applicable in

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A) 1994 in US to define dietry suppliments

B) 1924 in US to define dietry suppliments m

C) 1924 in INDIA to define dietry suppliments

D) 1994 in INDIA to define dietry suppliments

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Correct Answer is A
ph

49) Select the dietry antioxident

A) Vit C

B) -carotine
.b

C) Vit E
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D) All of these

Correct Answer is D
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50) Select the wrong statement for RUTIN

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A) Flavonoidal nature

B) Poorly absorbed from GIT

C) Dietry Antioxident
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D) Alkalodal nature

Correct Answer is D

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