MEDICINAL CHEMISTRY

Q1. Identify the synthesis of following compound

(i ) NH3 

o m
f.c
a. Acetyl choline
b. Carbachol
c. Methacholine

stu
d. Neostigmine

Q2. Identify the synthesis of following compound

m
ar
CH3 Br 
ph
.b

a. Edrophonium
w

b. Pyridostigmine
c. Methacholine
w

d. Neostigmine

Q3. Cyclohexyl nitrile and N, N-diethylamino is used as starting product in the synthesis of
w

a. Glycopyrrolate
b. Dicyclomine
c. Homatropine
d. Cyclopentolate
Q4. Xanthene 9-carboxylic acid N,N-diethylamino cholroethane is used in the synthesis of

a. Tropicamide
b. Propantheline
c. Procyclidine
d. Dicyclomine

Q5. Which of the following is the structure of Tropicamide

o m
f.c
a.

stu
m
b.
ar
ph
.b

c.
w
w
w

d.

Q6. Identify the synthesis of following compound

 m
a. Salbutamol

o
b. Terbutaline
c. Amphetamine

f.c
d. Isoprenaline

Q7. Identify the synthesis of following compound

stu
m
ar
a. Salbutamol
b. Noradrenaline
ph

c. Amphetamine
d. Phenylephrine

Q8. Identify the synthesis of following compound

.b
w
w
w

a. Salbutamol
b. Phenoxybenzamine
 c. Tolazoline
d. Naphthazoline

Q9. Identify the synthesis of following compound

om
f.c
a. Salbutamol

stu
b. Propranolol
c. Prazocin
d. Ephedrine m
Q10. Identify the synthesis of following compound
ar
ph
.b

a. Phenetolamine
w

b. Phenoxybenzamine
c. Prazocin
d. Ephedrine
w

Q11. Identify the synthesis of following compound

w
 om
f.c
a. Phenetolamine
b. Phenoxybenzamine
c. Prazocin

stu
d. Propranolol

Q12. Identify the synthesis of following compound

m
ar
ph

a. Diphenhydramine
b. Doxylamine
.b

c. Mepyramine
d. Pheniramine
w

Q13. Identify the synthesis of following compound

w

a. Diphenhydramine
b. Doxylamine
w

c. Mepyramine
d. Pheniramine
 NaH2 

Q14. Identify the synthesis of following compound

o m
f.c
a. Promethazine
b. Cyclizine

stu
c. Pheniramine
d. Methdilazine

Q15. Identify the synthesis of following compound

m
ar
ph
.b

a. Promethazine
b. Cyclizine
w

c. Pheniramine
d. Meclizine
w

Q16. Identify the synthesis of following compound

w

a. Phenindamine
b. Cyproheptadine
c. Triprolidine
d. Indomethacin
 m
Q17. Identify the synthesis of following compound

o
f.c
stu
a. Cimetidine
b. Ranitidine
c. Nizatidine
m
d. Famotidine
ar
Q18. Which heterocyclic ring is present in Amiloride?

a. Pyrimidine ring
ph

b. Pteridine ring
c. Pyrazine ring
d. Pyridine
.b

Q19. Which diuretic have steroid nucleus?

w

a. Amiloride
b. Chlorthalidone
w

c. Triamterene
d. Spironolactone
w

Q20. Diphenhydramine belongs to antihistaminic class of

a. Ethylene diamine
b. Amino alkyl ether
c. Alkyl amine
 d. Phenothiazine

Q21. Phenindamine belongs to class of

a. Piperidine
b. Piperazine
c. Ethylene diamine
d. Amino alkyl ether

m
Q22. Identify the synthesis of following compound

o
f.c
stu
a. Naproxen
b. Ketoprofen
c. Naphthazoline
m
d. Phenacetin
ar
Q23. Identify the synthesis of following compound
ph
.b
w

a. Sulindac
b. Indomethacin
w

c. Phenylbutazone
d. Mefenamic acid
w

Q24. Identify the synthesis of following compound

 a. Diclofenac

m
b. Piroxicam
c. Phenylbutazone

o
d. Mefenamic acid

f.c
Q25. Identify the synthesis of following compound

stu
m
ar
a. Diclofenac
b. Aminopyrine
ph

c. Phenylbutazone
d. Mefenamic acid
.b

Q26. Hydantoin posses the heterocyclic ring

a. Imidazoline 3,5-dione
w

b. Imidazoline 2,4-dione
c. Pyrazoline 3,5-dione
w

d. Thiazoline 2,4-dione

Q27. Phenytoin is
w

a. 5,5-diphenylimidazoline-2,4 dione
b. 4,4-diphenylimidazoline-2,4-dione
c. 4,4-diphenylimidazoline-3,5-dione
d. 5,5-diphenylpyrazoline-3,5-dione
Q28. Antipyretic activity of NASIDS is mostly exhibited due to inhibition of

a. PGE2
b. PGD2
c. PGI2
d. PGF2α

Q29. Which enantiomers of profens are more active?

m
a. S(+)
b. S(-)

o
c. R(+)

f.c
d. R(-)

Q30. Ephedrine how has many Chiral center

stu
a. 2
b. 3
c. 1
d. 0
m
Q31. Antazoline a NASID have
ar
a. Imidazoline ring
b. Pyrazoline ring
c. Thiazoline ring
ph

d. Oxazoline ring

Q32. Which of the following is tertiary amine and crosses the BBB?
.b

a. Pyridostigmine
b. Physostigmine
w

c. Neostigmine
d. Edrophonium
w

Q33. 4-chloro-6-amino-1,3-benzenesulfonamide and formic acid are starting material for synthesis of
w

a. Hydrochlorthiazide
b. Chlorthiazide
c. Benzthiazide
d. Polythiazide
Q34. 2,4-dichloro benzoic acid and furfurylamine are starting product for synthesis of

a. Furosemide
b. Bumetanide
c. Chlorthalidone
d. Chlorthiazide

Q35. Pthalic anhydride and chlorobenzene are starting product for synthesis of

m
a. Phenindamine
b. Cyproheptadine

o
c. Chlorthalidone

f.c
d. Chlorthiazide

Q36. 2,3-dichlorophenoxyacetic and butrylchloride are stating product for the synthesis of

stu
a. Ethacrynic acid
b. Triamterene
c. Amiloride
d. Furosemide
m
Q37. Pteridine ring is present in
ar
a. Amiloride
b. Triamterene
c. Chlorthalidone
ph

d. Spirolactone

Q38. Benzylnitrile and nitrosopyrimidine are the starting product for

.b

a. Amiloride
b. Triamterene
w

c. Chlorpheniramine
d. Naphthazoline
w

Q39. 2,6-dichloro5-formylpyrimidine and hydrazine are starting product of

w

a. Allopurinol
b. Colchicine
c. Probenecid
d. Sulfinpyrazone
Q40. 4-hydroxy-3-hydroxymethyl Benzaldehyde and tertiary butylbenzylamine are involved in the synthesis
of

a. Terbutaline
b. Salbutamol
c. Isoprenaline
d. Albuterol

m
Q41. Identify the synthesis of following compound

o
f.c
a. Halothane

stu
b. Enflurane
c. Isoflurane
d. Methoxyflurane m
Q42. Identify the synthesis of following compound
ar
ph
.b
w

a. Phenobarbitone
b. Mephobarbitone
w

c. Secobarbitone
d. Pentobarbitone
w

Q43. Identify the synthesis of following compound

a. Amobarbitone
b. Secobarbitone
c. Pentobarbitone
 d. Phenobarbitone

mo
Ethylisopentylethylmalonate urea
 

f.c
Q44. Identify the synthesis of following compound

stu
m
ar
ph

a. Glutethimide
b. Methqualone
.b

c. Meprobamate
d. Paraldehyde
w

Q45. Identify the synthesis of following compound

w

a. Diazepam
b. Nitrazepam
w

c. Flurazepam
d. Alprazolam
 om
Q46. Identify the synthesis of following compound

f.c
stu
m
ar
a. Phenytoin
b. Trimethadione
ph

c. Phensuximide
d. Primidone

Q47. Identify the synthesis of following compound

.b
w
w
w

a. Imipramine
b. Carbamazepine
c. Amitriptyline
d. Primidone
Q1. Which of the following anthelmintics is not a carbamic methyl ester?

1. Cyclobendazole 2. Thiabendazole 3. Albendazole 4. Parbendazole

Q2. Acyclovir is a analogue of

1. Uracil 2. Adenine 3. Guanine 4. Thymidine

Q3. Sulfamethoxazole is having

m
1. Isoxazole ring 2. Oxazole ring 3. 1, 3, 4 thiadiazole 4. Imidazole

o
Q4. Which of the following drug is amphoteric in nature?

f.c
1. Chloramphenicol 2. Amphotericin B 3. Macrolides 4. Penicillins

Q5. Which isomer of Chloramphenicol is more active?

stu
1. R, R 2. R, S 3. S, S 4. All are equally active

Q6. Which of the following is not true about cycloserine?

1. It is derived from amino acids

nephrotoxic
m
2. It inhibits cell wall synthesis 3. Having oxazolidine ring 4. Highly
ar
Q7. How many chiral centers are present in oxytetracycline?

1. 4 2. 5 3. 6 4. 7
ph

Q8. Which of the following drug is para-hydroxy acetanilide derivative?

1. Niclosamide 2. Diloxanide 3. Pyrazinamide 4. Teclozan

.b

Q9. How many chiral centers are present in steroid nucleus?

w

1. 4 2. 5 3. 6 4. 7

Q10. Primaquine is derivative of-

w

1. 8-aminoquinoline 2. 4-aminoquinoline 3. Biguanides 4. Napthaquinone

w

Q11. In steroid nucleus A/B, B/C, C/D rings are fused in the manner of-

1. Cis- Cis -Trans 2. Trans-Cis-trans 3. Cis-Trans-Cis 4. Trans-Cis-Cis

Q12. Which of the following is not having steroid nucleus?

 1. Finastride 2. Nondrolone 3. Flutamide 4. Megestrol

Q13. 9α fluoro - 11β,17,21-trihydroxy -16α-methyl pregna1,4-diene 3,20 dione is

1. Paramethsone 2. Triamcinolone 3. Prednesolone 4. Betamethasone

Q14. . 9α fluoro - 11β,16α,17,21-tetrahydroxy pregna1,4-diene 3,20 dione is

1. Paramethsone 2. Triamcinolone 3. Fludrocortisone 4. Betamethasone

m
Q15. Which of the following is antiandrogenic?

o
1. Tamoxifen 2. Mifepristone 3. Clomiphene 4. Flutamide

f.c
Q16. Which heterocyclic ring is present in Amiloride?

1. Pyrimidine ring 2. Pteridine ring 3. Pyrazine ring 4. Pyridine

stu
Q17. Which diuretic have steroid nucleus?

1. Amiloride 2. Chlorthalidone 3. Triamterene 4. Spironolactone

m
Q18. Benorylate is condensation product of ……………………………………………………………….

Q19. Diphenhydramine belongs to antihistaminic class of

ar
1. Ethylene diamine 2. Amino alkyl ether 3. Alkyl amine 4. Phenothiazine
ph

Q20. Match the following heterocyclic ring present in drugs-

1. Imidazole a. Cimetidine 1.

2.
.b

2. Thiazole b. Ranitidine

3. Furan c. Astemizole 3.
w

4. Benzimidazole d. Terfenadine 4.
w

5. 1,1 dioxothiazine e. Thiazolidine 5.

6. Sulbactam f. Oxazolidine 6.
w

7. Clavulinic acid g. Albendazole 7.

h. Piroxicam

Q21. Choose the correct statement for estrogen

 1. Ring D is benzenoid and have OH grp at C17 Phenolic

2. Ring A is quinonoid and have OH grp at C3 alcoholic

3. Ring A is benzenoid and have OH grp at C3 Phenolic

4. Ring D is quinonoid and have OH grp at C17 alcoholic

Q22. Phenindamine belongs to class of

m
1. Piperidine 2. Piperazines 3. Ethylene diamine 4. Amino alkyl ether

o
Q23. Match the following
1.

f.c
1. Benzimidazole Zalcitabine
2.
2. Imidazole Metronidazole
3.

stu
3. Thymidine Stavudine
4.
4. 17β hydroxy- 17α methyl 3 oxo androst-4ene Meconazol
m 5.
5. Salicylic acid derivative Nondrolone
6.
6. Piperazine ring Mthyltestosterone
7.
ar
7. Morpholino Diloxanide
8.
ph

8. Ethanol derivative Niclosamide

9.
9. Acetanilide derivative Nitrofurazone
10.
.b

10. Oxazolidine Nimorazole

Citerizine
w

Mebendazole
w

Q24. Which of the moiety is responsible for diuretic activity in acetazolamide?

1. 1, 3, 4-thiazole ring 2. N-acetyl grp 3. Sulphamoyl grp 4. Secondary amino grp

w

Q25. Which isomer of diethyl stilbosterol is more active?

1. Cis 2. Trans 3. E 4. Z

Q26. Identify True/False (T/F) statement

 1. In steroid nucleus confirmation is boat shape (T/F)

2. Paramethsone have 9α fluoro, 16α-methyl-17α-hydroxy grp (T/F)

3. Halofantrine is quinoline methanol (T/F)

4. Sesquiterpene lactone is artimisnin (T/F)

5. Ciprofloxacin have Piperazine ring attached to 1st position (T/F)

m
6. Vidarabine is adenine analogue (T/F)

o
7. Pyrantel is pyridine analogue (T/F)

f.c
8. Trimethoprim is pyrimidine analogue (T/F)

9. Sulphalene have Pyrazine ring (T/F)

stu
10. Azteonam is monobactam (T/F)

11. Clavulinic acid thiazolidine ring (T/F)

m
12. Active anti inflammatory metabolite of sulfasalazine is pyridyl sulphanilamide (T/F)

13. Phenyl butazone is synthesized from hydrazine derivative (T/F)

ar
14. Fenbufen is carbonyl propionic acid (T/F)
ph

15. Mefenamic acid is arylacetic acid derivative (T/F)

16. Oxicams are N-heteroaryl carboxamide derivatives (T/F)

.b

17. Chlorthiazide have 1,1 dioxo 1,2 thiazine ring (T/F)

w
w
w

Synthesis of some important drugs

1. Acetazolamide 14. Allopurinol

2. Polythiazide 15. Phenylbutazone

3. Mebendazole 16. Indomethacin

4. Niclosamide 17. Mepyramine

5. Metronidazole 18. Promethazine

6. Diloxanide 19. Cimetidine

m
7. Mefenide 20. Nalixidic acid

o
8. Meconazol

f.c
9. Proquanil

10. Trimethoprim

stu
11. Clofazimine

12. Chlorthalidone

13. Mefenamic acid

m
ar
ph
.b
w
w
w