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Product Information

S1526 AC-220
FLT3

Novel Life Science Reagents


for Cell Signaling Research

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Technical Data:
M.Wt: Formula: Solubility: Purity: Storage: CAS No.: 560.67 C29H32N6O4S DMSO 99% at -20 2 years 950769-58-1

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Biological Activity
AC220 is a uniquely potent and selective FLT3 inhibitor with IC50 of 0.56 0.3 nM and >10 mM for MC4-11 and A375, respectively. It exhibits low nanomolar potency in biochemical and cellular assays and exceptional kinase selectivity, and in animal models is efficacious at doses as low as 1 mg/kg given orally once daily. The data reveal that the combination of excellent potency, selectivity, and pharmacokinetic properties is unique to AC220, which therefore is the first drug candidate with a profile that matches the characteristics desirable for a clinical FLT3 inhibitor.[1][2]

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References
[1] Zarrinkar PP et a. Blood. 2009 Oct 1;114(14):2984-92 [2] Wiernik PH. Clin Adv Hematol Oncol. 2010 Jun;8(6):429-44

Return Policy
Please inspect packages immediately upon receipt and notify customer service within 3 days of delivery of any damage or discrepancies.Our team will take quick and appropriate action to correct any problem.

MSDS & CoA


Please visit www.selleckchem.com to download MSDS and CoA.

Goods ordered in error can only be accepted

Notes
PLEASE KEEP THE PRODUCT UNDER -20 FOR LONG-TERM STORAGE. NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
Specific storage and handling information for each product is indicated on the product datasheet. Most Selleck products, stored under the recommended conditions, are stable for two years. Products are sometimes shipped at a temperature that differs from the recommended storage temperature,most are recommended stored at -20 Many products are stable in the short-term at temperatures that differ from that . required for long-term storage. We ensure that the product is shipped under conditions that will maintain the quality of the product, but save your shipping charges by using the most economical storage conditons for an overnight shipment. Upon receipt of the product, follow the storage recommendations on the product data sheet.

for return if made within 3 days of delivery, are unopened,have been stored correctly and are in good condition. Should you wish to return any item(s), prior authorization must be received from our customer service team. Returns accepted will be subject to a 30% restocking charge.

For all product returns and product replacements,please contact Selleck directly by info@selleckchem.com or +1-713-922-4115 Please have on hand, the invoice number, purchase order number,air bill number and approximate date of shipment/receipt.

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