Product Information

S2217 Irinotecan HCl Trihydrate

Topoisomerase

Novel Life Science Reagents

for Cell Signaling Research

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O H2O O N N O H2 O HCl H2 O N N O OH O

Technical Data:
M.Wt: Formula: Solubility: Purity: Storage: CAS No.: 677.18 C33H38N4O6.HCl.3H2O Unknown 99% at -20 2 years 136572-09-3

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(chemistry support)

Synonyms: CPT

11, Camptosar, Campto

techbio@selleckchem.com
(bio support)

Biological Activity
Irinotecan hydrochloride trihydrate is a hydrochloride trihydrate of irinotecan (Camptosar, Campto, CPT-11) which is a topoisomerase I inhibitor with IC50 of 15.8 and 5.17 M for LoVo cells and HT-29 cells, respectively. As a Topo I inhibitor, Irinotecan (Camptosar, Campto, CPT-11) inhibits the religation step of the enzymes normal action, inducing single stranded DNA breaks. These single stranded breaks are then converted to double-stranded breaks within the course of DNA replication which is reported to induce apoptosis or repair mechanisms as a result. Irinotecan is activated by esterases to produce the activated metabolite and has been reported to be associated with cleavage of poly (ADP-ribose) polymerase (PARP) in colon carcinoma cells. Irinotecans active metabolite is additionally noted to activate p53 in the Huh7 cell line. [1][2][3]

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References
[1] http://en.wikipedia.org/wiki/Irinotecan [2] Pavillard V et al. Cancer Chemother Pharmacol. 2002 Apr;49(4):329-35. [3] Hofmann C et al. Anticancer Res. 2005 Mar-Apr;25(2A):795-804.

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Please inspect packages immediately upon receipt and notify customer service within 3 days of delivery of any damage or discrepancies.Our team will take quick and appropriate action to correct any problem.

MSDS & CoA

Please visit www.selleckchem.com to download MSDS and CoA.

Goods ordered in error can only be accepted for return if made within 3 days of delivery, are unopened,have been stored correctly and are in good condition. Should you wish to return any item(s), prior authorization must

Notes
PLEASE KEEP THE PRODUCT UNDER -20 FOR LONG-TERM STORAGE. NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
Specific storage and handling information for each product is indicated on the product datasheet. Most Selleck products, stored under the recommended conditions, are stable for two years. Products are sometimes shipped at a temperature that differs from the recommended storage temperature,most are recommended stored at -20 Many products are stable in the short-term at temperatures that differ from that . required for long-term storage. We ensure that the product is shipped under conditions that will maintain the quality of the product, but save your shipping charges by using the most economical storage conditons for an overnight shipment. Upon receipt of the product, follow the storage recommendations on the product data sheet.

be received from our customer service team. Returns accepted will be subject to a 30% restocking charge.

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