DRUG STUDY DRUG GENERIC NAME: Erythropoietin BRAND NAME: Eposino DOSE: 4000 IU ROUTE: S.

Q FREQUENCY: TID X 6 doses MUSCKULOSKELETAL: arthralgia RESPIRATORY: cough, shortness of breath. SKIN: infection site reactions, rash, urticaria. y y INDICATION Anemia caused by Chronic renal failure ACTION Mimics effects of erythropoietin. Functions as a growth factor and as a differentiating factor, enhancing RBC production. ADVERSE REACTION CNS: asthenia, dizziness, fatigue, headache, paresthesia, seizures. CV: edema, hypertension, increased clotting of arteriovenous grafts. GI: abdominal pain and constipation (in children) diarrhea, nausea, vomiting. y CONTRAINDICATIONS Contraindicated in patient hypersensitivity to products derived from mammal cells or albumin (human) and in those with uncontrolled hypertension. y NURSING CONSIDERATIONS Before starting therapy, evaluate patient s iron status. Patient should receive adequate iron supplementation beginning no later than when epoetin alfa treatment starts and continuing throughout therapy. Patient may need vitamin B12 and folic acid . Monitor BP before therapy. Blood pressure may increase, especially when hematocrit increases in the early part of therapy. Monitor blood counts; elevated hematocrit may cause excessive clotting Inform patient that pain in limbs and long may occur after injection(usually within 2 hours.) Patient may need additional heparin to prevent clotting during dialysis treatment. Tell patient to monitor blood pressure at home and to adhere to dietary restrictions.

y y

DRUG STUDY
DRUG GENERIC NAME: Pizotifen hydrogen maleate, Vitamin B complex, Nicotinamide BRAND NAME: Mosegor Vita DOSE: 1 tab ROUTE: P.O FREQUENCY: 0-0-1 GI: abdominal pain and constipation (in children) diarrhea, nausea, vomiting. MUSCKULOSKELETAL: arthralgia RESPIRATORY: cough, shortness of breath. SKIN: infection site reactions, rash, urticaria. y lack of appetite associated w/ vitamin B deficiency secondary to impaired dietary intake or absorption A coenzyme that stimulate metabolic function and is needed for cell replication, hematopoiesis, nucleoprotein and myelin synthesis. INDICATION ACTION ADVERSE REACTION CNS: asthenia, dizziness, fatigue, headache, paresthesia, seizures. CV: edema, hypertension, increased clotting of arteriovenous grafts. y CONTRAINDICATIONS Contraindicated in patient hypersensitivity to products derived from mammal cells or albumin (human) and in those with uncontrolled hypertension. y y NURSING CONSIDERATIONS Obtain sensitivity test history before administration Avoid IV administration because faster systemic elimination will reduce the effectiveness of vitamin. Don t give large doses of vitamin B 12 routinely; drug is lost through excretion. Monitor patient for hypokalemia for first 48 hours, as anemia corrects itself. Give potassium supplements as needed.

y y