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Product Information

S1224 Oxaliplatin
Technical Data:
M.Wt: Formula: Solubility: Purity: Storage: CAS No.: 397.29 C8H14N2O4Pt Unknown 99% at -20 2 years 61825-94-3 O H2 N O Pt O O N H2 Synonyms: Eloxatin

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for Cell Signaling Research

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Biological Activity
Cytotoxicity of platinum drugs is believed to result from the formation of platinum-DNA adducts. Eukaryotic cells respond to the presence of oxaliplatin adducts in DNA by activating signal transduction pathways that result in cell cycle arrest, an increase in DNA repair activity and apoptosis.[2] Oxaliplatin was found to be active against C32 and G361 cell lines with IC50 values of 49.48 and 9.07 M (1 h exposure), 9.47 and 1.30 M (4 h exposure), and 0.98 and 0.14 M (24 h exposure), respectively. [3]

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References
[1] Christin Tse et al. Cancer Res. 2008 May 1;68:3421-3428 [2] Alex R. Shoemaker et al. Clinical Cancer Research. 2008 June 1;14:3268-3277 [3] Mohammed MQ, Retsas S. Anticancer Drugs. 2000 Nov;11(10):859-63

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Please inspect packages immediately upon receipt and notify customer service within 3 days of delivery of any damage or discrepancies.Our team will take quick and appropriate action to correct any problem.

MSDS & CoA


Please visit www.selleckchem.com to download MSDS and CoA.

Goods ordered in error can only be accepted for return if made within 3 days of delivery, are unopened,have been stored correctly and are in good condition. Should you wish to return any item(s), prior authorization must

Notes
PLEASE KEEP THE PRODUCT UNDER -20 FOR LONG-TERM STORAGE. NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
Specific storage and handling information for each product is indicated on the product datasheet. Most Selleck products, stored under the recommended conditions, are stable for two years. Products are sometimes shipped at a temperature that differs from the recommended storage temperature,most are recommended stored at -20 Many products are stable in the short-term at temperatures that differ from that . required for long-term storage. We ensure that the product is shipped under conditions that will maintain the quality of the product, but save your shipping charges by using the most economical storage conditons for an overnight shipment. Upon receipt of the product, follow the storage recommendations on the product data sheet.

be received from our customer service team. Returns accepted will be subject to a 30% restocking charge.

For all product returns and product replacements,please contact Selleck directly by info@selleckchem.com or +1-713-922-4115 Please have on hand, the invoice number, purchase order number,air bill number and approximate date of shipment/receipt.

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