TECHNICAL SUMMARY SHEET Max Immune Probiotic Quattro (VL717) Indications Max Immune Probiotic Quattro has the

following benefits: Supports digestive health Promotes bodys natural defenses Probiotics Background and Application Probiotics are the term used for bacteria that colonize the digestive system and may improve the balance of gut flora. Cultured food products date back to historical times, and many cultures throughout the world still consume these foods as dietary staples. Recent research shows probiotics potential application to human health. An area of focus is immune function, as almost 80% of the immune system lies within the GI tract. Additionally, gut bacteria contribute to micronutrient synthesis (including vitamin B12, biotin and pantothenic acid). Mechanisms of Action The lining of the digestive tract undergoes constant, daily remodeling. Because the lymphatic system lies closely behind the intestinal endothelium, proper maintenance of the intestinal lining directly affects immune health. Probiotics help in the prevention of the attachment of pathogenic microorganisms and the entry of allergens1 and reinforces intestinal mucosa. In addition, they may possess antioxidant activity.1,2 Research Exclusively Utilizing Probio-Tec Quatro-Cap-4 A number of studies specifically using the ProbioTec Quatro-Cap-4 strain of bacteria have been published on various health conditions. 3, 4, 5 Digestive Health Probiotics may exert antimicrobial activity due to their ability to prevent pathogenic bacterial attachment to the gut mucosa, as well as secrete bacteriocins.1 Lactobacillus acidophilus and Bifidobacterium have been shown to promote immune phagocytic activity which may lead to the production of IgA in rotavirus-infected infants.1 A double-blind, placebo controlled study found a reduction in colonization of Clostridium difficile (pathogenic bacteria which causes diarrhea) in those supplemented with 3.5 billion CFUs of Probio-Tec

Quatro-Cap-4 twice daily compared to the control group.4 Immune Health Allergies result from an allergens entrance into the immune system. Theoretically, a well-maintained gut barrier via proper microfloral colonization may prevent intralumenal allergen entrance.1 Diarrhea resulting from food or water ingestion of pathogenic bacteria (often occurring in those traveling abroad) may be hampered by prophylactic consumption of certain probiotics.1 A double-blind, placebo controlled study showed the frequency of diarrhea was significantly reduced in healthy tourists consuming 3 billion CFU of Probio-Tec QuatroCap-4 daily, beginning two days before trip departure and throughout the trip.3 Physical and psychological assessments following surgery may also be optimized, according to a study using Probio-Tec Quatro-Cap-4 and oligofructose on patients undergoing colonic resection. The study found the supplemented group had reduced length of hospital stay and earlier tolerance to oral diet.5 Our Product Our Max Immune Probiotic Quattro provides a guaranteed 2 billion active cells per capsule, at the end of the best by date and does not require refrigeration. It contains four bacterial strains (Probio-Tec Quatro-Cap-4, a trademarked ingredient from Chr. Hansen). In addition, two of the four strains (Lactobacillus acidophilus and Bifidobacterium) constitute the majority of existing probiotic research. Dosage The dosage used in studies using Probio-Tec* Quatro-Cap-4 was at least 3 billion CFUs daily. Specifications
Product Name: Label Claim: How Supplied: Drop Count: Product Code: Max Immune Probiotic Quattro Supports Digestive Health #3 hard gelatin capsule 50, 100 ct VL717

References
1. 2. 3. 4. 5. 6. Physicians Desk Reference for Nutritional Supplements, 2001. Medical Economics Company, Inc. Montvale, NJ. Saide JA, et al. Antioxidative activity of lactobacilli measured by oxygen radical absorbance capacity. J Dairy Sci 2005 Apr;88(4):1352-7 Black FT, et al. Prophylactic efficacy of lactobacilli on travelers diarrhea. 1989 Travel Medicine; 333-335. Nord CE, et al. Oral supplementation with lactic acid bacteria during intake of clindamycin. 1997, Clinical Microbiology and Infection; 3(1):124-132. Anderson ADG, et al. Randomized clinical trial of multimodal optimization and standard perioperative surgical care. British Journal of Surgery, 2003;90:1497-1504. Perdigon G, et al. Interaction of lactic acid bacteria with the gut immune system. Eur J Clin Nutr 2002;Dec;56 Suppl4:S21-6 *Probio-Tec is a registered trademark of Chr. Hansen