TECHNICAL SUMMARY SHEET Max Prostate Support Softgels (VL154) Indications Max Prostate Support Softgels has the

following benefits:

reductions in skin, breast, prostate, digestive tract, cervix and bladder cancer risk. Research has shown that lycopene supplementation with 15 mg of the substance reduced the growth of prostate cancer in men newly diagnosed with the disease6. Additional research demonstrates that lycopene appears to interfere with IGF-I receptor signaling and cell cycle progression in mammary cancer cells7. Selenium A 2005 study in Neoplasma showed that low serum selenium concentrations were observed in both BPH and prostate cancer patients compared with healthy controls8. Our Product Our product contains 1200 mg Pumpkin Seed Oil, 300 mg Saw Palmetto, 150 mg Nettle, 100 mg Pygeum, 100 mg phytosterols (including betasitosterol), 100 mg green tea extract, 50 mg soy isoflavones, 30 mg Lycopene, and 30 IU vitamin E, 15 mg zinc, and 70 mcg selenium. Dosage Take one softgel twice daily. Specifications Product Name: Label Claim: How Supplied: Drop Count: Product Code: References
1. 2. 3. The Physicians Desk Reference for Herbal Medicines, 2004. Medical Economics Company, Inc. Montvale, NJ. Carbin, B.E., B. Larsson, O. Lindahl. 1990. Treatment of benign prostatic hyperplasia with phytosterols. Br J Urol 66(6):639641. Wadsworth TL, et al. Saw Palmetto Extract Suppresses Insulin-Like Growth Factor-I Signaling and Induces StressActivated Protein Kinase/c-Jun N-Terminal Kinase Phosphorylation in Human Prostate Epithelial Cells. 2004, Endocrinology Vol. 145, No. 7 3205-3214 Konrad L, et al. Antiproliferative effect on human prostate cancer cells by a stinging nettle root (Urtica dioica) extract. Planta Med. 2000 Feb;66(1):44-7. Santa Maria Margalef A, et al. Antimitogenic effect of Pygeum africanum extracts on human prostatic cancer cell lines and explants from benign prostatic hyperplasia. Arch Esp Urol. 2003 May;56(4):369-78. Omer K, et al. Phase II randomized Clinical Trial of Lycopene Supplementation before Radical Prostatectomy. Cancer Epidemiology, Biomarkers & Prevention, Vol.10,861-868, August 2001. Karas M. Lycopene interferes with cell cycle progression and insulin-like growth factor I signaling in mammary cancer cells. Nutr Cancer, 2000;36(1):101-111. Zachara BA, et al. Blood and tissue selenium concentrations and glutathione peroxidase activities in patients with prostate cancer and benign prostate hyperplasia. Neoplasma. 2005;52(3):248-54.

Promotes healthy circulation Provides antioxidant protection Promotes healthy prostate function

Prostate Health Background & Application As a normal part of aging, the prostate gland swells in size and may result in signs and symptoms of Benign Prostatic Hypertrophy (BPH). Certain nutrients influence the growth and blood flow to the prostate. Research Summaries Pumpkin Seed Oil Pumpkin seeds contain large amounts of long chain fatty acids and phytochemicals that have been shown to aid in prostate health. The German Commission E has approved Pumpkin Seed Oil for problems of Stage 1 or 2 levels of BPH. It also shows antiandrogenic and anti-inflammatory effects. Subjects in one study showed a decline in dihydrotestosterone levels in prostatic tissue when using pumpkin seed and saw palmetto1. Another study showed a reduction in symptoms in patients with BPH given pumpkin seed oil2. Saw Palmetto, Nettle & Pygeum Saw Palmetto has been extensively researched for its role in BPH and prostate cancer. A recent study published in Endocrinology showed Saw Palmetto inhibited IGF-1 signaling pathway thereby mediating antiproliferative effects on prostate cells3. Nettle, too, exhibits an antiproliferative effect in human prostate cancer development4. Pygeum has also shown this effect5 in both BPH and prostate cancer cells. Lycopene Lycopene may exert chemoprotective effects through hormone modulation, carcinogen metabolism, and immune system function. Research links it to

Max Prostate Support Softgels Supports Prostate Health Softgel capsule 60, 120 ct VL154

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