34

6. Ti liu tham kho

1. Arlen P A, Falconer R, Cherukumilli S, Cole A, Cole A M, Oishi K K,

Daniell H (2007) Field production and functional evaluation of chloroplastderived interferon-alpha2b. Plant Biotechnol. J., 5: 511525.
2. Arntzen C J (2008) Plant science. Using tobacco to treat cancer. Science,

321: 10521053.
3. Birch-Machin I, Newell C A, Hibberd J M, Gray J C (2004) Accumulation of

rotavirus VP6 protein in chloroplasts of transplastomic tobacco is limited by protein stability. Plant Biotechnol. J., 2004, 2: 261270. 4. Bock R (2007) Plastid biotechnology: prospect for herbicide and insect resistance, metabolic engineering and molecular farming. Curr Opin Biotechnol, 18:100106.
5. Daniell H (2002) Molecular strategies for gene containment in transgenic

crops. Nat. Biotechnol, 20: 581586.

6. Daniell H (2006) Production of biopharmaceuticals and vaccines in plants

via the chloroplast genome. Biotechnol J., 1:10711079.

7. Daniell H (2006) Production of biopharmaceuticals and vaccines in plants

via the chloroplast genome. Biotechnol. J., 1: 10711079.

8. Daniell H (2007) Transgene containment by maternal inheritance: effective

or elusive? Proc. Natl. Acad. Sci. U. S. A., 104: 68796880.

9. Daniell H, Carmona-Sanchez O, Burns B (2004) Chloroplast derived

antibodies, biopharmaceuticals and edible vaccines. Molecular Farming. Wiley-VCH Verlag, Weinheim: 113133.
10. Daniell H, Chebolu S, Kumar S, Singleton M, Falconer R (2005)

Chloroplast-derived vaccine antigens and other therapeutic proteins. Vaccine, 23: 17791783.
11. Daniell H, Kumar S, Dufourmantel N, (2005) Breakthrough in chloroplast

genetic engineering of agronomically important crops. Trends Biotechnol., 23: 238245.

12. Daniell H, Lee S B, Panchal T, Wiebe P O (2001) Expression of the native

Cholera toxin B subunit gene and assembly as functional oligomers in transgenic tobacco chloroplasts. J. Mol. Biol., 311(5): 1001-9.
13. Daniell H, Singh N D, Mason H, Streatfield S J (2009) Plant-made vaccine

antigens and biopharmaceuticals. Trends in Plant Science, Vol. 14(12): 669679.

14. Davoodi-Semiromi A, Samson N, Dainell H. (2009) The green vaccine: a

global strategy to combat infectious and autoimmune diseases. Hum. Vaccin., 5(7): 488493.

35

15. DeGray G, Rajasekaran K, Smith F, Sanford J, Daniell H (2001) Expression

of an antimicrobial peptide via the chloroplast genome to control phytopathogenic bacteria and fungi. Plant Physiol., 127: 852862.
16. Devine A (2005) Oral administration of chloroplast-derived cholera toxin B-

proinsulin fusion protein protects against development of insulitis in nonobese diabetic mice. M.S. Thesis, University of CentralFlorida, Orlando.
17. Ding S H, Huang L Y, Wang Y D, Sun H C, Xiang Z H (2006) High-level

expression of basic fibroblast growth factor in transgenic soybean seeds and characterization of its biological activity. Biotechnol. Lett., 28: 869875. Doherty T M, Olsen A W, van Pinxteren L, Andersen P (2002) Oral vaccination with subunit vaccines protects animals against aerosol infection with Mycobacterium tuberculosis. Infect. Immun., 70: 3111-3121. 18. Dufourmantel N, Pelissier B, Garcon F, Peltier G, Ferullo J M (2004) Generation of fertile transplastomic soybean. Plant Mol. Biol., 55: 479489.
19. Dufourmantel N, Tissot G, Goutorbe F, Garcon F, Muhr C (2005)

Generation and analysis of soybean plastid transformants expressing Bacillus thuringiensis Cry1Ab protoxin. Plant Mol. Biol., 58: 659668.
20. Eriksson K, Holmgren J (2002) Recent advances in mucosal vaccines and

adjuvants. Curr Opin Immunol, 14(5): 666-72.

21. Fernandez-San Millan A, Mingo-Castel A, Miller M, Daniell H (2003) A

chloroplast transgenic approach to hyper-express and purify human serum albumin, a protein highly susceptible to proteolytic degradation. Plant Biotechnol. J., 1: 7179.
22. Floss D M, Falkenburg D, Conrad U (2007) Production of vaccines and

therapeutic antibodies for veterinary applications in transgenic plants: an overview. Trans Res, 16: 315332.
23. Gaglani S (2006) Chloroplast genetic engineering a novel method to produce

therapeutic proteins. Harvard Science Review, fall 2006: 36 - 39. 24. Glenz K, Bouchon B, Stehle T, Wallich R, Simon MM, Warzecha H (2006) Production of a recombinant bacterial lipoprotein in higher plant chloroplasts. Nat. Biotechnol., 24: 7677.
25. Grevich J J, Daniell H (2005) Chloroplast genetic engineering: recent

advances and future perspectives. Crit. Rev. Plant Sci., 24: 83107.
26. Hefferon K L (2009) Biopharmaceuticals in Plants: Toward the Next

Century of Medicine. CRC Press: 59-69.

27. Heifetz P B (2000). Genetic engineering of the chloroplast. Biochimie, 82:

655666.
28. Hibberd J M, Linley P J, Khan M S, Gray J C (1998) Transient expression of

green fluorescent protein in various plastid types following microprojectile bombardment. Plant J, 16: 627632.

36

Iijima H, Takahashi I, Kiyono H (2001) Mucosal immune network in the gut for the control of infectious diseases. Reviews in Medical Virology Vol 11, issue 2: 117-133.
29. Kamarajugadda S (2006) Evaluation of immunogenicity and pathogen

challenge of chloroplast malarial vaccine antigens. M.S. Thesis, University of Central Florida. Orlando.
30. Kanamoto H, Yamashita A, Asao H, Okumura S, Takase H, Hattori M,

Yokota A, Tomizawa K (2006) Efficient and stable transformation of Lactuca sativa L. cv. Cisco (lettuce) plastids. Transgenic Res., 15:205217.
31. Kauffmann S H (2004) Nouvel vaccination strategies, Wiley-VCH Verlag

GmbH & Co KGaA Weinheim, 17-547.

32. Kim T G et al (2008) Expression of human growth hormone in transgenic

rice cell suspension culture. Plant Cell Rep. ,27: 885891

33. Knoblauch M et al. (1999) A galinstan expansion femotosyringe for

microinjection of eukaryotic organelles and prokaryotes. Nat. Biotechnol., 17: 906909.

34. Koya V, Moayeri M, Leppla S H, Daniell H (2005) Plant based vaccine:

mice immunized with chloroplast-derived anthrax protective antigen survive anthrax lethal toxin challenge. Infect. Immun., 73: 82668274.
35. Kumar A, Sopory S K (2008) Recent advances in plant biotechnology and its

applications. I.K. Internaional Publishing House.

36. Kumar S, Dhingra A, Daniell H (2004b) Stable transformation of the cotton

plastid genome and maternal inheritance of transgenes. Plant Mol. Biol., 56: 203216.
37. Kumar S, Dhingra A, Daniell H, (2004) Plastid-expressed betaine aldehyde

dehydrogenase gene in carrot cultured cells, roots, and leaves confers enhanced salt tolerance. Plant Physiol., 136: 28432854.
38. Langbecker C L, Ye G N, Broyles D L, Duggan L L, Xu C W, Hajdukiewicz

P T J, Armstrong C L, Staub J M (2004) High-frequency transformation of undeveloped plastids in tobacco suspension cells. Plant Physiology, Vol. 135: 3946.
39. Lee S M, Kang K, Chung H, Yoo S H, Xu X M, Lee S B, Cheong J J,

Daniell H, Kim M (2006) Plastid transformation in the monocotyledonous cereal crop, rice (Oryza sativa) and transmission of transgenes to their progeny. Mol. Cells, Vol. 21, No. 3: 401-410. Lee A, Chen M (1994) Successful immunization against gastric infection with Helicobacter species: use of a cholera toxin B-subunit-whole-cell vaccine. Infect Immun.,62(8): 35943597.
40. Lentz E M, Segretin M E, Morgenfeld M M, Wirth S A, Santos M G D,

Mozgovoj M V, Wigdorovitz A, Bravo-Almonacid F F (2010) High expression level of a foot and mouth disease virus epitope in tobacco transplastomic plants. Planta, 231:387395.

37

41. Limaye A, Koya V, Samsam M, Daniell H (2006) Receptor-mediated oral

delivery of a bioencapsulated green fluorescent protein expressed in transgenic chloroplasts into the mouse circulatory system. FASEB J., 20: 959961.
42. Maliga

P (2003). Progress towards commercialization transformation technology. Trends Biotechnol., 21(1): 2028. Biol, 55: 289313.

of

plastid

43. Maliga, P (2004) Plastid transformation in higher plants. Annu. Rev. Plant 44. Mason H S, Lam D M, Arntzen C J (1992) Expression of hepatitis B surface

antigen in transgenic plants. Proc. Natl. Acad. Sci. U. S. A., 89: 11745 11749.
45. Mayfield S P, Franklin S E, Lerner R A (2003) Expression and assembly of

a fully active antibody in algae. Proc. Natl. Acad. Sci. USA, 100: 438442.
46. McBride K E, Svab Z, Schaaf D J, Hogen P S (1995) Amplification of a

chimeric Bacillus gene in chloroplasts leads to extraordinary level of an insecticidal protein in tobacco. Biotechnology, 13: 362365.
47. Mett V, Lyons J, Musiychuk K, Chichester J A, Brasil T, Couch R,

Sherwood R, Palmer G A, Streatfield S J, Yusibov V (2007) A plantproduced plague vaccine candidate confers protection to monkeys. Vaccine, 25: 30143017
48. Molina A, Hervas-Stubbs S, Daniell H, Mingo-Castel A M, Veramendi J

(2004) High-yield expression of a viral peptide animal vaccine in transgenic tobacco chloroplasts. Plant Biotechnol. J., 2: 141153.
49. Moravec T, Schmidt M A, Herman E M, Woodford-Thomas T (2007)

Production of Escherichia coli heat labile toxin (LT) B subunit in soybean seed and analysis of its immunogenicity as an oral vaccine. Vaccine, 25: 16471657.
50. Morens D M, Folkers G K,Fauci A S (2004) The challenge of emerging and

re-emerging infectious diseases. Nature, 430: 242249.

51. Oey M, Lohse M, Scharff L B, Kreikemeyer B, Bock R (2009) Plastid

production of protein antibiotics against pneumonia via a new strategy for high-level expression of antimicrobial proteins. Proc. Natl. Acad. Sci. U. S. A., 106: 65796584.
52. Qian B, Shen H, Liang W, Guo X, Zhang C, Wang Y, Li G (2008)

Immunogenicity of recombinant hepatitis B virus surface antigen fused with preS1 epitopes expressed in rice seeds. Transgenic Res., 17: 621631. 53. Ralph Bock (2007) Plastid biotechnology: prospects for herbicide and insect resistance, metabolic engineering and molecular farming. Current Opinion in Biotechnology, 18:100106.
54. Ruhlman T, Ahangari R, Devine A, Samsam M, Daniell H (2007)

Expression of cholera toxin B-proinsulin fusion protein in lettuce and tobacco chloroplasts oral administration protects against development of insulitis in non-obese diabetic mice.

38

55. Plant Biotechnol. J., 5: 495510. Ryan E T, Butterton J R, Zhang T, Baker M A, Stanley S L Jr, and Calderwood S B (1997) Oral immunization with attenuated vaccine strains of Vibrio cholerae expressing a dodecapeptide repeat of the serine-rich Entamoeba histolytica protein fused to the cholera toxin B subunit induces systemic and mucosal antiamebic and anti-V. cholerae antibody responses in mice. Infect Immun., 65(8): 31183125.
56. Rybicki EP (2009) Plant-produced vaccines: promise and reality. Drug Disc

Today, 14:1624.
57. Sanford J, Smith F, Russel J (1993) Optimizing the biolistic process for

different biological applications. Methods in Enzymology, 217: 483-509.

58. Sardana, R. et al. (2007) Biologically active human GM-CSF produced in the

seeds of transgenic rice plants. Transgenic Res., 16: 713721

59. Seki M, Shigemoto N, Sugita M, Sugiura M, Koop H-U, Irifune K,

Morikawa H (1995) Transient expression of b-glucuronidase in plastids of various plant cells and tissues delivered by a pneumatic particle gun. J Plant Res., 108: 235240.
60. Shaaltiel Y, Bartfeld D, Hashmueli S, Baum G

(2007) Production of glucocerebrosidase with terminal mannose glycans for enzyme replacement therapy of Gauchers disease using a plant cell system. Plant Biotechnol. J., 5: 579590. challenge infection with the A/Indonesia/05/05 strain of avian influenza. Vaccine, 27: 10871092

61. Shoji, Y. et al. (2009) Plant-derived hemagglutinin protects ferretsagainst

62. Singh N D, Ding Y , Daniell H (2009) Chloroplast-Derived Vaccine Antigensand Biopharmaceuticals: Protocols for Expression, Purification, or Oral Delivery and Functional Evaluation. Methods in Molecular Biology, Recombinant Proteins From Plants. Humana Press, vol. 483.
63. Singleton M L (2003) Expression of CaF1 and LcrV as a fusion protein for

development of a vaccine against Yersinia pestis via chloroplast genetic engineering. M.S. Thesis, University of Central Florida, Orlando.
64. Sporlein B, Streubel M, Dahlfeld G, Westhoff P, Koop H-U (1991) PEG

mediated plastid transformation: a new system for transient gene expression assays in chloroplasts. Theor Appl Genet, 82: 717722.
65. Staub J M, Garcia B, Graves J, Hajdukiewicz P T

(2000) Highyield production of a human therapeutic protein in tobacco chloroplasts. Nat. Biotechnol., 18: 333338. vaccines in microalgae. Biologicals, 37: 133138.

66. Surzycki R, Greenham K, Kitayama K (2009) Factors effecting expression of 67. Tregoning J S, Nixon P, Kuroda H, Svab Z (2003) Expression of tetanus

toxin fragment C in tobacco chloroplasts. Nucleic Acids Res., 31: 1174 1179.

39

68. Tremblay R, Wang D, Jevnikar A M, Ma S (2010) Tobacco, a highly efficient green bioreactor for production of therapeutic proteins. Biotechnology Advances, 28: 214221. 69. Verma D, Daniell H (2007) Chloroplast vector systems for biotechnology applications. Plant Physiol., 145: 11291143.
70. Voinnet O, Rivas S, Mestre P, Baulcombe DC (2003) An enhanced transient

expression system in plants based on suppression of gene silencing by the p19 protein of tomato bushy stunt virus. Plant J., 33: 949956.
71. Watson J, Koya V, Leppla S H, Daniell H (2004) Expression of Bacillus

anthracis protective antigen in transgenic chloroplasts of tobacco, a nonfood/feed crop. Vaccine, 22: 43744384.
72. Xu K, Evans D, Carrin G, Aguilar-Rivera AM, Musgrove P, Evans T (2007)

Protecting households from catastrophic health spending. Health Aff., 26: 972983.
73. Yoshimoto K, Sakaiya M, Isono K, Kobayashi H (2001) Comparison of

strength of endogenous and exogenous gene promoters in Arabidopsis chloroplasts. Plant Biotechnology, 18: 135142. 74. Yusibov V, Rabindran S (2008) Recent progress in the development of plant derived vaccines. Expert Rev. Vaccines, 7:11731183.
75. Zhang G G, Rodrigues L, Rovinski B, White K A (2002) Production of HIV-

1 p24 protein in transgenic tobacco plants. Molecular Biotechnology, Vol. 20: 131 - 136. 76. Zhou F, Badillo-Corona J A, Karcher D, Gonzalez-Rabade N, Piepenburg K, Borchers A M I, Maloney A P, Kavanagh T A, Gray J C, Bock R (2008) High-level expression of human immunodeficiency virus antigens from the tobacco and tomato plastid genomes. Plant Biotechnology Journal, 6: 897 913. 77. Chlorogen Inc., URL: <http://www.chlorogen.com>