Received 1 December 2002; received in revised form 15 March 2003; accepted 18 June 2003
Abstract
Beginning in January 2001, it became legal for pharmacies, health care facilities and certain health care providers in New York State
(NYS) to sell or provide syringes (10 maximum) without prescription. Cross-sectional survey data from three research projects recruiting
active injection drug users (IDUs) in Harlem and the South Bronx (n = 682) were analysed by calendar quarter, from January 2001 through
September 2002, to assist in an evaluation of the impact of the program, the Expanded Syringe Access Demonstration Program (ESAP). The
outcome variable examined was having used a pharmacy as the source of the last injection syringe. The percent of IDUs who knew that it
was legal to buy a syringe from a pharmacy increased over time (25–54%, P < 0.001). Pharmacy as the source of the last injection syringe
increased to approximately 20%, and syringe exchange programmes (SEPs) remained the most common source (approximately 50%). In a
multiple logistic regression analysis, IDUs who knew it was legal were more likely to have purchased their last syringe from a pharmacy
(AOR = 4.65, CI = 2.58–8.36). Pharmacies were more likely to be used by those who were younger (AOR = 0.96, CI = 0.93–0.99)
and those who were White (AOR = 2.55, CI = 1.30–5.00), and calendar quarter was a significant independent predictor of pharmacy use
(AOR = 1.22, CI = 1.06–1.40). Overall, these data indicate that: (a) knowledge about the option of purchasing syringes from a pharmacy
has increased, but enhanced dissemination efforts to IDUs, especially particular sub-groups, are needed; and (b) pharmacies were becoming
a supplemental source of syringes for active IDUs (in communities served by SEPs).
© 2003 Elsevier B.V. All rights reserved.
Keywords: Injection drug use; Pharmacy; Syringe access; AIDS; HIV; Substance use
∗ Corresponding author. Tel.: +1-212-845-4463; fax: +1-917-438-0894. 3 Tel.: +1-212-419-3541; fax: +1-212-876-6220.
E-mail addresses: deren@ndri.org (S. Deren), cfuller@nyam.org 4 Tel.: +1-504-988-4535; fax: +1-504-584-3540.
(C. Fuller), pouget@ndri.org (E.R. Pouget), sblaney@nyam.org 5 Tel.: +1-212-845-4457; fax: +1-917-438-0894.
(S. Blaney), stortu@mailhost.tcs.tulane.edu (S. Tortu), kang@ndri.org 6 Tel.: +1-212-845-4553; fax: +1-917-438-0894.
0955-3959/$ – see front matter © 2003 Elsevier B.V. All rights reserved.
doi:10.1016/S0955-3959(03)00137-3
374 S. Deren et al. / International Journal of Drug Policy 14 (2003) 373–379
must not have participated in HIV/AIDS-related study or other two samples. The total sample is approximately 68%
attended HIV counselling and testing session in prior year. Latino, 20% Black and 9% White. Approximately, one-half
Male partners of eligible women must be 18 years of age of all participants were at least 40 years of age, and the av-
or older to participate. erage number of years injecting was 17. In all three studies,
The Centre for Urban Epidemiologic Studies at the New the mean number of days since last injection was less than
York Academy of Medicine provided baseline data from the seven.
Hepatitis C Cohort Study (Hep C) and data from their Urban The percent of IDUs who knew that it was legal to buy a
Research Centre (URC) Cross-sectional Survey (D. Vlahov, syringe from a pharmacy increased over time from 25% (in
PI). The cohort study targeted young (15–35 years of age) the first quarter of 2001) to 54% by the last period exam-
injection drug users who reported injection three or fewer ined, and this increase was significant (C–A = −4.72, P <
years, and the cross-sectional study targeted drug users in- 0.001) (see Table 2). This increase primarily occurred be-
jecting more than 3 years. Both studies street-recruited IDUs tween the first two periods (when approximately 25% knew
from East/Central Harlem and the South Bronx. Each study it was legal) and the last five periods (when this knowledge
captured high-risk injection and sexual risk behaviours, and was reported by about 50% of all participants). Knowledge
data from these two data sources, Hep C and URC, were that it was legal to get a needle from a clinic showed a signif-
combined for this analysis (Fuller et al., 2002). icant increase over time (C–A = −2.17, P < 0.05). Knowl-
edge that it was legal to obtain syringes from a hospital or
Analysis private doctor did not significantly change over time. Par-
ticipants were also asked if it was legal to carry a syringe,
Data from these three studies were combined (n = 682) and approximately 35–50% reported that it was legal during
and analysed by calendar quarter (based on the date of the each time period. The use of a pharmacy as the source of
last injection), from January 2001 through September 2002. the last syringe used remained relatively stable for the first
The quarters were defined as follows: (1) 1 January through five quarters, reported by 3–11% of IDUs, and increased to
9 April 2001 (this quarter is extended through 9 April be- 20–22% during the final two periods (C–A = −4.39, P <
cause NYSDOH began distributing information regarding 0.001) (Table 3). SEPs remained the most frequent sources
registered pharmacies on 10 April, the date that implemen- of the last syringe used during all quarters (approximately
tation was considered to be in effect for the purposes of 50%), but showed a significant decline over the study time
this evaluation); (2) 10 April through 30 June 2001; (3) 1 periods (C–A = 2.86, P < 0.01). The use of health care
July through 30 September 2001; (4) 1 October through facilities as a source of the last syringe used was not re-
31 December 2001; (5) 1 January through 31 March 2002; ported until 2002. Although relatively few participants re-
(6) 1 April through 30 June 2002; and (7) 1 July through ported this source, it resulted in a significant increase over
30 September 2002. Grouping the results by calendar quar- time (C–A = −2.84, P < 0.01). Friend/family was the sec-
ter produced roughly equal cells and facilitated analyses of ond most frequently cited source, with over 20% identifying
trends. it as a source through five of the seven quarters; it dropped
Cochran–Armitage (C–A) tests for trend (Armitage, 1955; below 20% during the fifth and sixth quarters, however, no
Cochran, 1954), using calendar quarter as an ordinal vari- statistically significant change over time was found.
able (i.e. 1–7), were used to assess the significance of An examination of socio-demographic characteristics re-
changes over time in knowledge of the law and syringe lated to pharmacy use indicated that both male and female
sources. Chi-square tests were conducted to assess the rela- IDUs were equally likely to report obtaining their last sy-
tionships between selected socio-demographic characteris- ringe from a pharmacy (Table 4). Pharmacy users were
tics and pharmacy use. Variables significant at P < 0.05 in younger (16% of those aged under 30 reported pharmacy
bivariate analyses were entered into a multiple logistic re- use, compared to 12 and 8% of those 30–39 and over 39,
gression model. In the multivariate model, age was entered respectively (χ2 = 6.6, d.f. = 2, P < 0.05). There was also
as a continuous variable and calendar quarter was coded as a significant difference by race/ethnicity (χ2 = 25.4, d.f. =
an ordinal variable. 3, P < 0.01), with Whites more likely to report pharmacy
use for the syringe used at the last injection (30%) than all
other race/ethnic groups. Those who knew it was legal to
Results purchase syringes from pharmacies were more likely to have
purchased their last syringe from a pharmacy (20% versus
The socio-demographic characteristics of participants 5%, χ2 = 39.6, d.f. = 1, P < 0.001).
from each of the three projects are consistent with the The three variables significant in the bivariate analyses
particular aims of the individual projects (Table 1). Thus, (age, race/ethnicity, knowledge of the pharmacy legality),
while males constitute approximately three quarters of the and the variable representing number of calendar quarters
participants in ARIBBA and URC, they are approximately since inception of ESAP, were entered into a multiple lo-
one-half of the CAR sample. The ARIBBA sample is 100% gistic regression to assess their independent contribution to
Latino, and Latinos represent the largest category in the predicting pharmacy use (Table 5). Knowledge of the legal-
376 S. Deren et al. / International Journal of Drug Policy 14 (2003) 373–379
Table 1
Socio-demographic characteristics and drug use behaviours among Harlem and Bronx IDUs, by project, 1 January 2001–30 September 2002 (n = 682)
ARIBBA (n = 110) CAR (n = 173) URC/Hep C (n = 399) Total (n = 682)
Table 2
Knowledge of the law by quarter among Harlem and Bronx IDUs, 1 January 2001–30 September 2002 (n = 675)
Percent who 1 January 2001–9 10 April 2001–30 1 July 2001–30 1 October 1 January 1 April 2002–30 1 July 2002–30
knew that it April 2001 June 2001 September 2001 2001–31 2002–31 March June 2002 September 2002
was legal to: (n = 68) (n = 136) (n = 106) December 2001 2002 (n = 110) (n = 81)
(n = 79) (n = 95)
Buy a needle from 25.0 27.9 45.3 46.8 46.3 48.2 54.3
a pharmacy∗∗∗
Get a needle from 19.1 8.8 14.2 12.7 8.4 15.6 17.5
a hospital
Get a needle from 10.3 10.3 15.1 13.9 12.6 16.4 21.3
a clinic∗
Get a needle from 8.8 9.6 13.2 10.1 7.4 14.5 11.3
a private doctor
Carry a needle 47.1 43.4 51.9 34.2 42.1 35.5 41.3
Note. For all items except “Buy a needle from a pharmacy”, one response was missing in the final (seventh) quarter.
∗ P < 0.05.
∗∗∗ P < 0.001.
Table 3
Source of syringe used for the last injection by quarter among Harlem and Bronx IDUs, 1 January 2001–30 September 2002 (n = 682) (percentage)
Source 1 January 2001–9 10 April 2001–30 1 July 2001–30 1 October 1 January 1 April 2002–30 1 July 2002–30
April 2001 June 2001 September 2001 2001–31 2002–31 March June 2002 September 2002
(n = 70) (n = 139) (n = 107) December 2001 2002 (n = 95) (n = 110) (n = 81)
(n = 80)
SEP∗∗ 54.3 66.2 56.1 43.8 57.9 48.2 43.2
Friend or family 27.1 20.9 24.3 30.0 17.9 13.6 24.7
member
Pharmacy∗∗∗ 10.0 2.9 7.5 11.3 6.3 21.8 19.8
Drug/needle 8.6 10.1 12.1 15.0 15.8 11.8 11.1
dealer
Health care 0.0 0.0 0.0 0.0 2.1 4.5 1.2
facilitya ,∗∗
aNo subjects indicated a private doctor as the source for their last syringe used.
∗∗ P < 0.01.
∗∗∗ P < 0.001.
S. Deren et al. / International Journal of Drug Policy 14 (2003) 373–379 377
Table 4 Discussion
Bivariate associations with pharmacy source for last syringe used among
Harlem and Bronx IDUs, 1 January 2001–30 September 2002 (n = 682)
Within the first 2 years of ESAP implementation, it ap-
Pharmacy source for last pears that knowledge about the legality of purchasing sy-
syringe used (%) ringes from pharmacies has increased, however, only half of
Gender the IDUs enrolled in the most recent period were aware of
Male 11.0
legal non-prescription pharmacy syringe sales. In addition,
Female 9.7
knowledge about availability of syringes from other new
Age∗ (categories) legal sources, health care facilities and private physicians,
Under 30 16.2
30–39 11.8
was not widespread. Further dissemination of information
40 and older 7.9 regarding the needle deregulation is needed. Initial efforts to
implement ESAP by the NYSDOH focused on registering
Age∗∗ (continuous)
Pharmacy mean (S.D.) 35.4 (8.4) pharmacies, and more recent efforts have begun to address
Non-pharmacy mean (S.D.) 38.6 (8.5) the expansion of ESAP providers. Continued monitoring of
Race/ethnicity∗∗∗
knowledge of these sources is needed as these expansion
Black 7.3 efforts are developed.
Latino 9.2 Although NYS Public Health Law states that persons
White 29.5 legally possessing syringes (e.g. through SEPs or ESAP) are
Other 13.0 not subject to arrest or prosecution, the fact that syringe pos-
Knowledge of pharmacy legality∗∗∗ session remains a criminal offence in the New York Penal
Knew it was legal 19.9 Law (220.45) (Penal Law of the State of New York, 2001),
Did not know 4.6
may still influence participation levels. The data showed that
Note. Data were missing for 7 subjects for gender, 3 subjects for age approximately one-third to one-half of the IDUs participat-
and ethnicity, and 7 subjects for knowledge of pharmacy legality. Also, ing thought that carrying a needle was either illegal or they
3 subjects indicated transgender or other gender and are not included in
were unsure about its legal status, and this remained rela-
analyses of gender.
∗ P < 0.05. tively constant over the study periods. The perceived crimi-
∗∗ P < 0.01. nality or uncertainty regarding criminality is likely to reduce
∗∗∗ P < 0.001.
the level of participation in ESAP as well as other efforts
to increase availability of sterile syringes. Furthermore, al-
though persons can legally possess syringes under certain
ity of pharmacy sales was the best predictor of having pur-
circumstances, implementation has often been inconsistent.
chased the last syringe from a pharmacy, with odds of pur-
Only recently (Weiser, 2002) being arrested for drug pos-
chasing their last syringe from a pharmacy almost five times
session as a result of drug residue left in a syringe was al-
greater for those who knew it was legal (AOR = 4.65, 95%
lowed until a judge ruled that this was not the “intention” of
CI = 2.58–8.36). Race/ethnic group and age remained sig-
increased access syringe laws (e.g. SEPs or ESAP). Knowl-
nificant predictors of pharmacy use: Whites were more likely
edge of this new ruling, however, may not be widespread
to report pharmacy use than the other race/ethnic groups
among IDUs and fear of arrest likely remains.
(AOR = 2.55, 95% CI = 1.30–5.00), and those who were
The finding that men and women were equally likely to
younger were more likely to have reported pharmacy use
report obtaining their last syringe from a pharmacy is en-
(AOR = 0.96, 95% CI = 0.93–0.99). Calendar quarter re-
couraging. Research on SEPs has indicated that women are
mained a significant independent predictor of pharmacy use
under-represented in terms of SEP use (Lurie, 1993), and
(AOR = 1.22, CI = 1.06–1.40).
thus pharmacies may provide an important alternative for
new syringes for women who prefer not to use SEPs.
Table 5 There are some limitations to these data. The question
Multivariate logistic regression predicting pharmacy use among Harlem was based on the last syringe used, therefore the distribution
and Bronx IDUs (n = 672) of sources of syringes for those using multiple sources was
Independent variable Adjusted odds 95% CI not available. The data were collected after a period of de-
ratio clining HIV incidence and prevalence among IDUs in New
Age∗ 0.96 0.93–0.99 York (Des Jarlais et al., 2000; Maslow, Friedman, Perlis,
White∗∗ 2.55 1.30–5.00 Rockwell, & Des Jarlais, 2002), and thus may not apply to
Black, Latino, other = 0 communities in which seroprevalence has stabilised or is in-
White = 1
creasing. In addition, these three projects may not represent
Knowledge of pharmacy legality∗∗∗ 4.65 2.58–8.36
Calendar quarter∗ 1.22 1.06–1.40 all IDUs in the communities studied, nor all IDUs in NYS.
∗
In fact, the wide availability of SEPs serving the commu-
P < 0.05.
∗∗ nities in which these participants were recruited is atypical
P < 0.01.
∗∗∗ P < 0.001. for most communities.
378 S. Deren et al. / International Journal of Drug Policy 14 (2003) 373–379
Nonetheless, some important implications regarding be likely to begin using pharmacies or those who tradition-
ESAP implementation emerge from these data. Although ally use SEP are likely to access syringes through pharma-
knowledge about the ESAP pharmacy syringe sales was cies as well.
increasing, additional efforts to disseminate information As pharmacy use increases, it may also be possible to
about the various aspects of ESAP are needed. Enhanced enhance services provided through pharmacies. For exam-
dissemination efforts to IDUs, either in locations where they ple, recent research indicates that while needle reuse has
are likely to be found (e.g. SEPs, drug treatment programs) declined, the sharing of injection-related paraphernalia (in-
or through service providers who have been able to contact cluding cookers and cottons) remains high (Deren et al.,
them in the past (e.g. HIV prevention outreach workers) 2003). The very positive response of the majority of phar-
are needed. This appears to be particularly important for macies in NYS to ESAP indicates that the possibility of
the groups that have thus far under-utilised the availability expanding pharmacy service provision to IDUs, including
of needles from pharmacies, including minority IDUs and provision of harm reduction-related equipment and other
older IDUs. To some extent, there may be a self-selection health-related services, should be assessed.
process operating in terms of utilisation of pharmacy-
based programs: different syringe availability programs
(e.g. SEPs, pharmacy) may appeal to consumers with dif- Acknowledgements
ferent demographic characteristics (Obadia, Feroni, Perrin,
Vlahov, & Moatti, 1999). Furthermore, a qualitative study This study was supported by NIDA grant numbers
of pharmacist practices during the first year of ESAP noted R01DA10424 (S. Deren, PI), P30DA11041 (S. Deren, PI),
that pharmacists were equally likely to sell syringes to a R01DA12805 (S. Tortu, PI), R01DA14219 (D. Vlahov,
diverse group of purchasers (Finkelstein, Tiger, Greenwald, PI), and CDC grant number U48/CCU209663 (D. Vla-
& Mukherjee, 2002), implying that differential utilisation of hov, PI). The authors also acknowledge the assistance and
pharmacies may be based on choices of the potential con- co-operation of Susan J. Klein of the NYS Department of
sumers rather than the pharmacists. Given the slow start of Health, AIDS Institute.
the implementation and utilisation of the changes brought
about by the ESAP regulations (e.g. only about one-half of
IDUs are aware that needles can be legally purchased from
pharmacies more than 1 year after ESAP implementation), References
the need to continue monitoring and evaluating the program,
with a particular emphasis on understanding the reasons for Armitage, P. (1955). Tests for linear trends in proportions and frequencies.
under-utilisation among particular subgroups, is warranted. Biometrics, 11, 375–386.
The data also indicate that pharmacies were likely to be- Case, P., Beckett, G. A., & Jones, T. S. (1998). Access to sterile syringes
in Maine: Pharmacy practice after the 1993 repeal of the syringe
come a supplemental syringe source for active IDUs in com- prescription law. Journal of Acquired Immune Deficiency Syndromes
munities with SEPs, such as those in which the participat- and Human Retrovirology, 18(Suppl. 1), S94–S101.
ing studies were conducted. Syringes were typically sold Cochran, W. G. (1954). Some methods for strengthening the common χ2
in pharmacies as 10-packs for US$ 2–8, or for US$ 0.50 tests. Biometrics, 10, 417–451.
each when sold singly (Finkelstein et al., 2002; Fuller et al., Cotton-Oldenburg, N. U., Carr, P., DeBoer, J. M., Collison, E. K., &
Novotny, G. (2001). Impact of pharmacy-based syringe access on
2002). The availability of free needles at SEPs, often with injection practices among injecting drug users in Minnesota, 1998
the addition of other harm reduction supplies and health- to 1999. Journal of Acquired Immune Deficiency Syndromes, 27(2),
related services (e.g. free condoms and referrals to health 183–192.
and human services), is likely to result in the continuation Deren, S., Oliver-Velez, D., Finlinson, A., Robles, R., Andia, J., & Colon,
of SEPs as the main source of syringes. Nonetheless, even H. M. et al. (2003). Integrating qualitative and quantitative methods:
Comparing HIV-related risk behaviours among Puerto Rican drug
in those communities well-served by SEPs, pharmacies may
users in Puerto Rico and New York. Substance Use and Misuse, 38(2),
play an important role in providing syringes for those IDUs 1–24.
who: (a) may prefer to use SEPs but need to obtain syringes Des Jarlais, D. C., Marmor, M., Friedmann, P., Titus, S., Aviles, E., &
during hours when the SEPs are not operating or (b) choose Deren, S. et al. (2000). HIV incidence among injection drug users
not to use SEPs, and are willing to pay for syringes for rea- in New York City, 1992–1997: Evidence for a declining epidemic.
American Journal of Public Health, 90(3), 352–359.
sons of convenience or privacy.
Des Jarlais, D. C., McKnight, C., & Friedmann, P. (2002). Legal syringe
Studies of the range of needle sources used by IDUs are purchases by injection drug users in Brooklyn and Queens, 2000–2001.
needed. Although the data indicate that an increase in phar- Journal of the American Pharmaceutical Association, 42, S73–S76.
macy use may be associated with a decline in SEP use, Finkelstein, R., Tiger, R., Greenwald, R., & Mukherjee, R. (2002). Phar-
an examination of IDUs’ sources of syringes over a longer macy syringe sales practices during the first year of expanded syringe
availability in New York City 2000–2001. Journal of the American
time period (not simply the last injection episode) can reveal
Pharmaceutical Association, 42, S83–S87.
changes in the frequency of use among the various sources. Fuller, C. M., Ahern, J., Vadnai, L., Coffin, P. O., Galea, S., & Factor,
Longitudinal research is needed to determine whether those S. H. et al. (2002). Impact of increased syringe access: Preliminary
who would normally get syringes from unsafe sources would findings of injection drug user syringe source, disposal, and pharmacy
S. Deren et al. / International Journal of Drug Policy 14 (2003) 373–379 379
sales in Harlem, New York. Journal of the American Pharmaceutical New York State Department of Health, AIDS Institute. (2002). ESAP
Association, 42, S77–S82. implementation provider registration update, September 2002. Albany,
Gostin, L. O., Lazzarini, Z., Jones, T. S., & Flaherty, K. (1997). Prevention NY: AIDS Institute.
of HIV/AIDS and other blood-borne diseases among injection drug Obadia, Y., Feroni, I., Perrin, V., Vlahov, D., & Moatti, J. P. (1999).
users. A national survey on the regulation of syringes and needles. Syringe vending machine for injection drug users: An experiment in
Journal of the American Medical Association, 277(1), 53–62. Marseille, France. American Journal of Public Health, 89(12), 1852–
Groseclose, S. L., Weinstein, B., Jones, T. S., Valleroy, L. A., Fehrs, 1854.
L. J., & Kassler, W. J. (1995). Impact of increased legal access Penal Law of the State of New York. (2001). Criminally possessing a
to needles and syringes on practices of injecting drug users and hypodermic needle 220.45. Binghamton, NY: Gould Publications.
police officers—Connecticut, 1992–1993. Journal of Acquired Immune Singer, M., Baer, H. A., Scott, G., Horowitz, S., & Weinstein, B.
Deficiency Syndromes and Human Retrovirology, 10(1), 82–89. (1998). Pharmacy access to syringes among injecting drug users:
Klein, S. J., Harris-Valente, K., Candelas, A. R., Radigan, M., Follow-up findings from Hartford, Connecticut. Public Health Reports,
Narcisse-Pean, M., & Tesoriero, J. M. et al. (2001). What do phar- 113(Suppl. 1), 81–89.
macists think about New York State’s new non-prescription syringe Tortu, S., McMahon, J., Hamid, R., & Pouget, E. R. (2002). Relationship
sale program? Results of a survey. Journal of Urban Health, 78(4), dynamics and disease risk among drug-using women and their primary
679–689. male sex partners in New York City. In Proceedings of the XIV
Lurie, P. (1993). The public-health impact of needle-exchange programs International Conference on AIDS, Barcelona, Spain.
in the United States and abroad: Summary, conclusions, and recom- Valleroy, L. A., Weinstein, B., Jones, T. S., Groseclose, S. L., Rolfs,
mendations. San Francisco, CA: Institute for Health Policy Studies, R. T., & Kassler, W. J. (1995). Impact of increased legal access to
University of California. needles and syringes on community pharmacies’ needle and syringe
Maslow, C. B., Friedman, S. R., Perlis, T. E., Rockwell, R., & Des Jarlais, sales—Connecticut, 1992–1993. Journal of Acquired Immune Defi-
D. C. (2002). Changes in HIV seroprevalence and related behaviours ciency Syndromes and Human Retrovirology, 10(1), 73–81.
among male injection drug users who do and do not have sex with Weiser, B. (2002, 21 November). Judge backs drug users in needle-
men: New York City, 1990–1999. American Journal of Public Health, exchange plans. The New York Times, B4.
92(3), 382–384. Wright-De Aguero, L., Weinstein, B., Jones, T. S., & Miles, J. (1998).
New York State Department of Health. (2001). Part 80—Rules and reg- Impact of the change in Connecticut syringe prescription laws on
ulations on controlled substances [Statutory authority: Public health pharmacy sales and pharmacy managers’ practice. Journal of Ac-
law article 33, Section 3381 (6)(e)]. Retrieved November 8, 2002 from quired Immune Deficiency Syndromes and Human Retrovirology, 18
http://www.health.state.ny.us/nysdoh/hivaids/esap/fullregs.htm. (Suppl. 1), S102–S110.