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Franklin Len Prof. Wilson Chicaiza, MD MED705-1 9 de octubre de 2011.

The potential role of RTN3 in monocyte recruitment and atherosclerosis.

The recruitment of monocytes to arterial wall and their transformation into macrophages are generally accepted as important early events in the pathogenesis of atherosclerosis (AS)1. Our research group found Reticulon3 (RTN3), a member of the reticulon family2, may be a candidate pathogenic element in the progress of AS3. But it is virtually unknown in which process RTN3 may participate in and regulate the pathogenesis of AS4. Here, we hypothesis that RTN3 may participate in the continuous process of circulating monocyte recruitment in AS5, including: (1) monocyte spreading and adhesion to luminal endothelium6; (2) transendothelial migration and may also contribute to the conversion of monocyte to macrophage in subendothelium7. Cardiovascular (CV) events are among the leading causes of morbidity and mortality in patients with inflammatory rheumatic diseases8. It has been hypothesized that, in addition to the traditional CV risk factors, inflammation is a major contributor to atherogenesis9. The metabolic effects of obesity have made this highly prevalent disease one of the most common risk factors for diabetes, hypertension, and atherosclerosis, the leading causes of end-stage renal failure10.

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BIBLIOGRAPHY 1. Chen Y, Xiang R, Zhao S. The potential role of RTN3 in monocyte recruitment and atherosclerosis. Molecular and cellular biochemistry. 2011. Available at: http://www.ncbi.nlm.nih.gov/pubmed/21964562 [Accessed October 4, 2011]. 2. Rojas,Juan I., Zurru,Mara Cristina, Patrucco,Liliana, et al. Registro de enfermedad cerebrovascular isqumica. Medicina (Buenos Aires). 66(6):547-551. Available at: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S002576802006000600008&lng=es&nrm=iso&tlng=es [Accessed October 4, 2011]. 3. Talayero BG, Sacks FM. The Role of Triglycerides in Atherosclerosis. Current cardiology reports. 2011. Available at: http://www.ncbi.nlm.nih.gov/pubmed/21968696 [Accessed October 9, 2011]. 4. Garcia-Rios A, Delgado-Lista J, Perez-Martinez P, et al. Genetic variations at the lipoprotein lipase gene influence plasma lipid concentrations and interact with plasma n-6 polyunsaturated fatty acids to modulate lipid metabolism. Atherosclerosis. 2011;218(2):416-22. Available at: http://www.ncbi.nlm.nih.gov/pubmed/21840003 [Accessed October 6, 2011]. 5. Nishimura S, Manabe I, Nagai R. Adipose tissue inflammation in obesity and metabolic syndrome. Discovery medicine. 2009;8(41):55-60. Available at: http://www.ncbi.nlm.nih.gov/pubmed/19788868 [Accessed October 9, 2011]. 6. Protogerou AD, Zampeli E, Fragiadaki K, et al. A pilot study of endothelial dysfunction and aortic stiffness after interleukin-6 receptor inhibition in rheumatoid arthritis. Atherosclerosis. 2011. Available at: http://www.ncbi.nlm.nih.gov/pubmed/21968316 [Accessed October 9, 2011]. 7. Santos MJ, Fonseca JE. Metabolic syndrome, inflammation and atherosclerosis - the role of adipokines in health and in systemic inflammatory rheumatic diseases. Acta reumatolgica portuguesa. 34(4):590-8. Available at: http://www.ncbi.nlm.nih.gov/pubmed/20852572 [Accessed October 9, 2011]. 8. Soltsz P, Dr H, Kerekes G, et al. A comparative study of arterial stiffness, flow-mediated vasodilation of the brachial artery, and the thickness of the carotid artery intima-media in patients with systemic autoimmune diseases. Clinical rheumatology. 2009;28(6):655-62. Available at: http://www.ncbi.nlm.nih.gov/pubmed/19224126 [Accessed October 9, 2011]. 9. Wisse BE. The inflammatory syndrome: the role of adipose tissue cytokines in metabolic disorders linked to obesity. Journal of the American Society of Nephrology: JASN. 2004;15(11):2792-800. Available at: http://www.ncbi.nlm.nih.gov/pubmed/15504932 [Accessed June 21, 2011]. 10. Yiu K-H, Tse H-F, Mok M-Y, Lau C-S. Ethnic differences in cardiovascular risk in rheumatic disease: focus on Asians. Nature reviews. Rheumatology. 2011;7(10):609-18. Available at: http://www.ncbi.nlm.nih.gov/pubmed/21912432 [Accessed October 9, 2011].

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