Dr. M.

Prakash HANDE
Publications list (as of November 2011)

1990

1. Hande MP, Uma Devi P, Jagetia GC, Ghosh MK 1990 Late haematological changes in mice after in
utero exposure to diagnostic X-rays. Arogya A Journal of Health Sciences (India) 16, 28-32.

2. Uma Devi P, Hande MP 1990 Effect of low dose of 70 kVp X-rays on the intrauterine development of
mouse. Experientia 46, 511-513 (Currently journal is known as Cell and Molecular Life
Sciences).

3. Hande MP, Uma Devi P, Jagetia GC 1990 Effect of in utero exposure to low doses of low energy X-
rays on the postnatal development of mouse. Journal of Radiation Research, 31, 354-360.
.
4.Hande MP†, Uma Devi P, Sharma ASKVS, Veena K 1990 Effect of in utero exposure to diagnostic X-
rays on the postnatal development of mouse AMPI Medical Physics Bulletin (India) 15, 144-148.

1992:

5. Hande MP†, Uma Devi P 1992 Effect of prenatal exposure to diagnostic ultrasound on the
development of mice. Radiation Research 130, 125-128.

6. Hande MP†, Uma Devi P, Veena K, Baskar R 1992 Effect of repeated exposure to diagnostic X-rays
and/or ultrasound on the prenatal development of mouse. Bulletin of Radiation Protection (India)
15, 1, 27-29.

1993:

7. Hande MP† 1993 Adaptive Response in Radiation Biology - A conference report. Current Science,
64, 2, 70-71.

8. Hande MP†, Veena K 1993 Teratogenic effect of hyperthermia during early organogenesis period in
mice. Teratogenesis, Carcinogenesis and Mutagenesis, 13, 3, 145-150.

9. Hande MP†, Uma Devi P, Karanth KS 1993 Effect of prenatal ultrasound exposure on adult behavior
in mice. Neurotoxicology and Teratology 15, 6, 433-438.

10. Hande MP†, Uma Devi P 1993 Effect of in utero exposure to diagnostic ultrasound on the postnatal
survival and growth of mouse. Teratology 48, 5, 405-411.

1994:

11. Uma Devi P, Baskar R, Hande MP 1994 Effect of exposure to low-dose gamma radiation during late
organogenesis in the mouse fetus. Radiation Research 138, 133-138.

1995:

12. Hande MP†, Uma Devi P 1995 Teratogenic effects of repeated exposures to diagnostic doses of X-
rays and/or ultrasound during mouse organogenesis. Neurotoxicology and Teratology 17, 2, 179-
188.

13. Uma Devi P, Suresh R, Hande MP 1995 Effect of fetal exposure to ultrasound on the behavior of the
adult mouse. Radiation Research 141, 3, 314-317.

14. Jha AN, Hande PM, Mullenders LHF, Natarajan AT 1995 Mimosine is a potent clastogen in primary
and transformed hamster fibroblasts and not in primary or transformed human lymphocytes.
Mutagenesis, 10, 5, 385-391.

1996:
15. Hande MP, Boei JJWA, Granath F, Natarajan AT 1996 The induction and persistence of cytogenetic
damage in mouse splenocytes following whole-body X-irradiation analysed by fluorescence in situ
hybridization, I. Dicentrics and Translocations. International Journal of Radiation Biology 69:
437-446.

16. Natarajan AT, Boei JJWA, Darroudi F, van Diemen PCM, Dulout F, Hande MP, Ramalho AT 1996
Current cytogenetic methods for detecting exposure and effects of mutagens and carcinogens.
Environmental Health Perspectives 104 (suppl 3): 445-448.

17. Hande MP, Boei JJWA, Natarajan AT 1996 The induction and persistence of cytogenetic damage in
mouse splenocytes following whole-body X-irradiation analysed by fluorescence in situ
hybridization. II. Micronuclei. International Journal of Radiation Biology, 70, 375-383.

18. Natarajan AT, Balajee AS, Boei JJWA, Darroudi F, Dominguez I, Hande MP, Meijers M,
Slijepcevic P, Vermeulen S, Xiao Y 1996 Mechanisms of induction of chromosomal aberrations
and their detection by fluorescence in situ hybridization. Mutation Research 372, 247-258.

1997:

19. Kawaguchi T, Nakajima H, Hongyo T, Fukuda K, Taniguchi E, Sutoh K, Wang H, Hande P, Li Ya Li,
Kurooka M, Iwasa T, Kurokawa N, Nezu R, Miyata M, Matsuda H, Nomura T 1997 Consecutive
maintenance of solitary and hereditary colorectal polyps in scid mice. Cancer Detection and
Prevention 21(2): 148-157.

20. Hande MP, Boei JJWA, Natarajan AT 1997 The induction and persistence of cytogenetic damage in
mouse splenocytes following whole-body X-irradiation analysed by fluorescence in situ
hybridization. III. Chromosomal Malsegregation / Aneuploidy. Mutagenesis 12, 125-131.

21. Nomura T, Nakajima H, Hongyo T, Taniguchi E, Fukuda K, Li LY, Kurooka M, Sutoh K, Hande PM,
Kawaguchi T, Ueda M, Takatera H 1997 Induction of cancer, actinic keratosis and specific p53
mutations by UVB light in human skin maintained in severe combined immunodeficient mice.
Cancer Research 57, 11, 2081-2084.

22. Sebastian S, Hoebee B, Hande MP, Kenkare UW, Natarajan. AT 1997 Assignment of
hexokinase types 1, 2, 3 (Hk1, 2,3) and glucokinase (Gck) to rat chromosome band 20q11, 4q34,
17q12 and 14q21 respectively by in situ hybridization. Cytogenetics and Cell Genetics 77, 3-4,
266-267.

23. Hande MP†, Balajee AS, Natarajan AT 1997 Induction of telomerase

activity by UV-irradiation in Chinese hamster cells. Oncogene 15: 1747-
1752.

24. Blasco MA, Lee H-W, Hande MP, Samper E, Lansdorp PM, DePinho RA,
Greider CW 1997 Telomere shortening and tumor formation by mouse
cells lacking telomerase RNA. Cell 91: 25-34 (with cover page picture).

25. Slijepcevic P, Hande MP, Bouffler SD, Lansdorp P, Bryant PE 1997

Telomere length, chromatin structure and chromosome fusigenic
potential. Chromosoma 106: 413-421.

26. Hande MP†, Natarajan AT 1997 Fluorescence in situ hybridization:

Applications in genetic toxicology. EMSI Newsletter (India), 20: 4-8 (Invited Review).

1998:

27. Oh HJ*, Hande MP*†, Lansdorp PM, Natarajan AT 1998 Induction of telomerase activity and
chromosome aberrations in human tumour cell lines following X-irradiation. Mutation Research,
401(1-2): 121-131 (Joint first author).
28. Hande MP†, Lansdorp PM, Natarajan AT 1998, Induction of telomerase activity by in vivo X-
irradiation of mouse splenocytes and its possible role in chromosome healing. Mutation
Research 404 (1-2): 205-214.

29. Zhu L, Hathcock KS, Hande P, Lansdorp PM, Seldin MF, Hodes RJ 1998 Telomere length
regulation in mice is linked to a novel chromosome locus. Proceedings of the National
Academy of Sciences, USA, 95: 8648-8653.

30. Hande MP†, Natarajan AT, 1998, Induction and persistence of cytogenetic damage in mouse
splenocytes following whole-body X-irradiation analysed by fluorescence in situ hybridization. IV.
Dose response. International Journal of Radiation Biology 74: 441-448.

31. Fukuda K, Nakajima H, Taniguchi, E, Sutoh K, Wang H, Hande PM, Li LY, Kurooka M, Mori K,
Hongyo T, Kubo, T, Nomura T 1998, Morphology and function of human benign tumors and
normal thyroid tissues maintained in severe combined immunodeficient mice. Cancer Letters
132: 153-158.

1999:

32. Hande MP, Samper E, Lansdorp P, Blasco MA, 1999, Telomere length dynamics and
chromosomal instability in cells derived from telomerase null mice. Journal of Cell Biology 144:
589-601.

33. Hande P*, Slijepcevic P*, Silver A, Bouffler S, van Buul P, Bryant P, Lansdorp P 1999 Elongated
telomeres in SCID mice. Genomics 56:221-223.

34. Lohwasser S, Hande P, Mager DL, Takei F, 1999, Cloning of murine NKG2A, B and C: Second
family of C-type lectin receptor on murine NK cells. European Journal of Immunology 29:755-
761.

35. Slijepcevic P*, Hande MP*, 1999, Chinese hamster telomeres are comparable in size to mouse
telomeres. Cytogenetics and Cell Genetics 85:3-4, 196-199 (Joint first author).

36. d’Adda di Fagagna, F*, Hande MP*, Tong WM, Lansdorp PM, Wang ZQ, Jackson SP 1999
Functions of poly(ADP-ribose) polymerase in controlling telomere length and chromosomal stability.
Nature Genetics 23: 76-80 (Joint first author).

37. Surralles J*, Hande MP*, Marcos R, Lansdorp PM 1999 Accelerated telomere shortening in the
human inactive X-chromosome, American Journal of Human Genetics
65:6, 1617-1622 (Joint first author)

2000:

38. Dhar S, Squire JA, Hande MP, Wellinger RJ, Pandita TK 2000
Inactivation of 14-3-3 influences ionising radiation induced
chromosomal stability and telomere behavior Molecular and Cellular
Biology 20(20):7764-7772.

39. Niida H*, Shinkai Y, Hande MP*, Matsumoto T, Takahara S, Tachibana M,

Oshimura M, Lansdorp PM, Furuichi Y 2000 Telomere Maintenance in
Telomerase Deficient Mouse Embryonic Stem Cells: Characterization of
an Amplified Telomeric DNA. Molecular and Cellular Biology 20(11):
4115-4127 (with cover page picture) (Joint first author)

40. Liu Y, Snow BE, Hande MP, Baerlocher G, Kickhoefer V, Yeung D, Wakeham D, Itie A, Siderovski
DP, Lansdorp PM, Robinson MO, Harrington L 2000 The telomerase-associated protein TEP1 is
not essential for telomerase activity or telomere length maintenance in vivo. Molecular and
Cellular Biology 20(21): 8178-8184.
41. Liu Y, Snow BE, Hande MP, Yeung D, Erdmann NJ, Wakeham A, Itie A, Siderovski DP, Lansdorp
PM, Robinson MO, Harrington L 2000 The telomerase reverse transcriptase is limiting and
necessary for telomerase function in vivo. Current Biology 10:1459-1462.

42. Hsu H-L, Gilley D, Galande SA, Hande MP, Allen B, Kim S-H, Li GC, Campisi J, Kohwi-Shigematsu
T, Chen DJ 2000 Ku acts in unique way at the mammalian telomere to prevent end joining. Genes
and Development 14: 2807-2812.

2001:

43. Wood LD, Halvorsen TL, Dhar S, Baur JA, Pandita RK, Wright WE,
Hande MP, Calaf G, Hei TK, Levine F, Shay JW, Wang JJY,
Pandita TK. 2001 Characterization of ataxia telangiectasia
fibroblasts with extended life-span through telomerase expression.
Oncogene 20: 278-288.

44. Hande MP, Balajee AS, Tchirkov A, Wynshaw-Boris A, Lansdorp PM

2001 Extra-chromosomal telomeric DNA in cells from Atm-/- mice
and patients with ataxia-telangiectasia. Human Molecular Genetics
10: 519-528 (with cover page picture).

45. Tong, W-M, Hande MP, Lansdorp PM, Wang Z-Q 2001 DNA strand break-sensing molecule PARP
cooperates with p53 in telomere function, chromosome stability and tumor suppression. Molecular
and Cellular Biology 21: 4046-4054.

46. di Fagagna FD*, Hande MP*, Tong W-M, Roth D, Lansdorp PM, Wang Z-Q, Jackson SP, 2001,
Effects pf DNA non-homologous end-joining factors on telomere length and chromosome stability
in mammalian cells Current Biology 11:1192-1196 (Joint first author)

47. Gilley D, Tanaka H, Hande MP, Kurimasa A, Li GC, Chen DJ 2001 DNA-PKcs is critical for telomere
capping. Proceedings of the National Academy of Sciences, USA, 98, no 26, 15084-15088.

48. Brenner DJ, Okladnikova N, Hande P, Burak L, Geard CR, Azizova T 2001 Biomarkers specific to
densely-ionising (high LET) radiations. Radiation Protection Dosimetry, 97(1):69-73.

2002:

49. Peitl Jr. P, Mello SS, Camparoto ML, Passos Jr. GAS, Hande MP, Cardoso RS, Sakamoto-Hojo ET
2002 Chromosome rearrangements involving telomeric DNA sequences Balb/ 3T3 cells
transfected with H-ras oncogene Mutagenesis 17, 1, 67-72.

50. Cheung AMY, Hande MP, Jalali F, Tsao M-S, Skinnider B, Hirao A. McPherson JP, Karaskova J,
Suzuki A, Wakeham A, Itie An, Elia A, Squire J, Bristow R, Hakem R, Mak TW 2002 Chromosomal
aberrations and enhanced p53-dependent tumorigenesis in Brca2-deficient mice. Cancer
Research 62 (21): 6194-6204

51. Tong W-M, Cortes U, Hande MP, Ohgaki H, Cavalli LR, Lansdorp PM, Haddad BR, Wang Z-Q
2002 Synergistic role of Ku80 and poly(ADP-ribose) polymerase in suppressing chromosomal
aberrations and liver cancer formation Cancer Research 62 (23): 6990-6996.

52. Brenner DJ, Sawant SG, Hande MP, Miller RC, Elliston CD, Fu Z, Randers-Pehrson G, Marino SA
2002 Routine screening mammography: How important is the radiation-risk side of the benefit-risk
equation? International Journal of Radiation Biology 78 (12):1065-1067.

2003:

53. Hande MP, Azizova TV, Geard CR, Burak LE, Mitchell CR, Khokhryakov VF, Vasilenko FK,
Brenner DJ 2003 Past exposure to densely ionizing radiation leaves a unique permanent
signature in the genome. American Journal of Human Genetics 72 (5): 1162-1170.
54. Abraham J, Lemmers B, Hande MP, Moynahan ME, Chahwan C, Ciccia A, Essers J, Hanada K,
Chahwan R, Khaw AK, McPherson P, Shehabeldin A, Laister R, Arrowsmith C, Kanaar R, West
SC, Jasin M, Hakem R 2003 Eme1 is involved in DNA damage processing and maintenance of
genomic stability in mammalian cells. EMBO Journal 22: 6137-6147.

2004:

55. Hande MP† 2004 DNA repair factors and telomere-chromosome integrity
in mammalian cells Cytogenetic and Genome Research 104: 116-122.

56. McPherson JP, Lemmers B, Hirao A, Hakem A, Abraham J, Migon E,

Matysiak-Zablocki E, Tamblyn L, Sanchez-Sweatman O, Khokha R,
Squire J, Hande MP, Mak TW, Hakem R 2004 Collaboration of Brca1
and Chk2 in tumorigenesis. Genes and Development 18: 1144-1153.
(with cover page picture).

57. McPherson JP, Lemmers B, Chahwan R, Pamidi A, Migon E, Matysiak-

Zablocki E, Moynahan ME, Essers J, Hanada K, Poonepalli A, Sanchez-
Sweatman, Khokha R, Kanaar R, Jasin M, Hande MP, Hakem R. 2004
Involvement of mammalian Mus81 in genome integrity and tumour
suppression. Science 304 (5678): 1822-1826.

58. Hopkins KM, Auerbach A, Wang XY, Hande MP, Hang H, Wolgemuth DJ, Joyner AL, Lieberman
HB 2004 Deletion of mouse Rad9 causes abnormal cellular responses to DNA damage, genomic
instability and embryonic lethality. Molecular and Cellular Biology 24 (16): 7235-7248.

59. McPherson, JP , Tamblyn L, Elia A, Migon E, Shehabeldin1 A, Matysiak-Zablocki E, Fish J,

Kassam F, Lemmers B, Salmena L, Hakem A, Wakeham A, Hande MP, Bruneau BG, Hakem
R. 2004 Lats2/Kpm is required for embryonic development, proliferation control and genomic
integrity EMBO Journal 23: 3677-3688.

60. Mitchell CR, Azizova TV, Hande MP, Burak LE, Tsakok JM, Khokhryakov VF, Geard CR, Brenner
DJ 2004 Stable intra-chromosomal biomarkers of past exposure to densely-ionising radiation in
several chromosomes of exposed individuals, Radiation Research 162 (3): 257-263.

2005:

61. Giavara S, Kosmidou E, Hande MP, Bianchi M, Morgan A, Di Fagagna FD, Jackson SP 2005
Yeast NHP6A/B and mammalian HMGB1 facilitate the maintenance of genome stability. Current
Biology 15: 68-72.
62. Lee MK, Hande MP, Sabapathy K 2005 Ectopic mTERT expression in mouse embryonic stem
cells does not affect differentiation but confers resistance to stress- and differentiation-induced
apoptosis. Journal of Cell Science, 118 (4): 819-829.

63. Hande MP†, Azizova TV, Burak LE, Khokhryakov VF, Geard CR, Brenner DJ 2005 Complex
chromosome aberrations persist in individuals many years after occupational exposure to densely
ionizing radiation: An mFISH study Genes, Chromosomes and Cancer 44 (1): 1-9.

64. Poonepalli A*, Balakrishnan L*, Khaw AK, Low GKM, Jayapal M, Bhattacharjee RN, Akira S,
Balajee AS, Hande MP† 2005 Lack of poly(ADP-ribose) polymerase – 1 (PARP-1) gene product
enhances cellular sensitivity to arsenite. Cancer Research 65: 10977-10983.

2006:

65. Roy D, Calaf G, Hande MP, Hei TK 2006 Allelic imbalance at 11q23-q24 chromosome associated
with estrogen and radiation-induced breast cancer progression. International Journal of
Oncology 28 (3): 667-674.

66. McPherson JP*, Hande MP†*, Lemmers B, Matysiak-Zablocki E, Migon E, Shehabeldin A, Porras
A, Karaskova J, Vukovic B, Sanchez-Sweatman OH, Squire J, Hakem R†. 2006 A role for Brca1
 in chromosome end maintenance, Human Molecular Genetics 15 (6): 831-838. (joint first
author and corresponding author)

67. Heng BC, Vinoth KJ, , Liu H, Hande MP, Cao T 2006 Low temperature tolerance of human
embryonic stem cells. International Journal of Medical Sciences 3: 124-129.

68. Francia S, Weiss RS, Hande MP, Freire R, di Fagagna FD 2006 Telomere and Telomerase
modulation by the Rad9/Rad1/Hus1 DNA-damage-checkpoint complex. Current Biology 16(15):
1551-1558.

69. Akiyama K, Yusa K, Hashimoto H, Poonepalli A, Hande MP, Kakazu N, Takeda J, Tachibana M,
Shinkai Y 2006 Rad54 is dispensable for the ALT pathway. Genes to Cells 11(11): 1305-1315.

2007:

70. Zhang S, Lin Y, Kim Y-S, Hande MP, Liu Z-G, Shen H-M 2007 c-Jun N-terminal kinase mediates
hydrogen peroxide induced cell death via sustained poly(ADP-ribose) polymerase-1 activation
Cell Death and Differentiation 14 (5): 1001-1010.

71. Niida H, Katsuno Y, Banerjee B, Hande MP, Nakanishi M 2007 Specific role of Chk1
phosphorylation in cell survival and checkpoint activation. Molecular and Cellular Biology
27(7): 2572-2581.

72. Banerjee B, Vadiraj HS, Ram A, Rao R, Jayapal M, Gopinath KS, Ramesh BS, Rao N, Kumar A,
Raghuram N, Hegde S, Nagendra HR, Hande MP† 2007 Effects of an integrated yoga program
in modulating psychological stress and radiation-induced genotoxic stress in breast cancer
patients undergoing radiotherapy. Integrative Cancer Therapies, 6 (3): 242-250.

73. Pamidi A, Cardoso R, Hakem A, Matysiak-Zablocki E, Poonepalli A, Tamblyn L, Perez-Ordonez,

Hande MP, Sanchez O, Hakem R 2007 Functional interplay of p53 and Mus81 in DNA damage
responses and cancer. Cancer Research 67(18): 8527-8535.

74. Wang J, Liu YX, Hande MP, Wong AC, Jin YJ, Yin Y 2007 TAp53 is a downstream target of p53
in controlling the cellular defense against stress Journal of Biological Chemistry 282
(40):29152-29162.

75. Khaw AK, Silasudjana M Banerjee B, Suzuki M, Baskar R, Hande MP† 2007 Inhibition of
telomerase activity and human telomerase reverse transcriptase gene expression by histone
deacetylase inhibitor in human brain cancer cells. Mutation Research 625 (1-2): 134-144.

76. Choong L-Y, Lim S, Loh MC, Man X, Chen Y, Toy W, Pan M, Chen CS, Poonepalli A, Hande
MP, Tan PH, Salto-Tellez M, Wong CY, Shah N, Druker BJ, Lim YP 2007 Progressive loss of
epidermal growth factor in a sub-population of breast cancers –implications in target-directed
therapeutics. Molecular Cancer Therapeutics 6(11):2828-2842.

77. Tan FCK, Lee KH, Gouk SS, Magalhaes R, Poonepalli A, Hande MP, Dawe GS, Kuleshova LL
2007 Optimization of cryopreservation of stem cells cultured as neurospheres: Comparison
between vitrification, slow-cooling and rapid cooling “freezing” protocols. Cryoletters 28 (6): 445-
460.

78. Li J, Tan J, Zhuang L, Banerjee B, Yang X, Chau JFL, Lee PL, Hande MP, Li B, Yu Q 2007
Ribosomal Protein S27-like a p53-inducible modulator of cell fate in response to genotoxic stress
Cancer Research 67 (23): 11317-11326.

2008:

79. Baskar R, Balajee AS, Geard CR, Hande MP† 2008 Isoform-specific activation of protein kinase c
in irradiated human fibroblasts and their bystander cells. International Journal of Biochemistry
 and Cell Biology 40(1): 125-134.

80. Banerjee B, Sharma S, Hegde S, Hande MP† 2008 Analysis of telomere damage by
fluorescence in situ hybridisation on micronuclei in lymphocytes of breast cancer patients after
radiotherapy. Breast Cancer Research and Treatment 107 (1):25-31.

81. Newman JPA, Banerjee B, Fang W, Poonepalli A, Balakrishnan L, Low GKM, Bhattacharjee RN,
Akira S, Jayapal M, Melendez AJ, Lee HW, Hande MP† 2008 Short dysfunctional telomeres
impair the repair of arsenite-induced oxidative damage in mouse cells. Journal of Cellular
Physiology 214 (3): 796-809.

82. Vinoth KJ, Heng BC, Poonepalli A, Banerjee B, Balakrishnan L, Lu K, Hande MP, Cao T 2008
Human embryonic stem cells may display higher resistance to genotoxic stress compared to
primary explanted somatic cells Stem Cells and Development 17 (3): 599-608.

83. Low GKM, Fok EDZ, Ting APL, Hande MP† 2008 Oxidative damage induced genotoxic effects in
human fibroblasts from Xeroderma Pigmentosum group A patients International Journal of
Biochemistry and Cell Biology 40(11):2583-2595.

84. Tsuruoka C, Suzuki M, Hande MP, Furusawa Y, Anzai K, Okayasu R 2008 The difference in LET
and Ion-species dependence for induction of initially measured and non-rejoined chromatin
breaks in nomrla human fibroblasts. Radiation Research 170 (2): 163-171.

85. Poonepalli A, Banerjee B, Ramanarayan K, Palanisamy N, Putti TC, Hande MP† 2008 Telomere
mediated genomic instability correlates with the clinico-pathological parameters of breast cancer
Genes Chromosomes and Cancer 47: 1098-1109.

86. Banerjee B, Peiris DN, Koo SH, Chui P, Lee EJD, Hande MP† 2008 Genomic imbalances in key
ion channel genes and telomere shortening in sudden cardiac death victims Cytogenetic and
Genome Research 122 (3-4): 350-355.

2009:

87. Tamblyn L, Li E, Sarras H, Srikanth P, Hande MP, McPherson JP 2009 A role for Mus81 in the
repair of chromium-induced DNA damage. Mutation Research 660 (1-2): 57-65.

88. AshaRani PV, Low GKM, Hande MP, Valiyaveettil S 2009 Cytotoxic and genotoxic effects of
silver nanoparticles in human cells. ACS Nano 3 (2): 279-290.

89. Chong YK, Toh TB, Zaiden N, Poonepalli A, Leong SH, Ee Ling Ong C, Yu Y, Tan PB, See SJ,
Ng WH, Ng I, Hande MP, Kon OL, Ang BT, Tang C 2009 Cryopreservation of neurospheres
derived from human glioblastoma multiforme Stem Cells 27 (1): 29-39.

90. Baskar R†, Hande MP† 2009 A comparative study of protein kinase C activation in -irradiated
proliferating and confluent human lung fibroblast cells. Journal of Radiation Research 50
(5):415-423.

91. Srikanth P, Banerjee B, Poonepalli A, Balakrishnan L, Low GKM, Hande MP† 2009 Telomere-
mediated genomic instability in cells from Ataxia Telangiectasia patients. Acta Medica
Nagasakiensia 53: 45-48.

92. AshaRani PV, Hande MP†, Valiyaveettil S† 2009 Anti-proliferative activity of silver nanoparticles.
BMC Cell Biology 10: 65.

2010:

93. AshaRani PV, Ng X, Hande MP†, Valiyaveettil S† 2010 DNA damage and p53 mediated growth
arrest in human cells treated with platinum nanoparticles. Nanomedicine 5(1): 51-64.

94. Jayapal M, Bhattacharjee RN, Melendez AM, Hande MP† 2010 Environmental Toxicogenomics: a
 post-genomic approach to analysing biological responses to environmental toxins. International
Journal of Biochemistry and Cell Biology 42 (2): 230-240.

95. Indran IR, Hande MP, Pervaiz S 2010 Tumor cell redox state and mitochondria at the center of
the non-canonical activity of telomerase reverse transcriptase. Molecular Aspects of Medicine
31(1) 21-28.

96. Ting APL, Low GKM, Hande MP† 2010 Genomic instability and telomere attrition in Xeroderma
Pigmentosum- B deficient fibroblasts under oxidative stress Journal of
Cellular and Molecular Medicine 14 (1-2): 403 - 416.

97. AshaRani PV, Sethu S, Vadukkumpuly S, Zhong S, Lim CT, Hande MP†,,
Valiyaveettil S† 2010 Investigations on the structural damage in human
erythrocytes exposed to silver, gold and platinum nanoparticles.
Advanced Functional Materials 20 (8) 1233 - 1242.

98. Hakem R, Hande P, Petrini J, Slijepcevic P 2010 Editorial: Genome

Integrity - a new open access journal. Genome Integrity 1:1.

99. Gurung RL, Balakrishnan L, Bhattacharjee RN, Manikandan J, Swaminathan S, Hande MP† 2010
Inhibition of poly(ADP-ribose) polymerase-1 in telomerase deficient mouse embryonic fibroblasts
increases arsenite-induced genome instability . Genome Integrity, 1: 5.

100. Nair S, Hande MP, Lim LHK 2010 Annexin-1 protects MCF-7 breast cancer cells against heat-
stress induced DNA damage and growth arrest. Cancer Letters 294(1):111 - 117.

101. Mistry H, Tamblyn L, Butt H, Sisgoreo D, Gracias A, Laqrin M, Gopalakrishnan K, Hande MP,
McPherson JP 2010 Uhrf1 is a genome caretaker that facilitates the DNA damage response to
gamma-irradiation. Genome Integrity 1: 7.

102. Fu X, Toh WS, Liu H, Lu K, Li M, Hande MP, Cao T 2010 Autologous feeder cells from embryoid
body outgrowth support the long-term growth of human embryonic stem cells more effectively
than those from direct differentiation. Tissue Engineering Part C Methods 16(4):719 – 733.

103. Bhattacharjee RN, Banerjee B, Akira S, Hande MP†, 2010 Telomere-mediated chromosomal
instability triggers TLR4 induced inflammation and death. PLoS ONE 5 (7): e11873.

104. Gurung RL, Lim SN, Khaw AK, Soon JFF, Shenoy K, Ali SM, Jayapal M, Sethu S, Baskar R,
Hande MP† 2010 Thymoquinone induces telomere shortening, DNA damage and apoptosis in
human glioblastoma cells. PLoS ONE 5(8): e12124.

105. Fong CY, Subramanian A, Biswas A, Gauthaman K, Srikanth P, Hande MP, Bongso A 2010
Derivation efficiency, cell proliferation, frozen-thaw survival, 'stemness' properties and
differentiation of human Wharton's jelly stem cells. Reproductive BioMedicine Online 21(3):
391 – 401.

106. Niida H, Murata K, Shimada M, Ogawa K, Ohta K, Suzuki K, Fujigaki H, Khaw AK, Banerjee B,
Hande MP, Miyamoto T, Miyoshi I, SHirai T, Motoyama N, Delhase M, Appella E, Nakanishi M
2010 Co-operative functions of Chk1 and Chk2 reduce tumor susceptibility in vivo. EMBO J
29(20): 3558 - 3570.

107. Gopalakrishnan K, Low GKM, Ting APL, Srikanth P, Slijepcevic P, Hande MP† 2010 Hydrogen
peroxide induced genomic instability in nucleotide excision repair-deficient lymphoblastoid cells
Genome Integrity 1(1): 16.

2011:

108. Wang X, Zeng L, Wang J, Chau JF, Lai KP, Jia D, Poonepalli A, Hande MP, Liu H, He G, He L,
Li B 2011 A positive role for c-Abl in Atm and Atr activation in DNA damage response. Cell Death
and Differentiation 18 (1): 5 – 15.
109. Inthran IR, Hande MP*, Pervaiz S* 2011 hTERT overexpression alleviates intracellular ROS
production, improves mitochondrial function, and inhibits ROS-mediated apoptosis in cancer
cells. Cancer Research 71: 266 - 276.

110. Jayapal M, Sethu S, Zeegers D, Banerjee B, Hande MP† 2011 Predictive genomics: a post-
genomic integrated approach to analysing biological signatures of radiation exposure. Defence
Science Journal (DRDO, India), 61 (2) 133 - 137..

111. Bohgaki T, Bohgaki M, Cardoso R, Panier S, Zeegers D, Li L, Stewart GS, Sanchez O, Hande
MP, Durocher D, Hakem A, Hakem R 2011 Genomic instability, defective spermatogenesis,
immunodeficiency and cancer in a mouse model of the RIDDLE syndrome. PLoS Genetics, 7(4),
e1001381.

112. El Ghamrasni S, Pamidi A, , Halaby MJ, Bohgaki M, Cardoso R, Li L, Venkatesan S, Sethu S,

Hirao A, Mak TW, Hande MP, Hakem A, Hakem R 2011 Inactivation of Chk2 and Mus81 leads to
impaired lymphocyte development, reduced genomic instability and suppression of cancer. PLoS
Genetics 7(5), e1001385.

113. Li JJ, Lo SL, Ng CT, Gurung RL, Hartono D, Hande MP, Ong CN, Bay BH, Yung LYL
2011Genomic instability of gold nanoparticle treated human lung fibroblast cells. Biomaterials
32, 5515 - 5523.

114. Teow Y, Asharani PV, Hande MP, Valiyaveettil S 2011 Health impact and safety of engineered
nanomaterials. Chem Commun (Camb) 47(25): 7025 – 7028.

*Equal contributions, †corresponding author

Conference Papers:

1. Hande MP, Uma Devi P 1992 Effect of in utero exposure to diagnostic doses of X-rays on the growth
and behaviour of mouse. In: Low Dose Irradiation and Biological Defense Mechanisms.
Volume 1013 T. Sugahara, LA Sagan, T Aoyama (eds.) Elsevier Science Publishers, Amsterdam,
pp. 163-166.

2. Hande MP†, Uma Devi P 1993 Teratogenic effects of repeated exposures to diagnostic doses of X-
rays and/or ultrasound during mouse organogenesis. In: Proceedings of the Fukui Workshop on
Health Risks: Perspectives and Research. T Sugahara, K Torizuka, S Koyabashi, Y Ishii (eds.)
Health Research Foundation, Kyoto, Japan, pp. 203-206.

3. Blasco MA, Lee HW, Hande MP, Samper E, DePhinho RA, Greider CW, Lansdorp PM 1997
Telomere shortening in mouse cells lacking telomerase RNA. Blood 90(10): 534-534.

4. Herrera E, Samper E, Hande P, Martin-Rivera L, Goytisolo F, Gonzalez E, Jurado P, Lansdorp P,

Blasco MA 1999 Telomere function: analysis of cells and mice lacking the mouse telomerase RNA.
European Journal of Cancer. 35: S45.

5. Tchirkov A, Chavez EA, Hande MP, Lansdorp PM 2000 Accelerated loss and defective repair of
telomeric DNA in cells from patients with ataxia-telangiectasia. Blood 96 (11): 695A-695A.

6. Asharani PVN Gong ZY, Hande MP, Valiyaveettil S 2007 Potential health impacts of silver
nanoparticles. Chemical Research in Toxicology, 20, 2009

7. Tan S, Hande MP, Melendez AJ 2008 Sphingosine kinase 1 in tumor immunology: Proliferation,
migration and invasion of colon carcinoma cells. Scandinavian Journal of Immunology 68 (2):
213-214 (Abstract 53; Aug 2008)

8. Hande MP†, Natarajan AT 2009 Induction and persistence of cytogenetic damage in mouse
 splenocytes following whole-body X-irradiation analysed by fluorescence in situ hybridization. V.
Heterogeneity/Chromosome specificity. In: Radiation Health Risk Sciences. Eds: M. Nakashima,
N. Takamura, K. Tsukasaki, Nagayama Y, S. Yamashita. Proceedings of First Symposium of the
Nagasaki University Global COE Program “Global Strategic Center for Radiation Health Risk
Control. Springer Japan. Pp. 143-149.

9. Low GKM, Hande MP† 2009 Role of DNA repair factors in telomere integrity and genome
maintenance in mammalian cells under oxidative stress. In: Proceedings of the 9th
International Congress on Cell Biology – ICCB 2008, Editors: Hun-Taeg Chung and Sang-Gi
Paik, Seoul, South Korea (October 07-10, 2008), Medimond International Proceedings, Bologna,
Italy pp. 113-120..

Book Chapters:

1. Hande MP†, Uma Devi P 1995 Biological effects of prenatal exposure to ultrasound. In: Radiation,
Radiomodifiers and Human Health. P Uma Devi, KS Bisht and BSS Rao (eds.), NISCOM, New
Delhi, India. pp. 196-209 (Invited Review).
2. Hande MP† 2006 Orchestration of telomeres and DNA repair factors in mammalian cells:
Implications for cancer and ageing. In: DNA repair and Human Diseases, Ed. A. S. Balajee,
Landes Biosciences, USA (book chapter).
3. Poonepalli A, Hande MP†, 2010 Telomeres and genomic instability in breast cancer. In: Genomic
Instability and Cancer. Ed(s): Hande MP and Hande VK, Research Signpost, Trivandrum, India.
Pp 85 – 108.
4. Bhattacharjee RN, Hande MP 2010 Toll-like receptors, inflammation and cancer. In: Genomic
Instability and Cancer. Ed(s): Hande MP and Hande VK, Research Signpost, Trivandrum, India.
Pp 129 – 143.
5. Jayapal M, Hande MP†, 2009 miRNAs and Cancer. In: Genomic Instability and Cancer. Ed(s):
Hande MP and Hande VK, Research Signpost, Trivandrum, India. 145 – 162.
6. Banerjee B, Hande P, Khaw AK, Hande MP†, 2009 Inhibiting telomerase in cancer therapy:
Prospects and Challenges. In: Genomic Instability and Cancer. Ed(s): Hande MP and Hande VK,
Research Signpost, Trivandrum, India. 201 – 220.

BOOK

TITLE: GENOME INSTABILITY AND CANCER

Year: 2010
EDITORS:
M. PRAKASH HANDE, Ph.D. and VEENA KUMARI HANDE,
Ph.D.

PUBLISHER: Research Signpost, India;

ISBN 978-81-308-0405-7