Assessment of health related quality of life in adolescents with transfusion dependent thalassemia.

Thesis submitted in partial fulfillment For the degree of

Doctor of Medicine (Pediatrics) 2009-2012 UNIVERSITY OF DELHI

Supervisor
Dr. Harish K. Pemde Proffesor Dept of Pediatrics LHMC and KSCH New Delhi

Co-Supervisor
Dr. Jagdish Chandra Proffesor Dept of Prediatrics LHMC and KSCH New Delhi

Investigator Dr. MohemmedAjij MBBS APRIL 2011

LADY HARDINGE MEDICAL COLLEGE & SMT. SUCHETA KRIPLANI HOSPITAL, NEW DELHI-110001

DECLARATION

I, Dr Mohemmed Ajij, Post Graduate in the Department of Pediatrics, Kalawati Saran Children Hospital, Lady Hardinge Medical College, hereby declare that this project has not been done in the last 5 years in the University of Delhi to the best of my knowledge Assessment of health related quality of life in adolescents with transfusion dependent thalassemia. I also give consent for permitting availability of the thesis for photocopying and interlibrary loan to other institutions.

Supervisor
Dr. Harish K. Pemde Proffesor Dept of Pediatrics LHMC and KSCH New Delhi

Co-Supervisor
Dr. Jagdish Chandra Proffesor Dept of Prediatrics LHMC and KSCH New Delhi

Investigator Dr. MohemmedAjij

CERTIFICATE
This is to certif y that the thesis titled Assessment of health related quality of life in adolescents with transfusion dependent thalassemia is a bonafide work of Dr. Mohemmed Ajij and was carried out in the Department of Pediatrics, Kalawati Saran Children Hospital, Lady Hardinge Medical College, New Delhi from November 2009 to April 2011 under our supervision and guidance.

Dr A K Dutta Director, Professor and Head Department of Pediatrics LHMC and Associated Hospitals New Delhi

Dr Atul Murari Director LHMC and Associated Hospitals New Delhi

Supervisor
Dr. Harish K. Pemde Proffesor Dept of Pediatrics LHMC and KSCH New Delhi

Co-Supervisor
Dr. Jagdish Chandra Proffesor Dept of Prediatrics LHMC and KSCH NewDelhi

Investigator Dr Mohemmed Ajij MBBS

ACKNOWLEDGEMENTS

All words fall short to express my sense of deep gratitude and heartfelt emotions for my highly esteemed Supervisor and Guide Dr. Harish K Pemde, Professor, Department of Pediatrics, Lady Hardinge Medical College and Kalawati Saran Children Hospital. I am thankful for the faith he has put in me to work on this study. He has been a father like figure for me, guiding at each step right from the inception of the thesis. He has been a constant source of inspiration. This thesis would not have been possible without his driving force, organizational skills and enthusiasm. I express my sincere thanks to my co-supervisor Dr. Jagdish Chandra, Professor, Department of Pediatrics, who rendered me individual help during the tenure of my study. He has mapped the road of this thesis to its completion. He ensured that the minutest of the details were looked into. I am greatly indebted to him for his extended support. I am equally grateful to Dr A K Dutta, Director Professor and Head of Department of Pediatrics. His depth of knowledge and dealing with students are beyond comparison. I feel proud that I am his student and shall try to imbibe some of his qualities. I would also like to thank Dr. Varinder Singh, Professor, Department of Pediatrics for his guidance and support. A special word of thanks to Dr. Rajni Sharma, Assistant Professor, Department of Pediatrics for her invaluable suggestions and help throughout the study. I would also like to thank Dr Himanshu Chaturvedi, Deputy Director, National Institute of Medical Statistics for his help and cooperation. I am indebted to all the study subjects for their patience and cooperation. Last but not the least- "The Almighty, I dedicate this work of mine to, enshrined as always in my heart and mind.

Mohemmed Ajij