DRUG STUDY Drug name Generic Name OMEPRAZOLE 20mg Action Gastric acid-pump inhibitor: suppresses gastric acid

secretion by specific inhibition of the hydrogenpotassium ATPase enzyme Indication -short term treatment of active duodenal ulcer -treatment of heartburn or symptoms of GERD Contraindication Contraindicated with hypersensitivity to omeprazole and its components. Use cautiously with pregnancy, lactation. Adversed reaction Increased serum CNS: Headache, levels and dizziness, potential increase asthenia, vertigo, in toxicity of insomnia, apathy, benzodiazepines, anxiety, dream phenytoin, abnormalities. warfarin; if these Dermatologic: combinations are rash, used, monitor inflammation, patient closely. urticarua, pruritus, alopecia, dry skin Decrease GI: diarrhea, absorption with abdominal pain, surcralfate, give nausea, vomiting, these drugs at constipation, dry least 30 min apart. mouth, tounge atrophy. Respiratory: URI symptoms, cough, epstaxis Other: Cancer in preclinical studies, back pain, fever Interaction Consideration -administer before meals. Caution patient to swallow whole-not to open, chew or crush them. If using oral suspension, empty packet into a small cup containing 2 tbsp of water. -administer antacids with, if needed -have regular medical follow up visits. -you may experience these side effects: dizziness( avoid driving or performing hazardous task) headache (request medication) nausea, vomiting, diarrhea, (maintain proper nutrition) -report severe headache ,

Brand Name : Prilosec

Classification: Antisecretory Proton-pump inhibitor

worsening of symptoms, fever, chills, severe diarrhea.

DRUG STUDY Drug name Action Indication Contraindication Interaction Adversed reaction Consideration

GENERIC NAME: Ranitidine 1 gm

BRAND NAME: Zantac

Competitively inhibits gastric acid secretion by blocking the effect of histamine on histamine H2 receptors. Both daytime and nocturnal basal gastric acid secretion, as well as food- and pentagastrinstimulated gastric acid are inhibited. Weak inhibitor of cytochrome P-450 (drugmetabolizing enzymes); thus, drug interactions involving inhibition of hepatic metabolism are not expected to occur.

- Short-term (4-8 weeks) and maintenance of duodenal ulcer Pathologic hypersecretory conditions such as Zollinger-Ellison syndrome and systemic mastocytosis. Short-term treatment of active, benign gastric ulcers and maintenance treatment after healing the acute ulcer - Treatment of GERD - Treatment of endoscopically diagnosed erosive esophagitis and maintenance of healing of erosive esophagitis. - IV in some hospitalized clients with pathological hypersecretory conditions or intractable

- Contraindicated in patients hypersensitive to drug and those with acute porphyria - Cirrhosis of the liver, impaired renal or hepatic function. PRECAUTION: - Use with caution during lactation, in the elderly, and in clients with decreased hepatic or renal function.

- Contraindicated in patients hypersensitive to drug and those with acute porphyria - Cirrhosis of the liver, impaired renal or hepatic function. PRECAUTION: - Use with caution during lactation, in the elderly, and in clients with decreased hepatic or renal function.

GI: Constipation, N&V, diarrhea, abdominal pain, pancreatitis (rare) CNS: Headache, dizzinessk, malaise, insomnia, vertigo, confusion, anxiety , agitation, depression, fatigue, somnolence, hallucinations. CV: Bradycardia or tachycardia, premature ventricular beats following rapid IV use (especially in clients predisposed to cardiac rhythm disturbances), vasculitis. Hematologic: Thrombocytopenia , ganulocytopenia, leucopenia, pancytoenia (sometimes marrow hypoplasia) Hepatic: Hepatotoxicity,

1. Assess patient for abdominal pain. Note presence of blood in emesis, stool or gastric aspirate. 2. Visually inspect parenteral drug product for particulate matter and discoloration before administration. 3. Determine if the patient is pregnant or lactating. 4. Skin tests using allergens may elicit false negative results; stop drug 24-72 hours prior to testing. 5. Monitor renal and hepatic function. 6. Instruct patient to take as directed with or immediately following meals. Wait 1 hour before taking an antacid. 7. Instruct patient

CLASSIFICATION: Anti-ulcer drug, H2 receptor antagonist

duodenal ulcers, or as an alternative to PO doses for shortterm use in those who are unable to take PO medication

jaundice, hepatitis, increase in ALT Dermatologic: Erythema multiforme, rash, alopecia Allergic: angioneuroticede ma (rare), rashes, fever, eosinophili Miscellaneous: Arthralgia, gynecomastia, impotence, loss of libido, blurred vision, pain at injection site, local burning or itching following IV use. ADVERSE EFFECTS: CV: cardiac arrest Hematologic: agranulocytosis, autoimmune hemolytic or aplastic anemia Allergic: Bronchospasm, anaphylaxis

not to drive or operate machinery until drug effects are realized; dizziness or drowsiness may occur. 8. Encourage patient to avoid, alcohol, aspirincontaining products, and beverages that contain caffeine (tea, cola, coffee); these increase stomach acid. 9. Urge patient to avoid cigarette smoking because this may increase gastric acid secretion and worsen disease; it interferes with healing and drugs effectiveness. 10. Advise patient to report any evidence of yellow discoloration of skin or eyes, or diarrhea. 11. Report as scheduled to

determine extent of healing and expected length of therapy.

DRUG STUDY

Drug name Generic name: Metoclopramide HCL 500mg Brand Name: ApoMetoclop,Clopra, Reglan

Action stimulates motility of upper GI tract, increases lower esophageal sphincter tone, and block dopamine receptor at the chemoreceptor trigger zone

Indication To prevent or reduce postoperative nausea and vomiting from emetogenic cancer chemotherapy, postoperative nausea and vomiting, and emesis during pregnancy.

Contraindicatio n contraindicated with hypersensitivity to the drug and in those pheochromocyto ma and seizure disorders.

Interaction Anticholinergics and opoiod analgesics: may antagonize GI motility effects of metopclopramide. Use together cautiously CNS depressants: may cause addictive effect. Avoid using together. Levodopa: levodopa and metoclopromide have opposite effects on dopamine receptor. Avoid using together MAO inhibitors: may increase release of catecholamines in patiet with hypertension. Phenothiazines: may increase risk of extrapyramidal effects. Monitor patient closely.

Classification: Antie metic drug

Adversed reaction CNS: restlessness, anxiety, drowsiness, fatigue, lassitude, fever, depression, akathisia, insomnia, confusion, suicide ideation, seizures, neuroleptic malignant syndrome, hallucinations, headache, dizziness, extrapyramidal effect. CV: transient hypertension, hypotension, supraventricular tachycardia, bradycardia, GI: constipation, dry mouth, nausea

Consideration 1. Monitor bowel sounds 2. Monitor VS prior to drug administration . 3. Tell the patient to avoid driving activities and heavy lifting. 4. Tell the patient to avoid activities that requires alertness for 2 hrs after doses. 5. Urge patient to report persistent or serious adverse reaction promptly. 6. Advise patient not to drink alcohol

during therapy.