Curriculum Vitae ________________________________________ Hiral V. Patel 463 Waterbury Dr. Eastlake, OH 44095 hp11abeaa@westpost.

net (440) 463-4109 ________________________________________ CAREER OBJECTIVE I have spent twelve years working in a research setting at Case Western Reserve University in Cleveland, Ohio. In that time I have learned the fundamental aspe cts of conducting major scientific research experiments. I have participated in the collection and interpretation of valuable data for publication. I have bee n responsible for analyzing patient data in order to write relevant reports for clinicians. I attended graduate school part-time in order to obtain a Masters D egree. I am looking forward to taking my skills, capabilities, and education el sewhere so that I may use learned research techniques to help another research t eam fulfill their goals. I am also looking forward to learning new techniques a nd new avenues of scientific research from my peers. EMPLOYMENT HISTORY Research Assistant II, Department of Pharmacology, School of Medicine Case Western Reserve University, Cleveland, OH November 2007 - present time * Supervisor of a clinical and research team in a pharmacology lab responsible f or the following duties: o Clinical/translational and basic science research on mitochondrial function as sociated with genetic and metabolic defects in humans o Biochemical analyses and clinical-diagnostic evaluation of human mitochondria, human tissue specimens, and human skin fibroblasts and lymphoblasts o Biochemical analyses of animal mitochondria from various tissue types o Use of spectrophotometric enzyme assays to perform clinical/translational and basic science research * Enzyme assays include enzymes of the electron transport chain, fatty acid oxid ation, and tricarboxylic acid cycle o Use of spectrophotometric enzyme assays in order to study mitochondrial bioene rgetics in two animal models * Canine model of pacing-induced heart failure and heart failure due to microemb olism * Rat model of heart disease comparing normal and high fat diets * Writing and reviewing laboratory protocols * Assay validation, Quality Assurance/Quality Control, and Assay Troubleshooting when protocols need to be revised/improved * Responsible for ordering laboratory supplies and chemicals * General maintenance of laboratory equipment * Responsible for participating in the interview process of potential candidates for laboratory positions * Responsible for playing a major role in the selection of candidates for hire * Responsible for training of new hires to be a part of the research team under my supervision * Responsible for ensuring all work is in compliance with CLIA (Clean Laboratory Inspection Act) guidelines, responsible for maintaining the CLIA database and n otebooks for yearly inspections * Cell culture of human skin fibroblast cell lines * Transformation of human blood lymphocytes into lymphoblasts by a transfection method using Epstein-Barr virus and further culture of the cell lines Research Assistant I, Department of Pharmacology, School of Medicine Case Western Reserve University, Cleveland, OH

November 1998 - November 2007 * Team member of a clinical and research team in a pharmacology lab responsible for the following duties: o Clinical/translational and basic science research on mitochondrial function as sociated with genetic and metabolic defects in humans o Biochemical analyses and clinical-diagnostic evaluation of human mitochondria, human tissue specimens, and human skin fibroblasts and lymphoblasts o Biochemical analyses of animal mitochondria from various tissue types o Use of spectrophotometric enzyme assays to perform clinical/translational and basic science research * Enzyme assays include enzymes of the electron transport chain, fatty acid oxid ation, and tricarboxylic acid cycle o Use of spectrophotometric enzyme assays in order to study mitochondrial bioene rgetics in two animal models * Canine model of pacing-induced heart failure and heart failure due to microemb olism * Rat model of heart disease comparing normal and high fat diets * Responsible for ensuring all work is in compliance with CLIA (Clean Laboratory Inspection Act) guidelines, responsible for maintaining the CLIA database and n otebooks for yearly inspections * Cell culture of human skin fibroblast cell lines * Transformation of human blood lymphocytes into lymphoblasts by a transfection method using Epstein-Barr virus and further culture of the cell lines Operations Supervisor Sterling Protective Services, Inc., Columbus, OH September 1997 - September 1998 * Programmed and downloaded security codes for home security systems into a cent ral station computer while working closely with the field technicians * Monitored security breaches received from the home security systems and took t he proper alert steps * Scheduled service duties for the field technicians Autotechnician I Centeon Bio-Services, Inc., Columbus, OH July 1997 - September 1997 * Prepared patients before plasma donation procedure * Operated and maintained plasma separation machinery Laboratory Assistant The Ohio State University Toxicology Department, Columbus, OH May 1997 - July 1997 * Prepared algae cultures for toxic substance testing * General maintenance of laboratory equipment and ordering of supplies

EDUCATION Bachelors of Science in Microbiology: June 12, 1998 The Ohio State University Columbus, OH Masters of Science in Nutrition: August 10, 2007 Case Western Reserve University Cleveland, OH

PUBLICATIONS * Rennison JH, McElfresh TA, Okere IC, Vazquez EJ, Patel HV, Foster AB, Patel KK , Chen Q, Hoit BD, Tserng KY, Hassan MO, Hoppel CL, Chandler MP. High-fat diet postinfarction enhances mitochondrial function and does not exacerbate left vent ricular dysfunction. Am J Physiol Heart Circ Physiol. 2007 Mar;292(3):H1498-506 . * Rennison JH, McElfresh TA, Okere IC, Patel HV, Foster AB, Patel KK, Stoll MS, Minkler PE, Fujioka H, Hoit BD, Young ME, Hoppel CL, Chandler MP. Enhanced acyl -CoA dehydrogenase activity is associated with improved mitochondrial and contra ctile function in heart failure. Cardiovasc Res. 2008 Jul 15;79(2):331-40. * O'Toole JF, Patel HV, Naples CJ, Fujioka H, Hoppel CL. Decreased cytochrome c mediates an age-related decline of oxidative phosphorylation in rat kidney mito chondria. Biochem J. 2010 Mar 15:427(1):105-12. AFFILIATIONS * CIDEM: Center for Inherited Disorders of Energy Metabolism * UMDF: United Mitochondrial Disease Foundation COMPUTER SKILLS * MS Office Applications (reports, correspondence, data organization and analysi s) * GraphPad Prizm (data organization and analysis) * Internet skills (scientific searches) SPOKEN LANGUAGES * English, Gujarati

REFERENCES * Dr. Edith Lerner, PhD. Associate Professor and Department Vice-Chair Department of Nutrition Case Western Reserve University 10900 Euclid Avenue School of Medicine, WG-48 Cleveland, OH 44106 (216) 368-2443 exl2@case.edu * Dr. Michelle Puchowicz., PhD. Co-Director, Mouse Metabolic Core, MMPC Departments of Nutrition & Anatomy Case Western Reserve University 10900 Euclid Avenue BRB-927

Cleveland, OH 44106 (216) 368-2501 map10@case.edu * Dr. Janos Kerner, PhD. Associate Professor Departments of Nutrition and Pharmacology Case Western Reserve University 10900 Euclid Avenue School of Medicine, W-165 Cleveland, OH 44106 (216) 368-4783 janos.kerner@case.edu * Dr. Mariana Rosca, MD. Research Associate Department of Pharmacology Case Western Reserve University 10900 Euclid Avenue School of Medicine, W-149 Cleveland, OH 44106 (216) 368-6029 mariana.rosca@case.edu