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1) Thiazide used in t/t of a/e a) Idiopathic hypercalceuria with nephrocalcinosis b) Hyperlipidemia c) CCF 2) IPC prohibits the disclosure of the identity of victims in rape under A) Section 225A B) Section 226A C) Section 227A D) Section 228A 3) Sham rage is seen in a) Decerebrate animals b) Decorticate animals c) Hypothalamic lesions 4) Sham rage is seen in a) Decerebrate animals b) Decorticate animals c) Hypothalamic lesions 5) Doc for syphilis in pregnant lady a) Penicillin B.ERYTHROMYCIN C. D. 6) Glasgow coma scale- Verbal Makes inappropriate words a) 4 b) 3 c) 2 d) 1 7) pt. was infected with MRSA. All of the following can be given except A) Cotrimoxazole B) Ceflacor D) Ciprofloxacin D) Vancomycin 8) In Japan, known as detergent suicide, a near-instant death achieved by mixing common household chemicals into a poisonous cloud of gas a. detergent effect of household chemicals b. h2s c.

d. production of poisonous gasses by mixing household chemicals Pancreas on CT shows grape like clusters and dilated pancreatic duct a) Ductectatic Mucinous Cystic Neoplasms 9) Cholera toxin acts via secondary messenger a) cAMP b) cGMP c) Ca2+ d) IP3 10) Rheumatoid factor is a) IgM antibody directed against IgG b) IgG antibody directed against IgM 11) Temozolamide is a) Oral alkylating agent b) Antibiotic antitumor Ref Temozolomide is an oral alkylating agent used for the treatment of Grade IV astrocytoma an aggressive brain tumor, also known as glioblastoma multiforme as well as for treating melanoma, a form of skin cancer. Temozolomide is also indicated for relapsed Grade III Anaplastic Astrocytoma and not indicated for, but as of 2011 used to treat oligodendroglioma brain tumors in some countries, replacing the older (and less welltolerated) PCV (Procarbazine-Lomustine-Vincristine) regimen. The agent was developed by Malcolm Stevens and his team at Aston University in Birmingham, A derivative of imidazotetrazine, temozolomide is the prodrug of MTIC (3methyl-(triazen-1-yl)imidazole-4-carboxamide). It has been available in the US since August 1999, and in other countries since the early 2000s. The therapeutic benefit of temozolomide depends on its ability to alkylate/methylate DNA, which most often occurs at the N-7 or O-6 positions of guanine residues. This methylation damages the DNA and triggers the death of tumor cells. However, some tumor cells are able to repair this type of DNA damage, and therefore diminish the therapeutic efficacy of temozolomide, by expressing an enzyme called O-6-methylguanine-DNA methyltransferase (MGMT) or O-6-alkylguanine-DNA alkyltransferase (AGT or AGAT). In some tumors, epigenetic silencing of the MGMT/AGT gene prevents the synthesis of this enzyme, and as a consequence such tumors are more sensitive to killing by temozolomide. Conversely, the presence of MGMT protein in brain tumors predicts poor response to temozolomide and these patients receive little benefit from chemotherapy with temozolomide 12) Person with accident unable to abduct shoulder and flex at elbow due to a) Shoulder dislocation b) Medial cord injury c) Lateral cord injury d) Upper trunk injury 13) Which fluoroquinolone shows the longest half-life? a) Levofloxacin b) Lomefloxacin c) Grepafloxacin d) Moxifloxacin 14) A Gram-negative marine bacterium causing ear infection a) Vibrio cholera b) Vibrio parahemolyticus c) Vibrio alginolyticus d) Vibrio mimicus

15) Apixaban a) Inhibits factor Xa B)tnf a inhibitor C)anti platelet ref Apixaban (manufacturer's designation BMS-562247-01, tradename Eliquis) is a compound being investigated as an anticoagulant. It is a direct factor Xa inhibitor. It is presently undergoing phase III trials in the prevention of venous thromboembolism, together with a number of related competing compounds, such as rivaroxaban.[1] It is being developed in a joint venture by Pfizer and Bristol-Myers Squibb 16) Most common cause of Mobius Syndrome while pregnant is use of the drug a) Misoprostol b) Thalidomide 17) In a case of repeated chalazion on upper eye lid, the biopsy was done. The most probable diagnosis on histopathology a) Sebaceous cell Ca b) Basal cell Ca c) Squamous cell Ca 18) Median is Imp for all except a) Blood pressure, b) Survival Time, c) Incubation Period, d) Health Expenses 19) Electromechanical systole a) Q wave onset to peak S1 b) Q wave onset to peak S2 20) Dilator pupillae is supplied by a) Postganglionic cervical sympathetic chain b) Postganglionic parasympathetic neurons 21) All of the following are bactericidal except a) Daptomycin b) Tigecycline 22) Langerhans histiocytosis a) CD1a 23) Individual intraoperative awareness is evaluated by a) Pulse oximetry b) Bispectral index c) Color Doppler d) End tidal CO 24) A patient with BP 220/120, sudden death, pathological finding of kidney? a) Petechial hemorrhage on cortex with normal size kidney b) Small kidney with granular surface c) Large edematous kidney with waxy surface d) Small contracted kidney with scars Kegels exercise is advised a) Immediately after delivery b) 3 months after delivery c) 24 hrs. after delivery ref --- Kegel exercise

A pelvic floor exercise, more commonly called a Kegel exercise (named after Dr. Arnold Kegel), consists of contracting and relaxing the muscles that form part of the pelvic floor, which are now sometimes colloquially referred to as the "Kegel muscles". Several tools exist to

help with these exercises, though many are ineffective. Exercises are usually done to reduce urinary incontinence and aid with childbirth in women, and reduce premature ejaculatory occurrences in men,as well as increase the size and intensity of erections.

The aim of Kegel exercises is to improve muscle tone by strengthening the pubococcygeus muscles of the pelvic floor. Kegel is a popular prescribed exercise for pregnant women to prepare the pelvic floor for physiological stresses of the later stages of pregnancy and vaginal childbirth. Kegel exercises are said to be good for treating vaginal prolapse and preventing uterine prolapse in women and for treating prostate pain and swelling resulting from benign prostatic hyperplasia (BPH) and prostatitis in men. Kegel exercises may be beneficial in treating urinary incontinence in both men and women.Kegel exercises may also increase sexual gratification and aid in reducing premature ejaculation.Many actions that are controlled by Kegel muscles include "holding in" urine or avoiding defecation. Reproducing these types of muscle actions can yield stronger Kegel muscles.

A Kegel exerciser Pelvic toning devices A pelvic toning device (generically referred to as a Kegel exerciser, pelvic floor toner, pelvic floor muscle toner or pelvic toner) is a medical or pseudo-medical device designed to help women exercise their pelvic floor muscle and improve the muscle tone of the pubococcygeal or vaginal muscle. The original pelvic toning device was the perineometer invented by Arnold Kegel to facilitate the measurement of the strength of the pubococcygeus muscle when it was resting and being actively squeezed - sometimes referred to as the Kegel tone. Unfortunately his device was a combination of rubber balloons and tubes that measured pressure using a column of water. It was neither easy to use nor portable. During the latter part of the 20th century a number of medical and pseudo-medical devices were developed and launched onto the market. Some of these are used in a clinical setting, but most are designed for women to use in the privacy of their own home. Pelvic toning devices fall into a number of different types: barbells, vaginal weights or cones designed to be held in the vagina. The action of passively/actively retaining the device internally is supposed to improve muscle tone. Barbells are made of smooth, polished solid stainless steel, cylindrical in shape, with a rounded bulge at each end. They typically weigh one pound (454 g) and measure approximately 6 inches (17.1 cm) in length with a diameter of one inch (2.5 cm) at the widest part. Being made of stainless steel, vaginal barbells are nonporous and can be wiped clean with a cloth moistened with mild soap and water. electro-stimulation or TENS devices that administer an electrical current through an internal probe. The current stimulates the adjacent muscles to twitch. rubber resistance balls and indicators. These devices provide a nominal resistance to squeeze against. An advantage of rubber bulb devices is that they provide visual feedback (via a gauge) of how much pressure is being applied. progressive resistance vaginal exercisers with springs are the only devices that meet all of Kegel's criteria. They provide a biofeedback that the correct muscles are being engaged and are capable of fulfilling the basic fundamentals of an exercise regime by applying a variable and increasing resistive force to maximise the exercise effort. Unfortunately there are a number of products on the market that have no impact at all on the pubococcygeus muscle. If the PC muscle is not engaged then it is impossible to improve the

muscle tone or strengthen the muscle. Devices that are used externally, for example between the thighs, may exercise the adductor muscle but do nothing for the pelvic floor. Benefits for women Factors such as pregnancy, childbirth, aging, being overweight, and abdominal surgery such as cesarean section, often result in the weakening of the pelvic muscles. This can be assessed by either digital examination of vaginal pressure or using a Kegel perineometer. Kegel exercises are useful in regaining pelvic floor muscle strength in such cases. Urinary incontinence The consequences of weakened pelvic floor muscles may include urinary or bowel incontinence, which may be helped by therapeutic strengthening of these muscles. A metaanalysis of randomized controlled trials by the Cochrane Collaboration concluded that "PFMT [Pelvic floor muscle training] be included in first-line conservative management programs for women with stress, urge, or mixed, urinary incontinence...The treatment effect might be greater in middle aged women (in their 40s and 50s) with stress urinary incontinence alone...". Pelvic prolapse The exercises are also often used to help prevent prolapse of pelvic organs. A meta-analysis of randomized controlled trials by the Cochrane Collaboration concluded that "there is some encouragement from a feasibility study that pelvic floor muscle training, delivered by a physiotherapist to symptomatic women in an outpatient setting, may reduce severity of prolapse". Benefits for men

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join this website for get updated Though most commonly used by women, men can also use Kegel exercises. Kegel exercises are employed to strengthen the pubococcygeal muscle and other muscles of the pelvic diaphragm. Kegels can help men achieve stronger erections and gain greater control over ejaculation.[5] The objective of this may be similar to that of the exercise in women with weakened pelvic floor: to increase bladder and bowel control and sexual function' Incontinence Regarding postprostatectomy urinary incontinence, a meta-analysis of randomized controlled trials by the Cochrane Collaboration found "conflicting information about the benefit of pelvic floor muscle training for either prevention or treatment of urine leakage". Sexual function Kegel workouts can provide men with stronger erections.Research published in 2005 issue of BJU International, have shown that pelvic floor exercises could help restore erectile function in men with erectile dysfunction. There are said to be significant benefits for the problem of premature ejaculation from having more muscular control of the pelvis. It is also possible that strengthening the pelvic floor may allow some men to achieve a form of orgasm without allowing ejaculation, and thereby perhaps reach more than one "climax" during sexual activity.In men, this exercise lifts up the testicles, also strengthening the cremaster muscle, as well as the anal sphincter muscles, as the anus is the main area contracted when a Kegel is done. This is because the pubococcygeus muscle begins around the anus and runs up to the urinary sphincter.

25) Doesnt pass anterior to the ureter? 1. Terminal ileum 2. Vas deferens 3. Inferior epigastric artery 4. Genitofemoral nerve 26) The appearance of cortical cataracts show up small linear opacities like "spokes of a wheel". a) Lamellar cataract b) Punctate cataract c) Cataract centralis pulverulenta d) Coronary cataract 27) Dermatome of little finger a) C6 b) C7 c) C8 d) T1 28) Congenital aplastic anemia a) FANCONI ANEMIA 29) Erythematous lesions with Collarets of scales on trunk a) Pityriasis rubra b) Pityriasis rosea 30) What is not a complication in fracture head of femur? a) Shortening b) Malunion c) Non union 31) Itchy lesion, linear IgA deposit in basilar membrane a) Dermatitis herpetiformis b) Chronic bullous disease of child 32) Small vessels vasculitis seen in a) giant cell arteritis b) takayasu arteritis c) PAN d) Microscopic Polyangitis 33) Sex ratio of children between 0-6 years a) 914 b) 923 c) 940 d) 944 34) Man with asbestos exposure for 20 yrs with involvement of lower lobe and Comet tail sign a) Round atelectasis b) Mesothelioma 35) Smallest AP diameter of skull in a) Trignocepahaly b) Brachycephaly c) Oxycepahly d) Dolichocephaly 36) Renal scarring detect in infected kidney is detected by a) DTPA b) DMSA 37) Salmonella typhi - dose needed to infect human a) 1 bacilli

b) 10 bacilli c) 10^2 - 10^5 bacilli d) 10^8 10^10 bacilli 38) Drug induced osteomalacia a) steroid b) Heparin c) Phenytoin 39) anterior relation of ureter a/e 1- vas deferens 2- terminal ileum 3- iliocolic artery 4- genitofemoral nerve 40) Investigation of choice in Hirschsprungs disease A. rectal biopsy B.Barium enema C.MR angiography D.manometry 41) Type of hypersensitivity in myasthenia gravis a) Type 1 b) Type 2 c) Type 3 d) Type 4 42) Pt. has external strabismus, ptosis and uniocular diplopia. It shows the involvement of a) Trochlear b) Occulomotor 43) Agent is there in the environment but no transmission is taking place A) Elimination B) Control C) Eradication d) Holoendemic 44) In Preeclampsia a) GFR low b) GFR high c) remains same 45) In ARDS a) Diffuse alveolar damage 46) IUCD not necessary to change after 3 - 5 yrs. a) Cu 380A b) Cu 200 47) Which of the following is a cause of psychosis on a cocaine user? A. tolerance B. Withdrawal C. regular intake D. Reverse tolerance 48) Functioning of a gene can be best demonstrated by a) Western blotting b) Southern blotting c) Gene knock out d) Transgenic animals 49) Amylin is secreted by: a) Alpha cells

b) Beta cells c) Gamma cells d) Delta cells ref Amylin, or Islet Amyloid Polypeptide (IAPP), is a 37-residue peptide hormone secreted by pancreatic -cells at the same time as insulin (in the roughly 1:100 ratio of amylin to insulin) Amylin functions as part of the endocrine pancreas and contributes to glycemic control. The peptide is secreted from the pancreatic islets into the blood circulation and is cleared by peptidases in the kidney. It is not found in the urine. 50) Porphyria with autosomal recessive inheritance a) Congenital erythropoietic porphyria 51) Least likely to cause infective endocarditis a) Small VSD b) Small ASD c) AS d) AR 52) All Structures Are derivatives of pharyngeal arches except? a) Tensor veli palatine. b) LPS c) Stapedius. d) Palatine Tonsils 53) All nerves supply the auricle except. a) Greater Auricular b) Lesser Occipital. c) Tympanic Branch of glossopharyngeal d) Auricular branch of Xth nerve 54) Diabetic elderly male with painful lesion in external ear, bone erosion with facial nerve palsy and resistant to antibiotics. Diagnosis a) Malignant Otitis Externa b) Nasopharyngeal carcinoma c) CSOM 55) Disease spread by culex, anopheles and aedes globally 1) Malaria 2) Filaria 3) Dengue 4) Yellow fever 56) 57) All cause Conduction Deafness Except? a) Endolymphatic Hydrops b) Otosclerosis. c) Serous Otitis Media d) Suppurative otitis media 57) 58) All are mixed germ cell tumor except a) Granulosa cell tumor b) Dysgerminoma c) Endodermal sinus tumor d) Choriocarcinoma 58)59) In active management of 3rd stage of labour, all are done except a) Controlled cord traction b) inj Methergine c) inj Syntosin d) Massage of uterus

59) 60) Old blood stain is detected using? a) LUMINOL SPRAY b) Infrared rays ans c) ultraviolet 60) 61) Common enzyme utilized in cholesterol and ketone synthesis a) HMG Co-A synthetase b) HMG Co-A reductase 61) Lesion developed from Olfactory Mucosa? a) Esthesionneuroepithelioma 62) In Kallman syndrome, which of the following is increased? a) LH b) FSH c) TSH d) GHRELIN 63) mitochondria involved in a/e 1fatty acid synthesis 2chromosome 3 fatty acid redn 4protin 64) person wid accident unable to abduct shlder nd flex at elbow due to a.shoulder dislocatn b.medial cord injry c.lat cord injry d.post cord injry 65) Electromechanical point?? R wave to S1 Q wave to S2 66) LN enlargement seen in invovlment of a/e a. Middle Ear Disease b. Nasopharyngeal involvement c d 67) All cause Conduction Deafness Except? a. menieres disease ( Hydrops) b. otosclerosis. c. serous OTitis Media d. 68) 12 yr old girl, rapid gain in height since last 11 months, inability to sit with legs crossed and difficulty in squatting, on bending knee reaches same side axilla, whats the most probable diagnosis? a. SCFE b. c. d. 69) middle aged male comes wiyth shortening of leg by 7 cms, Hip in Flexion and External Rotation, clinically hard mass palpable in lateral gluteus region, whats the most probable Diagnosis? a Post Dislocation. b, Central Dislocation. c. Grade 4 Dislocation. d. Fracture of acetabulum with dislocation of Hip joint.

70) Inability to Abduct Shoulders and inability to flex elbow.. Most Likely Cause? a. Shoulder Dislocation b Lateral Cord Injury c Anterior Trunk Injury. d Medial Cord Injury 71) All Are True about SACH- ic10 Except? a. Full Form is 'Solid Ankle Cushion Heel. b. managed by ... c. woody heel.... d. 72) . Proximal Segment of Scaphoid Fracture goes into AVN Due To? a. REtrograde Blood Supply to Scaphoid b. c. d. 73) . Tuberculosis Bone Is due to? a. Hematogenous Spread b. Lymphatic Spread. 74) Deep ant. chamber with scar on limbus with 10D lens: 1.Aphakia 2.Pseudophakia 3.post dislocation lens 75) Q most resistant to disinfectants and antiseptics: 1.spore 2.prions 3.bacteria 4.virus. 76) mosquito- culex anap aedes commonly transmits? a.JE B.YF C.filariasis 77) O site for binding of oligosacharide is seen in which amino acid ? A.Asparagine B. threonine C.serine 78) autosomal recessive inheritance in porphyria... A.acute intermittent B.heriditary C.congenital D.porphyria cutanea tarda 79) Pt has external strabismus, ptosis and uniocular diplopia. Involvement of ? A.Trochlear B. Occulomotos C. abducent What causes increased triglycerides and lipid dystrophy? 1. Nevirapine 2. Lamivudine 3. Zidovudine 4. Ritonavir. ANS

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80) . Blood group A will have which genotype? A. OO B. AO C. AB C. BO 81) east likely to develop endocarditis? a.vsd b.asd c.mr d.ar 82) immune complex shoes what protein structure? A.primary B.secondary C.tertiary D.quarternary 83) Spleen is a common site for metastasis from A. Pancreatic Ca B. Stomach Ca C. Ovarian Ca D. endometrial Ca 84) . pyrogenic cytokinin, a/e: 1. il-6 2. il-18? 3. tnf 4.inf-a 85) design effect is used for??? 1. stratified sampling 2. simple random sampling 3. cluster sampling 86) alcohol consumption amount was measured b4 and after an intervention program? Test used 2 analyse significance of diff in amount of alcohol?? Paired T Chi square Unpaired T --?? Ans: paired T 87) definite method of identifying gene functn? Western blot southern blot productn of transgenic animals productn of knock out animals 88) Clozapin except More potent block D2? greater than D1? Blood level below 350 should be maintaines shoud be stoppped at wbc<3000 Not used with Carbamazepine 89) difference between 20% and 10% lipid solution of lipids all except? A. Less hyper triglyceridemia

B. Less hpyer cholesterolemia C. less energy supplied D.? 90) A young boy came with dyspnea and was found to have a mediastinal mass. which of the following is known to produce mediastinal lymphadenopathy? A.diffuse large B cell Lymphoma B. B cell rich T cell lymphoma C. T cell ALL D. 91) 209. Which of these is not a cause of increased MCV and normal MCH ? A. Aplastic bone marrow B. Thalasemia C. Vit B12 deficiency D. 92) 16YRS Macro adenoma is defined as being above what size A. 1.5 cm B 1 cm C. 2 cm D. 2.5 cm 93) 94) Which muscle relaxant causes pain on injection ? A. Succinyl choline B. Vecuronium C. Rocuronium D. 95) Retinoblastoma most commonly metastasize by? A. Hematogenous route B. Lymphatic C Optic nerve D. Direct extension 96) . A young man living in a metropolitan city comes with abuse to a particular drug. He says he Sees sounds and hears colours. What substance is he taking? A. LSD ans B. PCP C. cocaine D. 97) 98) which of these is the most common tumor in a fetus? A. Wilms tumor B. Neuroblastoma C. D. 99) newborn of diabetic mother with blood glucose levels 35 mg per 100ml. what should be line of treatment. a. fortified expressed breast milk b. 10%dextose @10ml/kg b.wt. by oral route c. 10%dextrose i.v. 100) Which of these causes Central retinal arterial occlusion ? A. Orbital mucormycosis B. Cytomegalovirus virus retinitis

C. Diabetes mellitus D. ? 101) A 70 years old male after catarct surgery complained of diminished vision. On FFA Petals of flower appearance was noticed and_____ whats the probable diagnosis ? A. Cystoid macular edema B. Central serous retinopathy C. Endophthalmitis D. 102) drug efficacy between 2 drugs compared in which phase of trial? A. Phase 1 B. Phase 2 C. Phase 3 D. Phase 4 103) which tumor erupting from nasal neuro epithelium ? A. B. astrocytoma C. glioma D. 104) Case control studies differ from cohort studies in A. Case control does not measure the exposure in study and exposure group B. cohort studies require long term exposure studies C. 105) after 12-24 hrs starvation, what will not happen? 1. Increase free fatty acid 2. increase ketone bodies. 3. decreased glycogen 4. decreased serum protiens. ANS 106) There is no conduction deficit in electro physiological studies in ? A.Diffuse motor neuropathy B. leprosy C.AIDP ANS 107) extensor plantar, ankle and knee reflex absent ? A.Friedrichs ataxia B. 108) Not useful in MRSA ? A.Cefaclor, B.ciprofloxacin, C. vancomycin repeat 109) Hb values, mean is 10 gm/dl. sample size - 100 , SD 1. Wat is the standard Error ? A.0.1, ANS B.10... REPEAT 110) Sexual function controlled by which part of hypothalamus ? A.Supraoptic, B.paraoptic,C. posterior hypoth, D.lat hypothal 111) A person arrested for sodomy. Confesses tHat he is an active agent. Wat is not found in him ? A.Constriction in mid shaft B. presence of smegma, ANS C. tear in frenulum

112) basal exudates, infarcts, hydrocephalus? A.TB meningitis. ANS... B.VIRAL MENINGITIS 113) Cordotomy done to relieve pain in right lower limb . Wat kind ? A.Right spinothalamic tract, B.left spinothalamic tract ANS.... REPEAT 114) which part of the brain must be stimulated using...... in Parkinsonism ? A.Substantia nigra ANS ,B. putamen, ... 115) mean blood sugar of d. patient 105, range for 95% confidence limit? A.85-125,ANS B. 65-100,

116) child with recurrent infection by bac havin polysaccaride capsule, what assay to b done: IgA, A.IgG1, B.IgG2 C.IgA D. IgG2 117) least common presentation in multiple myeloma ? A.hyperviscosity B. anemia C.bone pains, D. infections

118) child involved in repetitve tasks, no communication? A. Autism... ANS B. ADHD C. S D. 119) . Drug of choice in IBS (constipation type) A.LUBIPROST ANS B. C. D.

103.scholastic performance impeded by all except ? A.ADHD B.PICA 120) lymphoma least commomly inA.ataxia telengiectasia, B. comb C.imm def D.SLE

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