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Misuse of propoxyphene, either alone or in combination with other CNS depressants, has been a major cause of drug-related deaths. Many psychotherapeutic and CNS-active agents exhibit hypotensive effects, especially during initiation and dose escalation.
Misuse of propoxyphene, either alone or in combination with other CNS depressants, has been a major cause of drug-related deaths. Many psychotherapeutic and CNS-active agents exhibit hypotensive effects, especially during initiation and dose escalation.
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Misuse of propoxyphene, either alone or in combination with other CNS depressants, has been a major cause of drug-related deaths. Many psychotherapeutic and CNS-active agents exhibit hypotensive effects, especially during initiation and dose escalation.
Hak Cipta:
Attribution Non-Commercial (BY-NC)
Format Tersedia
Unduh sebagai DOCX, PDF, TXT atau baca online dari Scribd
Generic Name Trade Name Classification Dose Route Time/frequency
propoxyphene Darvocet-N opioid analgesics 100-200 mg PO q 4 hours PRN napsylate/acetaminophen Peak Onset Duration For IV meds, compatibility with IV drips and /or 2-3 hr 15-60 min 4-6 hr solutions N/A Mechanism of action and indications Nursing Implications (what to focus on) (Why med ordered) Contraindications/warnings/interactions Mild to moderate pain Appears on Beers list. Elderly or debilitated patients require Binds to opiate receptors in the CNS reduced dosages Alters the perception of and response to painful stimuli, while producing Undiagnosed abdominal pain, Hypothyroidism, generalized CNS depression Common side effects dizziness, weakness, nausea Interactions with other patient drugs, OTC or herbal medicines (ask Lab value alterations caused by medicine patient specifically) May cause ↑ serum amylase and lipase levels, May cause ↑ Lisinopril: Many psychotherapeutic and CNS-active agents (e.g., AST, ALT, serum alkaline phosphatase, LDH, and bilirubin anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants) exhibit hypotensive effects, especially during Be sure to teach the patient the following about this initiation of therapy and dose escalation. Coadministration with medication antihypertensive agents, in particular vasodilators and alpha-blockers, Instruct patient on how and when to ask for pain medication may result in additive effects on blood pressure and orthostasis. Encourage patient to turn, cough, and breathe deeply every Lexapro, Restoril, Percocet, morphine, Reglan, Phenergan: Sedatives, 2 hr to prevent atelectasis tranquilizers, muscle relaxants, antidepressants, and other central nervous Advise patient to change positions slowly to minimize system (CNS) depressants may have additive CNS- and/or respiratory- orthostatic hypotension depressant effects with propoxyphene. Misuse of propoxyphene, either Advise patient that good oral hygiene, frequent mouth alone or in combination with other CNS depressants, has been a major rinses, and sugarless gum or candy may decrease dry mouth cause of drug-related deaths, particularly in patients with a history of emotional disturbances, suicidal ideation, or alcohol and drug abuse. Nursing Process- Assessment Assessment Evaluation (Pre-administration assessment) Why would you hold or not give this Check after giving Assess type, location, and intensity of pain prior to and 2 hr med? Decrease in severity of pain (peak) following administration. Assess blood pressure, pulse, and without a significant Assess bowel function routinely. Prevention of constipation respirations before and periodically alteration in level of should be instituted with increased intake of fluids and bulk, during administration. If respiratory rate consciousness and laxatives to minimize constipating effects. Stimulant is <10/min, assess level of sedation. laxatives should be administered routinely if opioid use Physical stimulation may be sufficient to exceeds 2-3 days, unless contraindicated prevent significant hypoventilation. Dose Geriatric patients may be more sensitive to CNS effects; may need to be decreased by 25-50%. monitor closely and assess falls risk Initial drowsiness will diminish with continued use