Clinical features of the initial cases 2009 Pandemic influenza A (H1N1) virus infection in china

BACKGROUND
The first case of 2009 pandemic influena A (H1N1)virus infection in china was documented on may 10. Subsequently, persons with suspected cases of infection and contacts of those with suspected infection were tested. Persons in whom infection was confirmed were hospitalized and quarantined, and some of them were closely observed for the purpose of investigatingthe nature and duration of the disease Kasus pertama tahun 2009 pandemi infeksi influena A (H1N1) di cina didokumentasikan pada 10 Mei. Selanjutnya, orang dengan kasus yang dicurigai infeksi dan kontak mereka dengan infeksi dicurigai diuji. Orang di antaranya infeksi dikonfirmasi dirawat di rumah sakit dan dikarantina, dan beberapa dari mereka erat diamati untuk tujuan alam investigatingthe dan durasi penyakit

METHODS
During may and june 2009, we observed with the 2009 pandemic influena A (H1N1) virus who were quarantined in 61 hospital in 20 provinces. Realtime reverse polymerase china-reaction (RT-PCR) testing was used to confirm infection, the clinical features of the disease were closely monitored, and 254 patients were treated with oseltamivir within 48 hours after the onset of disease. Selama mungkin dan Juni 2009, kami mengamati dengan virus 2009 (H1N1) pandemi influena Seorang yang dikarantina dalam 61 rumah sakit di 20 provinsi. Reverse-polimerase-cina-reaksi realtime (RT-PCR) pengujian digunakan untuk mengkonfirmasi infeksi, fitur klinis dari penyakit yang diawasi secara ketat, dan

254 pasien dirawat dengan oseltamivir dalam waktu 48 jam setelah onset penyakit were treated with oseltamivir within 48 hours after the onset of disease.

RESULTS
The mean age of the 426 patients was 23.4 years, and 53.8% were male. The diagnosos was made atpots of entry (in 32.9%), during quarantime (20,2%),and in the hospital (46.9%) . the median incubation period of the virus was 2 days (range,1 to 7). The most common symptoms were fever (in 67.4%of the patients) and vomiting was 1.9%. lymphopenia, which was common in both adults (68.1%) day 7 ( range, 6 to 9). Hypokalemia was observed in 25.4%of the patients . duration of fever was typically 3day (range, 1 to 11). The median length of time during which patients had positive real-time RT-PCR test results was 6 days (range,1 to 17.) independent risk factors for prolonged real-time RT-PCR positivity included an age of less than 14 years ,male sex, and a delay from the onset of symptoms to treatment with oseltamivir of more than 48 hours. Usia rata-rata dari 426 pasien adalah 23,4 tahun, dan 53,8% adalah laki-laki. Para diagnosos dibuat atpots masuk (dalam 32,9%), selama quarantime (20,2%), dan di rumah sakit (46,9%). masa inkubasi rata-rata virus adalah 2 hari (kisaran, 1 sampai 7). Gejala yang paling umum adalah demam (di 67,4% dari pasien) dan muntah adalah 1,9%. limfopenia, yang umum pada orang dewasa (68,1%) hari 7 (kisaran, 6 sampai 9). Hipokalemia diamati pada 25,4% pasien. durasi demam biasanya 3day (kisaran 1 sampai 11). Panjang rata-rata waktu di mana pasien telah positif real-time RT-PCR hasil tes adalah 6 hari (kisaran, 1 sampai 17.) Faktor risiko independen untuk berkepanjangan positif real-time RT-PCR termasuk usia kurang dari 14 tahun, kelamin laki-laki, dan penundaan dari timbulnya gejala untuk pengobatan dengan oseltamivir lebih dari 48 jam.

CONCLUSIONS
Surveillance of the 2009 H1N1 virus in china shows that the majority of those infected have a mild illness. The typical period during which the virus can be detected with the use of real-time RT-PCR is 6 days (whether or not fever is

present). The duration of infection may be shortened if oseltamivir is administered. In early april 2009, cases of human infection with 2009 pandemik influena A (H1N1)virus were identified in the united. Pengawasan virus H1N1 2009 di cina menunjukkan bahwa mayoritas dari mereka yang terinfeksi memiliki penyakit ringan. Periode yang khas selama virus dapat dideteksi dengan menggunakan real-time RT-PCR adalah 6 hari (apakah atau tidak demam hadir). Durasi infeksi dapat dipersingkat jika oseltamivir diberikan. Pada awal April 2009, kasus infeksi pada manusia dengan 2009 pandemik influena A (H1N1) telah diidentifikasi dalam bersatu. States and maxico virus then spread rapidly to other regions of the world the 2009 H1N1virus is a triple-reassortant influenza virus containing genes from human , swini, and avian influenza virus after documentation of human-to-human transmission of the virus in at least three countries in two of the six world regiaons defined by the world health organization (who) the WHO raised the pandemic level from 5 to 6 the highest level. Negara dan maxico virus maka menyebar dengan cepat ke daerah-daerah lain di dunia yang H1N1virus 2009 adalah triple-reassortant virus influenza yang mengandung gen dari manusia, swini, dan virus flu burung setelah dokumentasi dari manusia ke manusia penularan virus dalam setidaknya tiga negara di dua dari enam regiaons dunia didefinisikan oleh organisasi kesehatan dunia (yang) WHO menaikkan tingkat pandemi dari 5 sampai 6 tingkat tertinggi.