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Contents

part one

General Embryology ...1

chapter 1

Gametogenesis: Conversion of Germ Cells Into Male and

Female Gametes ...3

chapter 2

First Week of Development: Ovulation to


Implantation ...31

chapter 3

Second Week of Development: Bilaminar Germ


Disc ...51

chapter 4

Third Week of Development: Trilaminar Germ


Disc ...65

chapter 5

Third to Eighth Week: The Embryonic Period


...87

chapter 6

Third Month to Birth: The Fetus and Placenta


...117

chapter 7

Birth Defects and Prenatal Diagnosis ...149

part two

Special Embryology...169

chapter 8
Skeletal System ...171

ix

xContents

chapter 9

Muscular System ...199

chapter 10

Body Cavities ...211

chapter 11

Cardiovascular System ...223

chapter 12

Respiratory System ...275

chapter 13

Digestive System ...285

chapter 14

Urogenital System ...321

chapter 15

Head and Neck ...363

chapter 16

Ear ...403

chapter 17

Eye ...415

chapter 18

Integumentary System ...427


chapter 19
Central Nervous System ...433

part three
Appendix...483
Answers to Problems ...485
Figure Credits ...499
Index ...507

Preface
The ninth edition of Langman’s Medical Embryology adheres to the tradition established by the
original publication—it provides a concise but thorough description of embryology and its clinical
significance, an awareness of which is essential in the diagnosis and prevention of birth defects. Recent
advances in genetics, developmental biology, maternal-fetal medicine, and public health have
significantly increased our knowledge of embryology and its relevance. Because birth defects are the
leading cause of infant mortality and a major contributor to
disabilities,andbecausenewpreventionstrategieshavebeendeveloped,understanding the principles of
embryology is important for health care professionals. To accomplish its goal, Langman’s Medical
Embryology retains its unique approach of combining an economy of text with excellent diagrams and
scanning electron micrographs. It reinforces basic embryologic concepts by providing numerous
clinical examples that result from abnormalities in developmental processes. The following pedagogic
features and updates in the ninth edition help facilitate student learning:

Organization of Material: Langman’s Medical Embryology is organized into two parts. The first
provides an overview of early development from gametogenesis through the embryonic period; also
included in this section are chapters on placental and fetal development and prenatal diagnosis and
birth defects. The second part of the text provides a description of the fundamental processes of
embryogenesis for each organ system.

Molecular Biology: New information is provided about the molecular basis of normal and abnormal
development.

Extensive Art Program: This edition features almost 400 illustrations, including new 4-color line
drawings, scanning electron micrographs, and ultrasound images.

Clinical Correlates: In addition to describing normal events, each chapter contains clinical correlates
that appear in highlighted boxes. This material is designed to provide information about birth defects
and other clinical entities that are directly related to embryologic concepts.

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