Cell signaling can best be defined as the process of cells communicating with each other and within the cell. The three stages of cell signaling are reception, transduction, and response. Some different ways cells receive signals are through G-proteins, ligands, tyrosine-kinase, and steroids and hormones. All of these involve the phospholipid bilayer and its protein. These communication mechanisms depend heavily on extracellular signal molecules, which are produced by the cells to signal to their neighbors or to cells further away. The signal molecules are mainly proteins. These proteins include cell-surface receptor proteins, which bind the signal molecule, plus a variety of intracellular signaling proteins that distribute the signal to appropriate parts of the cell.
Secreted Molecules Mediate Three Forms of Signaling: Paracrine, Synaptic, and Endocrine
Paracrine Signaling: Signal molecules released to local cells. It depends on signals that are released into the extracellular space and act locally on neighboring cells. Cells can communicate with cells in the immediate environment. It is especially important in the local immune response. Growth factor and clotting factors are paracrine signalling agents. Synaptic Signaling: Signal molecules released to close neighboring cell. It is performed by neurons that transmit signals electrically along their axons and release neurotransmitters at synapses, which are often located far away from the body. Endocrine Signaling: Signal molecules released into circulatory system and signaling is done at a distance. It occurs through the presence of hormones. Hormones are biologically active substances which are secreted into the bloodstream. It depends on endocrine cells which secrete hormones into the bloodstream that are then distributed widely throughout the body.
There Are Three Known Classes of Cell-Surface Receptor Proteins: IonChannel-linked, G-Protein-linked, and Enzyme-linked
Ion channel receptors 1. ligand gated ion channel 2. part of receptor acts as a gate when ligand binds to it
G proteins function as molecular switches. When they bind guanosine triphosphate (GTP), they are 'on', and, when they bind guanosine diphosphate (GDP), they are 'off'. G proteins regulate metabolic enzymes, ion channels, transporters, and other parts of the cell machinery, controlling transcription, motility, contractility, and secretion, which in turn regulate systemic functions such as embryonic development, learning and memory, and homeostasis. Human vision and smell require these receptors.