Endocrine Glands
• Are ductless glands
• Consists of cells that produce internal secretions called hormones
Hormones are
• Chemical messengers
• Enter directly into the bloodstream
• Regulate and integrate body functions
• Play role in body’s metabolism and growth
• Cells of endocrine glands secrete hormones into the extracellular fluid
• Hormones enter the capillaries through diffusion and secrete directly into the
bloodstream (plasma part of the blood)
• Through blood circulation, these hormones can be distributed all over our body.
Functions of the Endocrine System
Controls the processes involved in movement and physiological equilibrium
Includes all tissues or glands that secrete hormones into the blood
Secretion of most hormones is regulated by a negative feedback system
The number of receptors for a specific hormone can be altered to meet the body’s
demand
2. Thyroid and steroid hormones cross the membrane and bind to receptors in
the cytoplasm or nucleus:
• Pass through the cell membrane.
• Binds to specific receptors
• Then enters the nucleus to bind with the cells DNA which then activates certain
genes (Direct gene activation).
• mRNA is synthesized in the nucleus and enters the cytoplasm and promotes
protein synthesis for:
• Enzymes as catalysts
• Tissue growth and repair
• Regulate enzyme function
Negative Feedback
Negative feedback is the primary mechanism through which your endocrine
system maintains homeostasis
Secretion of a specific hormone s turned on or off by specific physiological
changes (similar to a thermostat)
EXAMPLE: plasma glucose levels and insulin response
Number of Receptors
Down-regulation: is the decrease of hormone receptors which decreases the
sensitivity to that hormone
Up-regulation: is the increase in the number of receptors which causes the cell to
be more sensitive to a particular hormone
Pituitary Gland (Master of endocrine gland)
The pituitary gland is a pea shaped structure that measures 1-1.5cm (0.5 inch) in
diameter and lies in the hypophyseal fossa of the sella turica of the sphenoid bone. It
attaches to the hypothalamus by a stalk, the infundibulumand has two functionally
separate lobes.
The anterior pituitary (anterior lobe ), also called the adenohyphophysis, accounts for
about 75% of total weight of the gland.
The anterior pituitary consist of two parts in an adult :
The pars distalis is the larger portion.
The pars tuberalis forms sheath around the infundibulum.
The posterior pituitary (posterior lobe ), also called the neurohypophysis consist of
two parts: the pars nervosa-the larger bulbar portion , and the infundibulum.
Pars intermedia atrophies during human fetal development and ceases to exist as a
separate lobe in adult.
Anterior Pituitary
The anterior pituitary or adenohypophysis secrete hormone that regulate a wide range of
bodily activities, from growth to reproduction. Release of anterior pituitary hormone is
stimulated by releasing hormone and suppressed by inhibiting hormone from
hypothalamus.
Figure 3: The Anatomy and Orientation of the Pituitary Gland
The Hypophyseal Portal System
Prolactin (PH)
• Stimulates the development of mammary glands and milk production
Growth hormone (hGH or somatotropin)
• Stimulates cell growth and replication through release of somatomedins or
IGF(Insulin like Growth factor)
• Growth-hormone releasing hormone
(GH-RH)
• Growth-hormone inhibiting hormone
(GH-IH)
• May be secreted by the pars intermedia during fetal development, early
childhood, pregnancy or certain diseases
• Stimulates melanocytes to produce melanin
Oxytocin:
During and after delivery of baby, oxytocin affects two target tissues: the mother uterus
and breasts. During delivery oxytocin enhance contraction of smooth muscle cell in the
wall of the uterus ; after delivery , it stimulates milk ejection from the mammary gland in
response to mechanical stimulus provided by suckling infant .
Thyroid gland
The butterfly – shaped thyroid gland is located just inferior to the larynx.
It is composed of right and left lateral lobes, one on either side of trachea, that are
connected by an isthmus anterior to the trachea.
ADRENAL GLAND:
The paired adrenal (suprarenal) gland, one of which lies superior to each kidney,
has flattened pyramidal shape.
In an adult, each adrenal gland is 3-5 cm in height, 2-3 cm width, little less than 1 cm
thick, mass of 3.5-5 gm only half its size of birth.
During embryonic development, the adrenal glands differentiate into two structurally
and functionally distinct regions, a large, peripherally located adrenal cortex,
comprising 80-90% of the gland and a small centrally located adrenal medulla.
A connective tissue capsule covers the gland.
The adrenal cortex produces steroid hormones that are essential for life.
Complete loss of adrenocortical hormone leads to death due to dehydration and
electrolyte imbalance in a few days to week.
Adrenal medulla produces three catecholamine hormones, NE, Epinephrine and
small amount of dopamine.
Figure 11: Adrenal gland and its microscopic structure.
Adrenal cortex
It is subdivided into three zone each of which secretes different hormones.
The outer zone just deep to connective tissue capsule is the zona glomerulosa.
Its cell, which is closely packed and arranged in spherical clusters and arched
columns secrete hormones called mineralcorticoids because affect mineral
homeostasis.
Androgens
In both male and female, the adrenal cortex secretes small amounts of week
androgens.
The major androgens secreted by the adrenal gland are dehydroepiandrosterone
(DHEA).
After puberty in males, the androgens testosterone is also released in much greater
quantity by the testes.
In females, however, adrenal androgens play important role. They promote libido (sex
drive) and are converted into estrogen.
Adrenal androgens also stimulate growth of axillary and pubic hair in boys and girls;
contribute to the prepubertal growth spurt.
Adrenal medulla
It is modified sympathetic ganglion of ANS. The cell of adrenal medulla secrete
hormone. The hormone producing cells, called chromaffin cells.
Two major hormones synthesized by the adrenal medulla are epinephrine and
norepinephrine. It increases blood flow to vascular organ dilate airways to lungs.
Increased blood level of glucose and fatty acids.
Glucocorticoids
Cell types in pancreatic islets: Each pancreatic islets includes four types of hormone
secreting cells.
• Alpha or A cells: Constitute about 17% of pancreatic islets and secrete glucagon.
• Beta or B cells : Constitute about 70% pancreatic islets cells secrete insulin .
• Delta cell about 70% of pancreatic islets cells and secrete somatostatin.
• F cells: Constitute the remainder of pancreatic islets cells secrete polypeptide
• Insulin lowers blood glucose by increasing the rate of glucose uptake and
utilization
• Glucagon raises blood glucose by increasing the rates of glycogen breakdown
and glucose manufacture by the liver.
Blood glucose level is the most important regulator of insulin and glucagons, several
hormones and neurotransmitter also regulates the release of these two hormones.
Male Gonads
The testes are oval glands that lie in the scrotum.
The main hormone produced and secreted by the testes is testosterone, an androgen or
male sex hormone.
Testesterone develops and regulates sperm and stimulates the developments and
maintainance of male secondary sex characteristics, such as beard growth, deepening of
voice.
Testes also produce inhibin, which inhibits secretion of FSH.
Pineal gland
It is a small endocrine gland that attached to the roof of third ventricle of the brain at the
midline .
Part of the epithalamus , it is position between the two superior colliculi.
It has a mass 0.1-0.2 g and is covered by capsule formed by the pia matter.
The gland consists of masses of neuroglia and secretory cells called pinealocytes.
Pineal gland secrete melatonin , an amine hormone derived from serotonin, and that
more melatonin is released in darkness and less in strong sunlight.
In darkness, norepinephrine released by the sympathetic fibers, stimulates, synthesis and
secretion of melatonin which promote sleepiness.
Melatonin is thought to contribute to setting the body’s biological clock, which is
controlled from the suprachiasmatic nucleus of the hypothalamus.
During sleep melatonin level is increased tenfold and then decline to a low level again
before awakening.
Melatonin is also potent antioxidant that may provide some protection against damaging
oxygen free radicals.
Thymus
It is located behind the sternum between the lungs.the hormone produced by the
thymus,-thymosin, thymic humoral factor(THF), thymic factor(TF) and thymopoietin
promote maturation of T-cells and may retard aging process.`