Anti aging cream Review Wadher et al, 2009 formulated and evaluated cream of Azadirachta indica leaves on skin

n renewal rate. Three creams containing 0.5 %, 1.0 % and 2.0 % w/w of hydroalcoholic macerate extracts of leaves of neem were prepared. Creams were prepared in model FAPG base. Students t test shows that 1.0 % and 2.0 % hydroalcoholic macerate creams shows increase in skin renewal rate , which is significant at p<0.005 level of significance. While 0.5 % hydroalcoholic macerate extracts cream is significant at p<0.05 level of significance. Bernantoniene et al, 2010 formulated and evaluated hydrophilic cream of Callendula officinalis (L.) with antioxidant activity. Different formulation with 0.3 %, 0.6% and 0.9% concentration of the extract were prepared. In case of the cream with 0.3% of Calendula extract was content of the active constituents low and weak antioxidant activity, the values did not differ from these of the cream base. Measured values of the active compounds in the cream with 0.9% of Calendula extract differed statistically significant (p < 0.05), therefore this cream was chosen for further microscopic evaluation and stability testing. This cream was then examined microscopically, and stability studies including evaluation of organoleptic properties, microbiologic quality and antioxidant activity.

Kamakaen et al, 2010 developed peacock flower extract as anti- wrinkle formulation. This study supports the traditional. The use of Caeselpinia pulcherrima (0.7% w/w) as an ingredient in cosmetic products with antioxidant and with antiwrinkle activity. The best effect was achieved by the ethanolic extract which corresponds to the traditional extraction practice. The results of DPPH radical scavenging assay showed the strongest activity (IC50= 34.74 g/ml) of the crude extract from the red petals of C. pulcherrima, followed by the extract of the orange petals (IC50=35.63 g/ml) and the yellow petals

(IC50=102.27 g/ml), respectively. The ABTS cation radical scavenging assay demonstrated the strongest activity (IC50=227.66 g/ml) for the orange petals followed by the red petals (IC50=243.01 g/ml) and the yellow petals (IC50=338.72 g/ml). The amount of phenolic compounds in term of gallic acid suggests that the flowers of C. pulcherrima may be a good source of natural antioxidants which may be incorporated into a range of cosmetics and health products. Rasul et al, 2011 formulated and evaluated anti- aging effects of an emulsion containing basil extract using non-invasive biophysical techniques. A single blinded study was conducted using non-invasive methods. Formulation containing 3% of the concentrated extract of Basil was developed by entrapping in the inner aqueous phase of w/o emulsion and base contained no extract. Both creams were stored at different storage conditions of 8C, 25C, 40C and 40C+ 75% relative humidity to predict their stabilities. The formulation and base were evaluated for their effects on various skin parameters i.e., moisture and trans epidermal water loss (TEWL), volume, energy and surface evaluation of the living skin (SELS). Significant effects (p0.05) were observed for both creams in the case of TEWL. The base showed insignificant (p0.05) while formulation showed significant effects on skin moisture. Volume, SELS SEr (skin roughness), SEsc (skin scaliness), SEsm (skin smoothness), SEw (skin wrinkles) parameter showed significant decline while texture parameter of Energy showed significant increase. Sabale et al, 2011 formulated and evaluated topical antiaging preparation of fruit of Benincasa hispida. Two formulas were prepared for cream base. The effect of the Benincasa hispida fruit extract (5%) cream on skin renewal was evaluated. The results show that Formula no. 2 had good spreadability (average spreadability 18.4 1.38) as compared with Formula no. 1 (average spreadibility 8.8 1.22). Formula no. 1 showed a decrease in water number as compared with Formula no. 2, which represents its less-water-absorbing

capacity (3.0 ml vs. 2.0 ml). Formula no. 2 showed good diffusibility (average diffusibility 2.05 0.07) than Formula no. 1 (average diffusibility 1.35 0.05). Thus, Formula no. 2 was found to satisfy all the desirable properties of oil-inwater cream base and was decided to be the final cream base. Akhtar et al, 2011 evaluated various functional parameters using a topical cream of Calendula officinalis extract. Base without active and formulation having 3% extarct of calendula in the aqueous phase were prepared. Samples were stored at different storage conditions that is, 8, 25, 40, 40C+75% RH for four weeks to predict their stability. The newly formulated base and formulation were applied to the cheeks of 21 healthy human volunteers for a period of 8 weeks. The base showed insignificant (p>0.05) effects while the formulation decreased TEWL however this decrease was statistically insignificant (p> 0.05). Skin moisture content was significantly (p_0.05) increased by the formulation. The base showed insignificant (p>0.05) effects while the formulation showed statistically significant (p_0.05) decrease in skn melann content. Skn erythema was significantly reduced by the formulation. Skin sebum was significantly (p_0.05) incresaed by both creams (base and formulation). Both creams were aesthetic with respect to sensory evaluation. The topical noninvasive application of Calendula officinalis cream showed a positive rejuvenating effect on human skin. Sahu et al, 2011 formulated and evaluated curcuminoid (2% w/w) based herbal face cream. Evaluation of formulated cream with parameters - type of emulsion, ashing at 600 oC, pH, homogeneity and sensory parameters has been conducted. Accelerated stability testing of 16 prepared formulations has been conducted at elevated temperature of 40 oC 1oC for 20 days. 4 out of 16 products have shown stability with no signs of bleeding and no change in the color of the product. The Draize test for sensitivity testing has shown that the stable formulations are safe in respect to skin irritation and allergic. The formulated turmeric based herbal face cream is a cosmeceutical that contains quantified amount of curcuminoids. It is safe and stable too.

Bambal et al, 2011 studied the sunscreen activity of herbal cream containing flower extracts of Nycanthes arbortristis L.(1% w/w) and Tagetes erecta L.(1% w/w). The in vitro SPF of the formulations was determined according to the UV Spectrophotometric method of Mansur et al. The sunscreen cream containing ethanolic extract of N. arbortristis under study produced high absorbance at 290-320 nm wavelength range and SPF obtained was 10.212.18. The sunscreen cream containing ethanolic extract T. erecta obtained the SPF 8.671.35. From the result obtained in the study, we can positively conclude that N. arbortristis sunscreens will enhance and significantly contribute to the UV absorbing properties of conventional sunscreen formulation. It will also help in broadening the UV protection ability of the sunscreen along with the greatest advantage of avoiding the adverse and undesired effects of synthetic sunscreen compounds.

Rasul et al, 2012 formulated and evaluated anti- aging potential of a cream containing milk thistle (Silybum marianum) extract. The study was designed to formulate and evaluate ant-agng effects of a topical cream (water in oil (w/o) emulsion) containig extract of milk thistle (Silybum marianum) against its vehicle (Base) as control. Base containing no extract and a formulation containing 4% concentrated extract of Silybum marianum was developed by entrapping in the inner aqueous phase of w/o emulsion. Both the base and formulation were stored at 8C0.1C (in refrigerator), 25C0.1C, 40C0.1C and 40C0.1C with 75% RH (in incubator) for a period of 8 weeks to predict their stability. The evaluation parameters consisted of colour, smell, type of emulsion, electrical conductivity, liquefaction and pH.