Drug Classificatio n
ACE inhibitor Antihypertensi ve
Action
Side Effects
Nursing Responsibilities
Converted in the liver into active perindopril, an ACE inhibitor (prevents conversion of Angiotensin I to Angiotensin II, a potent vasoconstrictor). Blocks stimulation of beta1-adrenergic receptor within vascular smooth muscle to produce negative chronotropic and positive inotropic activity(Decrease HR, cardiac output, peripheral resistance, cardiac O2 consumption. synthetic lipid-lowering agent. Selectively inhibits HMG-CoA reductase, converts HMG-CoA mevalonate, a precursor of sterols. Lowers cholesterol and lipoprotein levels.
Palpitation. Headache, upper respiratory infection, depression, somnolence, upper respiratory infection. Bradycardia, cardiac arrhythmias, dizziness, fatigue.
Assess pt.s blood pressure before therapy. Monitor for hypotension. Encourage patient change position/rise slowly to sitting or standing position to minimize orthostatic hypotension. Check for baseline in renal, liver function tests before therapy begins. Assess for edema in feet, legs daily.
Antianginal Antihypertensi ve
Dyslipidaemic Agents
Monitor cholesterol, triglycerides and liver function tests before therapy and reassess regularly. LDL and VLDL should be watched closely; if increased, drug should be discontinued.
A competitive DDP4 inhibitor that slows the inactivation of the incretin hormones, thereby increasing their blood-stream concentrations and reducing fasting and post prandial glucose concentrations in a glucose-dependent manner. Bactericidal: Inhibits synthesis of bacterial cell wall, causing cell death. Distention of the colon due to increased fluid enhances intestinal motility and secretion resulting to passage of soft stools. Blocks ADP receptors, which prevent fibrinogen binding at that site, preventing clumping of platelets. Required in every cell for our health.
Teach client, when taking medication it is indicated as an adjunct to diet and exercise to improve blood sugar control.
Headache, dizziness, lethargic, nausea, vomiting Transient flatulence, intestinal cramps, diarrhea, nausea Headache, dizziness, weakness, nausea, constipation, diarrhea No known side affects
Take full course of therapy even if you are feeling better. Monitor fluid and electrolyte status: Urine output, input-output to identify fluid loss, hypokalemia and hypernatremia Assess for symptoms of stroke, MI during treatment. Monitor signs of bleeding.
Monitor for s/s of bleeding and haemorrhage. Discontinue drug in patient who develop unstable renal function or severe renal impairment while receiving medication, notify position. Use cautiously in patients with heart failure or hypertension and in elderly patients.
Anti-anginal
decrease myocardial oxygen requirement by decreasing the HR, ventricular volume, BP and contractility.