The

University of British Columbia

Centre for Blood Research

The Centre for Blood Research presents

The Earl W. Davie Symposium

Guest Lecturers: Ken Mann and Dsir Collen
Leaders in Blood Clotting and Thrombolysis
November 4, 2010, Vancity Theatre, 1181 Seymour St., Vancouver This annual 1-day symposium, in honour of Dr. Earl W. Davie, will also feature presentations by local experts in vascular biology, hemostasis-thrombosis, cardiovascular and neurologic disease. Registration is free but seating is limited. So, reserve a spot early! There will be a poster session for selected abstracts which should be submitted by October 27, 2010 to CBR.events@exchange.ubc.ca
Dr. Earl Davie's research has elucidated many areas of coagulation and led to effective treatments for patients with a range of bleeding disorders. He and his colleagues devised the revolutionary Waterfall Sequence for Blood Clotting. Dr. Davie applied cutting edge technologies to identify and characterize the coagulation proteins in detail throughout the 1960s and '70s, and subsequently isolated, sequenced, and expressed the genes for these clotting factors. For his many critical achievements, Dr. Davie has been widely acclaimed and has received numerous international awards. He is a member of the US National Academy of Science and is a Professor of Biochemistry at the University of Washington in Seattle. Kenneth G. Mann received his Ph.D. in Biochemistry at the University of Iowa and postdoctoral training at Duke University. His interest in applying physical biochemical techniques to the complexities of the blood coagulation system led to a joint appointment at the Mayo Clinic Medical School and University of Minnesota. He later became Professor and Chair of Biochemistry at the University of Vermont., held until 2005. Dr. Mann has received many distinguished awards for his contributions to our understanding of thrombosis and hemostasis. Dsir Collen received his MD and PhD in Biochemistry at the University of Leuven, Belgium. His early studies of coagulation and fibrinolysis in the 1970s led to his discovery of alpha2-antiplasmin. Dr. Collen has since made multiple contributions to coagulation and vascular biology. His landmark achievement was the development of the "clot-buster" tissue type plasminogen activator (tPA), used worldwide to treat heart attacks and stroke. Until 2008, Dr. Collen was Director of the Center for Transgene Technology and Gene Therapy. He is currently the Chairman of ThromboGenics.

For more information and to register, please contact Natasha Wheatley: CBR.events@exchange.ubc.ca or Ed Conway: emconway@interchange.ubc.ca
This event is supported in part by a generous grant from Novo Nordisk Canada

The University of British Columbia

Centre for Blood Research

The Centre for Blood Research presents

The Earl W. Davie Symposium

Guest Lecturers: Ken Mann and Dsir Collen
Leaders in Blood Clotting and Thrombolysis Vancity Theatre, Vancouver, 1181 Seymour St., Vancouver

November 4, 2010 Register now! CBR.events@exchange.ubc.ca It's free!

Program
9:00-9:30 9:30-9:45 9:45-10:20 10:20-10:40 10:40-11:00 11:00-12:00 12:00-12:20 12:20-1:20 1:20-1:55 1:55-2:15 2:15-2:50 2:50-3:50 3:50-4:05 4:05-5 pm Coffee Introductions Linda Vickars Complex Bleeding / Clotting Cases Peter Schubert Proteomics in Transfusion Medicine Isis Carter Structuring a Novel Thrombin Ken Mann - Blood Clotting: The Good, the Bad and the Ugly "Shot-gun" Poster Talks Buffet lunch / Posters Keith Walley Variation in Thrombosis-related Genes & Sepsis Outcome Kaan Biron Do Clotting Abnormalities Underlie Alzheimer's Disease? Bruce Ritchie Managing Hemophilia During Orthopedics Procedures Desire Collen Biopharmaceutical Drug Development between Academia and Industry Closing remarks Wine / Posters For more information and to register, please contact Natasha Wheatley: CBR.events@exchange.ubc.ca or Ed Conway: emconway@interchange.ubc.ca
This event is supported in part by a generous grant from Novo Nordisk Canada

The University of British Columbia

Centre for Blood Research

The Centre for Blood Research presents

The Earl W. Davie Symposium

Guest Lecturers: Ken Mann and Dsir Collen

Poster Presentations
Presenter 1 2 3 4 5 6 7 8 9 10 12 13 14 15 16 17 18 19 20 21 22 Title Arash Khosrovi-Eghbal Exploring the Interaction Environment of Blood Cells: Proteomic Analysis of Platelet-Monocyte Interactions Amanda Vanden Hoek Identification of a Novel Coagulation Factor X Compound Heterozygous Mutation Associated with Differential Initiating Clotting Pathway Function Brian McSheffrey Taming an Inhibitor in an 11 year old Boy with factor IX Hemophilia and Anaphylaxis Dan Wang Induction of tolerance via PEGylated blood products Edwin Gershom Emilie Lameignere Kai Yu Katherine Thain Kathleen De Asis Les Burtnick Michael J. Krisinger Muhammad Imran ulhaq Peter Schubert Rafi Chapanian Robert Gruninger Jian Song Kim Talbot Scott Meixner Sung-Hye Grieco Guinevere Q Lee Luke C Swenson Herpesviruses enhance fibrinogen clot lysis Assembling the Type III Secretion System (T3SS) apparatus Synthesis of Biomimicking Glycopolymer Brushes Containing Different Carbohydrate Residues and Their Non-Biofouling Properties Discovery of Common Functional Polymorphisms in the Protein C Gene Thrombin activatable fibrinolysis inhibitor in adult males with hemophilia Alternative Activated Conformations of Gelsolin Family Proteins Molecular links between coagulation and complement Well-Defined Biocompatible Macromolecular Chelators for Iron Chelation Therapy Quality and safety of blood products in transfusion A Novel Cell Surface Engineering Method for Universal Red Blood Donor Cells Using a Combination of Enzymatic Treatment and Polymer Grafting Combating Antibiotic Resistance: Structure Based Design of Anti-bacterial Agents Targeting the Bacterial Cell Wall Biosynthetic Machinery Synthesis of Biodegradable Core Functionalized Hyperbranched Polyglycerol for extension of Protein Circulation Time Compound heterozygous factor V deficiency with severe clinical phenotype A Novel Blood Protein Application: Coagulation Factor Xa Becomes a ClotDissolving Agent Cell Culture & Fermentation at the CBR Prevalence and Virologic Consequences of Transmitted Drug Resistance Mutations in Uganda Deep Sequencing Using 454 Technology to HIV Tropism Screening

For more information and to register, please contact Natasha Wheatley: CBR.events@exchange.ubc.ca or Ed Conway: emconway@interchange.ubc.ca
This event is supported in part by a generous grant from Novo Nordisk Canada