Anda di halaman 1dari 77

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative

Status) Aldesleukin 22 million IU (1.3 mg) (Novartis) (F)(PFL) no preservative1 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes

1.2 mL SWI1,2 direct diluent against side of vial during reconstitution1 do not shake1

18 million IU/mL (1.1 mg/mL)1,2

48 h F1

50 mL D5W1 30 70 mcg/mL1 < 30 mcg/mL: dilute in D5W containing human albumin 0.1%2

48 h F1

- cytotoxic3 - do not use in-line filter1,2 - avoid bacteriostatic water for injection or NS due to increased aggregation1 - cytotoxic7 - do not shake8

Alemtuzumab 30 mg/mL (Genzyme previously Bayer)4 (F)(PFL) do not shake no preservative5

N/A

filter NOT required 30 mg/mL5

discard unused portion5

SC syringe

discard at the end of the day F or RT

100 mL NS or D5W5

8 h F or RT5 **(PFL)8

Alemtuzumab 30 mg/3 mL (Schering/Ilex) (F)(PFL) do not shake no preservative9

N/A

use 5 micron filter to withdraw drug from ampoule8 10 mg/mL9

discard unused portion9

SC syringe6

discard at the end of the day F or RT8

- cytotoxic7 - do not shake8

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

1/77

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes

100 mL NS or D5W9

8 h F or RT8 **(PFL)8

Amifostine 500 mg (MedImmune) (RT) no preservative10 Amsacrine 75 mg/1.5 mL (Erfa Canada) (RT) no preservative12

9.7 mL NS only10

50 mg/mL10

24 h F, 5 h RT10

2550 mL*NS only10

540 mg/mL: 24 h F,10 5 h RT

- noncytotoxic10 - discard cloudy solution11

glass syringes preferred during reconstitution; max. time in plastic syringe12: 15 min 13.5 mL supplied diluent (L-lactic acid)1 transfer 1.5mL from ampoule into the diluent vial12

5 mg/mL12

24 h RT12 PFL12

500 mL D5W12 (plastic or glass container)12

7 d F, 48 h RT12,13,14

- cytotoxic15

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

2/77

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Asparaginase16 (asparaginase E. coli) 10,000 units (Orphan Pharmaceutical International) (F) no preservative17 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes

do not shake; roll to reconstitute18,11 4 mL SWI19 Intradermal test11: Reconstitute with 5 mL SWI to give 2000 units/mL Transfer 0.1 mL to 10 mL vial (or 12 mL syringe) Add 9.9 mL SWI roll to dissolve to give 20 units/mL 2 unit test dose = 0.1 mL (Note: the rest of the reconstituted vial has a concentration of 2000 units/mL)11

2500 units/mL16

48 h F, RT16

syringe16

14 d F20, 16

- cytotoxic3

50 mL*NS or D5W20,13

14 d F,20,13 2 d RT20,21

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

3/77

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Erwinia asparaginase (asparaginase Erwinia chrysanthemi) 10,000 units (Orphan Pharmaceuticals International) (F) no preservative22 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes

do not shake; roll to reconstitute22 1-2 mL NS22

10000-5000 units/mL

15 min in original container; 8 h in a glass or polypropylene syringe22

glass or polypropylene syringe22

8 h in a glass or polypropylene syringe22

- cytotoxic3

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

4/77

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) PEG-asparaginase (pegasparagase) (pegylated asparaginase E. coli) 750 units/mL (Enzon) (F) no preservative23 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes

N/A

750 units/mL23

discard unused portion23

IM: maximum volume 2 mL; if >2 mL use multiple sites23

syringe: 4 h23,24

- cytotoxic3 - discard cloudy solution23 - do not shake23 - do not use if stored out of refrigerator for > 48 h23 - do not use if previously frozen23

IV: 100 mL NS or D5W23

bag: 4 h23,24

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

5/77

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Azacitidine 100 mg (Celgene) (RT) no preservative25 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes

4 mL SWI25 shake vigorously25

25 mg/mL25

8 h F, 45 min RT25

SC syringe25

45 min RT25 prepare immediately before use and use within 45 min, or discard.

- cytotoxic3 - discard if contains large particles25 - re-suspend syringe contents before injection by vigorously rolling syringe between palms25 - cytotoxic7

BCG 81 mg (Sanofi Pasteur) (F)(PFL) preservative26

do not shake; roll to reconstitute26 3 mL supplied diluent26 record time of reconstitution

10.5 8.7108 CFU/vial (Connaught strain)26

2 h F, RT26

50 mL NS26

2 h F or RT after reconstitution26 **(PFL)26

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

6/77

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) BCG (Tice substrain) 50 mg = 1 to 8 x 108 CFU (Hospira/Organon) (F)(PFL) no preservative27 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes

1 mL preservative free NS for injection27 use reconstitution device provided allow to stand for a few minutes, then gently swirl to suspend27

1 to 8108 CFU/vial27

2 h F (PFL)27

transfer from vial to 60 mL syringe, rinse vial with another 1 mL NS. Add rinse to same 60 mL syringe. qs to 50 mL with NS27

2 h F27

- cytotoxic3 - overfill unknown - protect from light27 - do not filter27

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

7/77

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Bendamustine 25 mg single-use vial 100 mg single-use vial (Cephalon) (RT)(PFL) no preservative28 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes

25 mg vial: add 5 mL SWI 100 mg vial: add 20 mL SWI28 Shake well to yield a clear, colourless to a pale yellow solution. Expected to completely dissolve within 5 minutes28

5 mg/mL28

30 minutes28

500 mL NS28 0.2-0.6 mg/mL28

24 h F, 3 h RT28

- cytotoxic3

Bevacizumab 100 mg/4 mL 400 mg/16 mL (Roche) (F)(PFL) do not shake no preservative29 Bleomycin 15 IU (NB: dose in units only) (Bristol) (F) no preservative31

N/A

25 mg/mL29

discard unused portion29

1.4-16.5 mg/mL30 100-250 mL NS only29,30

48 h F, RT21,29,30

- cytotoxic7 - do not shake29

6 mL*NS31

2.5 IU/mL

48 h F31

50 mL*NS31

24 h RT31

- cytotoxic7 - no overfill32

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

8/77

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Bleomycin 15 IU (NB: dose in units only) (Hospira) (F)(PFL) no preservative33 Bortezomib 3.5 mg (Ortho Biotech formally Millennium) (RT)(PFL) no preservative36 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes

6 mL*NS or SWI33

2.5 IU/mL33

48 h F, 24 h RT33

50 mL *NS, SWI33

24 h RT34

- cytotoxic7 - no overfill35

3.5 mL NS36

1 mg/mL36

2d RT13,37

syringe36

8 h RT38

- cytotoxic7

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

9/77

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Busulfan 60 mg/10 mL (Orphan Medical) (F) no preservative39 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes

N/A

use 5-micron nylon filter provided with ampoule to withdraw drug39 6 mg/mL39

discard unused portion39

NS or D5W (dilute in volume 10 times the busulfan volume to ~ 0.5 mg/mL)39

complete administration within 12 h F: NS39 8 h RT: NS, D5W

- cytotoxic7

Carboplatin 50 mg/5 mL 150 mg/15 mL 450 mg/45 mL (Hospira) (RT)(PFL) no preservative40

N/A

10 mg/mL40

discard unused portion40

0.3-10 mg/mL41 NS, D5W11,40 do NOT use aluminum-containing needle or syringe41

24 h RT,42 48 h F40

- cytotoxic7 - do NOT use aluminumcontaining needle, syringe or tubing41

Carboplatin 50 mg/5 mL 150 mg/15 mL 450 mg/45 mL (Novopharm) (RT)(PFL) no preservative43

N/A

10 mg/mL43

discard unused portion RT43

0.5-10 mg/mL44 NS, D5W11,43,45 do NOT use aluminum-containing needle or syringe43

8 h RT43

- cytotoxic7 - do NOT use aluminumcontaining needle, syringe or tubing43

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

10/77

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Carmustine 100 mg (Bristol Labs) (F) no preservative46 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes

3 mL diluent (supplied)46 diluent to reach RT, then dissolve drug with 3 mL diluent; add 27 mL SWI46 record time of reconstitution

3.3 mg/mL in 10% ethanol46

24 h F, 8 h RT46

glass46 or polyolefin container11 500 mL NS or D5W46

24 h F: in glass,46 or polyolefin container11 use within 4 h of reconstitution RT46

- cytotoxic7 - do not use if product has oily droplets46

Cetuximab 100 mg/50 mL 200 mg/100 mL (ImClone/BMS) (F) do not dilute do not shake no preservative47

N/A

2 mg/mL47

discard unused portion after 12 h F, 8 h RT47

syringe47

12 h F, 8 h RT47

sterile evacuated container or bag e.g. polyolefin, polyethylene, ethylene vinyl acetate, DEHP plasticized PVC, PVC bag, or glass47

12 h F, 8 h RT47

- cytotoxic3 - administer with a 0.2 or 0.22 micron low protein binding in-line filter47 - normal saline may be used to flush the line47 - solution may contain white particulates which do not affect product quality47

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

11/77

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Cisplatin 10 mg/10 mL 50 mg/50 mL 100 mg/100mL (Hospira) (RT)(PFL) no preservative48 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes

N/A

1 mg/mL48

48 h RT49

< 60 mg: 100 mL NS* > 60 mg: 250 mL NS* 500 or 1000 mL *NS, D5-NS, D5-1/2S; D5NS with mannitol; D51/2S with mannitol48,50; D5W1/3S with mannitol48 do NOT use aluminum-containing needle or syringe48

48 h RT49

- cytotoxic7 - do NOT use aluminumcontaining needle, syringe or tubing48

Cladribine 10 mg/10 mL (Janssen-Ortho) (F)(PFL) no preservative51

N/A

1 mg/mL51

discard unused portion51

SC syringe52 cassette51

48h F, end of day RT13,51,53,54

- cytotoxic7 - shake vigorously to dissolve any precipitates from refrigeration11 - bacteriostatic NS contains benzyl alcohol51

500 mL NS only51 Do NOT use D5W51

24 h RT51

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

12/77

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes

qs to 100 mL with bacteriostatic NS only via SIMS


DELTEC INC. MEDICATION CASSETTES51; filter

at least 7 days51

drug and diluent through 0.22u filter as each solution is being introduced into the medication Clodronate 300 mg/10 mL (Oryx) (RT) no preservative55 N/A 30 mg/mL discard unused portion55 500 mL NS or D5W55 12 h RT55 - noncytotoxic

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

13/77

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Cyclophosphamide 200 mg 500 mg 1000 mg 2000 mg (Baxter) (RT)(PFL) no preservative56 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes

NS56 200 mg: 10 mL 500 mg: 25 mL 1000 mg: 50 mL 2000 mg: 100 mL56

20 mg/mL56

72 h F,56,57 24 h RT56

< 1 g: 100 mL NS* > 1 g: 250 mL NS* high dose in BMT: may need 500 NS* NS, D5W, D5NS56

72 h F,56,57 24 h RT56

- cytotoxic7

Cyclosporine 50 mg/1 mL 250 mg/5 mL (Novartis) (RT)(PFL) no preservative58

N/A

50 mg/mL58

discard unused portion58

NS, D5W58 dilute to concentration between 1:20 and 1:10058

dilute immediately prior to use58

- cytotoxic3 - polyoxyethylated castor oil/ethanol vehicle58 - do NOT refrigerate or freeze58 - use non-PVC bag and tubing59

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

14/77

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Cytarabine 100 mg/1 mL 1000 mg/10mL 2000 mg/20mL (Hospira) (RT)(PFL) no preservative60 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes

N/A record time of puncture

100 mg/mL60

24 h RT60

100 mL*NS, Water for Injection, D5W, Lactated Ringers60

72 h F, 24 h RT from initial vial puncture60

- cytotoxic7 - do not use for IT injection

Cytarabine IT injection60 100 mg/1 mL 1000 mg/10mL 2000 mg/20mL (Hospira) (RT)(PFL) no preservative60

N/A record time of puncture

100 mg/mL60

24 h RT60

diluents containing preservatives should NOT be used for intrathecal administration60 qs to 6 mL with preservative free NS61

use within 4 h of initial vial puncture11,13

- cytotoxic7 - auxiliary label62: IT - label to include route in full (i.e., INTRATHECAL injection) attached to both syringe and outer ziplock bag62

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

15/77

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Cytarabine SC injection: 100 mg (Pfizer) (RT)(PFL) no preservative63 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes

100 mg: 5 mL BWI63

100 mg: 20 mg/mL63

48 h RT63,64

syringe

14 d F, 48 h RT64

- cytotoxic7 - for high dose use, do not use diluent containing benzyl alcohol65 - do not use for IT injection - cytotoxic7 - protect container from light during storage and administration67 - overfill unknown - cytotoxic7 - protect container from light during storage and administration67 - no overfill69,35

Dacarbazine 100 mg 200 mg (Abraxis) (F)(PFL) no preservative66

100 mg: 9.9 mL SWI66 200 mg: 19.7 mL SWI66

10 mg/mL66

72 h F, 8 h RT66

250-500 mL*NS or D5W

24 h F, 8 h RT66 **(PFL)11,66 see Special Precautions/Notes Column 24 h F68 **(PFL)67 see Special Precautions/Notes Column

Dacarbazine 200 mg 600 mg (Hospira) (F)(PFL) no preservative68

200 mg: 19.7 mL SWI68 600 mg: 59.1 mL SWI68

10 mg/mL68

48 h F, 8 h RT68 (PFL)69

0.193.0 mg/mL13,68 250-500 mL*NS or D5W

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

16/77

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Dactinomycin 0.5 mg (Ovation)70 (RT)(PFL) no preservative71 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes

1.1 mL SWI(preservative free)71 Do NOT use SWI with preservative (may form precipitate)71

0.5 mg/mL71 (500 mcg/mL)

24 h F, RT72

syringe71,73

24 h F, RT

74

- cytotoxic3 - do not filter71,73 .

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Daunorubicin 20 mg (Erfa Canada Inc.)75 (RT)(PFL)76 no preservative77 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes

4 mL SWI75

5 mg/mL75,78

48 h F, 24 h RT77

100-250 mL in isotonic solution e.g., NS75 no data for D5W77

24 h RT, 48 h F75

- cytotoxic3

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

17/77

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Daunorubicin 20 mg (Novopharm) (RT)(PFL) no preservative79 Dexrazoxane 250 mg 500 mg (Pfizer) (RT) no preservative80 Docetaxel 20 mg/0.5 mL 80 mg/2 mL (Sanofi-Aventis) (F, RT) (PFL) no preservative83 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes

4 mL SWI79

5 mg/mL79

24 h RT, 48 h F79 (PFL)79

100-250 mL NS or D5W11

48 h F, 24 h RT79 **(PFL)79 6 h RT81

- cytotoxic7

supplied diluent80: 250 mg: 25 mL 500 mg: 50 mL

10 mg/mL80

6 h F80

empty viaflex bag80

- cytotoxic82

supplied diluent : - if vials were refrigerated, allow to warm for 5 min at RT. Withdraw entire contents of the diluent and inject the entire contents of the syringe into the corresponding concentrate vial. Mix by repeated inversions for 45 sec DO NOT SHAKE Let sit for 5 minutes83,84

10 mg/mL83

48 h F, RT13,85

0.30.74 mg/mL (e.g., 250 mL NS or D5W)83

complete administration within 4 h F,83 48 h RT86,87

- cytotoxic7 - non-PVC bag and tubing only83

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

18/77

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Doxorubicin 10 mg 50 mg 150 mg (Hospira) (RT)(PFL) no preservative88 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes

NS, SWI, D5W88 (NS reconstitution takes longer) 10 mg: 5 mL 50 mg: 25 mL 150 mg: 75 mL

2 mg/mL88

48 h F, 24 h RT13,88

syringe88

48 h F, 24 h RT13,89

- cytotoxic7

0.22 mg/mL90 100 mL*NS88

48 h F, 24 h RT13,90

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

19/77

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Doxorubicin 10 mg/5 mL 20 mg/10 mL 50 mg/25 mL 200 mg/100 mL (Novopharm) (F)(PFL) no preservative91 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes

N/A record time of puncture

2 mg/mL

8 h91

syringe91

48 h F, 24 h RT91 from initial vial puncture

- cytotoxic7

Doxorubicin 10 mg/5 mL 50 mg/25 mL 200 mg/100 mL (Pfizer) (F) no preservative92 Doxorubicin Pegylated Liposomal 20 mg/10 mL 50 mg/25 mL (Schering) (F) no preservative93

N/A

2 mg/mL92

discard unused portion92,74

syringe92

48 h F, 24 h RT92

- cytotoxic3

N/A

2 mg/mL93

discard unused portion93

< 90 mg: 250 mL D5W only93 90 mg: 500mL D5W only

24 h F93

- cytotoxic7 - do not filter93

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

20/77

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Epirubicin 10 mg/5 mL 50 mg/25 mL 200 mg/100 mL (Pfizer) (F)(PFL) no preservative94 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes

N/A record time of puncture

2 mg/mL94

8 h94

syringe94

48 h F, 24 h RT from initial vial puncture94

- cytotoxic7

100 mL*NS or D5W11

2 d F, RT: NS or D5W49

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

21/77

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Etoposide 100 mg/5 mL 500 mg/25 mL 1000 mg/50 mL (BMS) (RT) preservative95 Etoposide 100 mg/5 mL 200 mg/10 mL 500 mg/25 mL 1000 mg/50 mL (Novopharm) (RT)(PFL) no preservative99 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes

N/A

20 mg/mL95

14 d RT11,13,96,97,98

0.2 0.4 mg/mL95 500 mL*NS or D5W95

0.2 mg/mL: 48 h RT13,95 0.4 mg/mL: 24 h RT95

- cytotoxic7 - use non-PVC bag and tubing only

N/A

20 mg/mL99

discard unused portion99

NS Stabilty is concentration dependent

0.2-0.3 mg/mL: 7 d F,100 2 d RT87,100 0.4-0.5 mg/mL: 1 d F,100 1 d RT100 0.6-9.0mg/mL: generally unstable100 9.5 mg/mL: 2 d F,100 1d RT100 10-12 mg/mL: 7 d F,100 2 d RT87,100 4 h RT99,101

- cytotoxic7 - use non-PVC bag and tubing only

D5W99

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

22/77

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Fludarabine 50 mg (Berlex) (F) no preservative102 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes

2 mL SWI102

25 mg/mL102

48 h F or RT13,49

dilute to maximum of 1 mg/mL102,103 100 mL*NS or D5W102

48 h F, RT13,49

- cytotoxic7

Fludarabine 50 mg (Novopharm) (F) no preservative104

N/A

25 mg/mL104

discard unused portion104

dilute to maximum of 1 mg/mL104 100 mL*NS or D5W

48 h F, 24 h RT104

- cytotoxic7

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

23/77

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Fluorouracil 5000 mg/100 mL (Hospira) (RT)(PFL) no preservative105 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes

N/A

50 mg/mL105

8 h RT105,106

syringe13

48 h RT13,21,106

- cytotoxic7

2-10 mg/mL in D5W105,106 50-1000 mL*D5W

24 h RT105,106

CIVI: ambulatory pump106

complete within 8 d11,13,107

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

24/77

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes

Gemcitabine 200 mg 1000 m g (Eli-Lilly) (RT) no preservative108

200 mg: 5 mL NS 1000 mg: 25 mL NS108

38 mg/mL108

48 h RT108,109

syringe108

48 h RT,13,108,109

- cytotoxic7

0.110 mg/mL NS108,109

48 h F, RT13,108,109

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

25/77

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Gemcitabine 200 mg 1000 mg 2000 mg (Hospira) RT110 no preservative111 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes

200 mg vial: 5 mL NS 1000 mg vial: 25 mL NS 2000 mg vial: 50 mL NS110

38 mg/mL110

48 RT110,112,74

syringe110

24 h RT110,112

- cytotoxic7

26 mg/mL-0.1 mg/mL NS110,112 Gemcitabine 200 mg 1000 mg (Novopharm) RT no preservative113 Gemcitabine 200 mg 1000 mg (Sandoz Standard) RT no preservative115 200 mg vial: 5mL NS 1000 mg vial: 25 mL NS114 38 mg/mL114 24 h RT114 38 mg/mL 0.1 mg/mL NS114

48 h RT112,74

24 RT114

- cytotoxic7

200 mg vial: 5 mL NS 1000 mg vial: 25 mL NS115

38 mg/mL115

48 h RT115,116

syringe115

48 h RT115,117,116

- cytotoxic7

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

26/77

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes

38 mg/mL-0.1 mg/mL NS or D5W115,118

48 h RT13,119

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

27/77

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Idarubicin 5 mg 10 mg (Pfizer) (RT)(PFL) no preservative120 Idarubicin 5 mg/5 mL 10 mg/10 mL 20 mg/20 mL (Pfizer) (F)(PFL) no preservative120 Ifosfamide 1000 m g 3000 mg (Baxter) (RT) 11 no preservative122 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes

vial under negative pressure120 5 mg: 5 mL SWI 10 mg: 10 mL SWI120 N/A

1 mg/mL120

48 h F,120 24 h RT (PFL)120

syringe

48 h F,13, 120 24 h RT13 (PFL)120

- cytotoxic7

1 mg/mL120

same as reconstituted solution121

syringe

Discard 48 h F,13,120 24 h RT13 (PFL)120

- cytotoxic7

1000 mg: 20 mL SWI122 3000 mg: 60 mL SWI shake well

50 mg/mL122

48 h F13,122

0.620 mg/mL122 5001000 mL*NS, D5W, D5-NS, D5-1/2NS, Lactated Ringers11,122

72 h F122 24 h F, RT when mixed with mesna11 D5W or Lactated Ringers when mixed 2 d F13,124

- cytotoxic7

Interferon Alfa -2b 18 million IU/3 mL (Schering) (F)(or up to 7 days at RT before use) no preservative123

N/A

6 million IU/mL123

48 h F13,123

syringe123

- cytotoxic7

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

28/77

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes

0.3 million IU/mL123 50 mL NS123 Interferon Alfa -2b 25 million IU/2.5 mL (Schering) (F)(or up to 7 days at RT before use) no preservative123 N/A 10 million IU/mL123 48 h F13,123 syringe123

24 h F, RT124

2 d F13,124

- cytotoxic7

0.3 million IU/mL123 50 mL NS123 Interferon Alfa -2b 10 million IU (Schering) (F) no preservative123 1 mL supplied diluent (SWI) 123 do not shake; roll to reconstitute123 > 0.1 million IU/mL124 100 mL NS125 10 million IU/mL123 24 h F123 syringe123

24 h F, RT124

24 h F, RT124

- cytotoxic7

48 h RT11,13

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

29/77

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes

1 mL BWI123 do not shake; roll to reconstitute123

48 h F, RT13,123

syringe125

14 d F, 48 h RT13,125

100 mL NS125 Interferon Alfa -2b 18 million IU (Schering) (F) no preservative123 1 mL supplied diluent123 do not shake; roll to reconstitute123 > 0.1 million IU/mL126 100 mL NS125 1 mL BWI123 do not shake; roll to reconstitute123 100 mL NS125 48 h F, RT13 syringe123 18 million IU/mL123 24 h F123 syringe123

48 h RT11,13 24 h F, RT124 - cytotoxic7

48 h RT11,13

14 d F13,125

48 h RT11,13

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

30/77

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Irinotecan 40 mg/2 mL 100 mg/5 mL 500 mg/25 mL (Hospira) (RT)(PFL) no preservative127 Irinotecan 40 mg/2 mL 100 mg/5 mL (Pfizer) (RT)(PFL) no preservative130 Irinotecan 40 mg/2 mL 100 mg/5 mL (Sandoz) (RT)(PFL) no preservative131 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes

N/A

20 mg/mL127

2 days RT13,128,129

0.12 2.8 mg/mL127 500 mL11 D5W (preferred), NS127

24 h RT: D5W, NS127 48 h F: D5W (PFL)127

- cytotoxic7 - do NOT refrigerate if in NS130

N/A

20 mg/mL130

discard unused portion130

0.12 2.8 mg/mL130 500 mL11 D5W (preferred), NS130

24 h RT: D5W, NS130 48 h F: D5W (PFL)130

- cytotoxic7 - do NOT refrigerate if in NS130

N/A

20 mg/mL131

discard unused portion131,74

0.12-2.8 mg/mL131 D5W (recommended) NS131

24 h RT: D5W NS131 48 h F: D5W131 (PFL)131

- cytotoxic3

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

31/77

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Ixabepilone 15 mg (contains 16 mg) 45 mg (contains 47 mg) (BMS) (F)(PFL) no preservative132 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes

8 mL supplied diluent 23.5 mL supplied diluent

2 mg/mL 2 mg/mL

1 h RT132

0.2 0.6 mg/mL in Lactated Ringers Injection USP (use non-PVC infusion container)132

6 h RT132

- cytotoxic3 - use 0.2-1.2 micron in-line filter132 - use non-PVC (i.e., DEHP-free) administration set132 - noncytotoxic

Leucovorin 50 mg/5 mL 500 mg/50 mL (Hospira) (F)(PFL) no preservative133

N/A

10 mg/mL133

5 mL vial: discard unused portion133 50 mL vial: 8 h

syringe134

7 d F134 48 h RT87,134

0.05-10 mg/mL133

24 h RT133: NS, D5W, Lactated Ringers, Ringers 8 h RT133: D10W, D5NS

50-250 mL* NS, D5W, Lactated Ringers, Ringers, D10W, D5-NS

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

32/77

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Leucovorin 50 mg/5 mL 500 mg/50 mL (Novopharm) (F)(PFL)135 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes

N/A135

10 mg/mL135

5 mL vial: discard unused portion135 50 mL vial: discard unused portion135

syringe

8 h135,13

- noncytotoxic

0.060-1.0 mg/mL135

24 h RT NS, Lactated Ringers, Ringers135 12 h RT D5W, D10W135 6 h RT D5NS135

50-250 mL* NS, D5W, Lactated Ringers, Ringers, D10W, D10NS135

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

33/77

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Mechlorethamine 10 mg (Ovation Pharmaceuticals/Merck) no preservative136 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes

do NOT use if discoloured or water droplets form in vial before reconstitution136 10 mL SWI or NS136 record time of reconstitution

1 mg/mL136

use within 4 h of reconstitution RT11,13

syringe136

complete administration 4 h of reconstitution RT11,13,136

- cytotoxic7

100 mL NS49,136

complete administration within 4 h of reconstitution RT13,49,136

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

34/77

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Medroxyprogesterone 250 mg/5 mL (Pfizer) (RT) preservative18 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes

N/A record time of puncture

50 mg/mL18

use within 4 h of initial puncture11,137

syringe: IM only18

use within 4 h of initial vial puncture11,137

- cytotoxic7 - auxiliary label: shake before use18

Medroxyprogesterone Depo 150 mg/1mL (Pfizer) (RT) preservative18 Melphalan 50 mg (GSK) (RT)(PFL) no preservative138

N/A record time of puncture 10mL supplied diluent138 immediately after adding diluent, shake vigorously138 record time of reconstitution

150 mg/mL18

use within 4 h of initial puncture11,137

syringe: IM only18

use within 4 h of initial puncture11,137

- cytotoxic7 - auxiliary label: shake before use18

5 mg/mL138

2 h RT138 do NOT refrigerate

0.1 0.45 mg/mL in NS only138 (e.g., > 45 mg and < 110 mg in 250 mL NS)*

complete administration within 60 min from time of initial reconstitution at RT11

- cytotoxic7

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

35/77

Mesna 1000 mg/10mL (PPC) (RT) preservative139 Methotrexate 50 mg/2mL 500 mg/20mL 1 g/40mL 5 g/200mL (Hospira) (RT)(PFL) no preservative140

N/A

100 mg/mL139

14 d F, RT13,139

> 1mg/mL139 NS or D5W

48 h F, 24 h RT139

- noncytotoxic

N/A

25 mg/mL140

50mg: discard unused portion140 500mg, 1 g, 5 g: 8 h F, RT140

syringe

2 d F, RT11,141,142

- cytotoxic7 - for high-dose regimens (e.g., 1-8 g/m2 as a single dose)143 use preservative-free methotrexate11 - do not use for IT injection

0.42 mg/mL140 100 mL* NS, D5W high dose (e.g., 1-8 g/m2 as a single dose)143,144-146: 500 1000 mL*

24 h RT140

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

36/77

Methotrexate IT Injection140: Only preservative free methotrexate may be administered by the intrathecal route140 50 mg/2mL147 (Hospira) (RT)(PFL) no preservative140 Methotrexate 50 mg/2mL 500 mg/20mL (Hospira) (RT)(PFL) preservative140

N/A

25 mg/mL140

discard unused portion140

qs to 6 mL with preservative free NS61

use within 4 h of initial puncture11,13

- cytotoxic7 - auxiliary label62: IT - label to include route in full (i.e., INTRATHECAL injection) attached to both syringe and outer ziplock bag62 - cytotoxic7 - high-dose regimen(e.g., 1-8 g/m2 as a single dose)144-146: use preservative-free methotrexate11 - do not use for IT injection

N/A

25 mg/mL140

24 h F141

syringe

14 d F87,141

0.42 mg/mL140 e.g., 100 mL*NS, D5W140 Mitomycin 5 mg 20 mg (Novopharm) (RT)(PFL) no preservative148 SWI 5 mg: 10 mL 20 mg: 40 mL shake well148 0.5 mg/mL148 48 h F, RT13,148 (PFL)148 syringe13

4 h RT140

14 d F, 48 h RT13,148

- cytotoxic7

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

37/77

0.02-0.04 mg/mL148 NS, D5W, sodium lactate148 Mitomycin 5 mg 20 mg (BMS) (RT)(PFL) no preservative149 SWI 5 mg: 10 mL 20 mg: 40 mL shake well149 0.020.04 mg/mL NS, D5W, sodium lactate149 0.5 mg/mL149 48 h F, RT13,149 (PFL)149 syringe11

3 h RT: D5W 12 h RT: NS 24 h RT: sodium lactate148 14 d F, 48 h RT11,21 - cytotoxic7

12 h RT: NS 3h: D5W 24 h: sodium lactate149

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

38/77

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Mitoxantrone 20 mg/10 mL 25 mg/12.5 mL (Hospira) (RT)(PFL) no preservative150 Mitoxantrone 20 mg/10 mL (Novopharm) (RT)(PFL) no preservative151 Mitoxantrone 20 mg/10 mL (Pharmaceutical Partners of Canada) (RT) no preservative153 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes

N/A

2 mg/mL150

discard unused portion150

0.2-0.6 mg/mL150 NS, D5W150 > 50 mL*150

NS: 24 h F, RT150 **(PFL)150

- cytotoxic7

N/A

2 mg/mL151

discard unused portion151

NS, D5W151 > 50 mL*151 NS, D5W2 > 50 mL*153

24 h RT151 **(PFL)152 24 h RT153

- cytotoxic7

N/A

2 mg/mL153

discard unused portion153

- cytotoxic7

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

39/77

Octreotide 50 mcg/mL; 100 mcg/mL; 500 mcg/mL (Novopharm) (F)(PFL) no preservative multidose vials (5mL): 200 g/mL (F)(PFL) 154 preservative

N/A

50 mcg/mL 100 mcg/mL 500 mcg/mL154

discard unused portion154

sc syringe154

single use vials: use within 4 h multidose vials: use within 14 d F74,154

- noncytotoxic

200 mcg/mL154

14 d F74,154

infusion: NS154

single use vials or multidose vials: 24 h RT154 24 h RT18 - noncytotoxic10

Octreotide (Sandostatin) 1000 mcg/5 mL (Novartis) (F)(PFL) preservative18

N/A

200 mcg/mL18

discard unused portion155

50200 mL NS18,11,156 SC infusion: adjust volume to ensure infusion rate of 25 mcg/h18

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

40/77

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Octreotide (Sandostatin) 50 mcg/1 mL 100 mcg/1 mL 500 mcg/1 mL (Novartis) (F)(PFL) no preservative18 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes

N/A

50 mcg/mL 100 mcg/mL 500 mcg/mL18

discard unused portion18

50-100 mL11,156 NS18 SC infusion: adjust volume to ensure infusion rate of 25 mcg/h18

24 h RT18

- noncytotoxic10

Octreotide (Sandostatin LAR) 10 mg 20 mg 30 mg (Novartis) (F)(PFL) preservative155

2 mL supplied diluent gently run 2 mL down sides of the vial; do NOT disturb for 25 min, then swirl moderately18 record time of reconstitution

10 mg: 5 mg/mL 20 mg: 10 mg/mL 30 mg: 15 mg/mL18

discard unused portion18

deep intragluteal administration only18

use within 4 h of initial reconstitution18,13

- noncytotoxic10 - do NOT shake

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

41/77

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Oxaliplatin 50 mg/10 mL 100 mg/20 mL 200 mg/40 mL (Sanofi-Aventis) (RT)(PFL) no preservative157 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes

N/A

5 mg/mL157

discard unused portion157

0.2-1.3 mg/mL158 1.32 mg/mL157,158 250500 mL D5W157 do NOT use NS or other chloridecontaining solution157 do NOT use aluminum-containing needle and syringe157

0.2-1.3 mg/mL: 14 d F, 48 h RT159,87,158 1.3-2 mg/mL: 48 h F, 24 h RT157

- cytotoxic7 - do NOT use aluminumcontaining needle, syringe or tubing157

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

42/77

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Oxaliplatin 50 mg 100 mg (Sigmacon) (RT) no preservative160 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes

SWI, D5W: 50 mg: 10 mL 100 mg: 20 mL do NOT use NS or other chloridecontaining solution160 do NOT use aluminumcontaining needle and syringe160

5 mg/mL160

24 h F160

500 mL D5W do NOT use NS or other chloridecontaining solutions (degrades)160 do NOT use aluminum-containing needle and syringe160

24 h F, 6 h RT160

- cytotoxic7 - do NOT use aluminumcontaining needle, syringe or tubing160

Paclitaxel 30 mg/5 mL 100 mg/16.7 mL 300 mg/50 mL (Biolyse) (RT)161 no preservative

N/A

6 mg/mL162

8 h RT162

0.31.2 mg/mL in NS, D5W162 (e.g., 1001000 mL)* 0.1 mg/mL in NS163 0.012-0.1 mg/mL164

0.3-1.2 mg/mL: 24 h RT162 0.1 mg/mL: 44 h F, RT163 0.012-0.09 mg/mL: 16 h RT164

- cytotoxic7 - use non-PVC bag and tubing with inline filter162

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

43/77

Paclitaxel 30 mg/5 mL 100 mg/16.7 mL 300 mg/50 mL (BMS) (RT)(PFL) no preservative165

N/A

6 mg/mL165

30 mg: 48 h RT13,165 100 mg: 48 h RT13,165 300 mg: 24 h RT165

0.31.2 mg/mL in NS, D5W, D5-NS, D5 in Ringers165 (e.g.,1001000 mL)*

24 h RT165

- cytotoxic7 - use non-PVC and tubing with in-line filter165

0.11 mg/mL in NS, D5W166 Devices with spikes e.g., chemo dispensing pins, should not be used with paclitaxel vials165

48 h F, RT166

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

44/77

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Paclitaxel, nab 100 mg paclitaxel and approximately 900 mg human albumin (Abraxis Oncology) (RT)(PFL) no preservative167 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes

inject 20 mL NS over > 1 min (a chemo pin may be used)168 - direct flow to INSIDE vial wall - stand solution for > 5 min - gently swirl and/or invert vial slowly for > 2 min167 N/A

5 mg/mL167

8 h F, PFL167

in empty sterile PVC or nonPVC infusion bag167,168

8 h RT167

- cytotoxic167 - do NOT filter167 - non-PVC tubing is NOT needed - the use of an inline filter is not recommended168

Pamidronate 30 mg/10 mL 60 mg/10 mL 90 mg/10 mL (Hospira) (RT) no preservative169

3 mg/mL 6 mg/mL 9 mg/mL169

discard unused portion169

0.060.36 mg/mL NS, D5W169 do NOT mix with calcium containing solution (e.g., Ringers)169 e.g., 250 mL NS170

24 h F followed by 24 h RT (total 48 h)169 **(PFL)169

- noncytotoxic171

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

45/77

Pamidronate 30 mg/10 mL 60mg/10 mL 90 mg/10 mL (Sandoz Canada) RT no preservative172

N/A172

3 mg/mL 6 mg/mL 9 mg/mL172

discard unused portion172,74

NS or D5W172 do NOT mix with calcium containing solution (e.g., Ringers)172

24 h RT172

- noncytotoxic171

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

46/77

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Panitumumab 100 mg/5 mL 200 mg/10 mL 400 mg/20 mL (Amgen) (F)(PFL) do not shake no preservative173 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes

N/A

20 mg/mL173

discard unused portion173

1000 mg: 100 mL NS173 >1000mg: 150 mL NS173 1-10mg/mL173,174

24 h F, 6 h RT173,174

- cytotoxic3 - administer with 0.2 or 0.22 micron low protein binding in-line filter173 - solution may contain particulates which do not affect product quality173 - do not administer if discoloured173 - cytotoxic7

Pemetrexed 100 mg 500 mg (Eli Lilly) (RT) no preservative175

100 mg: 4.2 mL preservative-free NS 500 mg: 20 mL preservative-free NS175

25 mg/mL175

24 h F, RT175

100 mL preservative-free NS175 do NOT mix with calcium containing solution (e.g., Ringers)176 syringe177

24 h F, RT175

Porfimer 15 mg 75 mg (Axcan) (RT)(PFL) no preservative177

6.6 mL D5W 31.8 mL D5W177 record time of reconstitution

2.5 mg/mL177

24 h F (PFL)177

use within 4 h of initial reconstitution13,178 **(PFL)177

- noncytotoxic7 - avoid contact with skin and eyes; protect exposed area from light177

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

47/77

Raltitrexed 2 mg (AstraZeneca) (F, RT)(PFL) no preservative179 Raltitrexed 2 mg (Hospira) (F, RT)(PFL) no preservative180

4 mL SWI179

0.5 mg/mL179

24 h F, RT179

50250 mL NS, D5W179

24 h F, RT179

- cytotoxic7

4 mL SWI180

0.5 mg/mL180

24 h F, RT180

50250 mL NS, D5W180

24 h F, RT180

- cytotoxic3

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

48/77

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Rituximab 100 mg/10 mL 500 mg/50 mL (Roche) (F)(PFL) no preservative181 Streptozocin 1g (Pfizer) (F)(PFL) no preservative182 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes

N/A

10 mg/mL181

discard unused portion181

14 mg/mL in NS, D5W) 181 (e.g., 500 mg/250 mL, 1000 mg/500 mL)*

24 h F + additional 12 h RT181

- noncytotoxic3

9.5mL NS, SWI, D5W182

100 mg/mL182

48 h F,182 24 h RT

syringe182 50-500 mL*NS, D5W, SWI182

48 h F, 24 h RT182 48 h F, 24 h RT182

- cytotoxic7

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

49/77

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Temozolomide 100 mg (Schering) (F) do not dilute183 do not shake183 no preservative183 Temsirolimus 30 mg/1.2 mL (Wyeth) (F)(PFL)184,185 no preservative186 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes

41 mL SWI183

2.5 mg/mL183

14 h F, RT183

empty 250 mL PVC bag183

14 h RT183

- cytotoxic{3

1.8 mL supplied diluent184,185

10 mg/mL184,185

24 h RT184,185 (PFL)184

250 mL NS184,185

Complete administration within 6 h184,185

- cytotoxic3 - use non-PVC bag and non-PVC tubing with in-line filter184,185 - cytotoxic7 - do NOT refrigerate18 - use non-PVC bag and tubing18

Teniposide 15 mg/1.5 mL (Bristol) (RT) preservative18

N/A

10 mg/mL18

discard unused portion18

0.1, 0.2, 0.4, or 1 mg/mL in NS or D5W18

0.1, 0.2, 0.4mg/mL: 24 h RT18 1 mg/mL: complete administration within 4h of preparation18

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

50/77

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Thiotepa 15 mg (Bedford) (F)(PFL) no preservative187 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes

1.5 mL SWI187 filter through 0.22 micron filter187 record time of reconstitution

10 mg/mL187

8 h F187

50 mL* NS187

use within 4 h of initial reconstitution188,187 **(PFL)187,189

- cytotoxic7 - do not use if precipitates or remains opaque187 - do not use for IT injection

syringe: reconstituted solution is hypotonic and must be further diluted with NS prior to use187 (final concentration of 0.5-1 mg/ml is nearly isotonic)190

use within 4 h of initial reconstitution188,187 **(PFL)187,189

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

51/77

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Thiotepa IT injection: 15 mg (Bedford) (F)(PFL) no preservative187 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes

diluents containing preservatives should NOT be used for intrathecal administration 1.5 mL SWI187 filter through 0.22 micron filter187 record time of reconstitution

10 mg/mL187

8 h F187

qs to 6 mL with preservative free NS191

use within 4 h of initial reconstitution188,187 **(PFL)187,189

- auxiliary label61 IT - label to include route in full (i.e., INTRATHECAL injection) attached to both syringe and outer ziplock bag61 - cytotoxic7 - do not use if precipitates or remains opaque187

Thyrotropin alfa 1.1 mg (Genzyme) (F)(PFL) no preservative192

1.2 mL SWI192 swirl contents192; do not shake

0.9 mg/mL192

24 h F192

syringe192

24 h F192

- noncytotoxic

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

52/77

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Tocilizumab 80 mg/4 mL 200mg/10 mL 400 mg/20 mL (Genentech) (F)(PFL) no preservative193 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes

N/A

20 mg/mL193

6 h193, 21

100 mL NS dilute to 100 mL final volume by withdrawing volume of NS from 100 mL bag equal to volume of drug required for dose prior to adding drug193

24h F193; 6 h RT194

- cytotoxic3 - to prevent foaming: slowly add drug to infusion bag and gently invert bag to mix193

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

53/77

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Topotecan 4 mg (GSK) (RT)(PFL) no preservative195,196 Topotecan 4 mg (GSK) (RT)(PFL) single use no preservative198 Trastuzumab 440 mg (Roche) (F) preservative199 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes

4 mL SWI195

1 mg/mL195

24 h F, RT195

0.010.5 mg/mL197 50 mL NS, D5W195

24 h F, RT195

- cytotoxic7

4 mL SWI198

1 mg/mL198

24 h F, RT198

0.020 0.5 mg/mL198

24 h F, RT198

cytotoxic3

20 mL supplied BWI swirl vial gently; allow to stand undisturbed for 5 min199

21 mg/mL199

14 d F13,199

250mL NS199 do NOT use dextrose containing solutions199

24 h F, RT199

- noncytotoxic3 - do NOT shake199

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

54/77

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Treosulfan 1g 5g (medac) (RT) no preservative200 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes

pre-heat SWI to 30C (not higher) shake vial carefully before adding the warmed SWI 1 g vial: 20 mL SWI, while slightly shaking vial and syringe; continue shaking the reconstituted solution for another 2 min{{10494}} 5 g vial: 100 mL SWI, while slightly shaking vial and syringe; continue shaking the reconstituted solution for another 2 min200

50 mg/mL200

48 h RT13,200

undiluted201 dilute with NS or D5W in empty infusion bag for final concentration = 20 mg/mL200

48 h RT13,200

- cytotoxic3 - compatible with polytetrafluoroethyl ene filters200 - may require vigorous shaking to reconstitute200

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

55/77

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Vinblastine 10 mg/10 mL (Hospira) (F)(PFL) no preservative154 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes

N/A

1 mg/mL154

discard unused portion154

syringe11,154

4 h F, RT202,203

- cytotoxic7 - label with: WARNING: FOR INTRAVENOUS USE ONLY FATAL IF GIVEN BY OTHER ROUTES204,205

100250 mL NS, D5W206

24 h F, RT202,203

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

56/77

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Vincristine 2 mg/2 mL 5 mg/5 mL (Hospira) (F)(PFL) no preservative207 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes

N/A

1 mg/mL207

8 h F, RT207

50 mL*NS, D5W207

24 h F, 6 h RT,207 **(PFL)207

- cytotoxic7 - label with: WARNING: FOR INTRAVENOUS USE ONLY FATAL IF GIVEN BY OTHER ROUTES204,205 - cytotoxic7 - label with: WARNING: FOR INTRAVENOUS USE ONLY FATAL IF GIVEN BY OTHER ROUTES204,205

Vincristine 1 mg/1 mL 2 mg/2 mL 5 mg/5 mL (Novopharm) (F)(PFL) preservative208

N/A

1 mg/mL208

14 d F, RT208

50 mL*NS, D5W208

72 h F, 24 h RT65 **(PFL)208

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

57/77

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Vinorelbine 10 mg/1 mL 50 mg/5 mL (GSK) (F)(PFL) no preservative209 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes

N/A

10 mg/mL209

discard unused portion209

syringe: 1.5 3.0 mg/mL in NS or D5W209

24 h F, RT209

- cytotoxic7 - label with: WARNING: FOR INTRAVENOUS USE ONLY FATAL IF GIVEN BY OTHER ROUTES204,205

0.5 2.0 mg/mL209 50 mL*NS, D5W, NS, D5NS, Ringers, Ringers Lactate209 Vinorelbine 10 mg/1 mL 50 mg/5 mL (Hospira) (F)(PFL) no preservative210 N/A 10 mg/mL210 discard unused portion210 syringe: 1.5 3.0 mg/mL in NS or D5W210

24 h F, RT209

24 h F, RT210

- cytotoxic7 - label with: WARNING: FOR INTRAVENOUS USE ONLY FATAL IF GIVEN BY OTHER ROUTES204,205

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

58/77

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes

0.5 2.0 mg/mL210 50 mL* NS, D5W, NS, D5NS, Ringers, Ringers Lactate210 Vinorelbine 10 mg/1 mL 50 mg/5mL (Pierre Fabre Pharma Canada) (F)(PFL) no preservative211 N/A211 10 mg/mL211 discard unused portion211 syringe: 1.5-3.0 mg/mL in D5W or NS211

24 h F, RT210

24 h F, RT211

- cytotoxic3 - label with: WARNING: FOR INTRAVENOUS USE ONLY FATAL IF GIVEN BY OTHER ROUTES204,205

0.5-2.0 mg/mL211 NS, D5W, NS, D5NS, Ringers, Ringers Lactate211

24 h F, RT211

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

59/77

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

60/77

* Suggested volume based on usual dose range and any concentration range of stability data ** Protect from light means minimizing exposure to direct sunlight over a storage period. More specific information on protection from light (eg, protecting container and tubing during administration) will be indicated in the Under the Special Precautions/Notes column.

Centres are not to change the content locally but should forward suggestions to the Cancer Drug Manual staff. Explanatory Notes
Stability data assume products prepared using standard aseptic technique in biological safety cabinet at low risk for contamination according to the classification outlined in USP 797.21,212 Vial stability: Stability of solution after first puncture or reconstituted solution Storage temperature: If information states same stability with refrigerator and room temperature storage, then bold refrigerated as preferred (ie, to minimize growth of micro-organisms). Cytotoxic: hazardous (see Policy II-20 for more details). Discard unused portion: Unused portion from single use vials should be discarded at the end of the day. State overfill known if the manufacturer states overfill within acceptable limits is present.

PFL = protect from light RT = room temperature F = refrigerated SWI = sterile water for injection NS = normal saline D5W = dextrose 5% BWI = bacteriostatic water for injection

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

61/77

References 1. Novartis Pharmaceuticals Canada Inc. PROLEUKIN product monograph. Dorval, Quebec; 6 July 2006. 2. McEvoy GK, editor. AHFS 2008 Drug Information. Bethesda, Maryland: American Society of Health-System Pharmacists, Inc. p. 917-925. 3. National Institute for Occupational Safety and Health (NIOSH). Preventing occupational exposures to antineoplastic and other hazardous drugs in healthcare settings. Cincinnati, Ohio: NIOSH - Publications Dissemination; September 2004. p. 31-40. 4. Rui Paiva. Personal communication. Business Unit Director, Transplant and Oncology; 1 June 2009. 5. Bayer HealthCare Pharmaceuticals. MabCampath Package Insert. Toronto, Ontario; 1 September 2007. 6. Lundin J, Porwit-MacDonald A, Rossmann ED, et al. Cellular immune reconstitution after subcutaneous alemtuzumab (anti-CD52 monoclonal antibody, CAMPATH-1H) treatment as first-line therapy for B-cell chronic lymphocytic leukaemia. Leukemia 2004(18):484-490. 7. National Institute for Occupational Safety and Health (NIOSH). Preventing Occupational Exposures to Antineoplastic and Other Hazardous Drugs in Healthcare Settings (Draft). Cincinnati, OH; 25 March 2004. 8. Berlex Canada Inc. Campath Drug Information. San Antonio, Texas; undated. 9. Schering AG. MABCAMPATH Package Leaflet. Berlin, Germany; April 2002. 10. MedImmune Pharma B.V. Ethyol Package Insert. The Netherlands; 2003. 11. Trissel LA. Handbook on Injectable Drugs. 13th ed. Bethesda, MD: American Society of Health-System Pharmacists, Inc.; 2005. 12. Erfa Canada Inc. AMSA PD injection product monograph. Westmount, Quebec; 16 August 2005.
BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010 62/77

13. BC Cancer Agency. Pharmacy Policy Number II-20: Guiding Principles for Chemotherapy Preparation Chart. Vancouver, British Columbia: BC Cancer Agency; 6 January 2006. 14. Tanya Leduc. Personal communication. Acting editor, BC Cancer Agency Cancer Drug Manual; 2 June 2008. 15. National Institute for Occupational Safety and Health (NIOSH). Preventing occupational exposures to antineoplastic and other hazardous drugs in healthcare settings. Cincinnati, Ohio: NIOSH - Publications Dissemination; 25 March 2004. p. 71-83. 16. Orphan Pharma International. Kidrolase Product Monograph. Limonest, France; 2005. 17. Robert Sarrazin B Pharm. Personal communication. Consultant, OPi Inc. February 2005. 18. Repchinsky C editor. Compendium of Pharmaceuticals and Specialties. 12th ed. Ottawa, Ontario: Canadian Pharmacists Association; 2004. 19. OPi SAS. Kidrolase Product Monograph. Laval, Quebec; 2003. 20. Rhone-Poulenc Rorer. Kidrolase Package Insert. Montreal, Quebec; 2004. 21. The United States Pharmacopeia (USP). General Chapter 797: Pharmaceutical compounding - sterile preparations. USP 27-NF 22. Rockville, Maryland: The United States Pharmacopeial Convention, Inc.; 2004. 22. Orphan Pharma International. Erwinase Product Monograph. Limonest, France; 2005. 23. Enzon Pharmaceuticals Inc. Oncaspar Product Monograph. Bridgewater, New Jersey; 2003. 24. BC Cancer Agency Provincial Systemic Therapy Program. Provincial Systemic Therapy Program Policy III-20: Prevention and Management of Extravasation of Chemotherapy. Vancouver, British Columbia: BC Cancer Agency; 1 September 2006. 25. Celgene. VIDAZA product monograph. Oakville, Ontario; 22 October 2009.

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

63/77

26. Carol Repchinsky. ImmuCyst monograph, Compendium of Pharmaceuticals and Specialties. Ottawa, Ontario; 2005. 27. Organon Canada Ltd. OncoTICE Product Monograph. Scarborough, Ontario; 24 October 2001. 28. Cephalon. TREANDA prescribing information. Frazer, PA; October 2009. 29. Roche. Bevacizumab for injection, Summary product information. Mississauga, Ontario; 2005. 30. Hoffmann-La Roche Limited. Ro 4876647 Avastin Investigator's Brochure. Mississauga, Ontario; 14th edition, November 2006. 31. Carol Repchinsky. Blenoxane monograph, Compendium of Pharmaceuticals and Specialties. Ottawa, Ontario; 2005. 32. Catherine Dehaut M.Sc. Personal communication. Medical Information Associate, Bristol Laboratories of Canada; February 2008. 33. Faulding (Canada) Inc. Bleomycin Product Monograph. Montreal, Quebec; 3 June 2002. 34. Sheila Ahmed. Personal communication Bleomycin. Regulatory Affairs Associate, Bleomycin, Mayne Pharma Canada. Ref JUN-128-2004; July 2, 2004. 35. Robert Caunce. Personal communication. Quality System Manager, Hospira Australia; 12 March 2008. 36. Millenium Pharmaceuticals Inc. Velcade product monograph. Cambridge, Massachusetts; May 2003. 37. Walker S, Milliken D, Law S. Stability of bortezomib vials reconstituted with 0.9% sodium chloride at 4C and room temperature (23C). Canadian Journal of Hospital Pharmacy 2006;59 (Suppl 1):62. 38. Janssen-Ortho Inc. VELCADE product monograph. Toronto, Ontario; 18 April 2006. 39. Orphan Medical Inc. Busulfex Package Insert. Flamborough, Ontario; August 1999.
BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010 64/77

40. Mayne Pharma (Canada) Inc. Carboplatin Package Insert. Montreal, QC; Undated. 41. Nancy Grioriadis. Personal communication. Regulatory Affairs Associate, Mayne Pharma (Canada) Inc. 2 October 2006. 42. Nancy Griogoriadis. Personal communication. Regulatory Affairs Associate, Mayne Pharma (Canada) Inc. 2 October 2006. 43. Novopharm Limited. Carboplatin Package Insert. Toronto, Canada; Undated. 44. Manjinder S Kang. Personal communication. Regulatory Affairs Drug Information Pharmacist, Novopharm Canada. 14 March 2005. 45. Repchinsky C. Paraplatin-AQ, Compendium of Pharmaceuticals and Specialties. 12th ed. Ottawa, Ontario: Canadian Pharmacists Association; 2004. 46. Bristol Laboratories of Canada. BiCNU Package Insert. Montreal, Canada; 2002. 47. ImClone Systems Incorporated and Bristol-Myers Squibb Company. ERBITUX product monograph. Branchburg, NJ, USA; March 2009. 48. Mayne Pharma (Canada) Inc. Cisplatin Package Insert. Montreal, QC; Undated. 49. Trissel LA. Handbook on Injectable Drugs. 12th ed. Bethesda, MD: American Society of Health-System Pharmacists, Inc.; 2003. 50. Repchinsky C. Cisplatin CPhA monograph, Compendium of Pharmaceuticals and Specialties. 12th ed. Ottawa, Ontario: Canadian Pharmacists Association; 2004. 51. Janssen-Ortho Inc. LEUSTATIN Product Monograph. Toronto, Ontario; 31 July 2006. 52. BC Cancer Agency Lymphoma Tumour Group. (LYCDA) BCCA Protocol Summary for Treatment of Hairy Cell Leukemia with Cladribine. Vancouver, British Columbia: BC Cancer Agency; 1 February 2007.
BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010 65/77

53. Myrna O'Brodovich. Personal communication. Senior Medical Information Associate Ortho Biotech; 2 April 2008. 54. de Lemos ML, Hamata L. Stability issues of parenteral chemotherapy drugs. J Oncol Pharm Pract 2007;13(1):27-31. 55. Oryx Pharmaceuticals Inc. Clasteon Product Monograph. Mississauga, Ontario; 25 November 2004. 56. Baxter Corporation. Procytox Package Insert. Toronto, Ontario; 2004. 57. Paul Agro. Personal communication. Medical Information, cyclophosphamide, Baxter. 12 July, 2006. 58. Novartis Pharmaceuticals Canada Inc. NEORAL & SANDIMMUNE I.V. product monograph. Dorval, Quebec; 30 September 2008. 59. Trissel LA. Handbook on Injectable Drugs. 13th ed. Bethesda, Maryland: American Society of Health-System Pharmacists, Inc; 2005. p. 418-420. 60. Mayne Pharma (Canada) Inc. Cytarabine Injection Product Monograph. Montreal, Quebec; 25 July 2003. 61. BC Cancer Agency Miscellaneous Origin Tumour Group. BCCA protocol summary for solid tumours using intrathecal methotrexate and/or thiptepa and/or cytarabine (MOIT). Vancouver, British Columbia: BC Cancer Agency; 1 July 2005. 62. BC Cancer Agency. Systemic Therapy Policy III-50: Administration of Cytotoxic Drugs by the Intrathecal Route via Lumbar Puncture or Ommaya Reservoir. Vancouver, British Columbia; 31 October 2002. 63. Pfizer Canada Inc. CYTOSAR Sterile Powder Product Monograph. Kirkland, Quebec; 17 March 2004. 64. BPharm Yamina Chikhaoui PhD. Personal communication. Medical Information, Pfizer Canada. February 2005. 65. Novopharm Limited. Vincristine product monograph. Scarbough, Canada; 1999.

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

66/77

66. Abraxis Pharmaceutical Products. Dacarbazine product information package. Schaumburh, IL; December 2006. 67. Trissel L. Handbook on injectable drugs. 13th ed. Bethesda, Maryland: American Society of Health-System Pharmacists; 2005. p. 428-431. 68. Mayne Pharma (Canada) Inc. DACARBAZINE FOR INJECTION product monograph. Montreal, Quebec; 25 July 2003. 69. John Korontzis. Personal communication. Regulatory Affairs Associate, Dacarbazine, Mayne Pharma Canada; #FEB-14-2005 (february 8, 2005). 70. Jane Stachura. Personal communication. Ovation Pharmaceuticals Inc; 12 January 2009. 71. Ovation Pharmaceuticals Inc. COSMEGEN product monograph. Deerfield, Illinois; 19 August 2008. 72. Patricia Hamelin-Dandridge RN. Personal communication. Medical Information Research Associate, Ovation Pharmaceuticals; 24 October, 2008. 73. Trissel LA. Handbook on Injectable Drugs. 13th ed. Bethesda, Maryland: American Society of Health-System Pharmacists, Inc; 2005. p. 431. 74. BC Cancer Agency. Pharmacy Policy Number II-20: Guiding Principles for Chemotherapy Preparation Chart. Vancouver, British Columbia: BC Cancer Agency; 19 September 2007. 75. Erfa Canada Inc. Daunorubicin injection product monograph. Westmount, Quebec; 6 December 2002. 76. Erfa Canada Inc. Material Safety Data Sheet. Montreal, Quebec; 3 October 2007. 77. Henri Knafo MD. Personal communication. Medical Director, Erfa Canada Inc; 14 July 2008. 78. Henri Knafo MD. Personal communication. Medical director, Erfa Canada Inc; 09 July 2008.

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

67/77

79. Novopharm Limited. Daunorubicin Package Insert. Toronto, Canada; Undated. 80. Pharmacia & Upjohn Inc. Zinecard Package Insert. Mississauga, Ontario; 2004. 81. Pharmacia & Upjohn Company. Zinecard: US Prescribing Information. Kalamazoo, Michigan; September 2003. 82. Emmanuelle Laflamme B.Pharm. Personal communication. Medical Information Officer, Dexrazoxane, Pfizer. February 2005. 83. Aventis Pharma Inc. Taxotere Package Insert. Laval (Quebec) Canada; 2004. 84. Maureen Coughlin BSc Pharm. Personal communication. SOLUTIONS in Health; 28 September 2009. 85. Walker S, Charbonneau F, Law S. Stability of docetaxel in normal saline at room temperature (abstract). Can J Hosp Pharm 2003;56 (Suppl PPC):S51. 86. Walker S, Charbonneau F, Law S. Stability of docetaxel in normal saline at room temperature. Can J Hosp Pharm (in press). 87. The United States Pharmacopeial Convention, Inc. General Chapter 797: Pharmaceutical compounding sterile preparations. USP 27-NF 22. Rockville, Maryland: The United States Pharmacopeial Convention, Inc.; 2003. 88. Mayne Pharma (Canada) Inc. Doxorubicin Package Insert. Montreal, QC; Undated. 89. Mayne Pharma (Canada) Inc. Doxorubicin Product Monograph. Montreal, Quebec; 2002. 90. John Korontzis. Personal communication. Regulatory Affairs Associate, Doxorubicin, Mayne Pharma Canada; February 2005. 91. Novopharm Limited. Doxorubicin Product Monograph. Scarborough, Ontario; 8 November 1996. 92. Pfizer Canada Inc. Adriamycin injection product monograph. Kirkland, Quebec; 28 August 2007.

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

68/77

93. Schering Canada Inc. Caelyx Package Insert. Pointe-Claire, Quebec; September 2001. 94. Pharmacia Canada Inc. Pharmorubicin PFS Package Insert. Mississauga, Ontario; May 2003. 95. Bristol Laboratories of Canada. Vepesid Package Insert. Montreal, Canada; March 2000. 96. Nicole Hojm and Kinda Karra. Personal communication. Medical Information, etoposide, Bristol-Myers Squibb. February 2005. 97. The United States Pharmacopeial Convention, Inc. General Chapter 797 proposed revisions. ; 2006. 98. The United States Pharmacopeial Convention, Inc. General Chapter 51: Antimicrobial effectiveness testing. USP 28-NF 23. Rockville, Maryland: The United States Pharmacopeial Convention, Inc.; 2004. 99. Novopharm Limited. Etoposide Product Monograph. Toronto, Ontario; 2000. 100. Lepage R, Walker S, Godin J. Stability and compatibility of etoposide in normal saline. Canadian Journal of Hospital Pharmacy 2000;53(5):338-345. 101. Angie Chan. Personal communication. Drug Information Pharmacist, Novopharm. 29 September 2006. 102. Berlex Canada Inc. Fludara Package Insert. Lachine, Quebec; December 1998. 103. Trissel's2 Clinical Pharmaceutics Database (Parenteral Compatibility) [database on the internet]. Fludarabine. Thomson MICROMEDEX, Available at: http://www.micromedex.com/. Accessed 14 September, 2007. 104. Novopharm Limited. Fludarabine product information package. Toronto, Ontario; 21 June 2007. 105. Mayne Pharma (Canada) Inc. Fluorouracil Package Insert. Montreal, Quebec; Undated. 106. John Korontzis. Personal communication. Regulatory Affairs Associate, Fluorouracil, Mayne Pharma Canada; reference # FEB-43-2005.February 16, 2005.
BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010 69/77

107. Stiles ML, Allen Jr LV, Tu YH. Stability of fluorouracil administered through four portable infusion pumps. American Journal of Hospital Pharmacy 1989;46(10):2036-2040. 108. Eli Lilly Canada Inc. Gemzar Package Insert. Toronto, Ontario; 16 January 2002. 109. Marilyn Bain BSc N. Personal communication. Sr Therapeutic Area Specialist Medical Information, Gemzar. September 2004. 110. Hospira Healthcare Corporation. Gemcitabine for injection, USP product monograph. Montreal, Quebec; 3 November 2008. 111. Rose Toussaint. Personal communication. Clinical Specialist, Hospira Canada Healthcare Corporation; 26 May2009. 112. Hospira Canada Clinical Support Team. Personal communication. Hospira Healthcare Corporation; 13 March 2009. 113. B.C. Cancer Agency - Pharmacy. Pharmacy Provincial Policy II-30: Guiding principles for chemotherapy preparation chart. Vancouver, British Columbia: BC Cancer Agency; 24 March 2004. 114. Novopharm Limited. Gemcitabine product monograph. Toronto, Ontario; 08 February 2008. 115. Sandoz Standard. Gemcitabine for injection product monograph. Boucherville, Quebec; 13 November 2007.2007. 116. Amelie Fontaine B.Sc (N). Personal communication. Drug Information Specialist, Sandoz (vial); 9 April 2009. 117. Stephane Jean B. Pharm. Personal communication. Sandoz Canada Drug Information; 7 May 2008. 118. Stephane Jean. Personal communication. Drug Information Specialist; 25 September 2009. 119. Amelie Fontaine B.Sc (N). Personal communication. Drug Information Specialist, Sandoz (infusion); 9 April 2009.
BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010 70/77

120. Pharmacia & Upjohn Inc. Idamycin Package Insert. Mississauga, Ontario; July 1997. 121. Natalie Groves BScN. Personal communication. Medical Information Specialist, Pfizer Canada Inc. 7 March 2007. 122. Baxter Corporation. Ifex Package Insert. Toronto, Ontario; Undated. 123. Schering Canada Inc. Intron A Package Insert. Pointe-Claire, Quebec; January 2003. 124. Julie Lacasse BScN RN. Personal communication. Associate Medical Information, Schering. February 2005. 125. Schering Canada. Intron A Product Monograph. Pointe Claire Quebec; December 2004. 126. Edward Kavalec. Intron A (interferon alpha-2b). Schering Canada - Medical Services. 2006. 127. Mayne Pharma (Canada) Inc. Irinotecan Package Insert. Montreal, Quebec; 28 April 2005. 128. Beryl Chan. Personal communication. Mayne Pharma (Canada) Inc. Scientific Affairs Manager, Irinotecan. 2 February 2006. 129. Walker S, Iazzetta J, Law S. Irinotecan stability in vials following puncture when stored at 23c or 4c. Can J Hosp Pharm 2006;59 (Suppl 2):36. 130. Pharmacia Canada Inc. Camptosar Package Insert. Mississauga, Ontario; May 2002. 131. Sandoz Canada Inc. Irinotecan injection package insert. Boucherville, Quebec; April 2008. 132. Bristol-Myers Squibb. IXEMPRA product monograph. Princeton, New Jersey; 01 October 2007. 133. Faulding (Canada) Inc. Leucovorin Package Insert. Montreal, QC; Undated. 134. John Korontzis. Personal communication. Regulatory Affairs Associate, Leucovorin Calcium, Mayne Pharma Canada; February 2005.

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

71/77

135. Novopharm Limited. Leucovorin Calcium injection product information package. Toronto, Ontario; undated. 136. Ovation Pharmaceuticals Inc. MUSTARGEN Package Insert. Deerfield, Illinois; October 2005. 137. BC Cancer Agency. Systemic Therapy Policy III-20: Extravasation of Chemotherapy, Prevention and Management of Extravasation of Chemotherapy. Vancouver, British Columbia: BC Cancer Agency; 1 July 2006. 138. GlaxoSmithKline Inc. Alkeran Package Insert. Mississauga, Ontario; Montreal, Quebec; 2004. 139. Pharmaceutical Partners of Canada Inc. Mesna Package Insert. Richmond Hill, Ontario; November 2001. 140. Mayne Pharma Canada. Methotrexate Product Monograph. Montreal, Quebec; December 2003. 141. John Korontzis. Personal communication. Regulatory Affairs Associate, Methotrexate, Mayne Pharma Canada; February 2005. 142. John Korontzis. Personal communication. Regulatory Affairs Associate, Fluorouracil, Methotrexate, Vincristine, Mayne Pharma Canada; 14 March 2005. 143. BC Cancer Agency Lymphoma Tumour Group. BCCA protocol summary for treatment of primary intracerebral lymphoma with high dose methotrexate (LYHDMTXP). Vancouver, British Columbia: BC Cancer Agency; 1 June 2004. 144. BC Cancer Agency Lymphoma Tumour Group. BCCA protocol summary for treatment of leptomeningeal lymphoma or recurrent intracerebral lymphoma with high dose methotrexate (LYHDMTXR). Vancouver, British Columbia: BC Cancer Agency; 1 June 2004. 145. BC Cancer Agency Miscellaneous Origin Tumour Group. BCCA protocol summary for treatment of meningeal disease (miscellaneous tumour origins) using high dose methotrexate with leucovorin rescue (UMOHDMTX). Vancouver, British Columbia: BC Cancer Agency; 21 September 1999.

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

72/77

146. BC Cancer Agency Sarcoma Tumour Group. BCCA protocol summary for treatment of osteosarcoma using high dose methotrexate with leucovorin rescue (OSHDMTX). Vancouver, British Columbia: BC Cancer Agency; 1 August 2000. 147. BC Cancer Agency. Pharmacy Policy Number III-50-02: Methotrexate Intrathecal Injection. Vancouver, British Columbia: BC Cancer Agency; 27 January 2006. 148. Novopharm Limited. Mitomycin for Injection Product Monograph. Scarborough, Ontario; 23 December 1996. 149. Bristol Laboratories of Canada. Mutamycin Package Insert. Montreal, Canada; 2000. 150. Hospira Healthcare Corporation. Mitoxantrone Injection, USP Product Monograph. Saint-Laurent, Quebec; 13 June 2007. 151. Novopharm Limited. Mitoxantrone Injection Product Monograph. Toronto, Ontario; 19 May 2005. 152. Angie Chan. Personal communication. Drug Information Pharmacist, Novopharm; 7 Mar 2008. 153. Pharmaceutical Partners of Canada. Mitoxantrone Injection, USP Package Insert. Richmond Hill, Ontario; February 2007. 154. Novopharm Limited. Octrotide Injection Product Monograph. Scarborough, Ontario; 15 March 2007. 155. Repchinsky C. Sandostatin LAR monograph, Compendium of Pharmaceuticals and Specialties. Ottawa, Ontario: Canadian Pharmacists Association; 2005. p. 1912-1916. 156. Vancouver Hospital and Health Sciences Centre Pharmacy Department. Octreotide. Parenteral drug therapy manual. Vancouver, BC; February 2002. 157. sanofi-aventis Canada Inc. ELOXATIN product monograph. Laval, Quebec; 13 January 2009. 158. Eiden C, Philibert L, Bekhtari K, et al. Physicochemical stability of oxaliplatin in 5% dextrose injection stored in polyvinyl chloride, polyethylene, and polypropylene infusion bags. Am J Health Syst Pharm 2009;66.
BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010 73/77

159. Andre P, Cisternino S, Roy A-, et al. Stability of oxaliplatin in infusion bags containing 5% dextrose injection. American Journal of Health-System Pharmacy 2007;64(18):1950-1954. 160. Sigmacon Lifesciences. Oxaliplatin for injection. North York, Ontario; January 2006. 161. Claude Mercure. Personal communication. Production Manager Biolyse Pharma Corporation; 21 December 2009. 162. Biolyse Pharma. Paclitaxel Package Insert. Ontario, Canada; November 2002. 163. Mercure C. Stability of 0.1 mg/mL of paclitaxel for injection in sodium chloride (0.9%) solution. St Catharines, Ontario: Biolyse Pharma; 2 February 2007. 164. Zeng Z, Lazakovitch E. Study IR 120: Physical and Chemical Stability Study of Paclitaxel for Injection in 0.9 % Sodium Chloride in concentration range 0.012-0.12 mg/mL. Biolyse Pharma 10 March 2010. 165. Bristol-Myers Squibb Canada. Taxol Package Insert. Montreal, Quebec; September 2002. 166. Xu Q, Trissel LA, Martinez JF. Stability of paclitaxel in 5% dextrose injection or 0.9% sodium chloride injection at 4, 22, or 32 degrees C. Am J Hosp Pharm 1994;51(24):3058-60. 167. Abraxis Oncology. ABRAXANE Product Monograph. Richmond Hill, Ontario; 26 June 2006. 168. Abraxis BioScience. Reconstitution of ABRAXANE. Richmond Hill, ON; May 2008. 169. Mayne Pharma (Canada) Inc. Pamidronate Package Insert. Montreal, Quebec; 2002. 170. BC Cancer Agency Breast Tumour Group. BCCA protocol summary for treatment of acute bone pain secondary to breast cancer metastases using pamidronate or IV clodronate (BRAVPAM). Vancouver, British Columbia: BC Cancer Agency; 1 May 2001. 171. Novartis Pharmaceuticals Corporation. Aredia Product Monograph. East Hanover, New Jersey; 2003.

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

74/77

172. Sandoz Canada Inc. Pamidronate injection product monograph. Boucherville, Quebec; 28 February 2006. 173. Amgen Canada. VECTIBIX product monograph. Mississauga, Ontario; 5 March 2009. 174. Diane Lord. Personal communication. Amgen Canada Inc Medical Information Department; 19 June 2009. 175. Eli Lilly Canada. Pemetrexed product information. Toronto, Ontario; 2008. 176. Eli Lilly Canada Inc. ALIMTA Product Monograph. Toronto, Ontario; 21 May 2004. 177. Axcan Pharma Inc. Photofrin Package Insert. Mont-Saint-Hilaire, Quebec; 2004. 178. Marie-Helene Doyon B.Pharm. M.Sc. Personal communication. Medical Information Specialist, Porfimer, Axcan Pharma. 3 March 2005. 179. AstraZeneca. Tomudex Package Insert. Mississauga, Ontario; November 2001. 180. Hospira Healthcare Corporation. TOMUDEX product monograph. Saint-Laurent, Quebec; 23 April 2008. 181. Hoffmann-La Roche Limited. Rituxan Package Insert. Mississauga, Ontario; December 2002. 182. Pharmacia Canada Inc. Zanosar Package Insert. Mississauga, Ontario; March 2003. 183. Schering-Plough Canada. TEMODAL product monograph. Kirkland, Quebec; 5 January 2009. 184. Wyeth Canada. TORISEL product monograph. Montreal, Canada; 16 October 2008. 185. McEvoy GK, editor. AHFS 2008 Drug Information. Bethesda, Maryland: American Society of Health-System Pharmacists, Inc. p. 1226-1228. 186. Anna Sivojelezova M.Sc. Personal communication. Medical Information Associate, Wyeth. 6 January 2010. 187. Bedford Laboratories. Thiotepa for Injection USP Package Insert. Bedford, Ohio; April 2001.

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

75/77

188. Solimando D.A. Updates of melphalan and thiotepa. Hosp Pharm 1997;32(8):1082-1088. 189. Christina Hsu Pharm. D. Personal communication. Bedford Laboratories Professional Services Department; 29 August 2008. 190. Trissel LA. Handbook on Injectable Drugs. 13th ed. Bethesda, Maryland: American Society of Health-System Pharmacists, Inc.; 2005. p. 1395-1403. 191. BC Cancer Agency Miscellaneous Origin Tumour Group. (MOIT) BCCA Protocol Summary for Soild Tumours using Intrathecal Methotrexate and/or Thiotepa and/or Cytarabine. Vancouver, British Columbia: BC Cancer Agency; 1 July 2005. 192. Genzyme Canada. Thyrogen Product Monograph. Mississauga, Ontario; 2004. 193. Genentech Inc. ACTEMRA product information. South San Francisco, California; January 2010. 194. F. Hoffmann-La Roche Ltd. Provision of tocilizumab for a patient with multicentric Castleman's Disease: guidelines for compassionate use. May 2010. 195. GlaxoSmithKline. Hycamtin Package Insert. Mississauga, Ontario; Montreal, Quebec; 2001. 196. Victoria Vertesi. Personal communication. Oncology Marketing Manager GlaxoSmithKline; 30 October 2008. 197. Kramer I, Thiesen J. Stability of topotecan infusion solutions in polyvinylchloride bags and elastometric portable infusion devices. Journal of Oncology Pharmacy Practice 1999;5(2):75-82. 198. Sandoz Canada Inc. Topotecan product monograph. Boucherville, Quebec; 24 September 2009. 199. Hoffmann-La Roche Limited. Herceptin Package Insert. Mississauga, Ontario; October 2002. 200. medac UK. TREOSULFAN injection product monograph. Hamburg, Germany; 24 June 2008.

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

76/77

201. Henrik Fenger. Personal communication. Management Assiciate, International Division medac; 03 March 2010. 202. Jan Barrow. Personal communication. Supervisor, Hospira Canada Clinical Support. Saint-Laurent, Quebec; 03 December 2007. 203. Tanya Leduc. Personal communication. Acting editor, BC Cancer Agency Cancer Drug Manual; 18 Dec 2007. 204. World Health Organization. Information Exchange System: Alert No. 115 (QSM/MC/IEA.115). Geneva, Switzerland: World Health Organization; 18 July 2007. 205. BCCA Provincial Systemic Therapy Program. Labeling of vinca alkaloid syringes. Policy # V-40. Vancouver, British Columbia: BC Cancer Agency; 27 May 1999. 206. Repchinsky C. Vinblastine CPhA monograph, Compendium of Pharmaceuticals and Specialties. 12th ed. Ottawa, Ontario: Canadian Pharmacists Association; 2004. 207. Mayne Pharma (Canada) Inc. Vincristine Package Insert. Montreal, QC; Undated. 208. Novopharm Limited. Vincristine Package Insert. Toronto, Canada; Undated. 209. GlaxoSmithKline Inc. Navelbine Package Insert. Mississauga, Ontario; Montreal, Quebec; Undated. 210. Mayne Pharma (Canada) Inc. Vinorelbine Product Monograph. Montreal, QC; Undated. 211. Pierre Fabre Pharma Canada Inc. Vinorelbine injection package insert. St Bruno de Montarville, Quebec; undated. 212. Kastango ES. The ASHP discussion guide for compounding sterile preparations. Bethesda (MD): American Society of Health-System Pharmacists, Inc.; 2004. p. 5.

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 1 July 2010

77/77