Introduction :
Inheritance is the passing of traits from parents to offspring.
Genetics is the science that study inheritance and variation in living
organisms.
Mendel was the first person to study inheritance. He chose pea
plants to work on. Peas were an ideal choice because of the following :
1. __________________________________________.
2. __________________________________________.
3. __________________________________________.
4. __________________________________________.
He studied seven traits, each of which has two contrasting varieties.
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Dominant allele : an allele which has the same effect on the
phenotype of an organism weather the organism is homozygous or
heterozygous for the gene.
Recessive alleles : alleles which only shows in the phenotype when
no dominant allele is present.
So Mendel put his first law of inheritance ( Law of segregation ) :
Characteristics of an organism are determined by
alleles which occur in pairs
Only one allele can be present in a single gamete.
For the previous example :
Tall plant contained 2 dominant alleles TT
Short plant contained 2 recessive alleles tt.
When they were crossed, each plant formed gametes, so :
alleles segregate into different gametes
The tall plant gave two similar gametes __T__ and ___T__.
The short plant gave two similar gametes gametes t t
__t__ and ___t__. T Tt Tt
T Tt Tt
We can represent the different possible
combinations of gametes using Punnette square.
All F1 were heterozygous Tt.
In a heterozygous organism the dominant allele T masks the effect of
the recessive allele t
so all plants appears Tall.
TT homozygous dominant. tall
Tt heterozygous dominant ( coz. T masks t ).
tall
tt homozygous recessive. Short
Genotypes phenotypes
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Genotype : the alleles that an individual has (Gene make up of the
organism )
Phenotype : the way the alleles are expressed in the individual ( the
physical appearance of the organism )
environment.
Monohybrid inheritance :
Is the cross between two individuals to study the inheritance of a
single characteristic, one gene. ( Here 2 alleles are involved ).
Gametes
At fertilization
Game
tes
Gametes
Game At fertilization
tes
If a purple colored pea plant crossed with a white colored. All F1 were
purple.
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1. Which trait is the dominant ? ___________ . recessive? ____________.
2. Explain your answer in Q1 ?
___________________________________________________.
3. What is the genotype of the purple plant ? ____. of the white plant ?
_____.
4. What is the genotype of the F1 plants ? _______.
5. If two F1 plants were crossed, what will be the result? Calculate the
ratio of colors.
phenotype ______________ X ______________
Genotype ______ X ______
Gametes
At fertilization
Game
tes
A tall pea plant was crossed with a short one. Half F1 were tall, and half
short. What is the genotype of both parents?
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
______________________________
In pea plants, the allele for yellow seeds is dominant to the allele of green
seeds. Predict the genotypic ratio of offspring produced by crossing two
parents heterozygous for this trait.
_____________________________________________________________________
_____________________________________________________________________
_____________________________________________________________________
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_____________________________________________________________________
_____________________________________________________________________
______________________________
If a two yellow seeds pea plant were crossed, the results were as
following : 298 yellow seeds plant. 99 green seeds plant.
Test cross :
Complete :
- Recessive trait has one genotype, so it is always
___________________________.
- Dominant trait can be _______________________ or
______________________.
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- ex : short plant is always ________ , but tall plant can be ______ or
_____.
How can we tell if a tall pea plant is homo- or heterozygous ?
Test cross : is a cross carried to tell whether the dominant trait is
homozygous or heterozygous.
By crossing it with a recessive one.
1. If all offspring are dominant the tested organism is homozygous
( pure )
2. If 50% dominant and 50% recessive : it is heterozygous ( impure )
If black coat colour is dominant over white in guinea pigs. How to tell
whether a black colored guinea pig is homozygous or heterozygous ?
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Huntington`s disease
Genoty Phenoty
Is an inherited disease caused by dominant
pe pe
allele H . so it is enough for a person to show HH sufferer
the disease to have one allele only. Hh sufferer
hh normal
And the normal person is hh.
What is the probability to have child with Huntington disease if both parents
are heterozygous sufferers?
_______________________________________________________________________
_______________________________________________________________________
_______________________________________________________________________
_______________________________________________________________________
Incomplete dominance:
In this type of inheritance the two alleles of the gene are equally
dominant, and so they are both expressed in the heterozygous
genotype.
Example on incomplete dominant is the inheritance of blood types in
human
In human there are 4 different blood groups : A , B , AB , O
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Blood group is determined by 3 alleles ( IA , IB , i )
Both IA and IB are dominant over i . but none of the IA and IB dominate
over the other.
Genotype Phenotype
IA IA, IAi A
IB IB , IBi B
IA IB AB
ii O
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Sex determination :
In human each body ( somatic ) cell contains 46 chromosomes. These
chromosomes occur in homologous pairs. There are 23 homologous
pairs of chromosomes in each human cell.
Homologous chromosomes have the same size shape banding pattern
and the same genes in the same location.
22 pairs of these chromosomes are identical in male and female,
these are the autosome chromosomes. Only one pair is different
between male and female. This is the sex chromosomes.
Karyotype : arrangement of chromosomes in homologous pairs
according to their size, from the longest to the shortest. The last pair
is the sex chromosome.
Here the probability for having a male is 50% and female 50%.
Which chromosome is the responsible about sex determination ?
________________________________________________________________________
Which parent is responsible about sex determination ?
_____________________________________________________________________
___
What are the functions of sex chromosomes ?
1. ____________________________________.
2. ____________________________________.
Sex-linked traits :
Traits that have their genes carried on sex chromosomes are known as
sex-linked traits. The inheritance of these traits is different from the
inheritance of other traits because if the genes were carried on X
chromosome, the female has two copies of the gene and the male has
one copy. So the expression of genes differ in the two.
Examples of the sex-linked traits are : colour blindness, and haemophilia.
color blindness is a sex-linked genetic disease. It is caused by a
recessive allele c carried on the sex chromosome. The dominant allele
C results in normal sight.
If a cell has 2 pairs of chromosomes, there are two ways in which the
chromosomes arrange at the equator of the cell. So, 4 different types
of gametes produced.
What is the role for that?
Can you work out the number of different types of gametes the human
can produce?
2. crossing over :
During prophase-I of meiosis the homologous chromosomes come
together in pairs known as bivalents.
Each chromosome consist of two chromatids.
Two non-sister chromatids of the
homologous chromosomes twist
around each other and exchange
pieces ( genetic materials ) in a
process known as crossing over.
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The site of crossing over is known as chiasmata.
Crossing over resulted in new combination of genes and this increase
the variation between living organisms.
Terminology
nucleus.
All cells of the body ( except gametes ) are diploid , they contain two
sets of chromosomes.
Gametes are sex cells ( egg and sperm ) are haploid, they contain
DNA substance found in the chromosomes and carry codes for making
proteins.
locates.
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Dominant allele is an allele which has the same effect on the
organism
physical appearance ).
or impure.
Sex-linked trait is the trait that has it is genes carried on the sex
chromosomes.
Carrier is the heterozygous person who does not suffer the disease
prophase-I
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