ThePanaceaUniversitypresentsOPENSOURCEmaterialandminimumdonationresourceswhich helpuseducatetheworld.Thisonlineuniversityisnotofficiallyrecognizedoraregistered faculty.ThereasonPanaceacallsthisonlineresourceauniversityissimplybecausewepresent educationalmaterial. Welcometotheeducationalseriescoveringalternativemedicinetowardsbuildingourchildrena future.PanaceaBOCAFoperatesaneducationalnonprofitentityandisdedicatedtoeducational studyandresearch.Allcopyrightsbelongtotheirrespectiveownersandareacknowledged.All materialpresentedonthiswebsiteiseithernewsreportingorinformationpresentedfornonprofit studyandresearch.Allinfohaspreviouslybeenpubliclydisclosedorbeenimplicitlyputintothe publicdomain.NOTEFairUseappliesinthispresentation.Contactus.
BlackSalveAlternativeCancerTreatment
CentreForceHerbalBlack salveformula
DisclaimerWarning:Thisdocumentcontainsgraphicmedicalphotoswhichmaynotbesuitable tominorsorthefaintheartedetc.Ifyouareunderageorcannottakegraphicphotosyouare askedtogivethisdocumenttosomeonewhocanevaluateitforyouandtonotreadit.By choosingtoreadthisdocumentyouareacceptingourwarning,disclaimerandassumingyourown responsibilityinthesematters. TheinformationprovidedonthePanaceasiteandinthisdocumentisforinformationalpurposes only.ThesestatementshavenotbeenevaluatedbytheFoodandDrugadministrationorany othermedicalpolicingbody.Theinformationoranyproductsmentionedinthisdocumentisnot intendedtodiagnose,treat,cure,orpreventanydisease. Thisinformationisnotintendedtoreplaceprofessionalmedicalcare.Youshouldalwaysconsulta healthprofessionalaboutspecifichealthproblems.TheinformationpresentedinPanaceas documentsandvideosarenotintendedtoreplacetheservicesofaqualifiedhealthcare professional.Innowayshouldanyoneconsiderthisinformationtorepresentthepracticeof medicine. PanaceadoesnotrecommendyoumaketheblacksalveformulapresentedbyyourselfESPECIALY ifyouhavenoqualificationsorexperience.Therearemanytrustedvendorswhereyoucanobtain theGENUINEformula,forhorses,catsanddogs.Theintensionofthisdocumentistocreatea neededOPENSOURCEandSECUREpublicrecordtoPROTECTblacksalveinfo.Thispublicationis notintendedtoencourageyoutotakemattersintoyourownhands.Harmmayresult, Overviewandcredits................................................................................................................................ Blacksalvetestimonials............................................................................................................................ Howyoucanhelpbyusingblacksalve.....................................................................................................
Overviewandcredits
"Theissueoflegalityisacomplexissue.Inmostcountriesoftheworld,Cansema(blacksalve)is completelylegalasanherbalpreparation.InmostWesterncountriesoftheworld,however, Cansemacanbesoldasanherbalpreparation,butonecannotsaywhatitdoesorwhatit'sfor. Thatis,onecannotmakea"claim."Why?Aneffectivetopicalskincancersalve,suchasCansema, posesaseriousthreattoorthodoxtreatmentsforskincancersthatarefarmoreexpensive,butfar lesseffective.Itistrulyridiculous.GregCatonAltcancer Ifyouoranyoneyouknowusesblacksalvepleasesendusyourmedicalrecordsandorphoto report.Withoutyourreportswecannotstopthebanningofblacksalveandneedyourhelp. Panaceaoffersourownblacksalveapplicationwalkthroughforasmallmindonationtohelpus educatethepublic.Panaceasguidecoversbreast,skinandothercancers,plustheessentialcancer preventiondietandexerciseregimeneededforcancerprevention.Ifyourequirethisresource pleasecontactus.Everyoneofyourdonationshelpsustoeducatetheworld. Panaceahasproducedaneducationalvideoentitledthe"Panaceablacksalveproduction(reloaded)" tohelppubliceducationofalternativecancertreatments.ThisproductionfeaturesPanacea volunteerswhoobtainedmedicalproofofblacksalveworking.Thistreatmentlikemanyothershasa longhistoryofneglect.Theproductionalsooutlinesthedetailsneededforthecreationoffacilities oranalternativecancertreatmentresearchclinicforfurthersecurity,supportandpublic education. WehavemanymorealternativecancertreatmentsliketheGersontherapyandBudwigdietwhich criticallyneedpubliceducationandsecurityfromsuppression.Allthesetreatmentsincluding blacksalvearenontoxicandhavestatisticalefficacyoverthestandardchemo,surgeryand radiation,butremainunknowntocapacity.Thereisnosecuritytoensurethatdoctorsprovidethe publicwithinformedconsentofthesetreatmentsandoftheirsuccessfullystatistics.Nordothey haveanysecurityagainstvestedinterests.Therearemanyconflictsofinterestswiththishealth educationinwhatisnowamultibilliondollarpharmaceuticalindustry. Presentlyblacksalveisbeingbannedfromsale;tohelpgatherfurthermedicalproofandeducate thepublicPanaceahascreatedtheBlackSalvefacebooksite.AlternativetreatmenttoCancer,Black Salveinformationandrealcaseinformationwillbepostedhere.IfyouhaveusedBlackSalveplease usethispagetopostyourstorytosharewithothers.AlsoPanaceahascreatedanewPanacea medicalresearchsitetohelpgathermedicalrecordsofblacksalveworkinginhumansubjectsand
educatetheworld.blacksalve.org.au.IfyouhaveusedBlackSalvepleaseusethispagetopostyour storytosharewithothers. PublicWarning In2012PanaceaobservedtheTGA(Australianmedicalpolicingbody)tryingtostopthepublic fromaccessingblacksalve.TheTGAhasbannedthesaleofblacksalveevenforcats,dogsand horses!Thereisothersuspiciousbehaviorgoingon.PanaceahasemailedtheTGAandofferedour medicalproofofblacksalveworkingplusalivevolunteerwithcancerwillingtodemonstrateblack salvesefficacy.Theynowhavenoexcusetonotinvestigatetoconfirmthatthecorrectblacksalve formulaisnotharmfulanddoeswork.Wedidnothearbackfromthem.Theseemailrecordsare availabletoanybodyuponrequest.
LettertotheTGAsentbyaPanaceaTrustee
Publicwarningscontinuetobegiventothepublicwithoutanyfollowupoftheevidencepresented totheTGA.
BloodRoot(SanguinariaCanadensis)
Pleasenote,thetropicalapplicationoftheBloodrootbasedblacksalveisnotagentlehealer.Mild pain will be experienced which will require "pain management" medication. Usually there will be some scaring, in some cases, more than one black salve application may be required. This is especially advised for aggressive, deep, and metastasized cancers. Despite these factors, the black salve reports have shown to be more effective treatment of any form of conventional cancer treatmenttoday. Ourknowledgeoftheblacksalveprocessinhumancasescomesfromyearsofempiricalreports, observation,anddaytodayinteractionwithusers.TheearliestknownFAQonthemodeof operationcanbefoundonGregandCathrynCatonsCansema&EscharoticsFAQ(Coversall Cansemaproducts)Page. Ifyouuseblacksalvepleaseconsidergettingbeforeandaftermedicalrecordsandreportingyour successtoPanacea,withoutthishelpwecannotaccumulatetheneededreportstohelpothers andlearnourselves.Bewareofanymisrepresentationofblacksalve.Thisincludesfakeproducts andcounterfeitsalves.Quackwatchscoverageofblacksalvedoesnotdescribethegenuinesafe blacksalveformulareferencedinthisdocumentortheoneusedothersreports.Somesalvesmade fromunknownoriginswithunknowningredientsmaybeunsafe.Quackwatchhasdescribedthe wrongformulaandgeneralizedthatallblacksalveformulasarenotsafe.Thisisnotaccurateand canonlydescribeanunknownformulathatwasnotmadeproperlyorproperlyapplied.
StephenBarret,makeseitheradeliberateoruneducatedmistakeanddescribesblacksalvecontents thatarenotevenintheblacksalverecipe:Manysalves,pastes,poultices,andplastershavebeen applieddirectlytotumorswiththehopeofburningthemaway.Zincoxide,bloodroot,andseveral otherherbsarecommoningredients. ThisisENTIRLYincorrect;firstofallthecontentsdonotcontainZincOxide;theblacksalve formulainquestioncontainsZincchloride(ZnCl2,).NOTZincoxide(ZnO),ZnOcouldneverbe madetodothesamefunction.100%zincchlorideisnotdamagingtohealthytissue,itwill howeverstingifitcomesincontactwithanopencutandstingwhenitistreatingcanceroustissue inthebody.ToshowZincchloride(ZnCl2,)isnotcorrosivetohealthyskin,GregCatonfoinderof AlphaOmegalabshasgonetotheefforttoprovethisandhandledzincchloridewithhisbarehands intheescharoticsvideoontheMeditopiasite(2004).
GregCatonsAlphaOmegalabs
Lefttoright,1)applicationofthesalve,2/3)EsharformingSource
Lefttoright1)ExpelledCancertissue2)healingcommencing3)processcompleteSource
Improperingredientswhichmakeunsafeversionsofblacksalvearetheonlyonesknowntobe corrosivetohealthytissue.Alwaysapplyblacksalveasdirected. Thehorrorstoriesyoucanreadfromquackwatchandotherscouldonlyhaveresultedbythe useofimproperingredientsorimproperuse.AskBillifhisnoseisburntofftoday;infactaskthe MANYwhocantellyouthesamestory,theseareincludedinthetestimonialsection. ForthecompletebackgroundpleaserefertooAlphaOmedgalabsRebuttaltoQuackwatch's preposterousattackonescharoticpreparationsAdditionallytheArchivesofdermatologyalsohasa similarinaccuratetakeonblacksalve.Alwayssticktothegenuineblacksalverecipeorcheckthat youhavepurchaseditfromknowntrustedsourcesandapplieditproperly.Panaceahas investigatedanumberoftrustedsourcesandprovidesreferencetotheminthisdocument.Also wehavereferencedthecorrectapplicationprocedure.
Thisdocumentisdedicatedtothehealthfreedomadvocateswhohavesufferedandsacrificed theirtimetobringthisinformationtothepublic.TheoriginalblacksalvepioneerGregCaton, Panaceavolunteers1)PeterJames,2)MartyJuricaand3)BruceGorrie,ElaineHollingsworth, AdrianJones,BevanPotterandalltheindividualswhocontinuetohelpPanaceareportthe successofalternativecancertreatments. Todate,blacksalvehasbeenreportedtosuccessfullytreatBowelcancer,throatcancer,tongue cancer,LentigoMalignaMelanoma,Lymphnodeaffectedwithmetastaticbreastcancer,Ductal carcinomaoftherightbreast,otherbreastcancers,Cutaneousleishmaniasis(skininfection),warts, moles,plantarwarts,EwingSacroma(socalledincurablecancer),Melanomas,Basalcellcarcinoma (BCC)andSquamousCellCarcinoma(SCC).Innearlyallofthesecases,theapplicationofblacksalve wassuccessfulwheresurgeryandothertreatmentscouldnothavebeenused.Thesetestimonial caseshavebeenpreservedinthisdocumentforhistoricalreferenceandstudy.
A clinic in Panam, Central America who use: Black Salve Treatment for Cutaneous Leishmaniasis (skin condition).
ACoreblacksalveingredientBloodRoot (SanguinariaCanadensis)
DrEliJones
Therehassincebeenmanyotherherbalistwhoproducedanticancerherbalpastesandusedthem successfullytotreatcancer.TheseincludeDr.RaymondChristopher,whousedanticancerherbs suchaspokerootandblackwalnutbark. DrJWeldonFellwasdescribedinan1857Americanmedicaljournal,operatingoutoftheUniversity ofNewYork,heacquiredconsiderablenotorietyinLondonincuringcancerbyasecretformula.The secretformulaisnotmuchmorethantheoriginalAmericanIndianherbalactiveingredient,it consistedofbloodroot,zincchlorideplusotheringredients.TheadditionofZincChloridemakesup oneofthecoremechanismusedinthemodernblacksalveformula.Themodernformulahas additionalanticancerherbsandinorganicsubstanceslikeGalangalroot,(Alpiniaofficinarium), Chaparral(Larreamexicata),andDMSO(Dimethylsulphoxidein).
GalangalOneoftheblacksalveingredients
Dr.PerryNichols,B.S.,M.D.
NurseReneCaisse&EssiacTea
TheHoxseyformula:includedRedclover,Burdockroot,Barberrybark,Licoriceroot,Buckthornbark, Pricklyash,pokeberriesandroot,Stillingiaroot,Cascaraamarga.
HarryHoxsey
DrRichardShulzesalve:RedCloverBlossoms,Garliccloves,Pokeroot,goldenseal,activated charcoal,TeaTreeOil,Bentoniteclay,SlipperyElminnerbark.
Iscador/MistletoeCannabis,CarnivoraChaparralGarlicEchinaceaRedCloverMushrooms CayennePepperDrRichardShulzeDrJohnChristopherBruess(sage).
Despitethelonghistoryofalltheseherbalingredientsbeingusedeffectively,modernresearchers aretodaytryingtorediscovertheirtherapeuticproperties.Iftheyappliedthemastheyhavedone inhistory,therewouldbenodoubtthattheyhavefunctionedasrecorded. ResearchersattheMedicalUniversityofSouthCarolinahaveshownaChaparralextractmayshrink sometumours.ChaparralteawaswidelyusedintheUSasanalternativeanticanceragentfromthe late1950stothe1970s.Chaparralforcancer Howeverlikebloodroot,chaparralhasalreadyprovenitselfbeyondhumantrials.AfewIndividuals haveREdiscoveredtheOLDsuccessfultreatmentsoftheseherbsandappliedthemtotreattheir cancers.TheincredibletruelifestoryofSirJasonWintersisoneexample.HeusedRedClover, HerbaleneandChaparraltotreathisterminalcancers.
SirJasonWintersTea
AlotofnewsmediaattentionhasbeengiventoamannamedJasonWintersandhisremarkable recoveryfromterminalcancer.WhenIvisitedhim,hewasalreadyingoodhealth,butgrossly underweight.Whenhewassenthometodieafterbeingtoldthattherewasnothingmorethatcould bedonetohelp,Mr.Wintersturnedtoherbsandprayer. HecontactedLordCoggan,themostreveredandrighthonorableArchbishopofCanterbury.Mr. WintersaskedwhatherbhethoughtwasmentionedintheBiblesomanytimesforbloodpurification andgoodhealth.LordCoggandidsomeresearchandinformedMr.Wintersthattheherbwasquite possiblyRedCloverwhichisaherbthathasbeenusedinEuropeforcenturies.Jasonhadalsoheard fromaBuddhistmonkthatHerbalenewasverygoodfortumors.JasonalsofoundthattheAmerican IndianpeopleuseherbscalledChaparralandSagetocleansethebody. Afterobtainingallthreeoftheseherbsfromthreecontinents,Mr.Winterswasmakingateaofeach oneseparatelywhichwastimeconsumingaswellasineffective.Itwasonlyaftermixingtheherbs togetherthattheeffectsofthecombinationwerefelt.Mr.Wintersrecoverywasquiterapidand noticeable.
Thenewsmediahadafielddaywiththisstory,itperkedmyinterestandIfinallytalkedwithMr. Winters.HegavemeasampleofthemixedherbsandIhadthemtestedinthelaboratory.Wefound thattheherbsarenotacureall,butmerelypurifiedthebloodtosuchanextentthataperson's naturalimmunesystemstartsworkingandthebodyhasachancetohealitself.Theseherbswould havethesameeffectonmostillnesses. Dr. I. Pierce MD -Source Itisnosurprisethattheseresultshaveneverhadaclearpassagetothepublic,thereisanimmense recordofaconflictofinterestwiththepharmaceuticalindustries(whoareunregulatedandhavea wellrecordedtiestotheFDA)Bloodroot,ChineseMedicine,andtheFDAKeepingthePublic MedicallyIgnorant Yourroleinhelpingusobtainmedicalproofoftheblacksalvetreatmentcancompletethetrue historyofblacksalve,onethatislongoverdue,afutureofhealthfreedomandofatruenontoxic healer. Thereareliterallycountlessvideo,photoandessaytestimonialspresentonthewebwhichallreport astatisticalefficacyintreatmentofblacksalve.Howeveryouroncologistcanneverbeformally trainedintheuseofthistreatmentinthepresentmedicalclimate.Theherbalformulathatmakes upblacksalvecontainsnaturalingredients.Naturaltherapiescannotbepatentedandmonopolized bypharmaceuticalinterestsforprofit.Drugcompaniescannotmakeasmuchmoneyfromthis alternativecancertreatmentovertheirpresentprescriptionsyntheticdrugsorsurgery. AnymedicalpolicingbodiesliketheTGA(Aust),Medsafe(NZ)orFDA(USA)etccouldneverreceivea paycheckforapprovingblacksalveasanalternativecancertreatment.Itsimportanttonotethat medicalpolicingbodieshaveapastandPRESENThistoryofcorruption.Thereisnolegislation preventingpharmaceuticalinterestfromfinancingorinfluencingapoliticianortheFDA.Norules, meansopenseason. "Themedicalestablishmentworkscloselywiththedrugmultinationalswhosemainobjectiveis profits,andwhoseworstnightmarewouldbeanepidemicofgoodhealth.LotsofdrugsMUSTbe sold.Inordertoachievethis,anythinggoes:lies,fraud,andkickbacks.Doctorsaretheprincipal salespeopleofthedrugcompanies.Theyarerewardedwithresearchgrants,gifts,andlavishperks. TheprincipalbuyersarethepublicfrominfantstotheelderlywhoMUSTbethoroughlymedicated andvaccinated...atanycost!WhydotheMedicalFascismPharmaceuticalcorporationsaccusedof GenocidebeforeICCinTheHagueauthoritiesforbidalternativemedicine?
Becausetheyareservingtheindustry,andtheindustrycannotmakemoneywithherbs,vitamins, andhomeopathy.Theycannotpatentnaturalremedies.Thatiswhytheypushsynthetics.They controlmedicine,andthatiswhytheyareabletotellmedicalschoolswhattheycanandcannot teach.Theyhavetheirownsetsoflaws,andtheyforcepeopleintothem.Thatisamafia.This sensationalexpose'alsouncoversthetruthbehindvaccines,AIDS,cancer,theWorldHealth Organization,theRockefellerFoundation,theWorldBank,andmore."Dr.GuylaineLanctot,M.D. TheFDA(andothercountriesmedicalpolicingbodies)hasnolawsprotectingthepublicfrom corruptvestedinterests.TheFDAinparticularisabrokenagencythatneedsacompletereformand restructuring.Presentlyrun,itshouldcomeasnosurprisethatdocumentariesandnewsreports continuetoremindusallthattheyObstructmedicalscienceandinnovation;Forbidsandcensors thecommunicationoflegitimate,peerreviewedscientificresearch;Protectsentrenchedmedical monopolieswhichpayitsbillsandhireitsemployees;InterfereswiththeUSArightsofconsumersto learnaboutgoodscience(especiallyrelatingtofoodandsupplements)thatcouldprolongandsave livesandpromotehealth;Andunnecessarilydrivesupthecostofhealthcaretothepointwhere employerscannolongeraffordtohireandtheentireAmericaneconomyisthreatened. Organizedmedicalgroupsandpharmaceuticalcompanies,usinglawyers,bribes,lobbyist,insurance companiesandthestrongarmoftheFoodandDrugAdministration,havebeenverybusy.Theyhave corruptedelectedofficialstopasslawstoremoveanycompetition. YoumayhavereadrecentnewspaperarticlesaboutagroupcalledFriendsofScienceinMedicine,a cofounderofwhichisProfessorJohnDwyer,whoarelobbyingtohavenaturalmedicinecourses removedfromUniversities,andalsoforhealthfundstobepreventedfromofferingrebateson naturalmedicinetherapies.ReadMore
Herbalremedies
TheyhavecrushedNaturalDoctors,NaturalMedicine,andnaturalremedyeducationonselfSelf Care.Theirgoalistomonopolizehealthcareandmakeusdependentonmedicaldoctorsand pharmaceuticaldrugs.Wehavewatchedthempassmoreandmorelawsrestrictingourrights;they havemademanyhealingherbs,foodsandevennutrientsillegal.CodexAlimentarius(meaningfood code)isoneexampleofthisattemptpresentlyineffect. Naturalhealthprofessionalsthatflourishedafewdecadesagoarenowbarredbylawtopractice, andNaturalDoctors,HolisticHealers,HealthFoodStoreOwnersandevenfamilymembersofthe sickhavebeenarrestedandjailedforusingnaturalremedies.Bigdrugcompanieshavebeen accusedofputtingprofitsabovepatients,spinningfalsePRcampaignsandmore.Herearesomeof themostshockingfactsaboutthepharmaceuticalindustry.ShockingFactsaboutthePharmaceutical
Industry.
CorruptionisRife
Reference
TheU.S.FoodandDrugAdministration,heavilypopulatedbyformer(andfuture)pharmaceutical industryexecutives,hasalonghistoryofaggressivelyattemptingtoclosedownbusinessesthat produceholistichealthcareproductsforcancerandotherseriousillnesses,evenif(especiallyif)the productswork.Thisofteninvolvesraiding,arresting,prosecuting,andimprisoningtheownersofthe companies.Terroristraidshavebecomethenewcureallforalternativecancerremedies.Bevan Potter Currentlyblacksalve(popularlyknownasthealphaomegalabsproductcalledCansema)isonly approvedtotreatcancerinhorses,catsanddogs.Itiscurrentlyillegaltoclaimanytherapeutic benefitsforhumans.Anywebsitesellingblacksalvecanlegallyonlylistitsapplicationfortreating catsanddogsetc.Despiteblacksalvebeingknownbysomeveterinarianstosuccessfultreatcancer (likeselenium)TheU.S.FoodandDrugAdministrationlistsCansema(blacksalve)asa"fakecancer cure"andhaspubliclywarnedconsumerstoavoidit.Isthisbasedonincompleteevidenceand suppression? Pharmaceuticalcompanieshavenofinancialinterestinpayingforhumantrialsofanynatural cancerremedy.SowhathappenswhenanaturalCUREisdiscovered?Publiceducationistheonly waytoensureitsSECURITY.Thatsright,publicknowledgecanonlypoliceit.Butwhoallocates thebudgettosupportthis?ThereareMANYalternativecancertreatmentswhichlikeblacksalve havestatisticalefficiencyoverthecurrentmedicalindustry(yesindustry).HoweverPanaceaand otherslackabudgetforthePUBLICEDUCATIONofthem.Neededareresourcesforbiofeedback (medicalrecords)studiesandforthepolicingofthesestudies.Thisdocumentwillalsodescribe Panaceasstratagemtoaddressthissituationandhowyoucanhelpthiseffort.
Bloodroot(SanguinareaCanadensis).
Thepublicuseofblacksalveforpetsandnothumansrepresentsonlyaminorcutofanestimated multibilliondollarcancerdrugindustry.Historyshowsthatwhenanaturalsubstanceshows promiseagainstcancer,drugcompaniesinvestalltheirtimeandmoneyintodevelopinga syntheticversionthatCANbepatented.Moreoftenthannot,itJUSTDOESN'TWORK.Sometimes itnotonlydoesntwork,butproducesdeathandharmfulsideeffects.OneoftheseMANYcasesto provethiscanbeseenintheAldaraskincancertreatmentwhichcostlives.Lettingthepublicknow thatthere'sacheap,NONTOXICnaturalcurewouldmeanmissingoutinabilliondollarrevenue stream. Thepublicneedtohelpuschangethis.Panaceahasproduceddetailedmedicalrecordsofblack salveworkinginahumansubject.Theserecordsarepresentedinthisdocumentforanyoneto evaluate.
SampleofPanaceasrecordsAterminalSCCcancer beingsuccessfullytreatedbyblacksalve.
PanaceaVolunteerPeterJamesPetersuccessfullytreateda terminalSCCCancerwithblacksalveMedicalproofsupplied.
Thedrugcompanieswillhaveaconflictofinterestwithpeoplesellingandusingblacksalvetotreat themselves.Thisissueisofcorruption,healthfreedomandisanunnecessarypubliceducational crisis.Panaceaisundertakinganeducationalprogramandneedsallthosewhodecidetouseblack salvetoparticipateinaneffortlessprogramtorecordmedicalproofandhelpPanaceaeducatethe public.PleasechecktheHowyoucanhelpbyusingblacksalvesectionofthisdocument. UntilenoughofthepublicparticipatewithPanaceatoaccumulatethisallopathic(conventional medicine)medicalproofofthistreatment,themajorityofthepublicwillhavenocounterproofand continuetobelievethepresenthalftruths,misleadingdata,andmanipulatedresultsofparticular alternativecancertreatments.Thesearethetacticspresentlyusedagainstnaturalremedies;they mayaswellbeunderlockandkey. Someindividualshavesufferedundersuppressiveandillegalactivities.Wemusthelpandhonour pioneersinhealthfreedomlikeGregCaton,whohasfoughthiswholelifetoensurethatthepublic getsinformedconsentofthecorruptionandtheirhealthfreedom.
OneofourHerosGregCatonofalphaomegalabs,Gregistheproducer andeducatoroftheoriginalblacksalvecansemaformula.
TheModernVersionofthisherbalremedy.TheFDA attemptedtoshutdownacompanycalledCansema forprovidingthistreatmenttothepublic.
ClicktoView
Thisresearchreportfeaturedmanyindividualswhosuccessfullyusedblacksalvetotreattheir cancercondition.TheseincludeAuthorGraemeHearson,alternativehealtheducatorBevanPotter, BilloLearyBoatbusinessoperator,TerryOreillycartagecontractor,JoeSimpson,MerylPowell boutiqueowner,WendyFoxbreastcancer(wheretheultrasoundfailedtorecognizethem), BeverlyBailliebreastcancer,RicciCarrterminalthyroidcancerandabowelcancercase. ONEANSWERTOCANCERispackedfullofamazingtestimonialsbypeoplewhohavereclaimedtheir health.Theyhaveeliminatedinvasivebreastcancers,deadlyEwing'sSarcoma,terminalthyroid cancer,bowelcancerandanarrayofskincancers,evenlargemelanomas.Intheirinterviewsmen andwomandescribeexactlyhowtheyusedthisnaturalsalve,andhaveevengenerouslyincluded startlingbeforeandafterphotos.
OneanswertocancerpresenterTonyBarry
Alsofeaturedinthisdocumentary,AustralianbasednaturopathAdrianJoneswhocontinuesto recordandpublishobservationalsuccessfulblacksalvereportsonhiswebsite.
AussienaturopathAdrianJones basedontheAustralianQueensland Goldcoast
SuccessfulGrapefruitseedextracttreatmentforSkincancer
SuccessfulCuradermCreamtreatment
TheexternallyandtopicallyappliedCuradermcreamappearstobepotentwhenappliedtoBasal cellcarcinomas.Containingaspeciallypurifiedplantextract,notonlyisCuradermreportedtobe effectiveonBasalcellcarcinomas(BCC)orSquamouscellcarcinomas(SCC)themostcommon formsofskincancerbuttheapplicationalsoworksonbenigntumourslikesunspots,agespots, KeratosesandKeratocanthmoas. OtherneglectedalternativeskincancertreatmentsincludemedicalCannabis.Cannabishasbeen reportedtocurealotofcancers.Hereisoneofthemanystories.Whyhasn'tTheU.S.National CancerInstituteorTheAmericanCancerSocietytestedCannabisOil?Isitlackofpersonnel(2,100 USNCIstaffmembers)orlimitedfinancialsupport(USNCI2010budgetof$5.1Billiondollars) CannabisConcentrateorextractisthesameasRickSimpson's"HempOil".Google"cannabinoids" and"cancer".Google"endocannabinoids"and"cancer"Google"THC"and"Cancer".Googlepubmed, andlookup"endocannabinoids"and"cancer",aswellas"cannabinoids"and"cancer".GoogleDr. RobertDrRobertMelamedeandcancer".Youwillsoonseehowfartherabbitholegoes.
Cured:ACannabisStory(AFilmbyDavidTriplett)
ScreenshotofPanaceasalternativecancertreatmentpage.
Panaceaispresentlyauthoringanextensivealternativecancertreatmentdocumenttoproveto thePUBLICthattheircancerknowledgeiscurrentlysufferingfromaneducationalcrisis.This
WholefoodmedicineFREEandnosideeffects
PanaceaVolunteerMartyoneofthemanywhohassuccessfully documentedblacksalvecuringhisskincancer.
Thisinformationcouldnothavebeenacquiredwithoutpeopleworkingtogether.Elaine Hollingsworthauthorofthedoctorsaredangerouswebsite,GregCatonandBevanpotterareall
BeautifulinsideandoutElaineHollingsworth
TanyaAndersontestifyingtohersuccessfulblacksalvetreatmentofanincurablecancer EwingSarcoma(bonecancer)TakenfromtheoneanswertoCancer DVDhttp://www.doctorsaredangerous.com/
TanyaAndersonsCancerbeingdrawnbytheblacksalvetreatmentTakenfrom theoneanswertoCancerDVDhttp://www.doctorsaredangerous.com/
OneofourHeroesTanyaAndersonCured!Takenfromtheone answertoCancerDVDhttp://www.doctorsaredangerous.com/
Weareonlyjustbeggingtofindoutabouttheseremarkablepropertiesduetocasesappearingby chance.Progresscouldbefargreater.Wecannotexpectrealtimeprogresswhenpeopleonlyfind outaboutthesecuresthroughwordofmouth.Sofaryoucanonlyaccessthemifyousearchfor themontheinternetorsomeonehappenstotellyouaboutthem.Itisobviousthatthisislimiting thisknowledgefrompublicaccess. ThepublicneedINFERSTRUCTUREspecificforpublicaccess,educationandSECURITY.Onethatis evidencebased,independent,nonalignedandNONProfit.Thesignificanceforpolicingthisneglect, suppressionandinherentroadblockswithindependentinfrastructurecanbeseenbysimply researchingthesheeramountofalternativecancercurecasesthatremainsuppressedtoday.There aremany.
DoctorSimoncini,oncologistRomeItaly.Simoncini istheInventorofthealternativeBiCarbcancertreatment.
altcancer.comtestimonials
altcancer.com
Sadlymostpeoplewillnotseeorgetaninformedconsentaboutthehundredsofpersonal testimonialsforCansemaorBlackSalve.InsteadtheymayseetheInternetsearchenginessitecalled "Quackwatch"orotherswhensearchingforanyBlackSalveinfo.Thereareenoughdoctors,patients andknownalternativetreatmentstojustifytrialsandstopBigPharmasresearchersfromwasting furtherresearchmoney. Panaceaaimstocollectmedicalrecordsofblacksalvetohelpfundraiseandcreateanalternative medicineresearchclinic,ortobegrantedtheuseoffacilitieswherewecanbringinproven biofeedback/medicalrecordsonawholerangeofalternativecancertreatmentsandalternative medicinethatcanmakeaslargeanimpacttopublichealthasBlacksalve. RecordingBiofeedbackandobtainingallopathicmedicalproofmeansthatthepublichavetheirown informedconsentonthesetreatmentsorwhatsomecallcures,andfurtherwecanalsoworkwith otherclinicsinothercountrieswheretheyhaveahighermedicalsuccessorstatisticallysignificant efficacyfromalternativetreatments,sadlytheyareforcedtooperateandadministertheir treatmentsinEcuadorandMexicowhocanbringintheirlifesavingdataandeducationforour populationstobenefitfrom.Doctorswillhelpusrecordlivebiofeedbackattheclinic,helpcollect datafromotherclinics,liketheoasisofhope,Gersonandothers.
Theclinicwillbenotunlikethecanhelpcancercliniconceprovidingalternativecancertreatments onQueenslandssunshinecoast.Thepurposeofthismedicalresearchcenterandclinicortheuseof facilitiesofferedistoprovidepublicaccesstothetonnageofevidenceconfirmingtheextentofthe suppressionofeffectivealternativetreatmentswhichare:(a)highlyeffective,(b)safe,withonly minorpossiblesideeffectsand(c)veryinexpensive;Giveabackground,inlayman'sterms,ofwhat formulasareusedandtheirhistory,aswellaswhatwehavedonetoimprovetheireffectiveness. Plusrecordtheproofthatthepublicneedsandpoliceit.Ifyoucanassistusinthisinanywayplease contactpleasecontactPanacea. ThisSUPPRESSEDinformationneedsyourhelptospreadeffectivelythroughblogs,friends,and communitygroupsandinthemedia.PleasehelpforwardthisPDFtoyourdoctors,government membersandtoasmanyaspossible.Weareallneededtoworktogether,thatistheveryessence ofthePanaceaspirit.Onlyasacommunitycanwecreatesecurity.Thereisnouniversity,doctor, facultyorcancerclinicteachingthismethodatthistime,ifyoucanhelpthiseffortpleasecontactus.
Blacksalvetestimonials
VideotestimonialsofCansema(blacksalve)takenfrom GregCatonsalphaomegalabsVideochannel
Tofindthetruecapacityoftheinternal(TonicIII)andtropicalblacksalveapplicationfurther investigationisrequired,onlythencanwefullyactualizeitspotential.Sofarwehaveabroadrange ofsocalledterminalcancerstogenericskincancerswhichhavebeenreportedtobesuccessfully treatedbytheuseofblacksalve.Weneedmore.Ifyoucannotfindyourcancerconditionlisted here,thisdoesnotnecessarilymeanitcannotbetreated.Untilwegetsupportandsponsorship,we canonlyreportcasesastheyappear.Allofthesecaseshaveshownconsistentresults,meaningthe cancerhasnotreturned.Thisisespeciallyvaluablewithskincancers,astheyfrequentlyreoccur afterallopathicmedicaltreatment(surgeryorliquidnitrogen). Wheretypicallyitwouldhaverequiredamassivebillforsurgery,drugsandskingraftingetc,black salvewascheapandeffectivewithouttheneedforanysurgeryorskingraftingetc.Othershadblack salvesuccessfullytreattheircancerwheresurgeryandothertreatmentscouldnothavebeenused. Panaceawishestopresentobservationaldataandmedicalrecordsobtainedbyourvolunteers.Our firstvolunteerBrucecantestifytotwoskincancersreturningaftersurgery.Whenyouaddupthe costofsurgeryandtheirsuccesscomparedtoblacksalve,thereisnoquestionthatblacksalvehas astatisticalefficiencyoverallopathicmedicalsurgery.
PanaceaVolunteerBruceGorrieBlacksalve applicationtoagenericskincancer
PanaceaVolunteerBruceGorrieblacksalvephotoessay
Thefollowingphotoshowstheexpelledcanceroustumour,thistimethecancerwasnotsolucky.
BruceGorrieTumour
ClickforArticle
http://www.ahfau.org/cansema.htm
KenMurrayssuccessfullyblacksalvetreatment
BarbaraHammKing
InOctof2009IdiscoveredaBreastLumpthatwasabouttochangemylife.Iprayedandresearched forawholemonth!OnDec12009IhadamammogramandanultrasoundwhichrevealedIhada TUMORbutIdidnotwanttodoaBiopsybecauseIhadreadandheardfromsomefirsthand experiencesthatbiopsiescancausecancertospreadorgrow.SoforawholeyearthiswaswhatI did:IfirstdidaLOTofresearchontheinternettofindoutallIcouldaboutBREASTCANCER. RadiationcanactuallycausecancerandChemotherapyispoisonandattacksALLcellsNOTjust cancercellsanddestroystheimmunesystem.IlearnedthatSUGARFEEDScancercells. CancerCellsGobbleUpsugar15timesfasterthannormalcellsdo.Carbohydratesinrefinedflour productsturntosugarswheningestedandFEEDSCANCERCELLSinthesameway.Ialsolearnedthat MILKcontainshormonesthatIdidNOTNEEDthatcouldalsobeacontributingfactor.SoIquit drinkingmilkandtotallyputsugaroutofmydiet.IfocusedonalowcarbALKALINEDIETbecause studieshaveshownthatmostpeoplewhohavecancerhaveadiettoohighinACID.Iwasalreadya vegetarianandhavebeenfor45years.I'mnotgoingtoputweblinksinthisinformation.I'llleave thatresearchtothereader.ThisismyPERSONALTESTIMONY.IaddedtomydietHighdosesof VitaminC....4,000mgperday,400IUVitaminEperday,FreshCarrotJuiceonceadayandEssiac Tea3timesperday.Essiacisabloodpurifierandgoodallroundcleanser.Italsoissaidtodraw cancercellsbacktotheiroriginalsite.
BarbaraHammKingsTumorremovedusingblacksalve
Mytumordidnotshrink,itfluctuatedslightlyandonNov.15,2010IfinallyhadaBIOPSYdoneto understandwhatIwasdealingwith.IwasdiagnosedwithInSituLowCellCarcinoma.Whichmeant thecancerWASSTILLINitsORIGINALPLACEandhadnotspreadtoanylymphnodesoranywhere else!MysurgeonwantedtodoalumpectomyANDremovethelymphnodesANDfollowupwith radiation.IsaidNO!Hesaid"Whatareyougoingtodo?Treatityourself?"Ijustnodded. WediscoveredthroughsomefriendsaBLACKSALVEtreatmentfortumors.Iwasgivenaman'sname andphonenumberwhereIcouldorderitwhichIdidrightaway.Myhusbandisanurseandhebegan doingmydressingsevery24hourswhichwedidfor2weekswhichincludedBlackSalvethefirstday andthenaYELLOWSALVEfor5days,thenBLACKSALVEagainandthencontinuedwithYELLOW SALVEuntilthetumorFELLOUT!!.TakentheBarbaraHammKingFacebookpage TheBarbaraHammKingFacebookpagelinkseemstobenolongeractive,asearchatthetimeof authoringthisdocumentrevealsthatitwasstillappearingintheGooglesearchengineresults, luckilyPanaceaarchivedit.
SecondlistedentryfromthetoprevealsBarbsfacebookpage
Presently,nooncologistgivestheirpatientsanyinformedconsentaboutthesuccessofblack salve.ThiswillcontinueunlessPanacearecruitsmorevolunteersandorthosewhouseit participatetohelpusaccumulatemedicalrecordsofthesuccess.Pleasecheckthehowyoucan helpblacksalvesectionofthisdocumentifyouplantuseoradviseotherstouseblacksalve. Withnopublicinterventionorawarenessforpolicingstatisticalefficacyonanyalternativecancver treatmentsthatwilltakerevenuereturnsoffbigpharmashoulditbenosurprisethat: DoctorsAretheThirdLeadingCauseofDeathintheUS,Killing225,000PeopleEveryYearThis articleintheJournaloftheAmericanMedicalAssociation(JAMA)isthebestarticleIhaveeverseen writteninthepublishedliteraturedocumentingthetragedyofthetraditionalmedicalparadigm. ThisinformationisafollowupoftheInstituteofMedicinereportwhichhitthepapersinDecemberof lastyear,butthedatawashardtoreferenceasitwasnotinpeerreviewedjournal.Nowitis publishedinJAMAwhichisthemostwidelycirculatedmedicalperiodicalintheworld. TheauthorisDr.BarbaraStarfieldoftheJohnsHopkinsSchoolofHygieneandPublicHealthandshe desribeshowtheUShealthcaresystemmaycontributetopoorhealth. ALLTHESEAREDEATHSPERYEAR: 12,000unnecessarysurgery 7,000medicationerrorsinhospitals 20,000othererrorsinhospitals 80,000infectionsinhospitals 106,000nonerror,negativeeffectsofdrugs Thesetotalto225,000deathsperyearfromiatrogeniccauses!! Whatdoesthewordiatrogenicmean?Thistermisdefinedasinducedinapatientbyaphysician's activity,manner,ortherapy.Usedespeciallyofacomplicationoftreatment.Source
Source
Source
Offurthersignificanceishowshedealtwiththehealingprocess.
Itgivesusgreatpleasuretogivegratitudetothislady,sheiswellontothetrueholisticwayof healingasshealsomentionswhatPanaceadoesinourguides,theneedfortherestofthestory. Thisincludestheapplicationofdietary(rawfoodandjuicing)andlifestyle(relaxation/meditation) changes. Thefollowingcommentistakenfromtheyoutubevideodisclosure.TostartRawfooddiet,juicing withaddedBrokenWallChlorella,HawaiianSpirulinaBarleyGrass.Stopintakeofalltoxins. Thenextbreastcancerconquerorhasthankfullyputherresultsintothepublicdomain.French CanadianborndoctorVeroniqueDesaulniersAKADr.Vhasdonetheessentialjobtoinspirewoman tobeproactivewithprevention,ofcausethisinvolvestherawfoodjuicing.DrVhaspresentedher 45dayessayofhersuccessfultreatmentofbreastcancerusingblacksalve.
DrVConquersBreastCancer
InhervideoDrVspresenthercourageousrecordsofeliminatingbreastcancerwithemphasisona holisticapproachincludingpreventionandutilizationofsulforaphane(broccolisprouts).Thankfully
DoctorVkeptrecordsofhercancercondition,herblacksalveapplicationandalsoofhercancerfree condition.ThiscanONLYhelpuseducateotherstocapacity.
DrVConquersBreastCancer
DrVConquersBreastCancer
DrVswebsitetestimonial
Tonguecancerremovedbyblacksalvealphaomegalabs
Detailsplusaphotoessayofblacksalvesuccessfullytreatingtonguecanercanbefoundatthe followinglinks.
http://altcancer.net/estes.htm http://altcancer.net/cansema_nuwais.htm Oncologistdidnottellthemhowtheycantakecontroloftheirhealth.Howfaroffwouldinformed consentbeiftheyeverfoundout?Animportantelementtounderstandintheblacksalve testimonialsectionisthefollowing:Atfirstmostpeoplemaybeputoffbythegraphicimages involvedintheprocessofblacksalvetreatingcancer(s).Howeveroneonlyneedstolookattheend resultstoseehowthehumanbodycanhealitself.WhatlooksbadinpartSOONHEALSUPinthe endwithhardlyanytraceleft. Ifyoustilldoubtthis,observethenextindividualscase,thisistakenfromaclinicinSouthAmerica wheretheyroutinelyuseblacksalvetotreatleishmaniasis(askincondition).Inthefirstphoto(top left)youcanseeadeepwoundinhisrightcheekaftertheesherwasremoved.Typicallyonemay thinkthathewouldbeleftwithapermanentdisfiguredscarorbigholeinhisface.Thisisnotthe case,thesameasitisnotthecase,aswithotherblacksalvecasesrecorded,thebodymendsnicely, theskinroutinelyhealsovertheholesotospeak.
leishmaniasistreatment.info
TotheNow
leishmaniasistreatment.info
Thiswascheaperthancosmeticsurgery.Thenexttestimonialinneedofbeingarchivedcomesfrom BOTANICALSURGERY"Dr.WeilonescharoticCancerSalvesSourcetruthquest2.com/cancersalves
Dr.Weil Dr.Weil:describesgettingaletterfromamaninCalifornia,praisingtheabilityoftheherb bloodroottodissolvemolesandskingrowths,andinoneobservedinstance,amalignant melanoma.HeurgedDr.WeiltoorderthesalvefromsomeoneinUtahwhomadeitup,andto experimentwithit. Dr.Weildidandgotthecontainerofoilyredsalvewithnoinstructions.Hedidsomeresearch andfoundthatitwasafavoriteofIndiansandEuropeansettlers,butthatitwasnowthought tobetoxictakeninternally,buthefound"manyreferencestoitspeculiarabilitytodissolve abnormalgrowthsontheskinwithoutharmingnormaltissue,eventodissolvingsomebreast cancersthaterodedtotheskin.."Hethoughtitsoundedsafetouseexternally.
Blacksalvehasbeenreportedtosuccessfullytreatmelanoma.Comparethesereportswiththe currentdrugsusedtotreatmelanomaonthemarket. USapprovesdrugforlatestagemelanoma.Thetreatmentonlyworksinabouthalfofpatients withadvancedmelanoma,thosewhosetumoursexpressagenemutationcalledBRAFV600E, meaningitcouldhelpabout10,000patientsintheUnitedStates,accordingtoexperts.Justafew treatmentsformelanomacurrentlyexist,withlittlesuccessinextendingthelifeofpatients.Just overaquarterofpatientsonZelborafdevelopedanotherformofskincancer,cutaneoussquamous cellcarcinoma,whichwasmanagedwithsurgery.Readmore:http://www.news.com.au/breaking news/usapprovesdrugforlatestagemelanoma/storye6frfku01226117087255#ixzz1lDO8iqXr ThankstoPanaceavolunteerPeterJames,thefollowingmedicalrecordsaretothebestofour knowledgetheworldsfirstdetailedmedicalproofofblacksalveworkinginahumansubject.Peter isanalternativeenergyresearcherwhopresentlyworkswithhydrogenondemandtechnology. PeterwasdiagnosedwithaTERMINALSCCskincancer.HerearethephotorecordsofPeter'sSCC condition.Notethatthename"PeterJames"iswrittenonthetopofthisform.Panaceacanprovide copiestoanypartiesneedingfurtherconfirmation.
PeterJamesSCCcancerconfirmed
PanaceaVolunteerPeterJamesBlacksalveresult
PeterJamesPathologyreportSCCcancerremovedbyblacksalve, nosurgerynecessary.Surgerycancelledbythegeneralsurgeon
Hereistheendresult.
BillO'Leary'sBlackSalveSkinCancerStory 3yearsupdateaftercancerremovedusingblacksalve BlackSalveinfowebsitePhotosofDramaticSuccessStories: TumorX(alternativenameforblacksalve)websitetestimonials VideoMelanomaskincancertreatedwithblacksalve VideoRemovedMolewithBlacksalve VideoCansemaBlackSalveYouTube BlacksalveSCCremoval whale.towebsitepageonblack_salve TreatmentofaPlantarWartusingBlackSalve
HowyoucanhelpbyusingblackSalve
VolunteerswhouseblacksalveareneededtohelpPanaceacollectmedicalrecords.Pleasesubmit themthroughPanaceasblacksalvesite.Whyishelpingprovideallopathicmedicalrecordsonthe useofblacksalveabsolutelyimperative?Sofarallpublicguidelinesandreportsfortheuseofblack salvehavebeenbasedonobservationonly.Thismeansthatthemedicalindustryhasnoobligation toacceptthesereportsorresultsastruthortoinformyouaboutthisoption.Theycansimply dismissitasahoaxormustnothavehadcanceretc. Theimportantpartofcollectingtheserecordsistoshowthepublicwhatisreportedasterminal doesnotnecessarilymeanterminal.PanaceavolunteerPeterlikemanyothersacquiredrecordsto provethatyouhaveoptions.Dohisparticularmedicalrecordsvalidatetheotherreports?Wefeel thatthattheydo.Howeverweneedyourhelptoacquiremore.
Despiteourrecordsandotherblacksalvereports,wemustgatherfurtherundeniableproofto reporttothepublicandensurethemedicalestablishmentprovidesinformedconsenttotheir patientsinregardstothepotentialnontoxicblacksalveoption.Ifyoucannotfollowtheeasy proceduretoobtainallopathicmedicalrecordsfromourguide,thenyourphotoandvideo testimonialessayMUSTbeusedinitsplace. 1)Allopathicmedicalrecordform 1.Getamedicaldiagnosisinwritingthatyouhavecancer.(ForexampleBiopsyimagingetc) 2.Takephotoandvideorecordeachdayofyourblacksalveapplication.Makesureyougeta before,duringandaftershots/video.Getafamilymemberorfriendtosignanaffidavitstatingthey havewitnessedyouapplythesalve.Foranexampleofaphotoessaypleasevisit http://www.adrianjonesnaturopath.com/success_stories.htm 3.Aftertreatment,getafollowupcheckup,toshowyourcancerfreeandgetitinwriting. Outcomesforpatientspresentingawrittenmedicaldiagnosis(biopsy,imagingetc),servetoconfirm thatnoallopathictreatmentwasmade;howeverthepatienthadcancerandisnowcancerfree. 2)PhotoandvideoEssayrecords 1)Takephotoandvideorecordseachdayofyourblacksalveapplication.Makesureyougeta before,duringandafter.Getafamilymemberorfriendtosignanaffidavitstatingtheyhave witnessedyouapplythesalve. Foranexampleofaphotoessaypleasevisit http://www.adrianjonesnaturopath.com/success_stories.htm AvideocanbemailedtoPanacea,oruploaddetailsofthePanaceaservercanbeprovided.Panacea willtheneditpublishthemonourYouTubechannelwithyourcredits.
BlackSalveRecipe
50gramseachofBloodroot(SanguinariaCanadensis),Chaparral(Larreamexicata)),Graviola (Annonamuricata)&Galangal(Alpiniaofficinarium). 500milofDistilledWater, 250gramsofZincChloride, 25mlofPharmaceuticalgradeDMSO(Dimethylsulfoxide) 25mlofGlycerine. Step1 Firstgather50gramsofBloodroot,Chaparral,GraviolaandGalangal. BloodrootSanguinariaCanadensis Chapparal(Larreamexicata) Graviola(Annonamuricata) Galangalroot(Alpiniaofficinarium)
Thenmixallingredientsintoabowltogether.
Thenadd250gramsofZincChloridetothewater
Step3 Bringthismixturetotheboilthensimmerstirringfrequentlytoensurethattherearenolumps
StircontinuouslyuntilALLthelumpsdisappear.
Step7 Whenthemixturecoolsandcuresitisntrunnyanymoreandhasapastelikeconsistency.
End
2ndrecipeEscharoticPreparationsGregCaton
GregCaton
ApplyingBlacksalve
Panaceacanprovideourownwalkthroughwiththeessentialdietandexerciseprogramneededfor preventionandtohelpreoccurrence.Contactus.Thereare2healthfreedomadvocatesthatwe knowofwhohavecoveredthebasicsofthesafeapplicationofblacksalve.AllcreditstoGregand Bevan. GregCatonCansemaUSERINSTRUCTIONS BevanpotterCenterforceinstructions
Modernresearchstudiesonbloodroot
GrowingandMarketingWoodlandBotanicalsJeanineM.Davis. Sourcehttp://www.hort.purdue.edu/newcrop/ncnu07/pdfs/davis274279.pdf Bloodroot(SanguinariacanadensisL.,Papaveraceae)isoneofthefirstplantstoemergeandbloom inthespring.Itisalowgrowingplantwithwaxylobedleavesandshowywhiteflowers.Thethick rhizomeisdarkontheoutside,withacreamcoloredfleshandbloodredsap(Fig.4).Therhizome hastraditionallybeenusedasadye,totreatskinlesions,andtopreventtoothdecay(Personsand Davis2005).Thedemandforbloodroothasbeenlowbutsteadyformanyyears,andasaresult,it hasbeenalmostexclusivelywildharvested.ThischangeddramaticallywhenaGermancompany beganusingitasanappetitestimulantincattlefeed. Itisnowalsobeingstudiedforthetreatmentofcancer(e.g.,Ahmadetal.2000).Themajoralkaloid believedtoberesponsibleforitsmedicinalandantimicrobialpropertiesissanquinarine(Leungand Foster1996). Bloodrootstudiesareinprogressonseedandvegetativepropagation,tillagesystems,and companionplantingwithotherwoodlandbotanicals(PersonsandDavis2005).Bloodrootis commonlypropagatedbyrhizomecuttingsandseed. AmericanAssociationforCancerResearch Sourcehttp://clincancerres.aacrjournals.org/cgi/content/full/6/4/1524#ABS NihalAhmad,SanjayGupta,MirzaM.Husain,KaisaM.HeiskanenandHasanMukhtar2 DepartmentofDermatology[N.A.,S.G.,M.M.H.,H.M.]andDepartmentofAnatomy,Schoolof Medicine[K.M.H.],CaseWesternReserveUniversity,Cleveland,Ohio44106 ABSTRACTSanguinarine,derivedfromtherootofSanguinariacanadendid,hasbeenshownto possessantimicrobial,antiinflammatory,andantioxidantproperties.Herewecomparedthe antiproliferativeandapoptoticpotentialofsanguinarineagainsthumanepidermoidcarcinoma (A431)cellsandnormalhumanepidermalkeratinocytes(NHEKs).Sanguinarinetreatmentwasfound toresultinadosedependentdecreaseintheviabilityofA431cellsaswellasNHEKsalbeitat differentlevelsbecausesanguinarinemediatedlossofviabilityoccurredatlowerdosesandwas muchmorepronouncedintheA431carcinomacellsthaninthenormalkeratinocytes.DNAladder
assaydemonstratedthatcomparedtovehicletreatedcontrol,sanguinarinetreatmentofA431cells resultedinaninductionofapoptosisat1,2,and5Mdoses.Sanguinarinetreatmentdidnot resultintheformationofaDNAladderinNHEKs,evenattheveryhighdoseof10M.Theinduction ofapoptosisbysanguinarinewasalsoevidentbyconfocalmicroscopyafterlabelingthecellswith annexinV.Thismethodalsoidentifiednecroticcells,andsanguinarinetreatmentalsoresultedinthe necrosisofA431cells.TheNHEKsshowedexclusivelynecroticstainingathighdoses(2and5M). WealsoexploredthepossibilityofcellcycleperturbationbysanguinarineinA431cells.TheDNAcell cycleanalysisrevealedthatsanguinarinetreatmentdidnotsignificantlyaffectthedistributionof cellsamongthedifferentphasesofthecellcycleinA431cells.Wesuggestthatsanguinarinecould bedevelopedasananticancerdrug. Galangal(ThaiGinger):Galangalrootisabitterusedtostimulatethereleaseofgastricjuicesto assistdigestion.Itrelievesbloating,constipation,sluggishdigestion,andgas.Althoughgalangalroot helpstheintestineprocessfats,oneofthechemicalsintheherb,5hydroxy7(4'hydroxy3' methoxyphenyl)1phenyl3heptanone(HPH),hasbeenshowntolowerbloodstreamcholesterolin laboratoryinvestigation.AccordingtotheGermanECommission,galangalcanbeusedfordyspepsia andlossofappetite,andisalsoconsideredtobeantispasmodicandantibacterial. 3176Vol.9,31763182,August1,2003ClinicalCancerResearch VaqarMustafaAdhami,MoammirHasanAziz,HasanMukhtar,andNihalAhmad2 DepartmentofDermatology,UniversityofWisconsin,Madison,Wisconsin53706 ActivationofProdeathBcl2FamilyProteinsandMitochondrialApoptosisPathwaybySanguinarine iniimmortalizedHumanHaCaTKeratinocytes1(clicklinktogotoarticlesiteSource http://clincancerres.aacrjournals.org AsummaryofresearchfindingsFromescharoticsalveexpertDanRaber'swebsite Sourcehttp://www.cancerx.org/science_of_bloodroot.html "INTRODUCTIONTOBLOODROOT"Sanguinarinecanadendid(bloodroot)isnativetothemoist woodlandsofEasternU.S.andCanada.ThissmallNorthAmericanherbisamemberofthe PapaveraceaeHerbaceousperennial(poppyfamily),andpossessattributesthatareremarkableand almostunbelievable.NumerousdoctorsandresearchershaveinvestigatedSanguinarine canadendid,i.e.,13methyl[1,3]benzodioxolo[5,6c]1,3dioxolo[4,5i]phenanthridinium;thesapof theplantisbrightredandisespeciallyabundantwiththealkaloidsanguinarinewhichisderived fromrhizome(rootsystem),abenzophenanthridinealkaloidandastructuralhomologueof chelerythrine.Sanguinarineisknownforitsanticancer/antitumor,antiinflammatory,anti microbial(SanguinarinebroadinvitroactivityagainstGrampositiveandGramnegativebacteria, fungi,andsomeprotozoa),antioxidant,andexpectorantproperties. Theeffectofsanguinarineanditsantiproliferativeandapoptosisnaturewasinvestigatedandthe followingfoundtobetrue: 1.Sanguinarinestopscancerouscellsrapidgrowth. 2.Sanguinarinestopscancerouscellsfromabnormallyincreasinginnumber. 3.Sanguinarinestopsthepromotionofhumanepidermoidcarcinomacells,i.e.,squamouscell (squamouscellisaninvasivemalignanttumorderivedfromepithelialtissuethattendsto
metastasizetootherareasofthebody). 4.Sanguinarinepromotesthenaturalselfdestruction(apoptosis)ofcancercells. 5.Sanguinarinewillnotpromoteapoptosisatanystrengthorconcentrationtohealthtissue. 6.Sanguinarinewillpromotenecrosis(celldeath)inhealthyepidermalkeratinocytes(keratinocytes arethepredominantcelltypeintheepidermisanddermisi.e.skintissue)inconcentrationsabove 10M(106perunit). SafetyofSanguinarineThesafetyofsanguinarinehasbeendemonstratedwithover400yearsof usebyprofessionalsandnovicesalike.Sanguinariaextract,sanguinarine,hasbeenusedinmany overthecounterproducts,includingtoothpaste(theantiinflammatorypropertiesinhuman'sto reducegingivalinflammationandsupragingivalplaque.),mouthwash,coughandcoldremedies,and homeopathicpreparationsforcancerremoval. SanguinariaKillsSquamousCellCarcinoma Sanguinarinetreatmentwasfoundtoresultinadose dependentdecreaseintheviabilityofsquamouscell carcinoma.Normallycancerouscellsareunabletoexperience apoptosisbynaturalmeans.Sanguinarine(13 methyl[1,3]benzodioxolo[5,6c]1,3dioxolo[4,5 i]phenanthridinium)at1,2,and5Mdoseswasabletokill thecanceroustissue.DNA(deoxyribonucleicacid)ladderassaydemonstratedthat,comparedto vehicletreatedcontrol,sanguinarinetreatmentofsquamouscellcarcinomaresultedinaninduction ofprogrammedcelldeathassignaledbythenucleiinfunctioningcells.Thisprocessischaracterized bycleavageoftheDNAintofragmentsthatgiveasocalledladderingpatternthenthesolidphaseof thecellliquefies. Theinductionofapoptosisbysanguinarinewasalsoespeciallyclearwhenviewedwithconfocal microscopy(Thismicroscopeallowstheobservertovisualizeobjectsinasingleplaneoffocus, therebycreatingasharperimage).Thismethodidentifiedthenecroticsquamouscellcarcinoma. SanguinariaWillNotPromoteNecrosisToHealthySkinTissue.Sanguinarinetreatmentdidnotresult intheformationofaDNAladderornecrosisinnormalhumanskintissue.Necrosisdidnotoccur evenattheveryhighdoseof2,5,and10Mofsanguinarine.Theresultswereviewedandverified withconfocalmicroscopy. TheDNAcellcycleanalysisshowedthatsanguinarinetreatmentdidnotsignificantlyaffectthe distributionofcellsamongthedifferentphasesofthecellcycleinsquamouscellcarcinoma.(Thisis especiallyimportantbecausethisprovesdefinitelythatsanguinarinewillnotaffecttheDNAofcells.) Theresearchers'workprovesthatsanguinarineisaneffectivenaturalanticancerchemical,and undernormalcircumstancesanguinarinewillnotpromotedamagetohealthytissue. Infact,thesafetyoftheproducthasbeendemonstratedwithover400yearsofusebyprofessionals andnovicesalike.Sanguinariaextract,sanguinarine,hasbeenusedinmanyoverthecounter products,includingtoothpaste(theantiinflammatorypropertiesinhuman'storeducegingival inflammationandsupragingivalplaque.),mouthwash,coughandcoldremedies,andhomeopathic preparationsforcancerremoval.
TheSearchForAncientAnticancerChemicalsContinues.Agentsthatcaneliminatethecancerous cellsviaaprogrammedcelldeathbutdonotaffectthenormalcellshaveatherapeuticadvantage fortheeliminationofcancercells. Sanguinarineisaantiproliferativeagentthathasbeendevelopedasaanticanceragentasfarback as1600A.D.,bythepeoplesthatinhabitedNorthAmericawhichiscurrentlytheUnitedStatesof AmericaandCanada. TheMechanismStudieshaveshownthatsanguinarineisainhibitoroftheactivationofnuclear transcriptionfactorNFB,whichhasbeenimplicatedtoplayakeyroleintheregulationofcell growth,cellcycleregulation,andapoptosis.Theantitumorpropertiesofthisalkaloidareconstantly beingreestablished.Atpresent,onlyafewagentsareknowntopossessthepotentialfor selective/preferentialeliminationofcancercellswithoutaffectingthenormalcells. TheUniversityofWisconsinstudiesprovidesmoredefinitiveevidencethatsanguinarineat micromolarconcentrationsimpartsacellgrowthinhibitoryresponseinhumansquamouscell carcinomaandepidermoidcarcinomacellsviaaninductionofapoptosis.Insharpcontrast,normal humanepidermalkeratinocytesdonotshowanyevidenceofapoptosis,butundergonecrosison treatmentwithhigherconcentrationsofsanguinarine.TheUniversityofWisconsinresearchisthe firststudyshowingthecompletecascadeofeventsthatleadtoapoptoticcelldeathbysanguinarine. TheUniversityofWisconsinresearchersshowedsanguinarinecausedapoptosisofimmortalized humanCarcinomatissue. ChemistryBehindSanguinarine'sApoptoticCellDeath.Normalkeratinocytesismediatedviacaspase activationtriggeredbymodulationsinBcl2(Bcelllymphoma2)familyproteinsmediated cytochromecreleaseandtheassociatedevents.Bcl2isanantiapoptoticgene.Infact,thelink betweenapoptosisandcanceremergedwhenBcl2,whichisthegenethatislinkedtoan immunoglobulinchromosometranslocationpertainingtolymphoma,wasfoundtoinhibitcelldeath. Thisunexpecteddiscoverygavebirthtotheconceptthatimpairedapoptosisisacrucialstepinthe processofcancerdevelopment.Inthisstudy,TheUniversityofWisconsinshowedthatsanguinarine treatmenttothehumanCarcinomatissuekeratinocytesresultsinsignificantdecreaseinthelevels ofantiapoptoticBcl2proteinandincreasesintheproapoptoticBaxprotein.Thusshiftingthe Bax/Bcl2ratioinfavorofapoptosis. StudieshaveshownthatBcl2(i.eanenzymethatdegradesDNAduringapoptosis,inhibitedbyA moleculewhichrepressesorpreventsanothermoleculefromengaginginareactionbytheprotein of343aminoacidscarryinganuclearlocalizationsignal.)formsaheterodimerwithBaxandmight therebyneutralizeitsproapoptoticeffects.Inaddition,Bcl2isalsoknowntopreventthereleaseof caspases.TheUniversityofWisconsinstudieshavealsoshowntheincreaseofproteinlevelsofother proapoptoticmembersofBcl2family,i.e.,BakandBid,bysanguinarinetreatment. Furthermore,sanguinarinetreatmentofhumanCarcinomatissuekeratinocytesresultedinincrease inthelevelsofcytochromec(i.e.aproteinwhichcarrieselectronsthatiscentraltotheprocessof respirationinmitochondria(i.e.asmallintracellularstructurallydiscretecomponentofacellwhich isresponsibleforenergyproductionandtheconversionwithinthecellofnutrients(suchasprotein molecules)intochemicalenergyintheformofATP(adenosinetriphosphate),byreactingthefood
withoxygen(O2)untilthefoodhascompletelybeendegradedintocarbondioxide(CO2)andwater (H2O.)andcaspase. TheseareimportantobservationsasitisknownthattheBcl2familyproteins(i.e.aprotooncogene, activatedbychromosometranslocationinhumanBcelllymphomas(hencebcl)..Encodesaplasma membraneprotein.Thegeneproductinhibitsprogrammedcelldeath(apoptosis)andishomologous withthespiralinggene.)regulatethereleaseofcytochromecfromthemitochondriaintocytosol. Cytochromecresidesintheintermembranespaceofmitochondria,whereasitscofactors,Apafl andprocaspase9,arebothcytosolicproteins.TheoverexpressionofBcl2hasbeenshowntoblock cytochromecreleaseinresponsetoavarietyofapoptoticstimuli.Onthecontrary,thepro apoptoticmembersofBcl2familyproteinssuchasBax,Bak,andBidpromotecytochromecrelease fromthemitochondria.Theexecutionmechanismofapoptosisismediatedbycaspases(cysteinyl aspartatespecificproteinases),whichcarryouttheapoptoticprogramthroughasequential activationcascadeofinitiatorandexecutionercaspases.Apaf1inducesactivationofinitiator caspase9.Apaf1bindscaspase9viathecaspaserecruitmentdomainsattheirNH2termini, triggeringtheformationofasupramolecularcomplex.Whenactivated,initiatorcaspase9triggers subsequentproteolyticactivationofexecutionercaspase3,caspase7,andcaspase8.Thiswhole processresultsinthecleavageofpolyadenosinediphosphateribosepolymerase(i.e.anenzymes thatcatalystthesynthesisofnucleicacidsonpreexistingnucleicacidtemplates,assemblingRNA fromribnucleotidesorDNAfromdeoxyribonucleotides.)andsubsequentDNAdegradationand apoptoticdeath." ContraindicationsContraindicationfrominternallyuse:bloodrootshouldnotbeusedifoneis pregnancy,hashighbloodpressure,esophagealvaricis,hiatushernia,gastritisofpepticulceration, andrecentconsumptionofcentralnervoussystemstimulants.Useofemeticsformorethanthreeto fourdayscanproduceaseriousmedicalconditioniftheassimilationoffluidsisdisrupted.Thiscan leadtodehydrationandsevereelectrolyteimbalances.Continualretchingactionfromchronic emesiswillstraintheabdominal,gastric,anddiaphragmmusclescausingseverecrampingand potentialdevelopmentofhernias. Bloodrootusedinternallyshouldnotbeadministeredtounconsciousordeeplysedatedindividuals orintheeventofconvulsions,sincebloodrootmaycauseaspirationofthegastriccontentsresulting inobstructionoftheairpassages.Dan Raber CancerResearch67,38883897,April15,2007.doi:10.1158/00085472.CAN063764 2007AmericanAssociationforCancerResearch Sourcehttp://cancerres.aacrjournals.org/cgi/content/abstract/67/8/3888 ExperimentalTherapeutics,MolecularTargets,andChemicalBiologySanguinarineDependent InductionofApoptosisinPrimaryEffusionLymphomaCellsAzharR.Hussain1,NaifA.AlJomah1, AbdulK.Siraj1,PulicatManogaran2,KhalidAlHussein2,JehadAbubaker1,LeonidasC.Platanias3, KhawlaS.AlKuraya1andShahabUddin1 1HumanCancerGenomicResearch,KingFahadNationalCenterforChildren'sCancerandResearch, 2BiologicalandMedicalResearch,ResearchCenter,KingFaisalSpecialistHospitalandResearch
Center,Riyadh,SaudiArabiaand3RobertH.LurieComprehensiveCancerCenterandDivisionof HematologyOncology,NorthwesternUniversityMedicalSchool,Chicago,Illinois Requestsforreprints:ShahabUddin,KingFaisalSpecialistHospitalandResearchCancer,KingFahad NationalCenterforChildren'sCancerandResearch,MBC#9816,P.O.Box3354,Riyadh11211,Saudi Arabia.Phone:96612055169;Fax:96612055170;Email:Shahab@kfshrc.edu.sa. Primaryeffusionlymphoma(PEL)isanincurable,aggressiveBcellmalignancythatdevelopsrapid resistancetoconventionalchemotherapy.Ineffortstoidentifynovelapproachestoblock proliferationofPELcells,wefoundthatsanguinarine,anaturalcompoundisolatedfromtheroot plantSanguinariacanadendid,inhibitscellproliferationandinducesapoptosisinadosedependent mannerinseveralPELcelllines.OurdatashowthatsanguinarinetreatmentofPELcellsresultsinup regulationofdeathreceptor5(DR5)expressionviagenerationofreactiveoxygenspecies(ROS)and causesactivationofcaspase8andtruncationofBid(tBid).Subsequently,tBidtranslocatestothe mitochondriacausingconformationalchangesinBax,leadingtolossofmitochondrialmembrane potentialandreleaseofcytochromectothecytosol.Sanguinarineinducedreleaseofcytochromec resultsinactivationofcaspase9andcaspase3andpoly(ADPribose)polymerase(PARP)cleavage, leadingtoinductionofcaspasedependentapoptosis.Inaddition,weshowthatpretreatmentofPEL cellswithcarbobenzoxyValAlaAspfluoromethylketone,auniversalinhibitorofcaspases, abrogatescaspaseandPARPactivationandpreventscelldeathinducedbysanguinarine. Moreover,treatmentofPELcellswithsanguinarinedownregulatesexpressionofinhibitorof apoptosisproteins(IAP).Finally,Nacetylcysteine,aninhibitorofROS,inhibitssanguinarineinduced generationofROS,upregulationofDR5,Baxconformationalchanges,activationofcaspase3,and downregulationofIAPs.Takentogether,ourfindingssuggestthatsanguinarineisapotentinducer ofapoptosisofPELcellsviaupregulationofDR5andraisethepossibilitythatthisagentmaybeof valueinthedevelopmentofnoveltherapeuticapproachesforthetreatmentofPEL.[CancerRes 2007;67(8):388897] CancerResearch66,37263736,April1,2006]2006AmericanAssociationforCancerResearch Cell,Tumor,andStemCellBiology Cyclooxygenase2RescuesLNCaPProstateCancerCellsfromSanguinarineInducedApoptosisbya MechanismInvolvingInhibitionofNitricOxideSynthaseActivityJacobHuh1,Andrejs Liepins1,{dagger},JacekZielonka2,ChristopherAndrekopoulos2,BalaramanKalyanaraman2and AndreySorokin1 Departmentsof1Medicineand2BiophysicsandFreeRadicalResearchCenter,MedicalCollegeof Wisconsin,Milwaukee,Wisconsin.Requestsforreprints:AndreySorokin,DepartmentofMedicine, MedicalCollegeofWisconsin,CVRC,8701WatertownPlankRoad,Milwaukee,WI53266.Phone: 4144564438;Fax:4144566515;Email:sorokin@mcw.edu. Expressionofcyclooxygenase2(Cox2),aninducibleenzymeresponsiblefortheproductionof prostaglandinsfromarachidonicacid,iselevatedinhumanprostatetumorsamples.Theaimofthis studywastoinvestigatewhetherexpressionofCox2iseffectiveagainstprostatecancercell apoptosistriggeredbysanguinarine,thequaternarybenzophenanthridinealkaloidwith antineoplasticproperties.SanguinarineeffectivelyinducedapoptosisinLNCaPhumanprostate
cancerepithelialcellsasassessedbycaspase3activationassay,AnnexinVstainingassay,orby visualanalysisfortheapoptoticmorphologychanges.Sanguinarinemediatedapoptosiswas associatedwiththeincreaseofnitricoxide(NO)formationinprostatecancercellsasassessedby measurementsofnitriteswithSieversnitricoxideanalyzeraswellasflowcytometryanalysisusing NOfluorescentsensor.ActivationofNOsynthase(NOS)activitywascrucialforsanguinarineinduced celldeathbecauseNOSinhibitorLNMMAefficientlyprotectedcellsfromapoptosis.Adenovirus mediatedtransferofCox2intoLNCaPcellsinhibitedsanguinarineinducedapoptosisandprevented anincreaseinNOproduction.Surprisingly,NOdonorsfailedtoinduceapoptosisinLNCaPcells, suggestingthatconstitutiveNOgenerationisnotsufficientfortriggeringapoptosisinthesecells. BesidesNOgeneration,NOSisalsocapableofproducingsuperoxideradicals.Sanguinarineinduced productionofsuperoxideradicals,andtheadditionofMnTBAP,ascavengerofsuperoxideradicals, efficientlyinhibitedsanguinarinemediatedapoptosis.TheseresultssuggestthatCox2expression rescuesprostatecancercellsfromsanguinarineinducedapoptosisbyamechanisminvolving inhibitionofNOSactivity,andthatcoadministrationofCox2inhibitorswithsanguinarinemaybe developedasastrategyforthemanagementofprostatecancer.(CancerRes2006;66(7):372636) OriginallypublishedInPressasdoi:10.1074/jbc.M501467200onMarch7,2005 J.Biol.Chem.,Vol.280,Issue19,1907819086,May13,2005 TheBenzo[c]phenanthridineAlkaloid,Sanguinarine,IsaSelective,CellactiveInhibitorofMitogen activatedProteinKinasePhosphatase1*AndreasVogt{ddagger},AletheiaTamewitz,JohnSkoko, RachelP.Sikorski,KennethA.Giuliano,andJohnS.LazoFromtheDepartmentofPharmacology, UniversityofPittsburgh,Pittsburgh,Pennsylvania15261 Mitogenactivatedproteinkinasephosphatase1(MKP1)isadualspecificityphosphatasethatis overexpressedinmanyhumantumorsandcanprotectcellsfromapoptosiscausedbyDNA damagingagentsorcellularstress.SmallmoleculeinhibitorsofMKP1havenotbeenreported,in partbecauseofthelackofstructuralguidanceforinhibitordesignanddefinitiveassaysforMKP1 inhibitioninintactcells.Hereinwehaveexploitedahighcontentchemicalcomplementationassay toanalyzeadiversecollectionofpurenaturalproductsforcellularMKP1inhibition.Usingtwo dimensionalKolmogorovSmirnovstatistics,weidentifiedsanguinarine,aplantalkaloidwithknown antibioticandantitumoractivitybutnoprimarycellulartarget,asapotentandselectiveinhibitorof MKP1.SanguinarineinhibitedcellularMKP1withanIC50of10MandshowedselectivityforMKP 1overMKP3.SanguinarinealsoinhibitedMKP1andtheMKP1likephosphatase,MKPL,invitro withIC50valuesof17.3and12.5M,respectively,andshowed510foldselectivityforMKP3and MKP1overVH1relatedphosphatase,Cdc25B2,orproteintyrosinephosphatase1B.Inahuman tumorcelllinewithhighMKP1levels,sanguinarinecausedenhancedERKandJNK/SAPK phosphorylation.Aclosecongenerofsanguinarine,chelerythrine,alsoinhibitedMKP1invitroand inwholecells,andactivatedERKandJNK/SAPK.Incontrast,sanguinarineanalogslackingthe benzophenanthridinescaffolddidnotinhibitMKP1invitroorincellsnordidtheycauseERKor JNK/SAPKphosphorylation.Thesedataillustratetheutilityofachemicalcomplementationassay linkedwithmultiparameterhighcontentcellularscreening. Receivedforpublication,February8,2005 *ThisworkwassupportedbyNationalInstitutesofHealthGrantsCA78039andCA52995andthe FiskeDrugDiscoveryFund.Thecostsofpublicationofthisarticleweredefrayedinpartbythe
paymentofpagecharges.Thisarticlemustthereforebeherebymarked"advertisement"in accordancewith18U.S.C.Section1734solelytoindicatethisfact.Currentaddress:Cellumen,Inc., 100TechnologyDr.,Pittsburgh,PA15219. {ddagger}Towhomcorrespondencemaybeaddressed:Dept.ofPharmacology,TheHillmanCancer CenterG.27a,UniversityofPittsburgh,Pittsburgh,PA15213.Tel.:4126231216;Fax:4126231212; Email:avogt@pitt.edu.Towhomcorrespondencemaybeaddressed:Dept.ofPharmacology, BiomedicalScienceTowerE1340,UniversityofPittsburgh,Pittsburgh,PA15261.Tel.:412648 9319;Fax:4126482229;Email:lazo@pitt.edu. Modernblacksalveresearchstudylinks http://www.cancerx.org/science_of_bloodroot.html AllTumorX(blacksalveproduct)listofPeerReviewedStudiesonBloodroot Chaparral
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