Source: http://www.precisionnutrition.com/all-about-coffee Summary: Coffee is among the most consumed and controversial beverages in the world.

d. While coffee should be treated with care and avoided altogether by those who metabolize it poorly, it also provides health benefits to many people. Read on to find out what they are and how to drink coffee responsibly. Coffee is the second most popular drink in the world, trailing only water and, debatably, tea. Caffeine, a key component of coffee, is a controversial compound. With 90% of North American adults consuming caffeine daily, it is the worlds most consumed psychoactive drug and coffee is the delivery method of choice. Perhaps thats why, in the fitness world, weve traditionally viewed coffee with some suspicion. But is coffee really bad for us? Should we give up our beloved cuppa joe? If its bad, why does it feel so good?

Coffees origins
The coffee plant originated in East Africa according to legend, a goat herder tried coffee cherries after he noticed his goats acting much more energetic after nibbling on the coffee bushes. The earliest evidence of coffee drinking occurred in the 15th century in Yemen. From Yemen, coffee quickly spread to Egypt and North Africa, and by the 16th century it was being enjoyed by the rest of the Middle East, Persia, and Turkey and soon thereafter Italy and the rest of Europe. Fast forward to today. Coffee is ubiquitous in our culture. Everywhere you look, theres a coffee shop on the corner. What effect might our cultural love of coffee have on our health? Short answer: Well, were not completely sure.

Coffees risks
Research on coffees safety is mixed, for several reasons: Metabolism matters. People vary genetically in how well they can process caffeine and coffee. Coffee interacts with many hormones and neurotransmitters in the body, such as cortisol, acetylcholine, and insulin. These relationships

are complex, and often depend on timing, amount, and peoples individual makeup. As a crop, coffee is less like corn or soy, and more like cacao or wine grapes: Its typically grown and processed in smaller batches by smaller-scale farmers and producers. Variations in soil and climate, as well as later roasting and brewing technique, will change the taste and chemical makeup. Its hard to standardize the exact chemical compounds in coffee from batch to batch. So its hard to say definitively that coffee is good or bad; healthy or unhealthy. Lets explore this in more depth. What about my metabolism? One reason that evidence on the health effects of coffee is so mixed is that people clear caffeine at different rates. Caffeine is broken down and cleared by the liver, and our genetic makeup shapes how quickly and effectively we can do this. On one hand, slow metabolizers of caffeine dont process caffeine effectively. These are people who are adversely affected by caffeine, get the jitters, and are wired for up to nine hours after consumption. Others just get a boost in energy and alertness for a couple of hours; they are considered fast metabolizers of caffeine. Research in the emerging field of nutrigenomics shows that about half of us have the gene variant that makes us slow metabolizers, while the other half enjoy the gene variant that allows them to get away with quad-espressos. Thus, whether coffee is better or worse for you depends on how well and quickly you metabolize caffeine. If you are a slow metabolizer of caffeine and coffee, steer clear (or at least, reduce your consumption). In your case, coffee can do more harm than good, and this may explain why high coffee consumption has been associated with: higher risk of miscarriage disrupted sleep worse PMS symptoms increased blood pressure, even in people without hypertension non-fatal myocardial infarction (aka a heart attack) On the plus side, low caffeine consumption still seems relatively safe for most folks, so a few daily cups of tea or squares of dark chocolate shouldnt harm you (and in fact, may greatly boost your wellbeing!).

And fortunately, not everyone is adversely affected. For those lucky enough to be fast metabolizers, there is good news and lots of it. Fast metabolizers dont show the same association between coffee and disease if youre a fast metabolizer, coffee might even improve your health! What about cortisol? Cortisol is a hormone produced by the adrenal glands. It increases blood pressure, spikes blood sugar and prepares the body for fight or flight mode. Coffee and caffeine tend to transiently increase cortisol levels; however, this depends on several factors, including when you drink coffee, how often you drink it, and whether you have high blood pressure. Cortisol is normally high in the morning, so if you drink some coffee at 6 a.m. and 10 a.m., you should be fine, as cortisol is naturally elevated at that time of day anyway. However, your body may not appreciate coffee as much in the afternoon or evening, when cortisol normally drops. At that point, consider tea or something decaffeinated. Again, theres individual variation: Habitual consumers of coffee seem to be less affected by the cortisol bump, while those with hypertension seem to be more affected. If cortisol levels are a problem for you, keep your coffee intake to first thing in the morning, and otherwise consume more tea. What about pesticides? Coffee plants are heavily sprayed with pesticides, which pose obvious health concerns. Fortunately, the plants structure offers some protection. While the outer berry does receive a lot of exposure, its the interior bean that is roasted and used for coffee, and its exposure is far less. In addition, the roasting process destroys the majority of pesticide residues. If youre especially wary of pesticides, choose organically grown coffee. (Hey, it cant hurt.) And while youre at it, look for the Fair Trade label, which helps insure that family farmers are paid a fair wage for their crops. What about my insulin sensitivity? While a high dose of caffeine tends to decrease insulin sensitivity and glucose tolerance acutely, it doesnt seem to cause chronic problems. While those at risk of developing diabetes may want to be cautious, overall coffee consumption is actually associated with a 35% decreased

risk of developing type II diabetes. What about my kids? Theres no clear guideline on when kids can safely consume coffee. Guidelines on caffeine consumption are based mostly on the size of the child, rather than their chronological ages. Nevertheless, Health Canada recommends: no more than 45 milligrams a day for kids aged 4 to 6; 62.5 milligrams for kids age 7 to 9; 85 milligrams for kids age 10 to 12; and no more than 2.5 milligrams per kilogram (2.2 pounds) of body weight for adolescents 13 and up. All this means that a 110 pound adolescent should not have more than 125 milligrams of caffeine a day about one 6-8 oz cup of coffee. Bear in mind, too, that kids may be getting plenty of caffeine from soft drinks, bottled tea, etc.

Coffees benefits
Caffeine & dehydration For years, fitness enthusiasts worried that coffee would dehydrate them. However, a recent review of 10 studies found that consuming up to 550 mg of caffeine per day (or about five 8-oz cups) does not cause fluidelectrolyte imbalances in athletes or fitness enthusiasts. In another review, researchers concluded that consuming caffeinecontaining beverages as part of a normal lifestyle does not lead to fluid losses exceeding the volume of fluid consumed (intake and output were roughly equal), nor is it associated with poor hydration status. Take-home: Dont drink coffee as your only beverage, and drink enough water, and youll be fine. Coffee & performance Lets be honest that first morning coffee can transform us from beast to philosopher (or at least, slightly more awake and nicer beast). Coffee, and more specifically its caffeine content, provide many noted mental and physical performance benefits. Caffeine reduces our rate of perceived exertion, so it doesnt feel like were working as hard as we actually are. People who regularly drink coffee perform better on tests of reaction time, verbal memory, and visuo-spatial reasoning. Another study found that women over the age of 80 performed significantly better on tests of cognitive function if they had regularly consumed coffee over the course of their lifetimes. Take-home: A little bit of coffee/caffeine before important tasks requiring alertness and energy can be a good thing.

Coffee & Parkinsons Parkinsons disease is a fatal and incurable brain disease that affects 1 percent to 2 percent of people over 65. Amazingly, at least six studies have found that regular coffee drinkers are up to 80% less likely to develop Parkinsons. Researchers have identified a gene called GRIN2A that appeared to protect people who drank coffee from developing Parkinsons. GRIN2A is linked to glutamate, a compound that is suspected of killing the brain cells that die off in Parkinsons patients. Glutamate can be affected by another compound called adenosine, and coffee interferes with this process. However: Only about 25% of the population has the gene variant of GRIN2A that boosts the protective effect of coffee. Take-home: Coffee may lower Parkinsons risk, but only in a small subset of people. Coffee & Alzheimers Speaking of neurodegenerative disorders, Alzheimers disease is the most common form of dementia. There is no cure for the disease, which gets progressively worse over time, and eventually leads to death. What separates the research on Alzheimers from most of the other information covered in this article is that it derived from directly controlled trials versus simple observation. Here, research indicates that people who drink about three cups of coffee a day show a marked reduction in cognitive impairment compared to non-drinkers. Once you got up to four or more cups per day, though, the associated protection disappears. This protection was not seen with tea or decaf coffee, so the benefit seems to be from the combination of the caffeine and some of coffees bioactive compounds. In fact, new research from the University of South Florida found that this combination boosts blood levels of a critical growth factor called GCSF (granulocyte colony stimulating factor) that seems to prevent the formation of Alzheimers disease. People with Alzheimers disease have less GCSF than the rest of the population. Increasing GCSF in mice improves their memory. In the U of South Florida study, the researchers compared the effects of regular and decaf coffee to those of caffeine alone. In both Alzheimers mice and normal mice, treatment with regular coffee dramatically increased blood levels of GCSF; neither caffeine alone nor decaf coffee provided this effect. GCSF seems to improve memory performance in the Alzheimers mice in three ways:

It recruits stem cells from bone marrow to enter the brain and remove the harmful beta-amyloid protein that initiates the disease. It creates new connections between brain cells. It increases the birth of new neurons in the brain. As the lead researcher, neuroscientist Dr. Chuanhai Cao, remarked: Coffee is inexpensive, readily available, easily gets into the brain, appears to directly attack the disease process, and has few sideeffects for most of us. According to the researchers, no other Alzheimers therapy being developed comes close to meeting all these criteria. Take-home: Coffee seems to contain compounds that may reduce Alzheimers risk; and may also be part of a treatment protocol in the future.

Coffee, antioxidants & cancer While dark chocolate and green tea gather a lot of acclaim for their antioxidant content, coffee actually outshines them both in this department. In fact, the antioxidants in coffee may make up as much as 50-70% of the total antioxidant intake of the average American! (Which is not necessarily a good thing, because it means that there are a lot of vegetables not getting eaten) Despite some general worries about the health effects of coffee, coffee consumption is associated with an overall decreased risk of cancer. In particular coffee consumption has been shown to be associated with a lower risk for oral, esophageal, pharyngeal, breast (in post-menopausal women), liver, colon, and aggressive prostate cancer. When it comes to the prostate, researchers recently found that men who drank the most coffee (6 or more cups per day) were nearly 60% less likely to develop advanced prostate cancer than non-coffee drinkers. Other research has shown that people who regularly consume two or more cups per day may have a 25% decreased risk of colon cancer. Again, the research is mixed in part because of the variation in response to coffee. Take-home: Coffee may lower your cancer risk, but dont count on it as your only health strategy. And eat some vegetables already. Coffee & cardiovascular health Drinking unfiltered types of coffee can increase your levels of LDL (aka bad) cholesterol. But overall the data seems to indicate that coffee consumption may moderately reduce your risk of dying from cardiovascular complications. Take-home: Research is mixed on cardiovascular disease and

coffee. Coffee & overall mortality A recent study in The New England Journal of Medicine showed that drinking two to three cups of coffee per day was associated with a 10% decreased risk of death for men at any age, and a 13% decreased risk of death for women at any age. In general, coffee drinkers were less likely to die from heart or respiratory disease, stroke, diabetes, injuries, accidents or infections. (Which makes us wonder what do they die of? Espresso steamer mishaps?) Take-home: Coffee appears to generally lower overall premature mortality slightly.

Summary & recommendations

Coffees not for everyone. And its not a magic bullet. Still, it seems to have significant health benefits for those who can tolerate it. This includes: better athletic and mental performance possibly lower rates of some types of cancer, neurodegenerative diseases, and Type 2 diabetes possibly some prevention of premature mortality and cardiovascular disease Most of the research on coffee is epidemiological. This means studies look at associations rather than cause and effect. Simply because coffee is associated with particular risks and benefits doesnt necessarily mean that coffee causes all of these risks or benefits. Just as with all foods (and nutrients for that matter), dosage matters. While some studies have found large intakes (5-6 cups) to have significant benefits, other research suggests that drinking that much coffee is counter-productive. In general, it appears that drinking some coffee is good, but more might not be better, especially if you are a slow metabolizer. For those who are greatly affected by coffee and caffeine, avoid it altogether or cut down your consumption. Want a quick and easy test of your coffee consumption? Ask yourself how you feel physically, mentally, and emotionally a few hours after you drink some as well as if you miss your daily dose. Also, go black if possible. Pumping your coffee full of cream, sugar, and other exotic additives reduces any potential health benefits by adding unnecessary calories and artificial flavours and sweeteners. (And Frappucinos or chocolate covered coffee beans? Cmon.) Taking all the data into consideration, it seems that your best bet is about 1-3 cups of coffee (8-24 oz) per day. This will maximize the

benefits while minimizing the risk. And keep this in mindwhile there is positive data on coffee, these benefits dont necessarily include things like energy drinks and caffeine pills. There are many antioxidants and bioactive compounds in coffee that are interacting with its caffeine content to provide the benefits. So, unfortunately, Red Bull doesnt count.

References
John K. Francis. Coffea arabica L. RUBIACEAE. Factsheet of U.S. Department of Agriculture, Forest Service. Freedman N, et al. Association of Coffee Drinking with Total and Cause-Specific Mortality. N Engl J Med 2012; 366:1891-1904 Hamza TH, et al. Genome-wide gene-environment study identifies glutamate receptor gene GRIN2A as a Parkinsons disease modifier gene via interaction with coffee. PLoS Genet. 2011 Aug;7(8):e1002237. Gavrieli A, et al. Caffeinated coffee does not acutely affect energy intake, appetite, or inflammation but prevents serum cortisol concentrations from falling in healthy men. J Nutr. 2011 Apr 1;141(4):703-7. Cornelis MC, et al. Coffee, CYP1A2 Genotype, and Risk of Myocardial Infarction. JAMA. 2006;295(10):1135-1141 Wisborg K, et al. Maternal consumption of coffee during pregnancy and stillbirth and infant death in first year of life: prospective study. BMJ. 2003 326 (7386): 420. Richelle M, et al. Comparison of the Antioxidant Activity of Commonly Consumed Polyphenolic Beverages (Coffee, Cocoa, and Tea) Prepared per Cup Serving. J. Agric. Food Chem., 2001, 49 (7), pp 34383442 Leitzmann WF, et al. A prospective study of coffee consumption and the risk of symptomatic gallstone disease in men. JAMA. 1999 281:210612 Leitzmann MF, et al. Coffee intake is associated with lower risk of symptomatic gallstone disease in women. Gastroenterology. 2002 Dec;123(6):1823-30 Webster Ross G, et al. Association of Coffee and Caffeine Intake With the Risk of Parkinson Disease. JAMA. May 24, 2000, 283:20 Hancock DB, et al. Smoking, Caffeine, and Nonsteroidal Antiinflammatory Drugs in Families With Parkinson Disease. Arch Neurol.

2007;64(4):576-580. Klatsky AL, et al. Coffee, Cirrhosis, and Transaminase Enzymes. Arch Intern Med. 2006;166:1190-1195. van Dam RM, Hu FB. Coffee consumption and risk of type 2 diabetes: a systematic review. JAMA. 2005 Jul 6;294(1):97-104. Tavani, A, et al. Coffee and tea intake and risk of oral, pharyngeal and esophageal cancer. Oral Oncol. 2003 39 (7): 695-700. Ganmaa D, Willett WC, Li TY, et al. Coffee, tea, caffeine and risk of breast cancer: a 22-year follow-up. Int J Cancer 2008 122 (9): 2071-6. Inoue M, Yoshimi I, Sobue T, Tsugane S. Influence of Coffee Drinking on Subsequent Risk of Hepatocellular Carcinoma: A Prospective Study in Japan. JNCI Journal of the National Cancer Institute 97 (4): 293-300 Nkondjock A. Coffee consumption and the risk of cancer: an overview. Cancer Lett. 2009 May 18;277(2):121-5. Arab L. Epidemiologic evidence on coffee and cancer. Nutr Cancer. 2010;62(3):271-83. Somoza V, et al. Activity-Guided Identification of a Chemopreventive Compound in Coffee Beverage Using in Vitro and in Vivo Techniques. J Agric Food Chem. 2003 51 (23), pp 68616869 American Association for Cancer Research Frontiers in Cancer Prevention Research Conference, Houston, Dec. 6-8, 2009. Jarvis MJ. Does caffeine intake enhance absolute levels of cognitive performance? Psychopharmacology. 2 December 2005, 110:1-2, 45-52. Johnson-Kozlow M, et al. Coffee Consumption and Cognitive Function among Older Adults. Am J Epidemiol 2002; 156:842-850 Lopez-Garcia E, et al. The Relationship of Coffee Consumption with Mortality. Annals of Internal Medicine 2008 Jun 17;148(12):904-14. Koizumi A, Mineharu Y, Wada Y, Iso H et al. Coffee, green tea, black tea and oolong tea consumption and risk of mortality from cardiovascular disease in Japanese men and women. Journal of Epidemiology and Community Health 2011 65: 230-240. Armstrong LE. Caffeine, body fluid-electrolyte balance, and exercise performance. Int J Sport Nutr Exer Metab. 2002 Jun;12(2):189-206. Maughan RJ, Griffin J. Caffeine ingestion and fluid balance: a review. J Hum Nutr Diet. 2003 16(6):411420. Eskelinen MH, et al. Midlife Coffee and Tea Drinking and the Risk of Late-Life Dementia: A Population-Based CAIDE Study. J Alzheimers Dis. January 2009. 16(1);85-91 Cao C, et al. Caffeine suppresses amyloid-beta levels in plasma and brain of Alzheimers disease transgenic mice. J Alzheimers Dis. 2009;17(3):681-97.