The All

New

Redefines Focused Ultrasound

The New Gold Standard in Non-invasive Fat Reduction & Body Contouring

The All

Results that Measure Up

New

Redefines Focused Ultrasound

The new UltraShape Contour I Ver3 fat reduction and body contouring system meets your patients needs for a non-invasive, convenient way to reduce localized fat deposits and body circumference. The UltraShape system is the first scientifically and clinically proven, non-invasive solution that offers measurable lasting body contouring results with no need for maintenance treatments.1 UltraShape is the only non-thermal focused ultrasound technology that selectively targets and disrupts only fat cells (adipocytes), leaving critical surrounding structures such as skin, blood vessels, nerves and connective tissue unharmed. UltraShape has been proven safe and clinically effective in a multi-center controlled trial and several independent clinical studies. Satisfied patients experience an average circumference reduction of four centimeters and as much as ten centimeters after three treatments.

Addressing the Unmet Needs of Physicians and Patients

The UltraShape procedure delivers a safe and effective non-invasive comfortable option for the reduction of localized fat deposits and smooth, uniform body shaping with high patient satisfaction. Both men and women experience impressive long-lasting body contouring of the abdomen, thighs and flanks.

Non-invasive option for reduction of localized fat deposits Attracts a new surgery-averse patient population Safe, simple, walk-in, walk-out procedure No bruising, swelling, or post-treatment discomfort No downtime or recovery period Measurable results in as little as two weeks post-treatment 100% delegable, requires no anesthesia, sedation, incisions, or injections Independent revenue and profit generator

Body Contouring by Non-invasive Transdermal Focused Ultrasound. J. Moreno-Moraga et al. LSM 2007

The All

New
Redefines Focused Ultrasound
Immediate selective fat cell disruption at a controlled depth
2

How It Works
The UltraShape fat reduction and body contouring system meets your patients need for a non-invasive, convenient way to reduce localized fat deposits and body circumference. The UltraShape system is the first scientifically and clinically proven non-invasive fat reduction and body contouring solution to selectively target and immediately disrupt unwanted fat.

Focused ultrasound energy: delivered only to tissue within a precise focal volume at a controlled depth Non-thermal, pulsed energy: no temperature increase Selective, mechanical effect: only fat cells are disrupted while skin, blood vessels, nerves and connective tissues remain unharmed Non-thermal Selective Focused Ultrasound
The pulsed acoustic waves of ultrasonic energy converge in a confined focal volume causing non-thermal, mechanical disruption of fat cells. Histology confirms fat cell disruption while surrounding structures exposed to these effects remain unharmed. Precision and safety are reinforced by an integrated acoustic contact sensor, which provides real-time feedback to ensure proper transducer-to-skin contact and efficient energy delivery to the treatment area. In addition, the advanced tracking and guidance software ensures complete and homogeneous energy delivery providing smooth, uniform body contouring results.

Natural Fat Clearance2

The UltraShape procedure is based on a natural fat clearance process where triglycerides and cell debris from the disrupted fat cells are processed by the bodys natural physiological and metabolic pathways. These pathways are the same pathways that handle fat during weight loss. Results from UltraShapes peer-reviewed published multi-center controlled clinical trial and other independent clinical studies show that the released triglycerides do not accumulate to a clinically significant extent in the blood or liver.3

With UltraShape finally there is a nearly painless, noninvasive, no downtime body contouring option that gives durable results. The system precisely delivers focused ultrasound energy powerful enough to destroy fat cells but leave neighboring tissue unharmed.
Steven Teitelbaum, M.D., Assistant Clinical Professor of Plastic Surgery at the David Geffen School of Medicine at UCLA and lead investigator for UltraShapes multi-center controlled clinical trial Plastic and Reconstructive Surgery, Journal of the American Society of Plastic Surgeons. PRS 120: 779, 2007

http://www.bodyclinic.ch/img/Fatmetabolism_after_treatment_with_Contour_I_by_Ultrashape.pdf

New Advanced Tracking & Guidance System

The UltraShape procedure is guided by an improved proprietary real-time tracking and guidance system. The system delivers optimized 3D mapping of the bodys curvature, guaranteeing adherence to a pre-determined treatment algorithm to deliver smooth, uniform body contouring results. This algorithm ensures complete and uniform energy delivery over the entire treatment area, minimizing the risk of contour irregularities, a common side effect of liposuction.

Highlighted treatment area is acquired by tracking and guidance software

Treatment only within marked treatment area Each point is treated only once Complete & uniform coverage of treatment area Uniform results with no risk of irregularities 100% delegable procedure
The tracking system, by addressing the dynamic nature of the treatment area as it monitors and synchronizes patient position in real-time, enables the patient to move freely without adversely affecting the treatment.
Yellow dot guides operator to location of each pulse

New Patient Data Management Software

The new Ver3 software comes with a comprehensive patient database application that is a powerful tool for treatment data management.
Blue dot confirms correct placement of transducer and allows energy delivery

Complete treatment showing successful energy delivery to all nodes in the treatment area

Clinically Proven Safe and Effective

The UltraShape Contour I system has been used to treat hundreds of thousands of patients in over 50 countries. The safety and effectiveness of the UltraShape procedure is supported by a peer-reviewed, published multi-center controlled clinical trial and independent clinical studies of over 550 patients.

Effectiveness
Histological evidence of selective fat cell disruption without damage to surrounding blood vessels, nerves and connective tissue, both in and around the focal volume Pre-clinical gross pathology shows immediate fat disruption CT scans demonstrate fat thickness reduction Average circumference reduction ranges from 3.5 to 6.3 cm1 Average response rate of 94%1

Satisfaction
86%-94% average patient satisfaction rate in independent clinical studies1

Safety
The vast majority of patients reported no pain or discomfort during or following treatment Normal blood and urine profiles in peer-reviewed published studies confirmed safe fat clearance No reported serious treatment-related adverse effects

Proven Tissue Effects

In-vivo Porcine Model: Immediate Acute Micro Effects
Histology demonstrating immediate selective fat cell disruption and intact surrounding structures such as blood vessels, nerves and connective tissue after a single UltraShape treatment.
Control Single treatment - selective fat cell lysis

Fat cell disruption

Single treatment - selective fat cell lysis

Single treatment - selective fat cell lysis Intact blood vessels

Intact blood vessels Intact nerves Fat cell disruption Intact connective tissue Fat cell disruption

Intact connective tissue

In-vivo Porcine Model: Immediate Acute Effects

Gross pathology shows treatment with non-thermal selective focused ultrasound causes immediate selective soft tissue disruption and full tissue recovery was observed as soon as 2 weeks post-treatment as: Multiple treatments result in incremental cavitationassociated fat specific destruction Multiple treatments can be performed at two week intervals resulting in greater cumulative fat reduction over a short period of time Full tissue recovery at two weeks confirms fast fat clearance from localized area resulting in quicker visible results
Tissue recovery two weeks post third treatment

Fat cells disruption after one treatment

Tissue recovery two weeks post first treatment

Fat cells disruption after three treatments

Fast full tissue recovery Allows multiple treatments at two week intervals Greater cumulative fat reduction

CT Scans Demonstrating Fat Thickness Reduction After Three UltraShape Treatments

Pre-treatment One month after 3 treatments

My clinical study demonstrated measurable circumference reduction in all patients. These results were further supported by CT scans in a subset of patients showing a sustained reduction in fat thickness. In addition, 94% of patients reported satisfaction with the UltraShape procedure confirming that it is meeting patient expectations and the high demand for safe and effective non-invasive fat reduction in todays aesthetic practice.
Hector Leal-Silva, M.D., Dermatologic Surgeon, Monterrey, Mexico

UltraShape Clinical Studies - Abdomen, Flanks and Thighs

Investigator Year Patient Teitelbaum S. et al , US, UK, Japan
1

Year 2004-05 2006 2007-08 2007-08 2008 2008 2005-06 2007-08 2007-08

Patient Population 164 30 25 36 26 21 148 83 20

Average Circumference Reduction 2.0 cm (Single Treatment) 3.95 cm 3.58 cm 5.0 cm 3.96 cm 3.48 cm 6.3 cm 3.8 cm 5.4 cm

Results 82% > 0.5 cm circumference reduction 100% measurable and visual improvement 83% > 1.0 cm circumference reduction 100% measureable reduction, 94% patient satisfaction 96% > 1.0 cm circumference reduction 93% > 3.5cm circumference reduction 93% patient satisfaction 93% measurable reduction, 86% patient satisfaction 86% patient satisfaction

Moreno-Moraga J et al1 Madrid, Spain Ascher B.2 Paris, France Leal-Silva H.3 Monterrey, Mexico Ad El D.3, Beilinson Med, Israel Mulholland S.2, Toronto, Canada Inglefield C.2, London, UK Benchetrit A.2, Montreal, Canada de Almeida G.2, Sao Paulo, Brazil

The UltraShape Procedure

UltraShape is a comfortable, walk-in, walk-out procedure that requires no downtime, no recuperation and no ongoing maintenance treatments. Lysed fat cells are cleared from the body naturally and as with liposuction the effects are long lasting when combined with a healthy lifestyle that includes diet and exercise. To optimize outcome, patients are recommended to undergo a series of three UltraShape treatments.

Before & After

Before

After

Courtesy of Dr. Moreno-Moraga et al, Madrid Spain

Courtesy of Dr. Mark Lupin, Victoria, British Columbia

Courtesy of Dr. Chris Inglefield, London, UK

Courtesy of Dr. Arie Benchetrit, Montreal, Quebec

Before & After

Pre-Treatment 20 Days Post 2nd Treatment 20 Days Post 3rd Treatment Combination Therapy 3 Sessions - UltraShape + RF + Deep Lymphatic Massage

Courtesy of Dr. Jorge Ottini, Buenos Aeries, Argentina

1

Published in peer-reviewed journal

Presented at scientific conferences

Data on File

About UltraShape
UltraShape is redefining aesthetic medicine by developing, manufacturing and marketing innovative non-invasive technologies for body contouring. Since 2000, the company has been dedicated to providing clinically proven safe and effective solutions that enhance the lives of patients worldwide. The UltraShape proprietary non-invasive body contouring technology is based on focused ultrasound that targets and selectively disrupts fat cells without affecting surrounding structures.

For more information visit www.ultrashape.com

UltraShape 1 Haatid Street, P.O. Box 80 New Industrial Park, Yoqneam 20692, Israel Tel: +972-4-9099200 Fax: +972-4-9592323 Email: info@ultrashape.com

UltraShape North America 206 Camino Ramon, 2nd Floor San Ramon, CA 94583, USA Tel: +1.925.242.2585 Fax: +1.925.242.2931 Email: info.north.america@ultrashape.com

Copyright 2008-2010 UltraShape Ltd. All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise, without written permission of UltraShape. This product and its use are protected by one or more patents and pending patent applications. UltraShape, the UltraShape wave, its logo and "The Shape of Things to Come" are trademarks or registered trademarks of UltraShape. Other trademarks are the property of their respective owners.
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