This audio program discusses the successful treatment of persistent methamphetamine-induced psychosis with electroconvulsive therapy; using functional MRI to differentiate activation of the amygdala in children with ADHD, bipolar disorder, and severe mood dysregulation; a longitudinal study finding criminality at age 23 to be related to poor fear conditioning at age 3; a long-term study showing that having a mother who experienced depressed mood during pregnancy increases the risk of schizophrenia in offspring with a family history of psychosis; and a clinical trial of integrated treatment for PTSD and substance use that tracked the temporal relationship of improvement in the two conditions. Articles can be viewed online at www.ajp.psychiatryonline.org.