The National Institute of Mental Health estimates that of the 43.4 million Americans who live with a mental illness, 16 million have depression. But how do you know if you’re one of them? And if you are, what does "depression" even mean? In Episode 1 of Life Effects, guest Dr. Jonathan Rottenberg describes how he learned to process his own depression, and explains what he’s discovered about the nuts and bolts of the condition after years of psychological research.