CONTENTS
NERVOUS SYSTEM
Functions of nervous tissue Classification of nervous systems Anatomical course of cranial nerve LYMPHATIC DRAINAGE Structure Anatomical distribution Site specific drainage Clinical correlations
ALL THE FUNCIONS ARE ACHIEVED BY THREE NERVOUS SYSTEMS OF THE BODY:
1. Central nervous system 2. Peripheral nervous system 3. Autonomic nervous system
2 divisions::
1. Sympathetic 2. parasympathetic
III
IV V VI
Occulomotor nerve
Trochlear nerve Trigeminal nerve Abducent nerve Opth.-Sensory
Motor
Motor Max.-Sensory Motor Mand.-Mixed
VII
IX X XI XII
Facial nerve
Glossopharyngeal nerve Vagus nerve Spinal accessory nerve Hypoglossal Nerve
Mixed
Sensory Mixed Mixed Motor Motor
OLFACTORY NERVE
OLFACTORY NERVE
Sensory in nature. Originates in upper nasal concha and superior part of nasal septum. Ends in medial surface of cerebral hemisphere & temporal lobe.
OLFACTORY NERVE
COURSE
Dissolution of inhaled
chemoreceptors.
Exaggeration of the action potential by olfactory receptor cells Pass through cribriform plate of ethmoid bone to synapse in secondary sensory neurons in olfactory bulb Amygdala
OLFACTORY NERVE
APPLIED ANATOMY
Smell is responsible for finer appreciation of taste. LOSS OF SMELL OR ANOSMIA: CAUSES
1. HEAD INJURIES: Sudden shift of cerebral hemisphere results in avulsion of olfactory bulb from brain. 2. FRACTURE OF CRIBRIFORM PLATE: May lead to damage to olfactory nerve and CSF rhinorrhoea. 3. TUMOURS: Tumours of the frontal lobe or those arising near the pitutary gland may cause pressure symptoms on olfactory tract. 4. CHRONIC TUBERCULOUS MENINGITIS
ROLE IN PROSTHODONTICS
1.Cobaltchromiumnickel damages nasal cells due to complex of carnosine with metal 2. methyl methacrylate-methacrylic acid.
OPTIC NERVE
OPTIC NERVE
Sensory nerve Not a peripheral nerve. Extension of the white matter of brain
OPTIC NERVE
COURSE
Begins the back of the eye Joins optic chiasma in cranial
cavity.
Extends to lateral geniculate nucleus in thalamus forming optic tract. Ends in visual cortex area in occiptal lobe
A) B)
WHEN A TUMUOR AFFECTS THE BASE OF FRONTAL LOBE , IT MAY PRESS UPON OPTIC NERVE:
Optic atrophy on the affected side, due to pressure.
eye prosthesis - to treat anopthalmous detailed anatomy should be kept in mind. Enucleation ,Evisceration
ROLE IN PROSTHODONTICS
Dr. Kalavathi S.D Restoring Ocular Esthetics Using Ocular Prosthesis Journal of Dental Sciences & Research 1:2: Pages 39-44
OCULOMOTOR NERVE
OCCULOMOTOR NERVE
OCCULOMOTOR NERVE
OCCULOMOTOR NERVE
APPLIED ANATOMY:
COMPLETE DIVISION OF OCCULOMOTOR NERVE ON ONE SIDE
a) Ptosis or drooping of the upper eyelid- paralysis of leavator palpebrae superioris b) External strabismus(squint)- unopposed action of lateral rectus c) Dilated or fixed pupil d) Loss of accommodation e) Apparent protrusion of eyeball- flaccid paralysis of ocular muscles. f) Diplopia- where false image is higher than true image.
TROCHLEAR NERVE
TROCHLEAR NERVE
intracranial course.
Supplies -superior oblique muscle.
TROCHLEAR NERVE
DEEP ORIGIN:
Periaqueductal grey
of 3rd nerve.
.
TROCHLEAR NERVE
COURSE
TROCHLEAR NERVE
APPLIED ANATOMY
IF TROCHLEAR NERVE IS INJURED
Patient is unable to turn his eye downward and laterally. NO difficulty in looking above horizontal plane. On attempting to look down, double vision is seen. To avoid, patient tilts his head forwards towards the sound side.
TRIGEMINAL NERVE
TRIGEMINAL NERVE
fifth cranial nerve mixed in nature It is the largest of the cranial nerves Nuclei 4 nuclei 1 motor and 3 sensory
TRIGEMINAL NERVE
GASSERION GANGLION
Also known as semilunar ganglion Developed from neural crest. Crescent shaped. Located in meckels cavity. Forms:
Central processes Peripheral processes
TRIGEMINAL CAVE
TRIGEMINAL NERVE
SENSORY ROOT OF TRIGEMINAL NERVE Fibres arise from the semilunar ganglion. Enter brainstem through side of pons.
TRIGEMINAL NERVE
SENSORY ROOT OF TRIGEMINAL NERVE Fibres arise from the semilunar ganglion. Enter brainstem through side of pons.
CENTRAL BRANCHES
(SENSORY ROOTS OF NERVE)
ASCENDING FIBRES
DESCENDING FIBRES
TRIGEMINAL NERVE
SENSORY ROOT OF TRIGEMINAL NERVE Fibres arise from the semilunar ganglion. Enter brainstem through side of pons.
CENTRAL BRANCHES
(SENSORY ROOTS OF NERVE)
ASCENDING FIBRES
DESCENDING FIBRES
TRIGEMINAL NERVE
SENSORY ROOT OF TRIGEMINAL NERVE Fibres arise from the semilunar ganglion. Enter brainstem through side of pons.
CENTRAL BRANCHES
(SENSORY ROOTS OF NERVE)
ASCENDING FIBRES
DESCENDING FIBRES
Terminate in SPINAL nucleus extending Caudally from upper sensory nucleus to 2nd cervical segment.
CONVEY:: Pain Temperature
OPTHALMIC nerve
MAXILLARY nerve
MANDIBULAR nerve
OPTHALMIC DIVISION:
Sensory in nature.
TRIGEMINAL NERVE
Route:
Leaves the anterior medial part of the ganglion and passes forward in the lateral part of cavernous sinus.
TRIGEMINAL NERVE
SUBDIVISIONS
LACRIMAL NERVE FRONTAL NERVE NASOCILLIARY NERVE
TRIGEMINAL NERVE
LACRIMAL NERVE::
Smallest of the three branches. Passes into orbit at lateral angle of
TRIGEMINAL NERVE
SUPRA ORBITAL NERVE: Largest branch Leaves orbit through Supra orbital foramen.
SUPPLIES: Skin of upper eyelid Ant. Scalp region to vertex of skull
TRIGEMINAL NERVE
NASOCILIARY NERVE::
Enters the orbit through superior orbital fissure. Supply- mucous membrane of the nose - the tip of the nose - the conjunctiva.
TRIGEMINAL NERVE
MAXILLARY DIVISION
SENSORY IN NATURE 2nd division of the trigeminal
nerve.
Tansmits afferent impulses from:
Upper lip
Lower eyelid
Tonsillar region Side of the nose Hard and soft palate
TRIGEMINAL NERVE
COURSE: Intracranial part:: Originates in the middle part of semilunar ganglion Passes forward in lower part of cavernous sinus Exits through foramen rotundum.
TRIGEMINAL NERVE
Extracranial part:: Enters pterygopalatine fossa. Enters inferior orbital fissure to enter orbital cavity. Runs laterally along infra orbital groove. Emerges through infra orbital foramen.
ZYGOMATIC SPHENOPALATINE POSTERIOR SUPERIOR ALVEOLAR MIDDLE SUPERIOR ALVEOLAR ANTERIOR SUPERIOR ALVEOLAR INFERIOR PALPEBRAL LATERAL NASAL SUPERIOR LABIAL
TRIGEMINAL NERVE
Emerges in the pterygopalatine fossa. Passes anteriorly and laterally through inferior orbital fissure into orbit.
DIVIDES INTO 2 PARTS::
1.
ZYGOMATICOFACIAL NERVE:
2.
ZYGOMATICOTEMPORAL NERVE:
TRIGEMINAL NERVE
BRANCHES:
ORBITAL NASAL -POSTERIOR SUPERIOR LATERAL NASAL
-MEDIAL OR SEPTAL BANCH
TRIGEMINAL NERVE
TRIGEMINAL NERVE
BRANCHES IN INFRAORBITAL GROOVE AND CANAL::
2. ANTERIOR SUPERIOR ALVEOLAR NERVE Descends from main trunk to emerge in infraorbital foramen.
TRIGEMINAL NERVE
As the infraorbital nerve is about to emerge from the foramen in front of maxilla it divides into:
3 TERMINAL BRANCHES ON FACE
LAT. NAS
TRIGEMINAL NERVE
MANDIBULAR DIVISION
Largest division of trigeminal nerve. Formed by SMALL MOTOR ROOT LARGE SENSORY ROOT SENSORY ROOT SUPPLIES:
Dura External ear Parotid gland TMJ articulation Lower teeth and gingiva Scalp over temporal region Ant. 2/3rd of the tongue. skin and mucous membrane of chin, cheek & lower lip. Muscles of mastication. Mylohyoid Anterior belly of digastric
TRIGEMINAL NERVE
COURSE
Motor root is located in middle cranial fossa Sensory root emerges from semilunar ganglion 2 roots pass alongside in cranium. Emerging from foramen ovale,they unite.
1. UNDIVIDED
NERVE:
posterior division
Auriculotemporal ,lingual, inferior alveolar
TRIGEMINAL NERVE
b.) NERVE TO INTERNAL PTERYGOID A branch passes to innervate internal pterygoid muscle. A sub branch passes for tensor veli palatini and tensor tympani muscles.
TRIGEMINAL NERVE
B.) MASSETER NERVE: Passes above the external pterygoid to traverse the mandibular notch and enter the deep side of masseter muscle.
Passes upwards crosses the infratemporal crest of sphenoid bone, enters the anterior deep part of the temporalis muscle.
TRIGEMINAL NERVE
TRIGEMINAL NERVE
POSTERIOR DIVISION
A. AURICULOTEMPORAL NERVE:
Arises by a medial and a lateral root. COURSE: Passes posteriorly,Deep to external pterygoid muscle. Between sphenomandibular ligament & neck of condyle.
TRIGEMINAL NERVE
ARTICULAR BRANCHES
AURICULAR BRANCHES MEATAL BRANCHES TERMINAL BRANCHES:: Supply scalp over the temporal region.
TRIGEMINAL NERVE
B. LINGUAL NERVE
Passes medially to external pterygoid muscle and descends, Lies between internal pterygoid muscle & ramus of mandible in pterygomandibular space. In pterygomandibular space,Lingual nerve lies parallel to inferior Alveolar
MYLOHYOID NERVE:
Branch of inferior alveolar nerve
APPLIED ANATOMY
TRIGEMINAL NEURALGIA
It is a neuropathic disorder characterized by episodes of intense pain in the face, originating from the trigeminal nerve Tic Doloureaux CLINICAL FEATURES Pain is unilateral (rarely bilateral). Duration of pain - few seconds to 1-2 minutes. Pain may occur several times a day;. patients typically experience no pain between episodes. Trigger zone
CAUSE 1. vascular compression superior cerebral artery 2. multiple sclerosis 3. Aneurysm 4. tumor 5. arachnoid cyst in the cerebellopontine angle 6. by a traumatic event such as a car accident or even a tongue piercing
Treatment
Medical Surgical
Medical Treatment
Carbamazepine Should be the initial Rx of choice for classical Trigeminal Neuralgia If get no or only partial response to carbamazepine, add or substitute another pharmacologic agent: Baclofen : 10 m- 80 mg daily Dilantin Lamictal
Surgical Treatment
Both percutaneous & open techniques
Glycerol injection Radio Rhizotomy Partial Rhizotomy Ballon Compression Gamma knife Microvascular decompression
ROLE IN PROSTHODONTICS
Trigger zone Development of a chronic pain state caused by injury to peripheral branches of the trigeminal nerve after surgical and nonsurgical procedures.
ABDUCENT NERVE
ABDUCENT NERVE Motor in nature Supplies lateral rectus muscle Lateral rectus muscle is responsible
Origin:
Nucleus situated beneath floor of fourth ventricle in dorsal part of pons.
ABDUCENT NERVE
Course
From pons, Pierces dura mater
cavernous sinus
Sup.Orbital fissure
ABDUCENT NERVE
APPLIED ANATOMY:
Involvement produces paralysis of lateral rectus,resulting in medial or convergent squint or diplopia. unable to look laterally
FACIAL NERVE
FACIAL NERVE
Mixed nerve Three nuclei -1 motor and 2 sensory Motor nucleus: it is present in the pons. sensory a) the superior salivatory nucleus: b)The nucleus of the tractus solitarius:
COURSE
Pons
COURSE
Behind the neck of mandible It divides into its Five terminal branches
BRANCHES
A.WITHIN THE FACIAL CANAL1.Greater petrosal nerve 2.Nerve to stapedius 3. Chorda tympani B.AT ITS EXIT FROM STYLOMASTOID FORAMEN 1.Posterior auricular 2.Digastric 3.Stylohyoid C.Terminal branches within parotid gland 1.Temporal 2.Zygomatic 3. Buccal 4.Mandibular 5.Cervical
APPLIED ANATOMY
GENICULATE GANGLION Ramsay hunt syndromeHerpes zoster infection of ganglion Signs Vesicles on ear, oral mucosa, tonsil, posterior one third of tongue Loss of taste Pain Decrease salivation Palatal paralysis
BELLS PALSY
Definition :- idopathic paralysis of facial nerve of sudden onset. Incidence :- 15 40 cases per one lac cases. Sex predilection :- F > M . It is 3.3 times more common in pregnant women ( especially in third trimester ) Age :- can occur at any age. More common in middle aged people. Side involvement :- equally involved left & right sides. Usually unilateral but in 1% cases bilateral involvement can be seen.
CLINICAL FEATURES Facial asymmetry Drooping of corner of mouth Inability to close eye Uncontrolled tearing Facial muscle atrophy Eyebrow droop Loss of forehead and nasolabial folds Pain near mastoid process Sensory loss Others- Hyperacusis,Dysgeusia
Congenital:i) Moebius Syndrome :Due to congenital nuclear aplasia. ii) MelkerssonRosenthal Syndrome :Cheilitis Granulomatosa + Facial Palsy + Scrotal Tongue
Neoplastic :-
ii) Viral causes :- Herpes zoster (Ramsay Hunt Syndrome ), mumps, infectious mononucleosis iii) Bacterial causes :- Diphtheria, Tuberculosis
TREATMENT
Eighty percent of patients with Bell's palsy have normal or nearnormal recovery without any treatment.
ROLE IN PROSTHODONTICS
Complete denture fabrication in patient with bells palsy
primary and final impressions excessive material is incorporated on the affected side The polished surface of denture base was contoured by functions of the tongue and action and tonus of affected and unaffected lips and cheek Occlusal wax Rims - Midline placed in the middle of the oral cavity rather than the facial midline Non anatomic posterior teeth are used to establish the centric occlusion Some improvement of the appearance can be achieved by: 1. Placing the mesio-incisal point in the middle of the mouth rather than the middle of the face 2. keep the cant of the occlusal plane on the affected side a little low for incisal show 3. Buccal sulcus support - Placing buccal support on the affected side to reduce the facial droop.This will also help reduce the accumulation of food in the affected buccal vestibule
Suresh S Prosthodontic management of complete edentulous patients with neuromuscular disorders Case reports. Journal of Advanced Dental Research Vol II : Issue I: January, 2011
VESTIBULOCOCHLEAR NERVE
VESTIBULOCOCHLEAR NERVE
This nerve is responsible for transmitting sound and equilibrium (balance) information from the inner ear to the brain. NUCLEUS -2 cochlear nucleii in inferior cereberal peduncle -4 vestibular nucleii in pons and medulla
COURSE
The cochlear nerve travels away from the cochlea of the inner ear where it starts as the spiral ganglia.Connects organ of corti to cochlear nuclei The vestibular nerve travels from the vestibular system of the inner ear. The vestibular ganglion houses the cell bodies of the bipolar neurons
APPLIED ANATOMY
Damage vestibulocochlear nerve may cause the following symptoms hearing loss, vertigo , false sense of motion , loss of equilibrium (in dark places) , nystagmus , motion sickness , tinnitus.
GLOSSOPHARYNGEAL
Mixed nerve Motor fibres stylopharyngeus Sensory fibres pharynx, tonsils, posterior part of tongue,parotid gland Nuclei - medulla
COURSE
COURSE Medulla Jugular foramen
Inferior
BRANCHES
1.TYMPANIC NERVE 2.CAROTID 3.PHARYNGEAL 4.MUSCULAR 5.TONSILLAR 6.LINGUAL
APPLIED ANATOMY
1.Tested clinically Tickling posterior wall of pharynx Taste sensibility on posterior one third of tongue 2.Isolated lesions- Unknown 3.Neuralgia 4. Involved in swallowing and gag reflex, considered to be as the taste nerve, mainly for the sweet and bitter tastes.
GLOSSOPHARYNGEAL NEURALGIA DEF.-It consists of recurring attacks of severe pain in back of throat near the tonsils and back of tongue due to malfunction of cranial nerve IX. Cause-unknown, -artery that compresses the glossopharyngeal nerve , -tumor in the brain or neck
CLINICAL FEATURES
ROLE IN PROSTHODONTICS
GAG REFLEX - Nausea manifests itself through an unpleasant feeling that precedes the sensation of vomiting
Lavinia Ardelean, et al .Gag reflex in dental practice etiological aspects. TMJ 2003, vol. 53, no. 3-4
PHYSIOLOGICAL MECHANISMS
Inborn reflex Regresses in first four years of life. It becomes more posterior after the appearance of the first dentition(tonsil pillars) The persistence - orofacial immaturity in forms of dysphagia. The sensor stimuli are detected by three types of receptors - orofacial, digestive, blood flow level.
OROFACIAL RECEPTORS
REAL REFLEX FIELD palatine veil, posterior pharynx ,tonsillar pillars , receptors,tongue papillae that carry the taste buds are rich in nociceptive
DIGESTIVE RECEPTORS
The afferences coming from the digestive tract, conveyed mainly through the vagus nerve, reach the solitary nucleus
BLOOD-FLOW RECEPTORS
Pathological humoral alterations, such as uremia or drug poisoning can act on the bulbar centre of vomiting. The hormonal changes inherent to pregnancy act through the blood flow and may induce nausea.
INBORN REFLEXES
Any risk of blocking the airways triggers the gag reflex. This depends mainly on two factors: oral breathing hypersalivation
ACQUIRED REFLEXES
GENERAL
LOCAL ORIGIN
Olfactory/taste stimuli Mechanical stimuli Acoustic stimuli Visual stimuli Psychic stimuli
Milind Limaye, Naveen HC, Aditi Samant. The gag reflex etiology and management. International Journal of Prosthetic Dentistry.2010:1(1):10-14. 2010 International Journal of Prosthetic Dentistry
PROSTHODONTIC TECHNIQUES
Borkin recommends low-fusing wax as an impression material Webb suggests that distortion of tissue contour due to injection of anesthetic solution can be minimized by adding hyaluronidase (I-3cc) to 2 % lidocaine HCI (1cc).
PALATE LESS DENTURES: A cast metal denture base of aluminum or chrome nickel alloy is recommended THE MARBLE TECHNIQUE SYSTEMATIC DESENSITIZATION ERRORLESS LEARNING- The patient is instructed to set aside time to position the denture closer each day and eventually into the mouth in successive approximations
Training bases - A thin acrylic denture base, without teeth is fabricated and the patient is asked to wear it at home, gradually increasing the length of time the training base is worn
VAGUS
Mixed nerve Nuclei-located in medulla
VAGUS
3.Superior laryngeal External Laryngeal (cricothyroid) Internal laryngeal (mucous membrane of the pharynx and larynx)
APPLIED ANATOMY
1.Tested clinically- Comparing palatal arches 2.Paralysis Nasal regurgitation-pharyngeal branch Nasal twang in voice - recurrent laryngeal nerve Hoarseness of voice recurrent laryngeal nerve Flattened palatal arch - pharyngeal branch Dysphagia pharyngeal branch
ACCESSORY NERVE
Motor nerve Nucleus nucleus ambiguus Formed by spinal and cranial roots
APPLIED ANATOMY
IT IS TESTED CLINICALLY1.ASKING PT. TO SHRUG HIS SHOULDERS 2.TURN FACE TO OPPOSITE SIDE WRY NECK
HYPOGLOSSAL NERVE
Motor nerve Nucleus- hypoglossal nucleus in medulla
COURSE OF NERVE
hypoglossal nucleus hypoglossal canal
It spirals behind the vagus nerve and passes between the internal carotid artery and internal jugular vein (carotid sheath)
submandibular region to enter the tongue
BRANCHES
1. Meningeal branch 2. Descending ramusOmohyoideus,Sternohyoideus , the Sternothyreoideus, and the inferior belly of the
Omohyod.
3. Thyrohyoid 4. Geniohyoid
APPLIED ANATOMY
Tested clinically- Protrude tongue Lesion of nerve- Paralysis of tongue A.Infranuclear lesions Gradual atrophy In motor neuron disease , syringobulbia
FUNCTION
To provide an accessory route for the excess plasma to get returned to the blood. Secondly the lymphatic organs play an important part in the immune system
LYMPH
Lymph is the fluid that circulates throughout the lymphatic system. The lymph is formed when the interstitial fluid is collected through lymph capillaries.It is then transported though lymph vessels to lymph nodes before emptying ultimately into the right or the left subclavian vein, where it mixes back with blood.
FUNCTION OF LYMPH
Lymph returns protein and excess interstitial fluid to the circulation. Lymph may pick up bacteria and bring them to lymph nodes where they are destroyed. Metastatic cancer cells can also be transported via lymph. Lymph also transports fats from the digestive system
LYMPH NODE
SURFACES
SUBCAPSULAR SINUS
OUTER CORTEX
INNER MEDULLA
INCLUDES
OCCIPITAL NODES
Location - the superior angle of the posterior triangle superficial to the upper attachment of trapezius
Drainage - the occipital scalp
Afferents from the parotid posterior-auricular , occipital , superficial cervical , submandibular , retropharyngeal and prelaryngeal lymph nodes
Drains wide areas of face , oral cavity , tongue , tonsils , nose , nasal cavity , nasopharynx , parotid and submandibular gland and supraglottic larynx .
afferents from the upper deep cervical nodes , submental nodes , suprahyoid nodes , prelaryngeal nodes , paratracheal nodes
CLINICAL CONSIDERATIONS
PREAURICULAR NODES
Stand behind the patient Gently tilt the head to the opposite side of node being palpated Roll your finger in front of the ear, against the bone.
POSTAURICULAR NODES
Stand behind the patient Gently tilt the head to the opposite side of node being palpated
Roll your finger behind the auricle , against the mastoid process.
SUBMANDIBULAR NODES
Stand behind the patient Gently tilt the head to the same side of node being palpated Roll your fingers against inner surface of mandible applying pressure against the bone.
SUBMENTAL NODES
Stand behind the patient Gently tilt the head in front . Roll your fingers against inner surface of symphysis applying pressure against the bone.
NEOPLASTIC
CAVERNOUS HEMANGIOMA GIANT CELL LYMPHOMA LYMPHOEPITHELIOMA LYMPHOENDOTHELIOMA LYMPHANGIOSARCOMA UNDIFFRENTIATED LYMPHOMA HODGKINS DISEASE NON-HODGKINS DISEASE
Lymphangitis Lymphadenitis Lymphoedema Lymphadenopathy
INFLAMMATORY
DEVELOPMENTAL PATHOLOGY
CYSTIC HYGROMA - A cystic hygroma is a congenital multiloculated lymphatic lesion that can arise anywhere, but is classically found in the left posterior triangle of the neck. This is the most common form of lymphangioma
CONGENITAL LYMPHEDEMA - Congenital lymphedema is a blockage of fluid in the developing fetal lymphatic system.
INFLAMMATORY PATHOLOGIES
LYMPHANGITIS - Lymphangitis is an inflammation of the lymphatic channels that occurs as a result of infection at a site distal to the channel. The most common cause of lymphangitis in humans is Streptococcus pyogenes LYMPHADENITIS is an infection of the lymph nodes.
Causes are Viral -Common upper respiratory infections,Infectious mononucleosis ,cytomegalo virus,Acquired immunodeficiency syndrome,Rubella,Varicella,Measles Bacterial Septicemia , Typhoid fever, Tuberculosis, Syphilis, Plague Protozoal - Toxoplasmosis Fungal - Coccidioidomycosis
LYMPHOEDEMA - Lymphedema is a
condition characterized by swelling in one or more extremities that results from impaired flow of the lymphatic system. Causes are most commonly filariasis in india, and after breast cancer surgery.
REFERENCES
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7.
N Torbica, S Krstev World at work: Dental laboratory technicians.Occup Environ Med2006;63:145-148 Lavinia Ardelean, et al .Gag reflex in dental practice etiological aspects. TMJ 2003, vol. 53, no. 3-4 Dr. Kalavathi S.D Restoring Ocular Esthetics Using Ocular Prosthesis Journal of Dental Sciences & Research 1:2: Pages 39-44 Delcanho RE Neuropathic implications of prosthodontic treatment.J Prosthet Dent. 1995 Feb;73(2):146-52 Suresh S Prosthodontic management of complete edentulous patients with neuromuscular disorders - Case reports. Journal of Advanced Dental Research Vol II : Issue I: January, 2011 Lavinia Ardelean, et al .Gag reflex in dental practice etiological aspects. TMJ 2003, vol. 53, no. 3-4 Milind Limaye, Naveen HC, Aditi Samant. The gag reflex etiology and management. International Journal of Prosthetic Dentistry.2010:1(1):10-14. 2010 International Journal of Prosthetic Dentistry Grays Anatomy Oral Anatomy Sichers B. D. Chaurasia's human anatomy Netters Atlas of Human Anatomy Clinically Oriented Anatomy Moore & Dalley Development of Human Body Moore & Persaud Medical Physiology- Ganong
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