Dental pulp
Dental pulp
Dental papilla becomes dental pulp after beginning of dentinogenesis Dental pulp is a specialized connective tissue
Positioned inside a rigid chamber Has a role in forming hard tissue Periphery contains
The rest of the dental pulp acts as a support system for peripheral components
Blood vessels and nerves that enter & leave through an apical foramen Cells and collagen fibers
Accessory canals
Forms a scaffold that stabilizes the structure of the tissue Controls cellular activity
Fibers
Collagen
Type I (56%)
Thin & scattered in young teeth Irregular arrangement Near predentine, fibers are regularly arranges parallel to predentine surface
Fibrillin
Non-fibrous matrix
Glycosaminoglycans Hydrophilic Swell when hydrated accounting for High pressure in the dental pulp Mechanical support Easy movement of water-soluble molecules Types Chondroiten sulphate - predominent Dermatan sulphate small amounts Heparan sulphate Hyaluronan sulphate mostly unbound to proteins Proteoglycans Act as adhesion molecules bound to cell membranes and bind signaling molecules like GFs Other adhesion molecules Fibronectin that regulates cell shape, migration & differentiation Lamenin Around endothelial cells of blood vessels & Schwann cells Coating cell bodies and processes of odontoblasts
Cells
Odontoblasts Fibroblasts Defence cells Undifferentiated cells
Odontoblasts
Formation of dentine Survive for as long as the tooth is vital Odontoblasts cannot divide but subodontoblasts can Polarized columnar cells with processes extending within a tubule In root region, cells are more cuboidal Odontoblastic cell layer has A membrane-like properties Acts as a barrier to protect the dental pulp from outside irritants A limited permeability due to Desmosomes Tight junctions Gap junctions
Fibroblasts
Linked by adherense type junctions & gap junctions Stellate cells with star-like extensions Undergo cell division Functions
Production of fibers & ground substance and participate in their degradation May produce bone-like mineralized tissue as a response to pulpal injury Production of GFs and cytokines
Defence cells
T-lymphocytes
Undifferentiated cells
Blood vessels
Run longitudinally through root canals from the apical foramena Gives off side branches while within the canals Branch profusely once they reach the pulp chamber Capillary loops extend towards the dentine Subodontoblastic capillary plexus Capillaries are present within & below the odontoblastic layer but do not enter the tubules Arteriovenous and venous-venous anastomosis Lymphatic vessels are hard to destinguish Nerve endings are associated with smooth muscles of arteriole walls Pulp has a high pulsatile interstitial fluid pressure which allows dentinal fluids to move outwards
Nerves
Dental pulp is highly innervated Scant perineurium or epineurium Two types of nerve fibers
90% of which are narrow A fibers 10% are wider A fibers Afferents or Autonomic
Unmyelinated C fibers
Nerves
Run along side the blood vessels in the center of the pulp Branch profusely in the odontoblastic & subodontoblastic regions In the crown, subodontoblastic plexus is known as plexus of Raschkow
Evident only after eruption Some branches reach between odontoblasts & predentine Others continue & join the processes within the tubules May be a site of sensory activation as evident because axons lack Schwann cell covering
A fibers A fibers
Afferents
Unmyelinated C fibers
Conduction of noxious stimuli to CNS Axon reflexes to control blood flow Sympathetic fibers supply the smooth muscles of arteriolic walls Evidence of parasympathetic supply is weak
Autonomic
*Some pulpal fibers may have a role in controlling the activity of odontoblasts
Nerve endings
Some A fibers enter the tubules in the coronal dentine Others end in predentine pulp junction It is suggested that there is a specialized junction between nerve endings & odontoblasts
Supraodontoblastic region
Not present in vital pulps Due to shrinkage of pulpal tissue during perparation Two structures are present
Regions
No cells are evident Only axons & cell processes of fibroblasts & other cells Usually absent in radicular pulp Appears in contrast to cell-free zone Capillaries and nerve plexuses that contain the cell bodies of Schwann cells, endothelial cells, etc.
Cell-rich zone
Central region
The bulk of the dental pulp Central neurovascular core Fibroblasts, defence cells, undifferentiated cells Collagenous matrix and ground substance
Regions
Age-related changes
Getting smaller Reduction in vascular, neural & cellular contents Increase in fibrous matrix Some degree of mineralization
Pulp stones
Single vs. groups True (dentine-like that may be lamellated) vs. false (bone-like) Free vs. attached Tiny spicules throughout the pulp