FUNGSI LUHUR
Fungsi yang menghubungkan struktur otak dengan perilaku manusia, mencakup 5 aspek : 1. Atensi ( perhatian ) 2. Bahasa 3. Memori (daya ingat ) 4. Visuospasial (pengenalan ruang) 5. Fungsi eksekutif (perencanaan, pengorganisasian dan pelaksanaan) Gangguan fungsi luhur : ringan berat (pikun)
The Division of Cognitive and Behavioral Neurology : provides a comprehensive, multidisciplinary approach to the diagnosis and management of patients who have problems with memory, executive functions, attention, language, emotion, or behavior due to disease, injury, or developmental disorders of the central nervous system. Patients receive the highest standard of neurologic, psychiatric, and social work care for the treatment of their conditions.
in the assessment and treatment of diverse clinical problems including: - Dementia (e.g., Alzheimers disease and related degenerative disorders, vascular dementia, frontotemporal dementia, dementia with parkinsonism) - Cognitive, Emotional, or Behavioral Problems due to Diverse Conditions (e.g., epilepsy, multiple sclerosis, stroke, traumatic brain injury, brain tumor, systemic diseases with central nervous system manifestations) - Developmental Disorders in Adults (e.g., Attention deficit disorder, learning disabilities, mental retardation, autism)
Basic brain biology A simplified model of the human brain consists of many parts: - Brain stem, hind brain, mid brain & cerebellum the most ancient parts, connected to the spine, controls movement, breathing and heartbeats. - Limbic system - consisting of many specialist organs including the Hypothalamus, hippocampus -developed in mammals. Some memory functions and generation of emotional responses. - Cerebral cortex - the distinguishing feature of human brains
Each hemisphere of the cortex can further be divided into four lobes: Occipital - visual processing Parietal - movement, orientation, calculation, recognition Temporal - sound and speech processing, aspects of memory Frontal - thinking, conceptualisation, planning.
Some specific differences between the two hemispheres resulted from this and subsequent research. The right-brain is better at:
Left Hemisphere Right Hemisphere
Specialities
Copying of designs, Discrimination of shapes e.g. picking out a camouflaged object, Understanding geometric properties, Reading faces, Music, Global holistic processing, Understanding of metaphors, Expressing emotions, Reading emotions. Sensations on both side of face, Sound perceived by both ears, Pain, Hunger, Position. Negative emotions (fearful mournful feelings), Higher levels of norepinephrine More white-matter (longer axons) on right
Shared
Positive emotions Higher levels of dopamine more grey-matter (cell bodies) on the left
SIRKUIT AMIGDALA
( LINTASAN EMOSI ) dengan bagian Otak lain
Hipokampus
Mendengar kata-kata
Mengucapkan kata-kata
PATOGENESIS
GAMBARAN PET Scan : Peningkatan aktifitas amigdala pada orang yang melihat kata-kata ancaman
DEMENTIA
DEFINITION:
Group of symptoms that can be caused by over 60-70 disorders. Syndrome which refers to progressive decline in intellectual functioning severe enough to interfere with persons normal daily activities and social relationships. (National
Institute on Aging-1995 No. 95-3782)
Dementia
Marked by progressive, irreversible declines in
memory. visual-spatial relationships performance of routine tasks language and communication skills abstract thinking ability to learn and carry out mathematical calculations.
Dementia
Two Types:
Reversible Irreversible
Individuals must have intensive medical physical to rule out reversible types of dementia.
Dementia
Reversible:
D= E= M= E= N= T= I= A Drugs, Delirium Emotions (such as depression) and Endocrine Disorders Metabolic Disturbances Eye and Ear Impairments Nutritional Disorders Tumors, Toxicity, Trauma to Head Infectious Disorders Alcohol, Arteriosclerosis (Dick-Mulheke- Overview of
Alzheimer's Disease)
Dementia
Irreversible:
Alzheimers Lewy Body Dementia Picks Disease (Frontotemperal Dementia) Parkinsons Heady Injury Huntingtons Disease Jacob-Cruzefeldt Disease
ETIOLOGI
Penyakit Alzheimer Demensia Vaskuler Pseudodemensia Demensia alkoholik Tumor intrakranial NPH Intoksikasi Huntington Penyakit lain 50% 10% 8% 7% 5% 5% 3% 2% 10%
Normal Cognition
Brain Aging
stable or stable or reversible reversible impairment impairment
Prodromal Dementia
revers
Dementia
other
Alzheimer's Disease
Estimated that 4,000,000 people in U.S. have Alzheimer's disease. Estimated that 25-35% of people over age 85 have some time of dementia. After age 65 the percentage of affected people, doubles with every decade of life. Caring for patient with Alzheimer's disease can cost $47,000 per year (NIH).
Genetic Theories
ApoE4 on chromosone 19 linked to late-onset Alzheimers Disease.
Metabolic Theories
Glucose metabolism declines dramatically in Alzheimers patients.
Calcium Theories
Too much calcium can kill cells. Suspect that it may reason why neurons die in Alzheimer's patients.
Viral
May be hidden in body and attack brain cells years later. (NIH-1995)
Neuronal Degeneration
The pathobiology of Alzheimers disease is characterized by: Amyloid plaques Neurofibrillary tangles
Neurofibrillary Tangles
Intracellular inclusion bodies consisting of paired helical filaments that appear in a characteristic double-helix shape. Filaments appear to be composed of a hyperphosphorylated microtubuleassociated protein called tau. Remains of damaged neuronal microtubules.
Amyloid Plaques
Plaques are extracellular structures that are more prevalent in the Alzheimers patients brain, particularly in the hippocampus and neocortex. Amyloid (neuritic) plaques in Alzheimers disease are dense and insoluble structures. Plaques consist of a central core of betaamyloid protein surrounded by abnormal axons and dendrites.
Apraxiainability to initiate complex learned motor movement or unable to perform activity on command Agnosia---inability to recognize familiar objects by sight, touch, taste, smell or sound
Diagnostic Tests
Neurological Exam Brain Imagingshrinkage, atrophy of brain (CT or MRI) Blood Work
Reprinted with permisssion from Crum RM, Anthony JC, Basset SS, Folstein MF. Population-based norms for the mini-mental state examination by age and educational level. JAMA 1993 ; 18 : 2386-91