Definisi
Hemostasis adalah mekanisme tubuh untuk menghentikan perdarahan dan mencegah perdarahan spontan
Haemostasis
Vascular injury
tissue thromboplastin
vaso constriction
F XII activation
primary platelet aggregation PF3 ADP 5 OH tryptamin TxA2 secondary platelet aggregation (semi permeable platelet plug) fibrin
Fungsi trombosit
Sistem koagulasi
Factor I Factor II Factor III Factor IV Factor V Factor VII Factor VIII Fibrinogen Prothrombin Thromboplastin jaringan Calsium ion Proaccelerin Proconvertin Anti hemophilic factor
Sistem koagulasi
Factor IX Christmas factor
Factor X
Factor XI
Factor XII
Factor XIII
Hageman factor
Fibrin stabilizing factor
Prekallikrein
Fletcher factor
Negative surface Kal. PK HMWK XII XIIa XI IX XIa IXa Ca++ VIII Pf 3 VIIIa X Pf3 Va Prothrombin Xa Ca++
Tissue thromboplastin
VIIa
VII
Ca++
F1.2
Fibrinogen
+ Thrombin
Fibrin monomer Fibrin polimer XIIIa
FPA FPB
XIII
Stabilized fibrin
Penyebab perdarahan
1. Kelainan vaskular 2. Kelainan trombosit 3. Kelainan sistem koagulasi
Pemeriksaan hemostasis
Tujuan : untuk mencari penyebab perdarahan
Pemeriksaan hemostasis
Penyaring: Khusus: Masa trombin Hitung trombosit Fibrinogen Uji pembendungan Agregasi trombosit M. Perdarahan D dimer Masa protrombin PT F VIII, F IX Antitrombin III Masa tromboplastin parsial teraktivasi APTT Protein C dan S Thrombotest Masa pembekuan Lupus anticoagulant
Persiapan pasien
Puasa : tidak mutlak Makanan : sayuran hijau (vit K INR), ginseng, bawang, jamur, rumput laut (agregasi trombosit) Obat-obatan: aspirin, NSAID (agregasi trombosit) obat yang mempengaruhi warfarin INR Exercise: sistem fibrinolisis (t-PA)
Coagulation disorders
Vascular disorders
Etiology :
Malformation of structure Inflammatory process or immunologic reaction
Classification :
Hereditary abnormalities Acquired disorders
Hereditary abnormalities
Hereditary hemorrhagic telangiectasia Ehlers-Danlos syndrome
Osteogenesis imperfecta
Pseudoxanthoma elasticum
Simplex purpura
Women during menstrual period The cause is unclear Tourniquet test and bleeding time : normal
Scurvy
Cause : vitamin C deficiency Collagen formation disturbed Increase vascular fragility
Perifollicular petechiae
Bleeding time : prolonged
Increase destruction:
Idiopathic thrombocytopenic purpura Drug-induced thrombocytopenia
Increase consumption:
Disseminated intravascular coagulation Thrombotic thrombocytopenic purpura
Thrombocytosis
Physiologic thrombocytosis : epinephrine, exercise Pathologic thrombocytosis :
primary thrombocytosis (thrombocythemia)
secondary thrombocytosis (reactive
thrombocytosis)
Hemophilia A
x-linked recessive affects man, women acts as carrier deficiency or dysfunction of F VIII
moderate : VIII 1 - 5%
mild : 5 - 20 %
PT
Thrombin Time APTT : prolonged F IX activity low
mucosal bleeding
Deficiency or dysfunction of vWF bleeding time prolonged aggregation by ristocetin abnormal PT, TT normal APTT : normal or prolonged F VIII activity: normal or low