Chih-Kang Chou, MD
Chief Complain
A 45 y/o male came to the ER with erythematous swelling of the right leg and multiple large hemorrhagic bullae.
Present Illness
Right leg erythematous swelling and multiple bullae since one day ago. Fever, chillness and pain over right leg, so he came to our ER on 100.10.24. No known history of any sea food contact, trauma, or insect bites. Under the impression of right leg necrotizing fasciitis, he was admitted to our ward.
10/24
10/25
10/26
10/27
10/24
10/25
10/28
10/29
10/31
11/1
10/26
10/28
11/3
11/6
11/7
11/8
11/07 11/01
Laboratory Data
data date WBC Hb Platelet Neutrophil Lymphocyte Bun Cr Na K CRP NH3 Alb GOT GPT Bil(T/D) Osm Digoxin
18
2.3
139
101
50
45
2.8
139
3.4
55
1.9
162 165
3.4 3.6
24
11/02
11/04 11/07
10400
8400 6200
11.0
9.1 7.2
25000
59000 25000 73.4 23.0 41 1.8
162
162 156 3.3 3.6 57.5 37 2.1 2.0 94
25.13/18 373
0.61
Bacterial Culture
Wound culture: Aeromonas hydrophila Blood culture: Aeromonas hydrophila/ caviae
Aeromonas hydrophila ()
Found in all freshwater environments as well as brackish, chlorinated, and unchlorinated water. Both a gram-negative rod and a facultative anaerobe. Can grow in temperatures as low as 4oC. These bacteria are motile by a polar flagella. Very toxic to many organisms. When it enters the body of its victim, it travels through the bloodstream to the first available organ. Produces Aerolysin Cytotoxic Enterotoxin (ACT), a toxin that can cause tissue damage. Considered to be opportunistic pathogens, meaning they rarely infect healthy individuals. Considered a major fish and amphibian pathogen, and its pathogenicity in humans has been recognized for decades.
Sepsis: bacteremia often associated with malignancy, hepatobiliary disease such as cirrhosis, less commonly with diabetes. Bone: osteomyelitis, septic arthritis CNS: meningitis (rare) Cardiac: endocarditis (rare)
Gastroenteritis
Through oral contact with contaminated water, food, soil, feces, and/or ingestion of contaminated fish or reptiles. Two types of gastroenteritis.
1. Similar to cholera, which causes rice-water diarrhea. 2. Dysenteric gastroenteritis, which causes loose stools filled with blood and mucus. Dysenteric gastroenteritis is the most severe out of the two types, and can last for multiple weeks.
Antibiotics treatment
Resistant to penicillin, ampicillin, carbenicillin, and ticarcillin. Susceptible to broad-spectrum cephalosporins, aminoglycosides, carbapenems, chloramphenicol, tetracycline, trimethoprim-sulfamethoxazole, and quinolones.
Classification
Type I, or polymicrobial, after trauma or surgery.
A variant of NF type I is saltwater NF, a Vibrio species.
Type II, or group A Streptococcal. Type III gas gangrene, or clostridial myonecrosis.
Fourniers Gangrene
Vibrio Vulnificus
Vibrio Vulnificus
Treatment of NF
Aggressive resuscitation to maintain hemodynamic stability. Broad-spectrum antibiotics to cover aerobic gram-positive & gram-negative organisms and anaerobes. Surgical debridement, early and aggressive, multiple and extensive. Following fluid resuscitation and nutritional support. Wound care, & wound reconstruction. Hyperbaric oxygen (HBO)
Conclusion
Aeromonas hydrophila infection is frequently the cause of necrotizing fasciitis in patients with suppressed immune systems, diabetes, burns, and trauma in an aquatic setting. These patients require aggressive antimicrobial therapy and debridement and the mortality rate is high. Individuals that fail to respond to these treatment measures may require amputation.